3n6k - Revision history

OCA at 10:28, 21 February 2024

2024-02-21T10:28:16Z

←Older revision		Revision as of 10:28, 21 February 2024
Line 1:		Line 1:

	==Human FPPS complex with NOV_823==		==Human FPPS complex with NOV_823==
-	<StructureSection load='3n6k' size='340' side='right' caption='[[3n6k]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='3n6k' size='340' side='right'caption='[[3n6k]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n6k]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3N6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n6k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N6K FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=BFH:1~~-~~(CARBOXYMETHYL)-1H-BENZO~~[G]~~INDOLE-~~2~~-CARBOXYLIC+ACID'>BFH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[~~[3n1v\|3n1v~~]~~], [[3n1w\|3n1w]], [[3n3l\|3n3l]], [[3n45\|3n45]], [[3n46\|3n46]], [[3n49\|3n49]], [[3n5h\|3n5h]], [[3n5j\|3n5j]]</td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFH:1-(CARBOXYMETHYL)-1H-BENZO[G]INDOLE-2-CARBOXYLIC+ACID'>BFH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6k OCA], [https://pdbe.org/3n6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n6k RCSB], [https://www.ebi.ac.uk/pdbsum/3n6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n6k ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3n6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6k OCA], [~~http~~://pdbe.org/3n6k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3n6k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3n6k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3n6k ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.	+	[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/3n6k_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/3n6k_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 21:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n6k ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n6k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Bisphosphonates are potent inhibitors of farnesyl pyrophosphate synthase (FPPS) and are highly efficacious in the treatment of bone diseases such as osteoporosis, Paget's disease and tumor-induced osteolysis. In addition, the potential for direct antitumor effects has been postulated on the basis of in vitro and in vivo studies and has recently been demonstrated clinically in early breast cancer patients treated with the potent bisphosphonate zoledronic acid. However, the high affinity of bisphosphonates for bone mineral seems suboptimal for the direct treatment of soft-tissue tumors. Here we report the discovery of the first potent non-bisphosphonate FPPS inhibitors. These new inhibitors bind to a previously unknown allosteric site on FPPS, which was identified by fragment-based approaches using NMR and X-ray crystallography. This allosteric and druggable pocket allows the development of a new generation of FPPS inhibitors that are optimized for direct antitumor effects in soft tissue.

-	Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.,Jahnke W, Rondeau JM, Cotesta S, Marzinzik A, Pelle X, Geiser M, Strauss A, Gotte M, Bitsch F, Hemmig R, Henry C, Lehmann S, Glickman JF, Roddy TP, Stout SJ, Green JR Nat Chem Biol. 2010 Sep;6(9):660-6. Epub 2010 Aug 15. PMID:20711197<ref>PMID:20711197</ref>	+	==See Also==
-		+	*[[Farnesyl diphosphate synthase 3D structures\|Farnesyl diphosphate synthase 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3n6k" style="background-color:#fffaf0;"></div>~~	+
-	== ~~References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Rondeau, J M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Bisphosphonate]]~~	+	[[Category: Rondeau J-M]]
-	~~[[Category: Cholesterol biosynthesis]]~~	+
-	~~[[Category: Fragment~~-~~based screening]]~~	+
-	~~[[Category: Isoprene biosynthesis]]~~	+
-	~~[[Category: Ransferase-transferase inhibitor complex]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 08:24, 8 November 2017

2017-11-08T08:24:52Z

←Older revision		Revision as of 08:24, 8 November 2017
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3n6k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3n6k" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Farnesyl diphosphate synthase\|Farnesyl diphosphate synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:03, 5 August 2016

2016-08-05T13:03:37Z

←Older revision		Revision as of 13:03, 5 August 2016
Line 1:		Line 1:
		+
	==Human FPPS complex with NOV_823==		==Human FPPS complex with NOV_823==
	<StructureSection load='3n6k' size='340' side='right' caption='[[3n6k]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='3n6k' size='340' side='right' caption='[[3n6k]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n6k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n6k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N6K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFH:1-(CARBOXYMETHYL)-1H-BENZO[G]INDOLE-2-CARBOXYLIC+ACID'>BFH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFH:1-(CARBOXYMETHYL)-1H-BENZO[G]INDOLE-2-CARBOXYLIC+ACID'>BFH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n1v\|3n1v]], [[3n1w\|3n1w]], [[3n3l\|3n3l]], [[3n45\|3n45]], [[3n46\|3n46]], [[3n49\|3n49]], [[3n5h\|3n5h]], [[3n5j\|3n5j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n1v\|3n1v]], [[3n1w\|3n1w]], [[3n3l\|3n3l]], [[3n45\|3n45]], [[3n46\|3n46]], [[3n49\|3n49]], [[3n5h\|3n5h]], [[3n5j\|3n5j]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n6k RCSB], [http://www.ebi.ac.uk/pdbsum/3n6k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6k OCA], [http://pdbe.org/3n6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n6k RCSB], [http://www.ebi.ac.uk/pdbsum/3n6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n6k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n6k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3n6k" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Rondeau, J M]]		[[Category: Rondeau, J M]]
	[[Category: Bisphosphonate]]		[[Category: Bisphosphonate]]

OCA at 02:41, 25 December 2014

2014-12-25T02:41:54Z

←Older revision		Revision as of 02:41, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n6k RCSB], [http://www.ebi.ac.uk/pdbsum/3n6k PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n6k RCSB], [http://www.ebi.ac.uk/pdbsum/3n6k PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:38, 9 December 2014

