3mph - Revision history

OCA at 16:36, 1 November 2023

2023-11-01T16:36:18Z

←Older revision		Revision as of 16:36, 1 November 2023
Line 1:		Line 1:

	==The structure of human diamine oxidase complexed with an inhibitor aminoguanidine==		==The structure of human diamine oxidase complexed with an inhibitor aminoguanidine==
-	<StructureSection load='3mph' size='340' side='right' caption='[[3mph]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='3mph' size='340' side='right'caption='[[3mph]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mph]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MPH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mph]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MPH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=BMA:BETA~~-~~D-MANNOSE'>BMA</scene>~~, ~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGQ:3-[(3E)-3-(CARBAMIMIDOYLHYDRAZONO)-4-HYDROXY-6-OXOCYCLOHEXA-1,4-DIEN-1-YL]-L-ALANINE'>AGQ</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGQ:3-[(3E)-3-(CARBAMIMIDOYLHYDRAZONO)-4-HYDROXY-6-OXOCYCLOHEXA-1,4-DIEN-1-YL]-L-ALANINE'>AGQ</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[3hi7\|3hi7]]~~, ~~[[3hig\|3hig]], [[3hii\|3hii]], [[3k5t\|3k5t]]~~<~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mph OCA], [https://pdbe.org/3mph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mph RCSB], [https://www.ebi.ac.uk/pdbsum/3mph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mph ProSAT]</span></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">ABP1~~ (~~[http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]~~)~~</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Diamine_oxidase Diamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.22 1.4.3.22]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mph OCA], [~~http~~://pdbe.org/3mph PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mph RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mph PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mph ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~ABP1_HUMAN ABP1_HUMAN]~~] Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.	+	[https://www.uniprot.org/uniprot/AOC1_HUMAN AOC1_HUMAN] Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Diamine oxidase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Guss~~, J M~~]]	+	[[Category: Guss JM]]
-	[[Category: McGrath~~, A P]]~~	+	[[Category: McGrath AP]]
-	~~[[Category: Aminoguanidine]]~~	+
-	~~[[Category: Cao]]~~	+
-	~~[[Category: Copper amine oxidase]]~~	+
-	~~[[Category: Dao]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Topaquinone]]~~	+
-	~~[[Category: Tpq~~]]	+

OCA at 13:43, 16 January 2019

2019-01-16T13:43:34Z

←Older revision		Revision as of 13:43, 16 January 2019
Line 17:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mp/3mph_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mp/3mph_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:07, 5 August 2016

2016-08-05T22:07:00Z

←Older revision		Revision as of 22:07, 5 August 2016
Line 1:		Line 1:
		+
	==The structure of human diamine oxidase complexed with an inhibitor aminoguanidine==		==The structure of human diamine oxidase complexed with an inhibitor aminoguanidine==
	<StructureSection load='3mph' size='340' side='right' caption='[[3mph]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3mph' size='340' side='right' caption='[[3mph]], [[Resolution\|resolution]] 2.05Å' scene=''>
Line 8:		Line 9:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_oxidase Diamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.22 1.4.3.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_oxidase Diamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.22 1.4.3.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mph OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mph RCSB], [http://www.ebi.ac.uk/pdbsum/3mph PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mph OCA], [http://pdbe.org/3mph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mph RCSB], [http://www.ebi.ac.uk/pdbsum/3mph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mph ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mph ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mph" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:19, 25 December 2014

