3men - Revision history

OCA at 10:25, 21 February 2024

2024-02-21T10:25:05Z

←Older revision		Revision as of 10:25, 21 February 2024
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	==Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak==		==Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak==
-	<StructureSection load='3men' size='340' side='right' caption='[[3men]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3men' size='340' side='right'caption='[[3men]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3men]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Burp1 Burp1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3men]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MEN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aphA, BURPS1710b_1309 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=320372 BURP1])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3men FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3men OCA], [~~http~~://pdbe.org/3men PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3men RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3men PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3men ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3men FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3men OCA], [https://pdbe.org/3men PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3men RCSB], [https://www.ebi.ac.uk/pdbsum/3men PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3men ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~APHA_BURP1 APHA_BURP1~~]~~] Acts on many types~~ of ~~acetylpolyamines. Has high affinity towards~~ acetylputrescine~~, acetylcadaverine, acetylspermidine,~~ and ~~acetylspermine. Acts on L~~-~~Lys-(epsilon-acetyl)-coumarin, but has very low activity towards acetylated peptides (By similarity)~~.	+	[https://www.uniprot.org/uniprot/APAHL_BURP1 APAHL_BURP1] Involved in polyamine metabolism. Catalyzes the deacetylation of various acetylated polyamines such as N-acetylputrescine and N-acetylcadaverine.[UniProtKB:Q48935]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3men ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3men ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The Seattle Structural Genomics Center for Infectious Disease (SSGCID) focuses on the structure elucidation of potential drug targets from class A, B, and C infectious disease organisms. Many SSGCID targets are selected because they have homologs in other organisms that are validated drug targets with known structures. Thus, many SSGCID targets are expected to be solved by molecular replacement (MR), and reflective of this, all proteins are expressed in native form. However, many community request targets do not have homologs with known structures and not all internally selected targets readily solve by MR, necessitating experimental phase determination. We have adopted the use of iodide ion soaks and single wavelength anomalous dispersion (SAD) experiments as our primary method for de novo phasing. This method uses existing native crystals and in house data collection, resulting in rapid, low cost structure determination. Iodide ions are non-toxic and soluble at molar concentrations, facilitating binding at numerous hydrophobic or positively charged sites. We have used this technique across a wide range of crystallization conditions with successful structure determination in 16 of 17 cases within the first year of use (94% success rate). Here we present a general overview of this method as well as several examples including SAD phasing of proteins with novel folds and the combined use of SAD and MR for targets with weak MR solutions. These cases highlight the straightforward and powerful method of iodide ion SAD phasing in a high-throughput structural genomics environment.
-
-	SAD phasing using iodide ions in a high-throughput structural genomics environment.,Abendroth J, Gardberg AS, Robinson JI, Christensen JS, Staker BL, Myler PJ, Stewart LJ, Edwards TE J Struct Funct Genomics. 2011 Jul;12(2):83-95. Epub 2011 Feb 27. PMID:21359836<ref>PMID:21359836</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3men" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Burp1~~]]	+	[[Category: Burkholderia pseudomallei 1710b]]
-	[[Category: ~~Structural genomic]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Acetylpolyamine aminohydrolase]]~~	+
-	~~[[Category: Histone deacetylase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:12, 9 January 2019

2019-01-09T07:12:55Z

←Older revision		Revision as of 07:12, 9 January 2019
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/3men_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/3men_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:38, 4 August 2016

2016-08-04T07:38:28Z

←Older revision		Revision as of 07:38, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak==		==Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak==
	<StructureSection load='3men' size='340' side='right' caption='[[3men]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3men' size='340' side='right' caption='[[3men]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3men]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MEN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3men]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Burp1 Burp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MEN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aphA, BURPS1710b_1309 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=320372 ~~Burkholderia pseudomallei 1710b~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aphA, BURPS1710b_1309 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=320372 BURP1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3men FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3men OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3men RCSB], [http://www.ebi.ac.uk/pdbsum/3men PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3men FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3men OCA], [http://pdbe.org/3men PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3men RCSB], [http://www.ebi.ac.uk/pdbsum/3men PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3men ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q3JUN4_BURP1 Q3JUN4_BURP1~~]] Acts on many types of acetylpolyamines. Has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine. Acts on L-Lys-(epsilon-acetyl)-coumarin, but has very low activity towards acetylated peptides (By similarity).	+	[[http://www.uniprot.org/uniprot/APHA_BURP1 APHA_BURP1]] Acts on many types of acetylpolyamines. Has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine. Acts on L-Lys-(epsilon-acetyl)-coumarin, but has very low activity towards acetylated peptides (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3men ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3men" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Burkholderia pseudomallei 1710b~~]]	+	[[Category: Burp1]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Acetylpolyamine aminohydrolase]]		[[Category: Acetylpolyamine aminohydrolase]]
	[[Category: Histone deacetylase]]		[[Category: Histone deacetylase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 06:59, 25 December 2014

2014-12-25T06:59:20Z

←Older revision		Revision as of 06:59, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3men FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3men OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3men RCSB], [http://www.ebi.ac.uk/pdbsum/3men PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3men FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3men OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3men RCSB], [http://www.ebi.ac.uk/pdbsum/3men PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q3JUN4_BURP1 Q3JUN4_BURP1]] Acts on many types of acetylpolyamines. Has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine. Acts on L-Lys-(epsilon-acetyl)-coumarin, but has very low activity towards acetylated peptides (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:02, 18 December 2014

