3mx0 - Revision history

OCA at 08:19, 8 November 2017

2017-11-08T08:19:28Z

←Older revision		Revision as of 08:19, 8 November 2017
Line 32:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 3mx0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3mx0" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ephrin\|Ephrin]]
-	*[[Ephrin receptor\|Ephrin receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:21, 5 August 2016

2016-08-05T14:21:54Z

←Older revision		Revision as of 14:21, 5 August 2016
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		+
	==Crystal Structure of EphA2 ectodomain in complex with ephrin-A5==		==Crystal Structure of EphA2 ectodomain in complex with ephrin-A5==
	<StructureSection load='3mx0' size='340' side='right' caption='[[3mx0]], [[Resolution\|resolution]] 3.51Å' scene=''>		<StructureSection load='3mx0' size='340' side='right' caption='[[3mx0]], [[Resolution\|resolution]] 3.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mx0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MX0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mx0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MX0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA2, ECK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), EFNA5, EPLG7, LERK7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA2, ECK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), EFNA5, EPLG7, LERK7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mx0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mx0 RCSB], [http://www.ebi.ac.uk/pdbsum/3mx0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mx0 OCA], [http://pdbe.org/3mx0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mx0 RCSB], [http://www.ebi.ac.uk/pdbsum/3mx0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mx0 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mx0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mx0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 38:		Line 40:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Atapattu, L]]		[[Category: Atapattu, L]]

OCA at 15:48, 18 December 2014

2014-12-18T15:48:56Z

←Older revision		Revision as of 15:48, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3mx0~~\| ~~PDB~~=3mx0 \| ~~SCENE~~= }}	+	==Crystal Structure of EphA2 ectodomain in complex with ephrin-A5==
-	===~~Crystal Structure~~ of ~~EphA2 ectodomain~~ in ~~complex~~ with ephrin-A5===	+	<StructureSection load='3mx0' size='340' side='right' caption='[[3mx0]], [[Resolution\|resolution]] 3.51Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20505120}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mx0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MX0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EPHA2, ECK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EFNA5, EPLG7, LERK7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mx0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mx0 RCSB], [http://www.ebi.ac.uk/pdbsum/3mx0 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN]] Genetic variations in EPHA2 are the cause of susceptibility to cataract cortical age-related type 2 (ARCC2) [MIM:[http://omim.org/entry/613020 613020]]. A developmental punctate opacity common in the cortex and present in most lenses. The cataract is white or cerulean, increases in number with age, but rarely affects vision.<ref>PMID:19573808</ref> <ref>PMID:19649315</ref> Defects in EPHA2 are the cause of cataract posterior polar type 1 (CTPP1) [MIM:[http://omim.org/entry/116600 116600]]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity.<ref>PMID:19573808</ref> <ref>PMID:19005574</ref> <ref>PMID:19306328</ref> <ref>PMID:22570727</ref> Note=Overexpressed in several cancer types and promotes malignancy.<ref>PMID:19573808</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN]] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.<ref>PMID:10655584</ref> <ref>PMID:16236711</ref> <ref>PMID:18339848</ref> <ref>PMID:19573808</ref> <ref>PMID:20679435</ref> <ref>PMID:20861311</ref> [[http://www.uniprot.org/uniprot/EFNA5_HUMAN EFNA5_HUMAN]] Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.<ref>PMID:10601038</ref> <ref>PMID:11870224</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/3mx0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Eph receptor tyrosine kinases and their ephrin ligands regulate cell navigation during normal and oncogenic development. Signaling of Ephs is initiated in a multistep process leading to the assembly of higher-order signaling clusters that set off bidirectional signaling in interacting cells. However, the structural and mechanistic details of this assembly remained undefined. Here we present high-resolution structures of the complete EphA2 ectodomain and complexes with ephrin-A1 and A5 as the base unit of an Eph cluster. The structures reveal an elongated architecture with novel Eph/Eph interactions, both within and outside of the Eph ligand-binding domain, that suggest the molecular mechanism underlying Eph/ephrin clustering. Structure-function analysis, by using site-directed mutagenesis and cell-based signaling assays, confirms the importance of the identified oligomerization interfaces for Eph clustering.

