3mjy - Revision history

OCA at 08:54, 6 September 2023

2023-09-06T08:54:59Z

←Older revision		Revision as of 08:54, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3mjy' size='340' side='right'caption='[[3mjy]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='3mjy' size='340' side='right'caption='[[3mjy]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mjy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Leima Leima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mjy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MJY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IJZ:5-AMINO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>IJZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.96Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3mhu\|3mhu]], [[3gye\|3gye]], [[3c3n\|3c3n]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IJZ:5-AMINO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>IJZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LmjF16.0530 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mjy OCA], [https://pdbe.org/3mjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mjy RCSB], [https://www.ebi.ac.uk/pdbsum/3mjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mjy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mjy OCA], [https://pdbe.org/3mjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mjy RCSB], [https://www.ebi.ac.uk/pdbsum/3mjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mjy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q4QEW7_LEIMA Q4QEW7_LEIMA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Leima~~]]	+	[[Category: Leishmania major]]
-	[[Category: Cheleski, J]]	+	[[Category: Cheleski J]]
-	[[Category: Montanari~~, C A~~]]	+	[[Category: Montanari CA]]
-	[[Category: Nonato~~, M C~~]]	+	[[Category: Nonato MC]]
-	[[Category: Pinheiro~~, M P~~]]	+	[[Category: Pinheiro MP]]
-	[[Category: Rocha~~, J R]]~~	+	[[Category: Rocha JR]]
-	~~[[Category: Dihydroorotate dehydrogenase]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Pyrd~~]]	+

OCA at 13:47, 4 May 2022

2022-05-04T13:47:35Z

←Older revision		Revision as of 13:47, 4 May 2022
Line 1:		Line 1:

	==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid==		==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid==
-	<StructureSection load='3mjy' size='340' side='right' caption='[[3mjy]], [[Resolution\|resolution]] 1.96Å' scene=''>	+	<StructureSection load='3mjy' size='340' side='right'caption='[[3mjy]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mjy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mjy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MJY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IJZ:5-AMINO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>IJZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IJZ:5-AMINO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>IJZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mhu\|3mhu]], [[3gye\|3gye]], [[3c3n\|3c3n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3mhu\|3mhu]], [[3gye\|3gye]], [[3c3n\|3c3n]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LmjF16.0530 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LmjF16.0530 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mjy OCA], [~~http~~://pdbe.org/3mjy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mjy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mjy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mjy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mjy OCA], [https://pdbe.org/3mjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mjy RCSB], [https://www.ebi.ac.uk/pdbsum/3mjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mjy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]	+	*[[Dihydroorotate dehydrogenase 3D structures\|Dihydroorotate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Leima]]		[[Category: Leima]]
	[[Category: Cheleski, J]]		[[Category: Cheleski, J]]

OCA at 00:24, 5 August 2016

2016-08-05T00:24:27Z

←Older revision		Revision as of 00:24, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid==		==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid==
	<StructureSection load='3mjy' size='340' side='right' caption='[[3mjy]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='3mjy' size='340' side='right' caption='[[3mjy]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mjy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Leishmania_major Leishmania major~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mjy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MJY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IJZ:5-AMINO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>IJZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IJZ:5-AMINO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>IJZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mhu\|3mhu]], [[3gye\|3gye]], [[3c3n\|3c3n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mhu\|3mhu]], [[3gye\|3gye]], [[3c3n\|3c3n]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LmjF16.0530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 ~~Leishmania major~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LmjF16.0530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Dihydroorotate_oxidase~~ Dihydroorotate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.1 1.3.3.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mjy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mjy RCSB], [http://www.ebi.ac.uk/pdbsum/3mjy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mjy OCA], [http://pdbe.org/3mjy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mjy RCSB], [http://www.ebi.ac.uk/pdbsum/3mjy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mjy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mjy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dihydroorotate oxidase]]~~	+	[[Category: Leima]]
-	~~[[Category: Leishmania major~~]]	+
	[[Category: Cheleski, J]]		[[Category: Cheleski, J]]
	[[Category: Montanari, C A]]		[[Category: Montanari, C A]]

OCA at 21:35, 3 January 2015

2015-01-03T21:35:35Z

←Older revision		Revision as of 21:35, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mjy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MJY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mjy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MJY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IJZ:5-AMINO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>IJZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IJZ:5-AMINO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>IJZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mhu\|3mhu]], [[3gye\|3gye]], [[3c3n\|3c3n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mhu\|3mhu]], [[3gye\|3gye]], [[3c3n\|3c3n]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LmjF16.0530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 Leishmania major])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LmjF16.0530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 Leishmania major])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase Dihydroorotate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.1 1.3.3.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase Dihydroorotate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.1 1.3.3.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mjy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mjy RCSB], [http://www.ebi.ac.uk/pdbsum/3mjy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mjy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mjy RCSB], [http://www.ebi.ac.uk/pdbsum/3mjy PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 15:
	Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery.,Cheleski J, Rocha JR, Pinheiro MP, Wiggers HJ, da Silva AB, Nonato MC, Montanari CA Eur J Med Chem. 2010 Dec;45(12):5899-909. Epub 2010 Oct 7. PMID:20965617<ref>PMID:20965617</ref>		Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery.,Cheleski J, Rocha JR, Pinheiro MP, Wiggers HJ, da Silva AB, Nonato MC, Montanari CA Eur J Med Chem. 2010 Dec;45(12):5899-909. Epub 2010 Oct 7. PMID:20965617<ref>PMID:20965617</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	[[Category: Dihydroorotate oxidase]]		[[Category: Dihydroorotate oxidase]]
	[[Category: Leishmania major]]		[[Category: Leishmania major]]
-	[[Category: Cheleski, J.]]	+	[[Category: Cheleski, J]]
-	[[Category: Montanari, C A.]]	+	[[Category: Montanari, C A]]
-	[[Category: Nonato, M C.]]	+	[[Category: Nonato, M C]]
-	[[Category: Pinheiro, M P.]]	+	[[Category: Pinheiro, M P]]
-	[[Category: Rocha, J R.]]	+	[[Category: Rocha, J R]]
	[[Category: Dihydroorotate dehydrogenase]]		[[Category: Dihydroorotate dehydrogenase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Pyrd]]		[[Category: Pyrd]]

