3mmk - Revision history

OCA at 08:48, 7 February 2024

2024-02-07T08:48:21Z

←Older revision		Revision as of 08:48, 7 February 2024
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	<StructureSection load='3mmk' size='340' side='right'caption='[[3mmk]], [[Resolution\|resolution]] 2.16Å' scene=''>		<StructureSection load='3mmk' size='340' side='right'caption='[[3mmk]], [[Resolution\|resolution]] 2.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mmk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MMK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MMK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.157Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[2rgt\|2rgt]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmk OCA], [https://pdbe.org/3mmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mmk RCSB], [https://www.ebi.ac.uk/pdbsum/3mmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mmk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmk OCA], [https://pdbe.org/3mmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mmk RCSB], [https://www.ebi.ac.uk/pdbsum/3mmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mmk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LHX4_MOUSE LHX4_MOUSE]] May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.	+	[https://www.uniprot.org/uniprot/LHX4_MOUSE LHX4_MOUSE] May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.[https://www.uniprot.org/uniprot/ISL2_MOUSE ISL2_MOUSE] Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.
-	~~<div style="background-color~~:~~#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	~~of LIM-homeodomain proteins form a transcriptional 'LIM code' to direct the specification of neural cell types. Two paralogous pairs of LIM-homeodomain proteins, LIM homeobox protein 3~~/~~4 (Lhx3~~/~~Lhx4) and Islet-1~~/~~2 (Isl1~~/~~Isl2) are expressed in developing ventral motor neurons. Lhx3 and Isl1 interact within a well-characterised transcriptional complex~~ that triggers motor neuron development, but it was not known if Lhx4 and Isl2 could participate in equivalent complexes. We have identified an Lhx3-binding domain (LBD) in Isl2 based on sequence homology with the Isl1(LBD) and show that both Isl2(LBD) and Isl1(LBD) can bind each of ~~Lhx3 and Lhx4. X-ray crystal and SAXS-derived solution structures of an Lhx4:Isl2 complex exhibit many similarities with~~ that ~~of Lhx3:Isl1; however, structural differences supported by mutagenic studies reveal differences~~ in the ~~mechanisms of binding. Differences in binding have implications for the mode of exchange of protein partners in transcriptional complexes,~~ and ~~indicate a divergence in functions of Lhx3/4 and Isl1/2~~. ~~The formation of weaker Lhx:Isl complexes would likely be masked by the availability of the other Lhx:Isl complexes in post mitotic motor neurons.~~	+
-		+
-	The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification.,Gadd MS, Bhati M, Jeffries CM, Langley DB, Trewhella J, Guss JM, Matthews JM J Biol Chem. 2011 Oct 24. PMID:22025611<ref>PMID:22025611</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3mmk" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Gadd, M S~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Guss, J M~~]]	+	[[Category: Gadd MS]]
-	[[Category: ~~Langley, D B~~]]	+	[[Category: Guss JM]]
-	[[Category: ~~Matthews, J M~~]]	+	[[Category: Langley DB]]
-	[[Category: ~~Dna-binding]]~~	+	[[Category: Matthews JM]]
-	~~[[Category: Homeobox]]~~	+
-	~~[[Category: Lim domain]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Protein-protein complex]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcriptional regulation]]~~	+
-	~~[[Category: Zn finger~~]]	+

OCA at 13:48, 4 May 2022

2022-05-04T13:48:27Z

←Older revision		Revision as of 13:48, 4 May 2022
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	<StructureSection load='3mmk' size='340' side='right'caption='[[3mmk]], [[Resolution\|resolution]] 2.16Å' scene=''>		<StructureSection load='3mmk' size='340' side='right'caption='[[3mmk]], [[Resolution\|resolution]] 2.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mmk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MMK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mmk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MMK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rgt\|2rgt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2rgt\|2rgt]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmk OCA], [~~http~~://pdbe.org/3mmk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mmk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mmk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mmk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmk OCA], [https://pdbe.org/3mmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mmk RCSB], [https://www.ebi.ac.uk/pdbsum/3mmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mmk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LHX4_MOUSE LHX4_MOUSE]] May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.	+	[[https://www.uniprot.org/uniprot/LHX4_MOUSE LHX4_MOUSE]] May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:01, 7 August 2019

2019-08-07T07:01:53Z

←Older revision		Revision as of 07:01, 7 August 2019
Line 1:		Line 1:

	==The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification==		==The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification==
-	<StructureSection load='3mmk' size='340' side='right' caption='[[3mmk]], [[Resolution\|resolution]] 2.16Å' scene=''>	+	<StructureSection load='3mmk' size='340' side='right'caption='[[3mmk]], [[Resolution\|resolution]] 2.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mmk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MMK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mmk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MMK FirstGlance]. <br>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gadd, M S]]		[[Category: Gadd, M S]]
	[[Category: Guss, J M]]		[[Category: Guss, J M]]

OCA at 11:14, 3 August 2017

2017-08-03T11:14:09Z

←Older revision		Revision as of 11:14, 3 August 2017
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	<StructureSection load='3mmk' size='340' side='right' caption='[[3mmk]], [[Resolution\|resolution]] 2.16Å' scene=''>		<StructureSection load='3mmk' size='340' side='right' caption='[[3mmk]], [[Resolution\|resolution]] 2.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mmk]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MMK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mmk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MMK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rgt\|2rgt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rgt\|2rgt]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gsh-4, Gsh4, Isl2, Lhx4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmk OCA], [http://pdbe.org/3mmk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mmk RCSB], [http://www.ebi.ac.uk/pdbsum/3mmk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mmk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmk OCA], [http://pdbe.org/3mmk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mmk RCSB], [http://www.ebi.ac.uk/pdbsum/3mmk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mmk ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lk3 transgenic mice]]
	[[Category: Gadd, M S]]		[[Category: Gadd, M S]]
	[[Category: Guss, J M]]		[[Category: Guss, J M]]

OCA at 18:33, 4 August 2016

2016-08-04T18:33:22Z

←Older revision		Revision as of 18:33, 4 August 2016
Line 1:		Line 1:
		+
	==The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification==		==The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification==
	<StructureSection load='3mmk' size='340' side='right' caption='[[3mmk]], [[Resolution\|resolution]] 2.16Å' scene=''>		<StructureSection load='3mmk' size='340' side='right' caption='[[3mmk]], [[Resolution\|resolution]] 2.16Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rgt\|2rgt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rgt\|2rgt]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gsh-4, Gsh4, Isl2, Lhx4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gsh-4, Gsh4, Isl2, Lhx4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mmk RCSB], [http://www.ebi.ac.uk/pdbsum/3mmk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmk OCA], [http://pdbe.org/3mmk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mmk RCSB], [http://www.ebi.ac.uk/pdbsum/3mmk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mmk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mmk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:56, 25 December 2014

2014-12-25T11:56:52Z

←Older revision		Revision as of 11:56, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mmk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MMK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mmk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MMK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rgt\|2rgt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rgt\|2rgt]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gsh-4, Gsh4, Isl2, Lhx4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gsh-4, Gsh4, Isl2, Lhx4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mmk RCSB], [http://www.ebi.ac.uk/pdbsum/3mmk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mmk RCSB], [http://www.ebi.ac.uk/pdbsum/3mmk PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LHX4_MOUSE LHX4_MOUSE]] May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification.,Gadd MS, Bhati M, Jeffries CM, Langley DB, Trewhella J, Guss JM, Matthews JM J Biol Chem. 2011 Oct 24. PMID:22025611<ref>PMID:22025611</ref>		The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification.,Gadd MS, Bhati M, Jeffries CM, Langley DB, Trewhella J, Guss JM, Matthews JM J Biol Chem. 2011 Oct 24. PMID:22025611<ref>PMID:22025611</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
-	[[Category: Gadd, M S.]]	+	[[Category: Gadd, M S]]
-	[[Category: Guss, J M.]]	+	[[Category: Guss, J M]]
-	[[Category: Langley, D B.]]	+	[[Category: Langley, D B]]
-	[[Category: Matthews, J M.]]	+	[[Category: Matthews, J M]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Homeobox]]		[[Category: Homeobox]]

OCA at 10:25, 28 May 2014

2014-05-28T10:25:03Z

←Older revision		Revision as of 10:25, 28 May 2014
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-	[[~~Image:~~3mmk.~~png~~\|~~left~~\|~~200px~~]]	+	==The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification==
		+	<StructureSection load='3mmk' size='340' side='right' caption='[[3mmk]], [[Resolution\|resolution]] 2.16Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mmk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MMK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rgt\|2rgt]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gsh-4, Gsh4, Isl2, Lhx4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mmk RCSB], [http://www.ebi.ac.uk/pdbsum/3mmk PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	of LIM-homeodomain proteins form a transcriptional 'LIM code' to direct the specification of neural cell types. Two paralogous pairs of LIM-homeodomain proteins, LIM homeobox protein 3/4 (Lhx3/Lhx4) and Islet-1/2 (Isl1/Isl2) are expressed in developing ventral motor neurons. Lhx3 and Isl1 interact within a well-characterised transcriptional complex that triggers motor neuron development, but it was not known if Lhx4 and Isl2 could participate in equivalent complexes. We have identified an Lhx3-binding domain (LBD) in Isl2 based on sequence homology with the Isl1(LBD) and show that both Isl2(LBD) and Isl1(LBD) can bind each of Lhx3 and Lhx4. X-ray crystal and SAXS-derived solution structures of an Lhx4:Isl2 complex exhibit many similarities with that of Lhx3:Isl1; however, structural differences supported by mutagenic studies reveal differences in the mechanisms of binding. Differences in binding have implications for the mode of exchange of protein partners in transcriptional complexes, and indicate a divergence in functions of Lhx3/4 and Isl1/2. The formation of weaker Lhx:Isl complexes would likely be masked by the availability of the other Lhx:Isl complexes in post mitotic motor neurons.