-	~~==Disease==~~	+	Architecture of Eph receptor clusters.,Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S Proc Natl Acad Sci U S A. 2010 May 26. PMID:20505120<ref>PMID:20505120</ref>
-	~~[[http://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN]] Genetic variations in EPHA2 are the cause~~ of ~~susceptibility to cataract cortical age-related type 2 (ARCC2) [MIM:[http://omim.org/entry/613020 613020]]. A developmental punctate opacity common in the cortex and present in most lenses~~. ~~The cataract is white or cerulean~~, ~~increases in number with age~~, ~~but rarely affects vision.<ref>PMID:19573808</ref><ref>PMID:19649315</ref> Defects in EPHA2 are the cause of cataract posterior polar type 1 (CTPP1) [MIM:[http://omim.org/entry/116600 116600]].~~ A ~~subcapsular opacity~~, ~~usually disk~~-~~shaped, located at the back of the lens~~. ~~It can have a marked effect on visual acuity~~.~~<ref>~~PMID:~~19573808</ref><ref>PMID:19005574</ref><ref>PMID:19306328</ref><ref>PMID:22570727</ref> Note=Overexpressed in several cancer types and promotes malignancy.~~<ref>PMID:~~19573808~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http://www.uniprot.org/uniprot~~/~~EPHA2_HUMAN EPHA2_HUMAN]] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells~~, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ~~ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects~~ of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ~~ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance~~. ~~With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis~~.<ref>PMID:10655584</ref><ref>PMID:16236711</ref><ref>PMID:18339848</ref><ref>PMID:19573808</ref><ref>PMID:20679435</ref><ref>PMID:20861311</ref> [[http://www.uniprot.org/uniprot/EFNA5_HUMAN EFNA5_HUMAN]] Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.<~~ref~~>~~PMID:10601038~~</~~ref~~>~~<ref>PMID:11870224</ref>~~	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[3mx0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MX0 OCA].	+

	==See Also==		==See Also==
		+	*[[Ephrin\|Ephrin]]
	*[[Ephrin receptor\|Ephrin receptor]]		*[[Ephrin receptor\|Ephrin receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020505120</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
-	[[Category: Atapattu, L.]]	+	[[Category: Atapattu, L]]
-	[[Category: Dhe-Paganon, S.]]	+	[[Category: Dhe-Paganon, S]]
-	[[Category: Himanen, J P.]]	+	[[Category: Himanen, J P]]
-	[[Category: Janes, P W.]]	+	[[Category: Janes, P W]]
-	[[Category: Lackmann, M.]]	+	[[Category: Lackmann, M]]
-	[[Category: Mensinga, A.]]	+	[[Category: Mensinga, A]]
-	[[Category: Nikolov, D B.]]	+	[[Category: Nikolov, D B]]
-	[[Category: Rajashankar, K R.]]	+	[[Category: Rajashankar, K R]]
-	[[Category: Walker, J R.]]	+	[[Category: Walker, J R]]
-	[[Category: Xu, K.]]	+	[[Category: Xu, K]]
-	[[Category: Yermekbayeva, L.]]	+	[[Category: Yermekbayeva, L]]
	[[Category: Ectodomain]]		[[Category: Ectodomain]]
	[[Category: Receptor-ligand complex]]		[[Category: Receptor-ligand complex]]
	[[Category: Receptor-receptor interaction]]		[[Category: Receptor-receptor interaction]]
	[[Category: Transferase receptor-signalling protein complex]]		[[Category: Transferase receptor-signalling protein complex]]

OCA at 23:49, 24 March 2013

2013-03-24T23:49:27Z

←Older revision		Revision as of 23:49, 24 March 2013
Line 1:		Line 1:
-	[[Image:3mx0.png\|left\|200px]]
-
	{{STRUCTURE_3mx0\| PDB=3mx0 \| SCENE= }}		{{STRUCTURE_3mx0\| PDB=3mx0 \| SCENE= }}
-
	===Crystal Structure of EphA2 ectodomain in complex with ephrin-A5===		===Crystal Structure of EphA2 ectodomain in complex with ephrin-A5===
		+	{{ABSTRACT_PUBMED_20505120}}

-	~~{{ABSTRACT_PUBMED_20505120}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN]] Genetic variations in EPHA2 are the cause of susceptibility to cataract cortical age-related type 2 (ARCC2) [MIM:[http://omim.org/entry/613020 613020]]. A developmental punctate opacity common in the cortex and present in most lenses. The cataract is white or cerulean, increases in number with age, but rarely affects vision.<ref>PMID:19573808</ref><ref>PMID:19649315</ref> Defects in EPHA2 are the cause of cataract posterior polar type 1 (CTPP1) [MIM:[http://omim.org/entry/116600 116600]]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity.<ref>PMID:19573808</ref><ref>PMID:19005574</ref><ref>PMID:19306328</ref><ref>PMID:22570727</ref> Note=Overexpressed in several cancer types and promotes malignancy.<ref>PMID:19573808</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN]] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.<ref>PMID:10655584</ref><ref>PMID:16236711</ref><ref>PMID:18339848</ref><ref>PMID:19573808</ref><ref>PMID:20679435</ref><ref>PMID:20861311</ref> [[http://www.uniprot.org/uniprot/EFNA5_HUMAN EFNA5_HUMAN]] Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.<ref>PMID:10601038</ref><ref>PMID:11870224</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020505120</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020505120</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]

OCA at 20:34, 20 October 2012

2012-10-20T20:34:44Z

←Older revision		Revision as of 20:34, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3mx0]] is a 4 chain structure ~~of [[Ephrin receptor]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MX0 OCA].	+	[[3mx0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MX0 OCA].

