3mrs - Revision history

OCA at 16:38, 1 November 2023

2023-11-01T16:38:40Z

←Older revision		Revision as of 16:38, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3mrs' size='340' side='right'caption='[[3mrs]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3mrs' size='340' side='right'caption='[[3mrs]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mrs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Campylobacter_pylori Campylobacter~~ pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MRS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mrs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MRS FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">AROK ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=85962 Campylobacter pylori])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mrs OCA], [https://pdbe.org/3mrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mrs RCSB], [https://www.ebi.ac.uk/pdbsum/3mrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mrs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mrs OCA], [https://pdbe.org/3mrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mrs RCSB], [https://www.ebi.ac.uk/pdbsum/3mrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mrs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AROK_HELPY AROK_HELPY]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:16291688</ref>	+	[https://www.uniprot.org/uniprot/AROK_HELPY AROK_HELPY] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:16291688</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Campylobacter~~ pylori]]	+	[[Category: Helicobacter pylori 26695]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Shikimate kinase]]~~	+	[[Category: Chen TJ]]
-	[[Category: Chen~~, T J~~]]	+	[[Category: Cheng WC]]
-	[[Category: Cheng~~, W C~~]]	+	[[Category: Lin SC]]
-	[[Category: Lin~~, S C~~]]	+	[[Category: Wang WC]]
-	[[Category: Wang~~, W C]]~~	+
-	~~[[Category: Helix-sheet complex]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 13:50, 4 May 2022

2022-05-04T13:50:27Z

←Older revision		Revision as of 13:50, 4 May 2022
Line 1:		Line 1:

	==Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori==		==Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori==
-	<StructureSection load='3mrs' size='340' side='right' caption='[[3mrs]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3mrs' size='340' side='right'caption='[[3mrs]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mrs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MRS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mrs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MRS FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mrs OCA], [~~http~~://pdbe.org/3mrs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mrs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mrs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mrs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mrs OCA], [https://pdbe.org/3mrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mrs RCSB], [https://www.ebi.ac.uk/pdbsum/3mrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mrs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AROK_HELPY AROK_HELPY]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:16291688</ref>	+	[[https://www.uniprot.org/uniprot/AROK_HELPY AROK_HELPY]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:16291688</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Shikimate kinase\|Shikimate kinase]]	+	*[[Shikimate kinase 3D structures\|Shikimate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Campylobacter pylori]]		[[Category: Campylobacter pylori]]
		+	[[Category: Large Structures]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]
	[[Category: Chen, T J]]		[[Category: Chen, T J]]

OCA at 22:10, 5 August 2016

2016-08-05T22:10:07Z

←Older revision		Revision as of 22:10, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori==		==Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori==
	<StructureSection load='3mrs' size='340' side='right' caption='[[3mrs]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3mrs' size='340' side='right' caption='[[3mrs]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mrs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Helicobacter_pylori Helicobacter~~ pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MRS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mrs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MRS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~210 Helicobacter~~ pylori])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mrs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mrs RCSB], [http://www.ebi.ac.uk/pdbsum/3mrs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mrs OCA], [http://pdbe.org/3mrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mrs RCSB], [http://www.ebi.ac.uk/pdbsum/3mrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mrs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mrs" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Helicobacter~~ pylori]]	+	[[Category: Campylobacter pylori]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]
	[[Category: Chen, T J]]		[[Category: Chen, T J]]

OCA at 22:21, 25 December 2014

2014-12-25T22:21:11Z

←Older revision		Revision as of 22:21, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mrs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MRS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mrs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MRS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mrs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mrs RCSB], [http://www.ebi.ac.uk/pdbsum/3mrs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mrs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mrs RCSB], [http://www.ebi.ac.uk/pdbsum/3mrs PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AROK_HELPY AROK_HELPY]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:16291688</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism.,Cheng WC, Chen YF, Wang HJ, Hsu KC, Lin SC, Chen TJ, Yang JM, Wang WC PLoS One. 2012;7(3):e33481. Epub 2012 Mar 16. PMID:22438938<ref>PMID:22438938</ref>		Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism.,Cheng WC, Chen YF, Wang HJ, Hsu KC, Lin SC, Chen TJ, Yang JM, Wang WC PLoS One. 2012;7(3):e33481. Epub 2012 Mar 16. PMID:22438938<ref>PMID:22438938</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Shikimate kinase\|Shikimate kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 27:
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]
-	[[Category: Chen, T J.]]	+	[[Category: Chen, T J]]
-	[[Category: Cheng, W C.]]	+	[[Category: Cheng, W C]]
-	[[Category: Lin, S C.]]	+	[[Category: Lin, S C]]
-	[[Category: Wang, W C.]]	+	[[Category: Wang, W C]]
	[[Category: Helix-sheet complex]]		[[Category: Helix-sheet complex]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:43, 28 May 2014