2014-12-09T08:38:50Z

←Older revision		Revision as of 08:38, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3n6k.~~png~~\|~~left~~\|200px]]	+	==Human FPPS complex with NOV_823==
		+	<StructureSection load='3n6k' size='340' side='right' caption='[[3n6k]], [[Resolution\|resolution]] 2.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3n6k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N6K FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFH:1-(CARBOXYMETHYL)-1H-BENZO[G]INDOLE-2-CARBOXYLIC+ACID'>BFH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n1v\|3n1v]], [[3n1w\|3n1w]], [[3n3l\|3n3l]], [[3n45\|3n45]], [[3n46\|3n46]], [[3n49\|3n49]], [[3n5h\|3n5h]], [[3n5j\|3n5j]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n6k RCSB], [http://www.ebi.ac.uk/pdbsum/3n6k PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/3n6k_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bisphosphonates are potent inhibitors of farnesyl pyrophosphate synthase (FPPS) and are highly efficacious in the treatment of bone diseases such as osteoporosis, Paget's disease and tumor-induced osteolysis. In addition, the potential for direct antitumor effects has been postulated on the basis of in vitro and in vivo studies and has recently been demonstrated clinically in early breast cancer patients treated with the potent bisphosphonate zoledronic acid. However, the high affinity of bisphosphonates for bone mineral seems suboptimal for the direct treatment of soft-tissue tumors. Here we report the discovery of the first potent non-bisphosphonate FPPS inhibitors. These new inhibitors bind to a previously unknown allosteric site on FPPS, which was identified by fragment-based approaches using NMR and X-ray crystallography. This allosteric and druggable pocket allows the development of a new generation of FPPS inhibitors that are optimized for direct antitumor effects in soft tissue.

-	~~{{STRUCTURE_3n6k\| PDB=3n6k \| SCENE= }}~~	+	Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.,Jahnke W, Rondeau JM, Cotesta S, Marzinzik A, Pelle X, Geiser M, Strauss A, Gotte M, Bitsch F, Hemmig R, Henry C, Lehmann S, Glickman JF, Roddy TP, Stout SJ, Green JR Nat Chem Biol. 2010 Sep;6(9):660-6. Epub 2010 Aug 15. PMID:20711197<ref>PMID:20711197</ref>

-	~~===Human FPPS complex with NOV_823===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20711197}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3n6k]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA].~~	+

	==See Also==		==See Also==
	*[[Farnesyl diphosphate synthase\|Farnesyl diphosphate synthase]]		*[[Farnesyl diphosphate synthase\|Farnesyl diphosphate synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020711197<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Rondeau, J M.]]	+	[[Category: Rondeau, J M]]
	[[Category: Bisphosphonate]]		[[Category: Bisphosphonate]]
	[[Category: Cholesterol biosynthesis]]		[[Category: Cholesterol biosynthesis]]

OCA at 11:45, 20 October 2012

2012-10-20T11:45:28Z

←Older revision		Revision as of 11:45, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3n6k]] is a 1 chain structure ~~of [[Farnesyl diphosphate synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA].	+	[[3n6k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA].

	==See Also==		==See Also==

OCA: Protected "3n6k" [edit=sysop:move=sysop]

2012-07-26T06:29:25Z

Protected "3n6k" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:29, 26 July 2012

OCA at 06:29, 26 July 2012

2012-07-26T06:29:23Z

←Older revision		Revision as of 06:29, 26 July 2012
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-	{{Seed}}
	[[Image:3n6k.png\|left\|200px]]		[[Image:3n6k.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3n6k", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3n6k\| PDB=3n6k \| SCENE= }}		{{STRUCTURE_3n6k\| PDB=3n6k \| SCENE= }}

	===Human FPPS complex with NOV_823===		===Human FPPS complex with NOV_823===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20711197}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20711197 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20711197}}		{{ABSTRACT_PUBMED_20711197}}

	==About this Structure==		==About this Structure==
-	~~3N6K~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA].	+	[[3n6k]] is a 1 chain structure of [[Farnesyl diphosphate synthase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA].
		+
		+	==See Also==
		+	*[[Farnesyl diphosphate synthase\|Farnesyl diphosphate synthase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20711197~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020711197</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Rondeau, J M.]]		[[Category: Rondeau, J M.]]
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	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:19:27 2010''

OCA at 05:11, 1 September 2010

2010-09-01T05:11:19Z

←Older revision		Revision as of 05:11, 1 September 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3n6k.~~jpg~~\|left\|200px]]	+	[[Image:3n6k.png\|left\|200px]]

	<!--		<!--
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	===Human FPPS complex with NOV_823===		===Human FPPS complex with NOV_823===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20711197}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20711197 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20711197}}

	==About this Structure==		==About this Structure==
	3N6K is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA].		3N6K is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20711197</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Rondeau, J M.]]		[[Category: Rondeau, J M.]]
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	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 18 11~~:47:56 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:19:27 2010''

OCA at 07:40, 18 August 2010

2010-08-18T07:40:25Z

←Older revision		Revision as of 07:40, 18 August 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3n6k.jpg\|left\|200px]]

-	The ~~entry 3n6k~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3n6k", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3n6k\| PDB=3n6k \| SCENE= }}

-	~~Authors: Rondeau, J.-M.~~	+	===Human FPPS complex with NOV_823===

-	Description: Human FPPS complex with NOV_823

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jun 10 10~~:58:13 2010''	+	==About this Structure==
		+	3N6K is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Rondeau, J M.]]
		+	[[Category: Bisphosphonate]]
		+	[[Category: Cholesterol biosynthesis]]
		+	[[Category: Fragment-based screening]]
		+	[[Category: Isoprene biosynthesis]]
		+	[[Category: Ransferase-transferase inhibitor complex]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:47:56 2010''