3n56 - Revision history

OCA at 09:08, 6 September 2023

2023-09-06T09:08:52Z

←Older revision		Revision as of 09:08, 6 September 2023
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	<StructureSection load='3n56' size='340' side='right'caption='[[3n56]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3n56' size='340' side='right'caption='[[3n56]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n56]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N56 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n56]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N56 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DIO:1,4~~-~~DIETHYLENE+DIOXIDE'>DIO</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.102Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[2g47\|2g47]], [[2wby\|2wby]], [[3cww\|3cww]], [[3h44\|3h44]], [[3e4z\|3e4z]], [[1yk1\|1yk1]], [[3n57\|3n57]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>HCG_1810909, IDE, RP11-366I13.1-001 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN]), NPPB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n56 OCA], [https://pdbe.org/3n56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n56 RCSB], [https://www.ebi.ac.uk/pdbsum/3n56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n56 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n56 OCA], [https://pdbe.org/3n56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n56 RCSB], [https://www.ebi.ac.uk/pdbsum/3n56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n56 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[https://www.uniprot.org/uniprot/ANFB_HUMAN ANFB_HUMAN]] Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>	+	[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>

	==See Also==		==See Also==
Line 19:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Insulysin~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Funke, T]]	+	[[Category: Funke T]]
-	[[Category: Guo, Q]]	+	[[Category: Guo Q]]
-	[[Category: Tang, W J]]	+	[[Category: Tang W-J]]
-	~~[[Category: A-beta degrading enzyme]]~~	+
-	~~[[Category: Cardiac]]~~	+
-	~~[[Category: Cardiovascular regulation]]~~	+
-	~~[[Category: Cryptidase]]~~	+
-	~~[[Category: Diabetes mellitus]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Human insulin-degradng enzyme]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hormone complex]]~~	+
-	~~[[Category: Insulin]]~~	+
-	~~[[Category: Insulinase]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Metalloprotease]]~~	+
-	~~[[Category: Natriuretic factor]]~~	+
-	~~[[Category: Natriuretic peptide]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 06:55, 12 May 2022

2022-05-12T06:55:15Z

←Older revision		Revision as of 06:55, 12 May 2022
Line 1:		Line 1:

	==Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)==		==Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)==
-	<StructureSection load='3n56' size='340' side='right' caption='[[3n56]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='3n56' size='340' side='right'caption='[[3n56]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n56]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3N56 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n56]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N56 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g47\|2g47]], [[2wby\|2wby]], [[3cww\|3cww]], [[3h44\|3h44]], [[3e4z\|3e4z]], [[1yk1\|1yk1]], [[3n57\|3n57]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2g47\|2g47]], [[2wby\|2wby]], [[3cww\|3cww]], [[3h44\|3h44]], [[3e4z\|3e4z]], [[1yk1\|1yk1]], [[3n57\|3n57]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HCG_1810909, IDE, RP11-366I13.1-001 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NPPB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HCG_1810909, IDE, RP11-366I13.1-001 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NPPB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3n56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n56 OCA], [~~http~~://pdbe.org/3n56 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3n56 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3n56 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3n56 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n56 OCA], [https://pdbe.org/3n56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n56 RCSB], [https://www.ebi.ac.uk/pdbsum/3n56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n56 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[~~http~~://www.uniprot.org/uniprot/ANFB_HUMAN ANFB_HUMAN]] Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>	+	[[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[https://www.uniprot.org/uniprot/ANFB_HUMAN ANFB_HUMAN]] Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>
		+
		+	==See Also==
		+	*[[Insulin-degrading enzyme 3D structures\|Insulin-degrading enzyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 18:		Line 21:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Insulysin]]		[[Category: Insulysin]]
		+	[[Category: Large Structures]]
	[[Category: Funke, T]]		[[Category: Funke, T]]
	[[Category: Guo, Q]]		[[Category: Guo, Q]]

OCA at 08:23, 8 November 2017

2017-11-08T08:23:55Z

←Older revision		Revision as of 08:23, 8 November 2017
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/ANFB_HUMAN ANFB_HUMAN]] Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>		[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/ANFB_HUMAN ANFB_HUMAN]] Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>
-
-	==See Also==
-	*[[Insulin-Degrading Enzyme\|Insulin-Degrading Enzyme]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:15, 5 August 2016

2016-08-05T18:15:06Z

←Older revision		Revision as of 18:15, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)==		==Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)==
	<StructureSection load='3n56' size='340' side='right' caption='[[3n56]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3n56' size='340' side='right' caption='[[3n56]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n56]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N56 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n56]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N56 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g47\|2g47]], [[2wby\|2wby]], [[3cww\|3cww]], [[3h44\|3h44]], [[3e4z\|3e4z]], [[1yk1\|1yk1]], [[3n57\|3n57]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g47\|2g47]], [[2wby\|2wby]], [[3cww\|3cww]], [[3h44\|3h44]], [[3e4z\|3e4z]], [[1yk1\|1yk1]], [[3n57\|3n57]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HCG_1810909, IDE, RP11-366I13.1-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), NPPB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HCG_1810909, IDE, RP11-366I13.1-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NPPB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n56 RCSB], [http://www.ebi.ac.uk/pdbsum/3n56 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n56 OCA], [http://pdbe.org/3n56 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n56 RCSB], [http://www.ebi.ac.uk/pdbsum/3n56 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n56 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Insulysin]]		[[Category: Insulysin]]
	[[Category: Funke, T]]		[[Category: Funke, T]]