OCA at 10:41, 28 May 2014

2014-05-28T10:41:20Z

←Older revision		Revision as of 10:41, 28 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3mjy.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid==
		+	<StructureSection load='3mjy' size='340' side='right' caption='[[3mjy]], [[Resolution\|resolution]] 1.96Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mjy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MJY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IJZ:5-AMINO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>IJZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mhu\|3mhu]], [[3gye\|3gye]], [[3c3n\|3c3n]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LmjF16.0530 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 Leishmania major])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase Dihydroorotate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.1 1.3.3.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mjy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mjy RCSB], [http://www.ebi.ac.uk/pdbsum/3mjy PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The enzyme dihydroorotate dehydrogenase (DHODH) has been suggested as a promising target for the design of trypanocidal agents. We report here the discovery of novel inhibitors of Trypanosoma cruzi DHODH identified by a combination of virtual screening and ITC methods. Monitoring of the enzymatic reaction in the presence of selected ligands together with structural information obtained from X-ray crystallography analysis have allowed the identification and validation of a novel site of interaction (S2 site). This has provided important structural insights for the rational design of T. cruzi and Leishmania major DHODH inhibitors. The most potent compound (1) in the investigated series inhibits TcDHODH enzyme with Kiapp value of 19.28 muM and possesses a ligand efficiency of 0.54 kcal mol(-1) per non-H atom. The compounds described in this work are promising hits for further development.

-	~~<!--~~	+	Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery.,Cheleski J, Rocha JR, Pinheiro MP, Wiggers HJ, da Silva AB, Nonato MC, Montanari CA Eur J Med Chem. 2010 Dec;45(12):5899-909. Epub 2010 Oct 7. PMID:20965617<ref>PMID:20965617</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3mjy"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3mjy\| PDB=3mjy \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20965617}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 20965617 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_20965617}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3mjy]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJY OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:20965617<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Dihydroorotate oxidase]]		[[Category: Dihydroorotate oxidase]]
-	[[Category: ~~Thermomicrobium roseum~~]]	+	[[Category: Leishmania major]]
	[[Category: Cheleski, J.]]		[[Category: Cheleski, J.]]
	[[Category: Montanari, C A.]]		[[Category: Montanari, C A.]]
Line 30:		Line 28:
	[[Category: Pinheiro, M P.]]		[[Category: Pinheiro, M P.]]
	[[Category: Rocha, J R.]]		[[Category: Rocha, J R.]]
		+	[[Category: Dihydroorotate dehydrogenase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Pyrd]]

OCA: Protected "3mjy" [edit=sysop:move=sysop]

2011-02-23T09:57:38Z

Protected "3mjy" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:57, 23 February 2011

OCA at 09:57, 23 February 2011

2011-02-23T09:57:37Z

←Older revision		Revision as of 09:57, 23 February 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3mjy.jpg\|left\|200px]]

-	The ~~entry 3mjy~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mjy", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mjy\| PDB=3mjy \| SCENE= }}

-	~~Authors: Pinheiro, M.P., Rocha, J.R., Cheleski, J., Montanari, C.A., Nonato, M.C.~~	+	===Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid===

-	Description: Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Aug 4 08~~:45:~~43 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20965617}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20965617 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20965617}}
		+
		+	==About this Structure==
		+	[[3mjy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJY OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20965617</ref><references group="xtra"/>
		+	[[Category: Dihydroorotate oxidase]]
		+	[[Category: Thermomicrobium roseum]]
		+	[[Category: Cheleski, J.]]
		+	[[Category: Montanari, C A.]]
		+	[[Category: Nonato, M C.]]
		+	[[Category: Pinheiro, M P.]]
		+	[[Category: Rocha, J R.]]

OCA at 04:38, 4 August 2010

2010-08-04T04:38:44Z

←Older revision		Revision as of 04:38, 4 August 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3mjy is ON HOLD	+	The entry 3mjy is ON HOLD until Paper Publication

	Authors: Pinheiro, M.P., Rocha, J.R., Cheleski, J., Montanari, C.A., Nonato, M.C.		Authors: Pinheiro, M.P., Rocha, J.R., Cheleski, J., Montanari, C.A., Nonato, M.C.
Line 7:		Line 7:
	Description: Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid		Description: Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 21 09~~:39:23 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 08:45:43 2010''

OCA: New page: '''Unreleased structure''' The entry 3mjy is ON HOLD Authors: Pinheiro, M.P., Rocha, J.R., Cheleski, J., Montanari, C.A., Nonato, M.C. Description: Crystal structure of dihydroorotate ...

2010-04-21T06:39:24Z

New page: '''Unreleased structure''' The entry 3mjy is ON HOLD Authors: Pinheiro, M.P., Rocha, J.R., Cheleski, J., Montanari, C.A., Nonato, M.C. Description: Crystal structure of dihydroorotate ...

New page

'''Unreleased structure'''

The entry 3mjy is ON HOLD

Authors: Pinheiro, M.P., Rocha, J.R., Cheleski, J., Montanari, C.A., Nonato, M.C.

Description: Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 09:39:23 2010''