2014-12-18T15:02:29Z

←Older revision		Revision as of 15:02, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3men\| PDB=3men \| SCENE= }}~~	+	==Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak==
-	===Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak===	+	<StructureSection load='3men' size='340' side='right' caption='[[3men]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21359836}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3men]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MEN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aphA, BURPS1710b_1309 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=320372 Burkholderia pseudomallei 1710b])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3men FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3men OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3men RCSB], [http://www.ebi.ac.uk/pdbsum/3men PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/3men_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Seattle Structural Genomics Center for Infectious Disease (SSGCID) focuses on the structure elucidation of potential drug targets from class A, B, and C infectious disease organisms. Many SSGCID targets are selected because they have homologs in other organisms that are validated drug targets with known structures. Thus, many SSGCID targets are expected to be solved by molecular replacement (MR), and reflective of this, all proteins are expressed in native form. However, many community request targets do not have homologs with known structures and not all internally selected targets readily solve by MR, necessitating experimental phase determination. We have adopted the use of iodide ion soaks and single wavelength anomalous dispersion (SAD) experiments as our primary method for de novo phasing. This method uses existing native crystals and in house data collection, resulting in rapid, low cost structure determination. Iodide ions are non-toxic and soluble at molar concentrations, facilitating binding at numerous hydrophobic or positively charged sites. We have used this technique across a wide range of crystallization conditions with successful structure determination in 16 of 17 cases within the first year of use (94% success rate). Here we present a general overview of this method as well as several examples including SAD phasing of proteins with novel folds and the combined use of SAD and MR for targets with weak MR solutions. These cases highlight the straightforward and powerful method of iodide ion SAD phasing in a high-throughput structural genomics environment.

-	~~==Function==~~	+	SAD phasing using iodide ions in a high-throughput structural genomics environment.,Abendroth J, Gardberg AS, Robinson JI, Christensen JS, Staker BL, Myler PJ, Stewart LJ, Edwards TE J Struct Funct Genomics. 2011 Jul;12(2):83-95. Epub 2011 Feb 27. PMID:21359836<ref>PMID:21359836</ref>
-	~~[[http://www~~.~~uniprot.org/uniprot/Q3JUN4_BURP1 Q3JUN4_BURP1]] Acts on many types of acetylpolyamines. Has high affinity towards acetylputrescine~~, ~~acetylcadaverine~~, ~~acetylspermidine~~, ~~and acetylspermine~~. ~~Acts on L-Lys-~~(~~epsilon-acetyl~~)-~~coumarin, but has very low activity towards acetylated peptides (By similarity)~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3men]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3MEN OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021359836</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Burkholderia pseudomallei 1710b]]		[[Category: Burkholderia pseudomallei 1710b]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Acetylpolyamine aminohydrolase]]		[[Category: Acetylpolyamine aminohydrolase]]
	[[Category: Histone deacetylase]]		[[Category: Histone deacetylase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 08:25, 8 May 2013

2013-05-08T08:25:45Z

←Older revision		Revision as of 08:25, 8 May 2013
Line 1:		Line 1:
-	[[Image:3men.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3men", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3men\| PDB=3men \| SCENE= }}		{{STRUCTURE_3men\| PDB=3men \| SCENE= }}
-
	===Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak===		===Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak===
		+	{{ABSTRACT_PUBMED_21359836}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/Q3JUN4_BURP1 Q3JUN4_BURP1]] Acts on many types of acetylpolyamines. Has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine. Acts on L-Lys-(epsilon-acetyl)-coumarin, but has very low activity towards acetylated peptides (By similarity).
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21359836}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 21359836 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21359836}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021359836</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021359836</ref><references group="xtra"/><references/>
	[[Category: Burkholderia pseudomallei 1710b]]		[[Category: Burkholderia pseudomallei 1710b]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA at 17:58, 6 July 2011

2011-07-06T17:58:35Z

←Older revision		Revision as of 17:58, 6 July 2011
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	===Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak===		===Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21359836}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21359836 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21359836}}

	==About this Structure==		==About this Structure==
	[[3men]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEN OCA].		[[3men]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021359836</ref><references group="xtra"/>
	[[Category: Burkholderia pseudomallei 1710b]]		[[Category: Burkholderia pseudomallei 1710b]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA: Protected "3men" [edit=sysop:move=sysop]

2011-01-02T03:17:08Z

Protected "3men" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:17, 2 January 2011

OCA at 03:17, 2 January 2011

2011-01-02T03:17:06Z

←Older revision		Revision as of 03:17, 2 January 2011
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-	~~{{Seed}}~~	+	[[Image:3men.png\|left\|200px]]
-	[[Image:3men.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	~~3MEN~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEN OCA].	+	[[3men]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEN OCA].
	[[Category: Burkholderia pseudomallei 1710b]]		[[Category: Burkholderia pseudomallei 1710b]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
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	[[Category: Histone deacetylase]]		[[Category: Histone deacetylase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 11:11:29 2010''

OCA at 08:11, 21 April 2010

2010-04-21T08:11:32Z

←Older revision		Revision as of 08:11, 21 April 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3men.jpg\|left\|200px]]

-	The ~~entry 3men~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3men", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3men\| PDB=3men \| SCENE= }}

-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	===Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak===

-	Description: Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr ~~14 09~~:22:43 2010''	+	==About this Structure==
		+	3MEN is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEN OCA].
		+	[[Category: Burkholderia pseudomallei 1710b]]
		+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: Acetylpolyamine aminohydrolase]]
		+	[[Category: Histone deacetylase]]
		+	[[Category: Hydrolase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 11:11:29 2010''