OCA at 04:45, 25 December 2014

2014-12-25T04:45:08Z

←Older revision		Revision as of 04:45, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n56 RCSB], [http://www.ebi.ac.uk/pdbsum/3n56 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n56 RCSB], [http://www.ebi.ac.uk/pdbsum/3n56 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/ANFB_HUMAN ANFB_HUMAN]] Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>

	==See Also==		==See Also==
	*[[Insulin-Degrading Enzyme\|Insulin-Degrading Enzyme]]		*[[Insulin-Degrading Enzyme\|Insulin-Degrading Enzyme]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:28, 9 December 2014

2014-12-09T08:28:07Z

←Older revision		Revision as of 08:28, 9 December 2014
Line 1:		Line 1:
-	~~[[Image:3n56.png\|left\|200px]]~~	+	==Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)==
-		+	<StructureSection load='3n56' size='340' side='right' caption='[[3n56]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~{{STRUCTURE_3n56\| PDB=3n56 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3n56]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N56 FirstGlance]. <br>
-	===Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g47\|2g47]], [[2wby\|2wby]], [[3cww\|3cww]], [[3h44\|3h44]], [[3e4z\|3e4z]], [[1yk1\|1yk1]], [[3n57\|3n57]]</td></tr>
-	~~{{ABSTRACT_PUBMED_021098034}}~~	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HCG_1810909, IDE, RP11-366I13.1-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), NPPB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>
-	==~~About this Structure~~==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n56 RCSB], [http://www.ebi.ac.uk/pdbsum/3n56 PDBsum]</span></td></tr>
-	[[3n56]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA].	+	</table>

	==See Also==		==See Also==
	*[[Insulin-Degrading Enzyme\|Insulin-Degrading Enzyme]]		*[[Insulin-Degrading Enzyme\|Insulin-Degrading Enzyme]]
-		+	__TOC__
-	~~==Reference==~~	+	</StructureSection>
-	~~<ref group="xtra">PMID:021098034</ref>~~<~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Insulysin]]		[[Category: Insulysin]]
-	[[Category: Funke, T.]]	+	[[Category: Funke, T]]
-	[[Category: Guo, Q.]]	+	[[Category: Guo, Q]]
-	[[Category: Tang, W J.]]	+	[[Category: Tang, W J]]
	[[Category: A-beta degrading enzyme]]		[[Category: A-beta degrading enzyme]]
	[[Category: Cardiac]]		[[Category: Cardiac]]
Line 33:		Line 32:
	[[Category: Insulin]]		[[Category: Insulin]]
	[[Category: Insulinase]]		[[Category: Insulinase]]
-	[[Category: Insulysin]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Metalloprotease]]		[[Category: Metalloprotease]]

OCA at 12:47, 20 October 2012

2012-10-20T12:47:56Z

←Older revision		Revision as of 12:47, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3n56]] is a 4 chain structure ~~of [[Insulin-Degrading Enzyme]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA].	+	[[3n56]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA].

	==See Also==		==See Also==

OCA: Protected "3n56" [edit=sysop:move=sysop]

2012-07-26T09:55:45Z

Protected "3n56" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:55, 26 July 2012

OCA at 09:55, 26 July 2012

2012-07-26T09:55:41Z

←Older revision		Revision as of 09:55, 26 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3n56.png\|left\|200px]]
-	[[Image:3n56.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3n56", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3n56\| PDB=3n56 \| SCENE= }}		{{STRUCTURE_3n56\| PDB=3n56 \| SCENE= }}

	===Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)===		===Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)===

		+	{{ABSTRACT_PUBMED_021098034}}

	==About this Structure==		==About this Structure==
-	~~3N56~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA].	+	[[3n56]] is a 4 chain structure of [[Insulin-Degrading Enzyme]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA].
		+
		+	==See Also==
		+	*[[Insulin-Degrading Enzyme\|Insulin-Degrading Enzyme]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021098034</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Insulysin]]		[[Category: Insulysin]]
Line 40:		Line 40:
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:50:22 2010''

OCA at 21:39, 17 November 2010

2010-11-17T21:39:08Z

←Older revision		Revision as of 21:39, 17 November 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3n56.jpg\|left\|200px]]

-	The ~~entry 3n56~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3n56", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3n56\| PDB=3n56 \| SCENE= }}

-	~~Authors: Funke, T., Guo, Q., Tang, W.~~-J.	+	===Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)===

-	Description: Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Oct 6 05~~:45:35 2010''	+	==About this Structure==
		+	3N56 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N56 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Insulysin]]
		+	[[Category: Funke, T.]]
		+	[[Category: Guo, Q.]]
		+	[[Category: Tang, W J.]]
		+	[[Category: A-beta degrading enzyme]]
		+	[[Category: Cardiac]]
		+	[[Category: Cardiovascular regulation]]
		+	[[Category: Cryptidase]]
		+	[[Category: Diabetes mellitus]]
		+	[[Category: Disease mutation]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Hormone]]
		+	[[Category: Human insulin-degradng enzyme]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hormone complex]]
		+	[[Category: Insulin]]
		+	[[Category: Insulinase]]
		+	[[Category: Insulysin]]
		+	[[Category: Metal-binding]]
		+	[[Category: Metalloprotease]]
		+	[[Category: Natriuretic factor]]
		+	[[Category: Natriuretic peptide]]
		+	[[Category: Protease]]
		+	[[Category: Secreted]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:50:22 2010''