3mxx - Revision history

OCA at 16:41, 1 November 2023

2023-11-01T16:41:34Z

←Older revision		Revision as of 16:41, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3mxx' size='340' side='right'caption='[[3mxx]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3mxx' size='340' side='right'caption='[[3mxx]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mxx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mxx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MXX FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[3n0d\|3n0d]]~~, [[~~3n0e~~\|~~3n0e~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxx OCA], [https://pdbe.org/3mxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mxx RCSB], [https://www.ebi.ac.uk/pdbsum/3mxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxx OCA], [https://pdbe.org/3mxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mxx RCSB], [https://www.ebi.ac.uk/pdbsum/3mxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>	+	[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, R C]]	+	[[Category: Chen R-C]]
-	[[Category: Gao, Y]]	+	[[Category: Gao Y]]
-	[[Category: Wu, X H]]	+	[[Category: Wu X-H]]
-	[[Category: Wu, Y D]]	+	[[Category: Wu Y-D]]
-	~~[[Category: Asp-his-ser-trp tetrad]]~~	+
-	~~[[Category: Circular dichroism]]~~	+
-	~~[[Category: Folding energy]]~~	+
-	~~[[Category: Guanidine hydrochloride]]~~	+
-	~~[[Category: Thermostability]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Wd-repeat protein 5]]~~	+
-	~~[[Category: Wdr5~~]]	+

OCA at 18:31, 27 July 2022

2022-07-27T18:31:47Z

←Older revision		Revision as of 18:31, 27 July 2022
Line 3:		Line 3:
	<StructureSection load='3mxx' size='340' side='right'caption='[[3mxx]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3mxx' size='340' side='right'caption='[[3mxx]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mxx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3MXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mxx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MXX FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n0d\|3n0d]], [[3n0e\|3n0e]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3n0d\|3n0d]], [[3n0e\|3n0e]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3mxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxx OCA], [~~http~~://pdbe.org/3mxx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mxx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mxx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxx OCA], [https://pdbe.org/3mxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mxx RCSB], [https://www.ebi.ac.uk/pdbsum/3mxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>	+	[[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:00, 21 October 2020

2020-10-21T09:00:06Z

←Older revision		Revision as of 09:00, 21 October 2020
Line 1:		Line 1:

	==Crystal structure of WDR5 mutant (S62A)==		==Crystal structure of WDR5 mutant (S62A)==
-	<StructureSection load='3mxx' size='340' side='right' caption='[[3mxx]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='3mxx' size='340' side='right'caption='[[3mxx]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3MXX FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n0d\|3n0d]], [[3n0e\|3n0e]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n0d\|3n0d]], [[3n0e\|3n0e]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxx OCA], [http://pdbe.org/3mxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mxx RCSB], [http://www.ebi.ac.uk/pdbsum/3mxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3mxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxx OCA], [http://pdbe.org/3mxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mxx RCSB], [http://www.ebi.ac.uk/pdbsum/3mxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[WD ~~repeat~~-~~containing~~ protein\|WD ~~repeat~~-~~containing~~ protein]]	+	*[[WD-repeat protein 3D structures\|WD-repeat protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, R C]]		[[Category: Chen, R C]]
	[[Category: Gao, Y]]		[[Category: Gao, Y]]

OCA at 13:02, 16 January 2019

2019-01-16T13:02:27Z

←Older revision		Revision as of 13:02, 16 January 2019
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[WD-repeat protein 5\|WD-repeat protein 5]]	+	*[[WD repeat-containing protein\|WD repeat-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:03, 5 August 2016

2016-08-05T17:03:50Z

←Older revision		Revision as of 17:03, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of WDR5 mutant (S62A)==		==Crystal structure of WDR5 mutant (S62A)==
	<StructureSection load='3mxx' size='340' side='right' caption='[[3mxx]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3mxx' size='340' side='right' caption='[[3mxx]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MXX FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n0d\|3n0d]], [[3n0e\|3n0e]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n0d\|3n0d]], [[3n0e\|3n0e]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxx RCSB], [http://www.ebi.ac.uk/pdbsum/3mxx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxx OCA], [http://pdbe.org/3mxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mxx RCSB], [http://www.ebi.ac.uk/pdbsum/3mxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mxx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[WD-repeat protein 5\|WD-repeat protein 5]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, R C]]		[[Category: Chen, R C]]
	[[Category: Gao, Y]]		[[Category: Gao, Y]]

OCA at 04:16, 25 December 2014

2014-12-25T04:16:32Z

←Older revision		Revision as of 04:16, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxx RCSB], [http://www.ebi.ac.uk/pdbsum/3mxx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxx RCSB], [http://www.ebi.ac.uk/pdbsum/3mxx PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:27, 18 December 2014