-	~~<!--~~	+	The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification.,Gadd MS, Bhati M, Jeffries CM, Langley DB, Trewhella J, Guss JM, Matthews JM J Biol Chem. 2011 Oct 24. PMID:22025611<ref>PMID:22025611</ref>
-	The ~~line below this paragraph~~, ~~containing "STRUCTURE_3mmk"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3mmk\| PDB=3mmk \| SCENE= }}~~	+

-	~~===The structural basis for partial redundancy in~~ a ~~class~~ of ~~transcription factors,~~ the ~~lim-homeodomain proteins, in neural cell type specification===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22025611}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22025611 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+	[[Category: Lk3 transgenic mice]]
-	~~{{ABSTRACT_PUBMED_22025611}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3mmk]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus,_unidentified Mus musculus, unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022025611<~~/~~ref~~><~~references group="xtra"~~/>	+
-	[[Category: ~~Mus musculus, unidentified~~]]	+
	[[Category: Gadd, M S.]]		[[Category: Gadd, M S.]]
	[[Category: Guss, J M.]]		[[Category: Guss, J M.]]

OCA at 10:44, 16 November 2011

2011-11-16T10:44:12Z

←Older revision		Revision as of 10:44, 16 November 2011
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-	[[Image:3mmk.~~jpg~~\|left\|200px]]	+	[[Image:3mmk.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_3mmk\| PDB=3mmk \| SCENE= }}		{{STRUCTURE_3mmk\| PDB=3mmk \| SCENE= }}

-	===~~Crystal Structure~~ of ~~Lhx4 LIM domains 1 and 2 with~~ the ~~Lhx3~~-~~binding domain of Isl2~~===	+	===The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22025611}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22025611 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22025611}}

	==About this Structure==		==About this Structure==
	[[3mmk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus,_unidentified Mus musculus, unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA].		[[3mmk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus,_unidentified Mus musculus, unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022025611</ref><references group="xtra"/>
	[[Category: Mus musculus, unidentified]]		[[Category: Mus musculus, unidentified]]
	[[Category: Gadd, M S.]]		[[Category: Gadd, M S.]]

OCA: Protected "3mmk" [edit=sysop:move=sysop]

2011-07-13T07:46:26Z

Protected "3mmk" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:46, 13 July 2011

OCA at 07:46, 13 July 2011

2011-07-13T07:46:22Z

←Older revision		Revision as of 07:46, 13 July 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3mmk.jpg\|left\|200px]]

-	The ~~entry 3mmk~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mmk", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mmk\| PDB=3mmk \| SCENE= }}

-	~~Authors: Gadd, M.S., Langley, D.B., Guss, J.M., Matthews, J.M.~~	+	===Crystal Structure of Lhx4 LIM domains 1 and 2 with the Lhx3-binding domain of Isl2===

-	Description: Crystal Structure of Lhx4 LIM domains 1 and 2 with the Lhx3-binding domain of Isl2

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Thu May 20 09~~:17:~~44 2010''~~	+	==About this Structure==
		+	[[3mmk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus,_unidentified Mus musculus, unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMK OCA].
		+	[[Category: Mus musculus, unidentified]]
		+	[[Category: Gadd, M S.]]
		+	[[Category: Guss, J M.]]
		+	[[Category: Langley, D B.]]
		+	[[Category: Matthews, J M.]]
		+	[[Category: Dna-binding]]
		+	[[Category: Homeobox]]
		+	[[Category: Lim domain]]
		+	[[Category: Metal binding protein]]
		+	[[Category: Metal-binding]]
		+	[[Category: Nucleus]]
		+	[[Category: Protein-protein complex]]
		+	[[Category: Transcription]]
		+	[[Category: Transcriptional regulation]]
		+	[[Category: Zn finger]]