	==See Also==		==See Also==

OCA: Protected "3mx0" [edit=sysop:move=sysop]

2012-07-27T10:57:34Z

Protected "3mx0" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:57, 27 July 2012

OCA at 10:57, 27 July 2012

2012-07-27T10:57:31Z

←Older revision		Revision as of 10:57, 27 July 2012
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-	~~{{Seed}}~~	+	[[Image:3mx0.png\|left\|200px]]
-	[[Image:3mx0.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3mx0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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-	-->
	{{STRUCTURE_3mx0\| PDB=3mx0 \| SCENE= }}		{{STRUCTURE_3mx0\| PDB=3mx0 \| SCENE= }}

	===Crystal Structure of EphA2 ectodomain in complex with ephrin-A5===		===Crystal Structure of EphA2 ectodomain in complex with ephrin-A5===

-
-	<!--
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-	(as it appears on PubMed at http://www.pubmed.gov), where 20505120 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20505120}}		{{ABSTRACT_PUBMED_20505120}}

	==About this Structure==		==About this Structure==
-	~~3MX0~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MX0 OCA].	+	[[3mx0]] is a 4 chain structure of [[Ephrin receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MX0 OCA].
		+
		+	==See Also==
		+	*[[Ephrin receptor\|Ephrin receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20505120~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020505120</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
Line 41:		Line 32:
	[[Category: Receptor-receptor interaction]]		[[Category: Receptor-receptor interaction]]
	[[Category: Transferase receptor-signalling protein complex]]		[[Category: Transferase receptor-signalling protein complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:50:27 2010''

OCA at 09:44, 30 June 2010

2010-06-30T09:44:53Z

←Older revision		Revision as of 09:44, 30 June 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3mx0.jpg\|left\|200px]]

-	The ~~entry 3mx0~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mx0", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mx0\| PDB=3mx0 \| SCENE= }}

-	~~Authors: Himanen, J.P., Yermekbayeva, L., Janes, P.W., Walker, J.R., Xu, K., Atapattu, L., Rajashankar, K.R., Mensinga, A., Lackmann, M., Nikolov, D.B., Dhe~~-~~Paganon, S.~~	+	===Crystal Structure of EphA2 ectodomain in complex with ephrin-A5===

-	Description: Crystal Structure of EphA2 ectodomain in complex with ephrin-A5

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 12 10~~:48:26 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20505120}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20505120 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20505120}}
		+
		+	==About this Structure==
		+	3MX0 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MX0 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20505120</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Receptor protein-tyrosine kinase]]
		+	[[Category: Atapattu, L.]]
		+	[[Category: Dhe-Paganon, S.]]
		+	[[Category: Himanen, J P.]]
		+	[[Category: Janes, P W.]]
		+	[[Category: Lackmann, M.]]
		+	[[Category: Mensinga, A.]]
		+	[[Category: Nikolov, D B.]]
		+	[[Category: Rajashankar, K R.]]
		+	[[Category: Walker, J R.]]
		+	[[Category: Xu, K.]]
		+	[[Category: Yermekbayeva, L.]]
		+	[[Category: Ectodomain]]
		+	[[Category: Receptor-ligand complex]]
		+	[[Category: Receptor-receptor interaction]]
		+	[[Category: Transferase receptor-signalling protein complex]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:50:27 2010''

OCA: New page: '''Unreleased structure''' The entry 3mx0 is ON HOLD Authors: Himanen, J.P., Yermekbayeva, L., Janes, P.W., Walker, J.R., Xu, K., Atapattu, L., Rajashankar, K.R., Mensinga, A., Lackmann...

2010-05-12T07:48:26Z

New page: '''Unreleased structure''' The entry 3mx0 is ON HOLD Authors: Himanen, J.P., Yermekbayeva, L., Janes, P.W., Walker, J.R., Xu, K., Atapattu, L., Rajashankar, K.R., Mensinga, A., Lackmann...

New page

'''Unreleased structure'''

The entry 3mx0 is ON HOLD

Authors: Himanen, J.P., Yermekbayeva, L., Janes, P.W., Walker, J.R., Xu, K., Atapattu, L., Rajashankar, K.R., Mensinga, A., Lackmann, M., Nikolov, D.B., Dhe-Paganon, S.

Description: Crystal Structure of EphA2 ectodomain in complex with ephrin-A5

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:48:26 2010''