2014-12-18T17:27:03Z

←Older revision		Revision as of 17:27, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3mxx\| PDB=3mxx \| SCENE= }}~~	+	==Crystal structure of WDR5 mutant (S62A)==
-	===Crystal structure of WDR5 mutant (S62A)===	+	<StructureSection load='3mxx' size='340' side='right' caption='[[3mxx]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20939513}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MXX FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n0d\|3n0d]], [[3n0e\|3n0e]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxx RCSB], [http://www.ebi.ac.uk/pdbsum/3mxx PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We recently found that Asp-His-Ser/Thr-Trp hydrogen-bonded tetrads are widely and uniquely present in the WD40-repeat proteins. WDR5 protein is a seven WD40-repeat propeller with five such tetrads. To explore the effect of the tetrad on the structure and stability of WD40-repeat proteins, the wild-type WDR5 and its seven mutants involving the substitutions of tetrad residues have been isolated. The crystal structures of the wild-type WDR5 and its three WDR5 mutants have been determined by X-ray diffraction method. The mutations of the tetrad residues are found not to change the basic structural features. The denaturing profiles of the wild type and the seven mutants with the use of denaturant guanidine hydrochloride have been studied by circular dichroism spectroscopy to determine the folding free energies of these proteins. The folding free energies of the wild type and the S62A, S146A, S188A, D192E, W330F, W330Y, and D324E mutants are measured to be about -11.6, -2.7, -3.1, -2.9, -3.6, -7.1, -7.0, and -7.5 kcal/mol, respectively. These suggest that (1) the hydrogen bonds in these hydrogen bond networks are unusually strong; (2) each hydrogen-bonded tetrad provides over 12 kcal/mol stability to the protein; thus, the removal of any single tetrad would cause unfolding of the protein; (3) since there are five tetrads, the protein must be in a highly unstable state without the tetrads, which might be related to its biological functions.

-	~~==Function==~~	+	The Effect of Asp-His-Ser/Thr-Trp Tetrad on the Thermostability of WD40-Repeat Proteins.,Wu XH, Chen RC, Gao Y, Wu YD Biochemistry. 2010 Nov 30;49(47):10237-45. Epub 2010 Nov 8. PMID:20939513<ref>PMID:20939513</ref>
-	~~[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N~~-~~terminus of histone H3 for efficient trimethylation at 'Lys~~-~~4'. As part of the MLL1~~/~~MLL complex it is involved in methylation and dimethylation at 'Lys~~-4' of ~~histone H3~~. ~~H3 'Lys~~-~~4' methylation represents a specific tag for epigenetic transcriptional activation~~. ~~As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues~~. ~~May regulate osteoblasts differentiation.<ref>~~PMID:~~19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref>~~ <ref>PMID:~~16829960~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3mxx]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020939513</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, R C.]]	+	[[Category: Chen, R C]]
-	[[Category: Gao, Y.]]	+	[[Category: Gao, Y]]
-	[[Category: Wu, X H.]]	+	[[Category: Wu, X H]]
-	[[Category: Wu, Y D.]]	+	[[Category: Wu, Y D]]
	[[Category: Asp-his-ser-trp tetrad]]		[[Category: Asp-his-ser-trp tetrad]]
	[[Category: Circular dichroism]]		[[Category: Circular dichroism]]

OCA: Protected "3mxx" [edit=sysop:move=sysop]

2013-04-17T20:52:52Z

Protected "3mxx" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:52, 17 April 2013

OCA at 20:52, 17 April 2013

2013-04-17T20:52:49Z

←Older revision		Revision as of 20:52, 17 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3mxx.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3mxx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3mxx\| PDB=3mxx \| SCENE= }}		{{STRUCTURE_3mxx\| PDB=3mxx \| SCENE= }}
-
	===Crystal structure of WDR5 mutant (S62A)===		===Crystal structure of WDR5 mutant (S62A)===
		+	{{ABSTRACT_PUBMED_20939513}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20939513}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 20939513 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20939513}}~~	+

	==About this Structure==		==About this Structure==
-	~~3MXX~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA].	+	[[3mxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20939513~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020939513</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, R C.]]		[[Category: Chen, R C.]]
Line 37:		Line 24:
	[[Category: Wd-repeat protein 5]]		[[Category: Wd-repeat protein 5]]
	[[Category: Wdr5]]		[[Category: Wdr5]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 10:58:04 2010''

OCA at 07:46, 1 December 2010

2010-12-01T07:46:17Z

←Older revision		Revision as of 07:46, 1 December 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3mxx.~~jpg~~\|left\|200px]]	+	[[Image:3mxx.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Crystal structure of WDR5 mutant (S62A)===		===Crystal structure of WDR5 mutant (S62A)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20939513}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20939513 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20939513}}

	==About this Structure==		==About this Structure==
	3MXX is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA].		3MXX is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXX OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20939513</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, R C.]]		[[Category: Chen, R C.]]
Line 29:		Line 38:
	[[Category: Wdr5]]		[[Category: Wdr5]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 20 06~~:37:15 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 10:58:04 2010''