2014-12-25T22:19:22Z

←Older revision		Revision as of 22:19, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MPH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MPH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGQ:3-[(3E)-3-(CARBAMIMIDOYLHYDRAZONO)-4-HYDROXY-6-OXOCYCLOHEXA-1,4-DIEN-1-YL]-L-ALANINE'>AGQ</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGQ:3-[(3E)-3-(CARBAMIMIDOYLHYDRAZONO)-4-HYDROXY-6-OXOCYCLOHEXA-1,4-DIEN-1-YL]-L-ALANINE'>AGQ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hi7\|3hi7]], [[3hig\|3hig]], [[3hii\|3hii]], [[3k5t\|3k5t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hi7\|3hi7]], [[3hig\|3hig]], [[3hii\|3hii]], [[3k5t\|3k5t]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_oxidase Diamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.22 1.4.3.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_oxidase Diamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.22 1.4.3.22] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mph OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mph RCSB], [http://www.ebi.ac.uk/pdbsum/3mph PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mph OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mph RCSB], [http://www.ebi.ac.uk/pdbsum/3mph PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ABP1_HUMAN ABP1_HUMAN]] Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 28:
	Correlation of Active Site Metal Content in Human Diamine Oxidase with Trihydroxyphenylalanine Quinone Cofactor Biogenesis .,McGrath AP, Caradoc-Davies T, Collyer CA, Guss JM Biochemistry. 2010 Sep 1. PMID:20722416<ref>PMID:20722416</ref>		Correlation of Active Site Metal Content in Human Diamine Oxidase with Trihydroxyphenylalanine Quinone Cofactor Biogenesis .,McGrath AP, Caradoc-Davies T, Collyer CA, Guss JM Biochemistry. 2010 Sep 1. PMID:20722416<ref>PMID:20722416</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 34:		Line 36:
	[[Category: Diamine oxidase]]		[[Category: Diamine oxidase]]
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Guss, J M.]]	+	[[Category: Guss, J M]]
-	[[Category: McGrath, A P.]]	+	[[Category: McGrath, A P]]
	[[Category: Aminoguanidine]]		[[Category: Aminoguanidine]]
	[[Category: Cao]]		[[Category: Cao]]
	[[Category: Copper amine oxidase]]		[[Category: Copper amine oxidase]]
	[[Category: Dao]]		[[Category: Dao]]
-	[[Category: Diamine oxidase]]
-	[[Category: Human]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Topaquinone]]		[[Category: Topaquinone]]
	[[Category: Tpq]]		[[Category: Tpq]]

OCA at 13:10, 18 May 2014

2014-05-18T13:10:06Z

←Older revision		Revision as of 13:10, 18 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3mph.~~png~~\|~~left~~\|200px]]	+	==The structure of human diamine oxidase complexed with an inhibitor aminoguanidine==
		+	<StructureSection load='3mph' size='340' side='right' caption='[[3mph]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MPH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGQ:3-[(3E)-3-(CARBAMIMIDOYLHYDRAZONO)-4-HYDROXY-6-OXOCYCLOHEXA-1,4-DIEN-1-YL]-L-ALANINE'>AGQ</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hi7\|3hi7]], [[3hig\|3hig]], [[3hii\|3hii]], [[3k5t\|3k5t]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_oxidase Diamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.22 1.4.3.22] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mph OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mph RCSB], [http://www.ebi.ac.uk/pdbsum/3mph PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mp/3mph_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Copper-containing amine oxidases (CAOs) require a protein-derived topaquinone cofactor (TPQ) for activity. TPQ biogenesis is a self-processing reaction requiring the presence of copper and molecular oxygen. Recombinant human diamine oxidase (hDAO) was heterologously expressed in Drosophila S2 cells, and analysis indicates that the purified hDAO contains substoichiometric amounts of copper and TPQ. The crystal structure of a complex of an inhibitor, aminoguanidine, and hDAO at 2.05 A resolution shows that the aminoguanidine forms a covalent adduct with the TPQ and that the site is approximately 75% occupied. Aminoguanidine is a potent inhibitor of hDAO with an IC(50) of 153 +/- 9 nM. The structure indicates that the catalytic metal site, normally occupied by copper, is fully occupied. X-ray diffraction data recorded below the copper edge, between the copper and zinc edges, and above the zinc edge have been used to show that the metal site is occupied approximately 75% by copper and 25% by zinc and the formation of the TPQ cofactor is correlated with copper occupancy.

