3mdi - Revision history

OCA at 08:51, 6 September 2023

2023-09-06T08:51:48Z

←Older revision		Revision as of 08:51, 6 September 2023
Line 1:		Line 1:

	==Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA==		==Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA==
-	<StructureSection load='3mdi' size='340' side='right' caption='[[3mdi]], [[Resolution\|resolution]] 2.07Å' scene=''>	+	<StructureSection load='3mdi' size='340' side='right'caption='[[3mdi]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mdi]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MDI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mdi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MDI FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.07Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mdg\|3mdg]]~~, [[~~2cl3~~\|~~2cl3]], [[2j8q\|2j8q]], [[3bap\|3bap]], [[3bho\|3bho~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CFIM25, CPSF25, CPSF5, NUDT21 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdi OCA], [https://pdbe.org/3mdi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mdi RCSB], [https://www.ebi.ac.uk/pdbsum/3mdi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mdi ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdi OCA], [~~http~~://pdbe.org/3mdi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mdi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mdi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mdi ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN]] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref>	+	[https://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Doublie, S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Gilmartin, G M~~]]	+	[[Category: Doublie S]]
-	[[Category: ~~Yang, Q~~]]	+	[[Category: Gilmartin GM]]
-	[[Category: ~~Cf im]]~~	+	[[Category: Yang Q]]
-	~~[[Category: Cleavage factor]]~~	+
-	~~[[Category: Cpsf5]]~~	+
-	~~[[Category: Mrna processing]]~~	+
-	~~[[Category: Nudix protein]]~~	+
-	~~[[Category: Protein-rna complex]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rna binding-rna complex~~]]	+

OCA at 07:18, 9 January 2019

2019-01-09T07:18:49Z

←Older revision		Revision as of 07:18, 9 January 2019
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/3mdi_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/3mdi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:12, 5 August 2016

2016-08-05T07:12:45Z

←Older revision		Revision as of 07:12, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA==		==Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA==
	<StructureSection load='3mdi' size='340' side='right' caption='[[3mdi]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='3mdi' size='340' side='right' caption='[[3mdi]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mdi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MDI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mdi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MDI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mdg\|3mdg]], [[2cl3\|2cl3]], [[2j8q\|2j8q]], [[3bap\|3bap]], [[3bho\|3bho]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mdg\|3mdg]], [[2cl3\|2cl3]], [[2j8q\|2j8q]], [[3bap\|3bap]], [[3bho\|3bho]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFIM25, CPSF25, CPSF5, NUDT21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFIM25, CPSF25, CPSF5, NUDT21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mdi RCSB], [http://www.ebi.ac.uk/pdbsum/3mdi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdi OCA], [http://pdbe.org/3mdi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mdi RCSB], [http://www.ebi.ac.uk/pdbsum/3mdi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mdi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mdi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mdi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Doublie, S]]		[[Category: Doublie, S]]
	[[Category: Gilmartin, G M]]		[[Category: Gilmartin, G M]]

OCA at 16:47, 25 December 2014

2014-12-25T16:47:13Z

←Older revision		Revision as of 16:47, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mdi RCSB], [http://www.ebi.ac.uk/pdbsum/3mdi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mdi RCSB], [http://www.ebi.ac.uk/pdbsum/3mdi PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN]] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:39, 18 December 2014

2014-12-18T17:39:59Z

←Older revision		Revision as of 17:39, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3mdi\| PDB=3mdi \| SCENE= }}~~	+	==Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA==
-	===Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA===	+	<StructureSection load='3mdi' size='340' side='right' caption='[[3mdi]], [[Resolution\|resolution]] 2.07Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20479262}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mdi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MDI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mdg\|3mdg]], [[2cl3\|2cl3]], [[2j8q\|2j8q]], [[3bap\|3bap]], [[3bho\|3bho]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CFIM25, CPSF25, CPSF5, NUDT21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mdi RCSB], [http://www.ebi.ac.uk/pdbsum/3mdi PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/3mdi_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human Cleavage Factor Im (CFI(m)) is an essential component of the pre-mRNA 3' processing complex that functions in the regulation of poly(A) site selection through the recognition of UGUA sequences upstream of the poly(A) site. Although the highly conserved 25 kDa subunit (CFI(m)25) of the CFI(m) complex possesses a characteristic alpha/beta/alpha Nudix fold, CFI(m)25 has no detectable hydrolase activity. Here we report the crystal structures of the human CFI(m)25 homodimer in complex with UGUAAA and UUGUAU RNA sequences. CFI(m)25 is the first Nudix protein to be reported to bind RNA in a sequence-specific manner. The UGUA sequence contributes to binding specificity through an intramolecular G:A Watson-Crick/sugar-edge base interaction, an unusual pairing previously found to be involved in the binding specificity of the SAM-III riboswitch. The structures, together with mutational data, suggest a novel mechanism for the simultaneous sequence-specific recognition of two UGUA elements within the pre-mRNA. Furthermore, the mutually exclusive binding of RNA and the signaling molecule Ap(4)A (diadenosine tetraphosphate) by CFI(m)25 suggests a potential role for small molecules in the regulation of mRNA 3' processing.