2014-05-28T10:43:33Z

←Older revision		Revision as of 10:43, 28 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3mrs.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori==
		+	<StructureSection load='3mrs' size='340' side='right' caption='[[3mrs]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mrs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MRS FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mrs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mrs RCSB], [http://www.ebi.ac.uk/pdbsum/3mrs PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Shikimate kinase (SK), which catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP, is the enzyme in the fifth step of the shikimate pathway for biosynthesis of aromatic amino acids. This pathway is present in bacteria, fungi, and plants but absent in mammals and therefore represents an attractive target pathway for the development of new antimicrobial agents, herbicides, and antiparasitic agents. Here we investigated the detailed structure-activity relationship of SK from Helicobacter pylori (HpSK). Site-directed mutagenesis and isothermal titration calorimetry studies revealed critical conserved residues (D33, F48, R57, R116, and R132) that interact with shikimate and are therefore involved in catalysis. Crystal structures of HpSK.SO(4), R57A, and HpSKshikimate-3-phosphate ADP show a characteristic three-layer architecture and a conformationally elastic region consisting of F48, R57, R116, and R132, occupied by shikimate. The structure of the inhibitor complex, E114A * 162535, was also determined, which revealed a dramatic shift in the elastic LID region and resulted in conformational locking into a distinctive form. These results reveal considerable insight into the active-site chemistry of SKs and a selective inhibitor-induced-fit mechanism.

-	<!--	+	Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism.,Cheng WC, Chen YF, Wang HJ, Hsu KC, Lin SC, Chen TJ, Yang JM, Wang WC PLoS One. 2012;7(3):e33481. Epub 2012 Mar 16. PMID:22438938<ref>PMID:22438938</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3mrs"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3mrs\| PDB=3mrs \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~shikimate kinase mutant (R57A) from Helicobacter pylori===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22438938}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22438938 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22438938}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3mrs]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022438938<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]

OCA at 05:09, 30 May 2012

2012-05-30T05:09:10Z

←Older revision		Revision as of 05:09, 30 May 2012
Line 1:		Line 1:
-	[[Image:3mrs.~~jpg~~\|left\|200px]]	+	[[Image:3mrs.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori===		===Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22438938}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22438938 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22438938}}

	==About this Structure==		==About this Structure==
	[[3mrs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA].		[[3mrs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022438938</ref><references group="xtra"/>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]
Line 20:		Line 29:
	[[Category: Lin, S C.]]		[[Category: Lin, S C.]]
	[[Category: Wang, W C.]]		[[Category: Wang, W C.]]
		+	[[Category: Helix-sheet complex]]
		+	[[Category: Transferase]]

OCA: Protected "3mrs" [edit=sysop:move=sysop]

2011-05-04T06:58:37Z

Protected "3mrs" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:58, 4 May 2011

OCA at 06:58, 4 May 2011

2011-05-04T06:58:34Z

←Older revision		Revision as of 06:58, 4 May 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3mrs.jpg\|left\|200px]]

-	The ~~entry 3mrs~~ is ~~ON HOLD~~ ~~until Apr 29 2012~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mrs", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mrs\| PDB=3mrs \| SCENE= }}

-	~~Authors: Cheng, W.C., Chen, T.J., Lin, S.C., Wang, W.C.~~	+	===Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori===

-	Description: Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed May 26 08~~:22:~~10 2010''~~	+	==About this Structure==
		+	[[3mrs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRS OCA].
		+	[[Category: Helicobacter pylori]]
		+	[[Category: Shikimate kinase]]
		+	[[Category: Chen, T J.]]
		+	[[Category: Cheng, W C.]]
		+	[[Category: Lin, S C.]]
		+	[[Category: Wang, W C.]]

OCA at 04:17, 26 May 2010

2010-05-26T04:17:59Z

←Older revision		Revision as of 04:17, 26 May 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3mrs is ON HOLD	+	The entry 3mrs is ON HOLD until Apr 29 2012

	Authors: Cheng, W.C., Chen, T.J., Lin, S.C., Wang, W.C.		Authors: Cheng, W.C., Chen, T.J., Lin, S.C., Wang, W.C.
Line 7:		Line 7:
	Description: Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori		Description: Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ May ~~20 09~~:18:14 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:22:10 2010''

OCA at 06:18, 20 May 2010

2010-05-20T06:18:14Z

←Older revision		Revision as of 06:18, 20 May 2010
Line 3:		Line 3:
	The entry 3mrs is ON HOLD		The entry 3mrs is ON HOLD

-	Authors: ~~Wen-Chi~~ Cheng, ~~Tzu-Jung~~ Chen, ~~Shuang-Chih~~ Lin, ~~Wen-Ching~~ Wang	+	Authors: Cheng, W.C., Chen, T.J., Lin, S.C., Wang, W.C.

	Description: Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori		Description: Crystal structure of shikimate kinase mutant (R57A) from Helicobacter pylori

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ May ~~12 10~~:46:44 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:18:14 2010''