-	<!--	+	Correlation of Active Site Metal Content in Human Diamine Oxidase with Trihydroxyphenylalanine Quinone Cofactor Biogenesis .,McGrath AP, Caradoc-Davies T, Collyer CA, Guss JM Biochemistry. 2010 Sep 1. PMID:20722416<ref>PMID:20722416</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3mph"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3mph\| PDB=3mph \| SCENE= }}~~	+

-	~~===The structure~~ of ~~human diamine oxidase complexed with an inhibitor aminoguanidine===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20722416}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 20722416 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_20722416}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3mph]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPH OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020722416<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Diamine oxidase]]		[[Category: Diamine oxidase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Guss, J M.]]		[[Category: Guss, J M.]]
	[[Category: McGrath, A P.]]		[[Category: McGrath, A P.]]

OCA: Protected "3mph" [edit=sysop:move=sysop]

2012-04-18T07:04:35Z

Protected "3mph" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:04, 18 April 2012

OCA at 07:04, 18 April 2012

2012-04-18T07:04:33Z

←Older revision		Revision as of 07:04, 18 April 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3mph.png\|left\|200px]]
-	[[Image:3mph.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3MPH~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPH OCA].	+	[[3mph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPH OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20722416~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020722416</ref><references group="xtra"/>
	[[Category: Diamine oxidase]]		[[Category: Diamine oxidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 37:		Line 36:
	[[Category: Topaquinone]]		[[Category: Topaquinone]]
	[[Category: Tpq]]		[[Category: Tpq]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Sep 10 13:59:15 2010''

OCA at 09:50, 10 September 2010

2010-09-10T09:50:47Z

←Older revision		Revision as of 09:50, 10 September 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3mph.jpg\|left\|200px]]

-	The ~~entry 3mph~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mph", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mph\| PDB=3mph \| SCENE= }}

-	~~Authors: McGrath, A.P., Guss, J.M.~~	+	===The structure of human diamine oxidase complexed with an inhibitor aminoguanidine===

-	Description: The structure of human diamine oxidase complexed with an inhibitor aminoguanidine

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed May 26 08~~:22:03 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20722416}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20722416 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20722416}}
		+
		+	==About this Structure==
		+	3MPH is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPH OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20722416</ref><references group="xtra"/>
		+	[[Category: Diamine oxidase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Guss, J M.]]
		+	[[Category: McGrath, A P.]]
		+	[[Category: Aminoguanidine]]
		+	[[Category: Cao]]
		+	[[Category: Copper amine oxidase]]
		+	[[Category: Dao]]
		+	[[Category: Diamine oxidase]]
		+	[[Category: Human]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Topaquinone]]
		+	[[Category: Tpq]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Sep 10 13:59:15 2010''

OCA at 04:17, 26 May 2010

2010-05-26T04:17:52Z

←Older revision		Revision as of 04:17, 26 May 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3mph is ON HOLD	+	The entry 3mph is ON HOLD until Paper Publication

	Authors: McGrath, A.P., Guss, J.M.		Authors: McGrath, A.P., Guss, J.M.
Line 7:		Line 7:
	Description: The structure of human diamine oxidase complexed with an inhibitor aminoguanidine		Description: The structure of human diamine oxidase complexed with an inhibitor aminoguanidine

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May ~~5 11~~:41:31 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:22:03 2010''

OCA: New page: '''Unreleased structure''' The entry 3mph is ON HOLD Authors: McGrath, A.P., Guss, J.M. Description: The structure of human diamine oxidase complexed with an inhibitor aminoguanidine ...

2010-05-05T08:41:31Z

New page: '''Unreleased structure''' The entry 3mph is ON HOLD Authors: McGrath, A.P., Guss, J.M. Description: The structure of human diamine oxidase complexed with an inhibitor aminoguanidine ...

New page

'''Unreleased structure'''

The entry 3mph is ON HOLD

Authors: McGrath, A.P., Guss, J.M.

Description: The structure of human diamine oxidase complexed with an inhibitor aminoguanidine

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:41:31 2010''