-	~~==Function==~~	+	Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing.,Yang Q, Gilmartin GM, Doublie S Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10062-7. Epub 2010 May 17. PMID:20479262<ref>PMID:20479262</ref>
-	~~[[http://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN]] Component~~ of the ~~cleavage factor Im~~ (~~CFIm~~) ~~complex that plays~~ a ~~key~~ role in ~~pre-~~mRNA 3'-processing. ~~Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(~~A~~) site cleavage and poly~~(A) ~~addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence~~-~~specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides~~. May ~~have a role in mRNA export~~.~~<ref>~~PMID:~~9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref>~~ <ref>PMID:20479262</ref> ~~<ref>PMID:21295486</ref>~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3mdi]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020479262</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Doublie, S.]]	+	[[Category: Doublie, S]]
-	[[Category: Gilmartin, G M.]]	+	[[Category: Gilmartin, G M]]
-	[[Category: Yang, Q.]]	+	[[Category: Yang, Q]]
	[[Category: Cf im]]		[[Category: Cf im]]
	[[Category: Cleavage factor]]		[[Category: Cleavage factor]]

OCA: Protected "3mdi" [edit=sysop:move=sysop]

2013-04-10T23:32:06Z

Protected "3mdi" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:32, 10 April 2013

OCA at 23:32, 10 April 2013

2013-04-10T23:32:02Z

←Older revision		Revision as of 23:32, 10 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3mdi.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3mdi", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3mdi\| PDB=3mdi \| SCENE= }}		{{STRUCTURE_3mdi\| PDB=3mdi \| SCENE= }}
-
	===Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA===		===Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA===
		+	{{ABSTRACT_PUBMED_20479262}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN]] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20479262}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 20479262 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20479262}}~~	+

	==About this Structure==		==About this Structure==
-	~~3MDI~~ is a 3 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA].	+	[[3mdi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20479262~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020479262</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Doublie, S.]]		[[Category: Doublie, S.]]
Line 36:		Line 23:
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Rna binding-rna complex]]		[[Category: Rna binding-rna complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:11:29 2010''

OCA at 04:06, 16 June 2010

2010-06-16T04:06:49Z

←Older revision		Revision as of 04:06, 16 June 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3mdi.~~jpg~~\|left\|200px]]	+	[[Image:3mdi.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA===		===Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20479262}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20479262 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20479262}}

	==About this Structure==		==About this Structure==
	3MDI is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA].		3MDI is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20479262</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Doublie, S.]]		[[Category: Doublie, S.]]
Line 28:		Line 37:
	[[Category: Rna binding-rna complex]]		[[Category: Rna binding-rna complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:39:35 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:11:29 2010''

OCA at 04:35, 2 June 2010

2010-06-02T04:35:08Z

←Older revision		Revision as of 04:35, 2 June 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3mdi.jpg\|left\|200px]]

-	The ~~entry 3mdi~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mdi", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mdi\| PDB=3mdi \| SCENE= }}

-	~~Authors: Yang, Q.~~	+	===Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA===

-	Description: Crystal Stucture of NUDT21

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr~~ ~~7 10~~:22:41 2010''	+	==About this Structure==
		+	3MDI is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Doublie, S.]]
		+	[[Category: Gilmartin, G M.]]
		+	[[Category: Yang, Q.]]
		+	[[Category: Cf im]]
		+	[[Category: Cleavage factor]]
		+	[[Category: Cpsf5]]
		+	[[Category: Mrna processing]]
		+	[[Category: Nudix protein]]
		+	[[Category: Protein-rna complex]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Rna binding-rna complex]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:39:35 2010''

OCA: New page: '''Unreleased structure''' The entry 3mdi is ON HOLD Authors: Yang, Q. Description: Crystal Stucture of NUDT21 ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:2...

2010-04-07T07:22:41Z

New page: '''Unreleased structure''' The entry 3mdi is ON HOLD Authors: Yang, Q. Description: Crystal Stucture of NUDT21 ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:2...

New page

'''Unreleased structure'''

The entry 3mdi is ON HOLD

Authors: Yang, Q.

Description: Crystal Stucture of NUDT21

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:22:41 2010''