3n7y - Revision history

OCA at 09:10, 6 September 2023

2023-09-06T09:10:14Z

←Older revision		Revision as of 09:10, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3n7y' size='340' side='right'caption='[[3n7y]], [[Resolution\|resolution]] 2.02Å' scene=''>		<StructureSection load='3n7y' size='340' side='right'caption='[[3n7y]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n7y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N7Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n7y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N7Y FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=011:7~~-~~AMINOHEPTANOIC+ACID'>011</scene>~~, ~~<scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.02Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1bm2\|1bm2]], [[3n84\|3n84]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=011:7-AMINOHEPTANOIC+ACID'>011</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">GRB2, ASH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7y OCA], [https://pdbe.org/3n7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n7y RCSB], [https://www.ebi.ac.uk/pdbsum/3n7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n7y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7y OCA], [https://pdbe.org/3n7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n7y RCSB], [https://www.ebi.ac.uk/pdbsum/3n7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n7y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>	+	[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Clements~~, J H~~]]	+	[[Category: Clements JH]]
-	[[Category: Martin~~, S F~~]]	+	[[Category: Martin SF]]
-	[[Category: Whiddon~~, B B]]~~	+	[[Category: Whiddon BB]]
-	~~[[Category: Golgi apparatus]]~~	+
-	~~[[Category: Host-virus interaction]]~~	+
-	~~[[Category: Ligand preorganization]]~~	+
-	~~[[Category: Macrocycle]]~~	+
-	~~[[Category: Macrocyclic ligand]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein binding-peptide complex~~]]	+

OCA at 06:57, 12 May 2022

2022-05-12T06:57:00Z

←Older revision		Revision as of 06:57, 12 May 2022
Line 1:		Line 1:

	==Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV==		==Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV==
-	<StructureSection load='3n7y' size='340' side='right' caption='[[3n7y]], [[Resolution\|resolution]] 2.02Å' scene=''>	+	<StructureSection load='3n7y' size='340' side='right'caption='[[3n7y]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n7y]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3N7Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n7y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N7Y FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=011:7-AMINOHEPTANOIC+ACID'>011</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=011:7-AMINOHEPTANOIC+ACID'>011</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bm2\|1bm2]], [[3n84\|3n84]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bm2\|1bm2]], [[3n84\|3n84]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2, ASH ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2, ASH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3n7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7y OCA], [~~http~~://pdbe.org/3n7y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3n7y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3n7y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3n7y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7y OCA], [https://pdbe.org/3n7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n7y RCSB], [https://www.ebi.ac.uk/pdbsum/3n7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n7y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>	+	[[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Growth factor receptor-bound ~~protein~~\|Growth factor receptor-bound ~~protein~~]]	+	*[[Growth factor receptor-bound proteins 3D structures\|Growth factor receptor-bound proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Clements, J H]]		[[Category: Clements, J H]]
	[[Category: Martin, S F]]		[[Category: Martin, S F]]

OCA at 08:56, 4 August 2016

2016-08-04T08:56:54Z

←Older revision		Revision as of 08:56, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV==		==Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV==
	<StructureSection load='3n7y' size='340' side='right' caption='[[3n7y]], [[Resolution\|resolution]] 2.02Å' scene=''>		<StructureSection load='3n7y' size='340' side='right' caption='[[3n7y]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n7y]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N7Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n7y]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N7Y FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=011:7-AMINOHEPTANOIC+ACID'>011</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=011:7-AMINOHEPTANOIC+ACID'>011</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bm2\|1bm2]], [[3n84\|3n84]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bm2\|1bm2]], [[3n84\|3n84]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2, ASH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2, ASH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7y RCSB], [http://www.ebi.ac.uk/pdbsum/3n7y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7y OCA], [http://pdbe.org/3n7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n7y RCSB], [http://www.ebi.ac.uk/pdbsum/3n7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n7y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3n7y" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Clements, J H]]		[[Category: Clements, J H]]
	[[Category: Martin, S F]]		[[Category: Martin, S F]]

OCA at 07:33, 25 December 2014

2014-12-25T07:33:59Z

←Older revision		Revision as of 07:33, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7y RCSB], [http://www.ebi.ac.uk/pdbsum/3n7y PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7y RCSB], [http://www.ebi.ac.uk/pdbsum/3n7y PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:06, 18 December 2014

2014-12-18T16:06:33Z

←Older revision		Revision as of 16:06, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3n7y\| PDB=3n7y \| SCENE= }}~~	+	==Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV==
-	===Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV===	+	<StructureSection load='3n7y' size='340' side='right' caption='[[3n7y]], [[Resolution\|resolution]] 2.02Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21116482}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3n7y]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N7Y FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=011:7-AMINOHEPTANOIC+ACID'>011</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bm2\|1bm2]], [[3n84\|3n84]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRB2, ASH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7y RCSB], [http://www.ebi.ac.uk/pdbsum/3n7y PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The thermodynamic and structural effects of macrocyclization as a tactic for stabilizing the biologically-active conformation of Grb2 SH2 binding peptides were investigated using isothermal titration calorimetry and x-ray crystallography. 23-Membered macrocycles containing the sequence pYVN were slightly more potent than their linear controls; however, preorganization did not necessarily eventuate in a more favorable binding entropy. Structures of complexes of macrocycle 7 and its acyclic control 8 are similar except for differences in relative orientations of corresponding atoms in the linking moieties of 7 and 8. There are no differences in the number of direct or water-mediated protein-ligand contacts that might account for the less favorable binding enthalpy of 7; however, an intramolecular hydrogen bond between the pY and pY+3 residues in 8 that is absent in 7 may be a factor. These studies highlight the difficulties associated with correlating energetics and structure in protein-ligand interactions.

-	~~==About this Structure==~~	+	Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions.,Delorbe JE, Clements JH, Whiddon BB, Martin SF ACS Med Chem Lett. 2010 Nov 11;1(8):448-452. PMID:21116482<ref>PMID:21116482</ref>
-	~~[[3n7y]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3N7Y OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Growth factor receptor-bound protein\|Growth factor receptor-bound protein]]		*[[Growth factor receptor-bound protein\|Growth factor receptor-bound protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021116482<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Clements, J H.]]	+	[[Category: Clements, J H]]
-	[[Category: Martin, S F.]]	+	[[Category: Martin, S F]]
-	[[Category: Whiddon, B B.]]	+	[[Category: Whiddon, B B]]
	[[Category: Golgi apparatus]]		[[Category: Golgi apparatus]]
	[[Category: Host-virus interaction]]		[[Category: Host-virus interaction]]

OCA at 12:13, 18 March 2013

2013-03-18T12:13:26Z

←Older revision		Revision as of 12:13, 18 March 2013
Line 1:		Line 1:
-	[[Image:3n7y.png\|left\|200px]]
-
	{{STRUCTURE_3n7y\| PDB=3n7y \| SCENE= }}		{{STRUCTURE_3n7y\| PDB=3n7y \| SCENE= }}
-
	===Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV===		===Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV===
-
	{{ABSTRACT_PUBMED_21116482}}		{{ABSTRACT_PUBMED_21116482}}

Line 11:		Line 7:

	==See Also==		==See Also==
-	*[[Growth factor receptor-bound protein 2\|Growth factor receptor-bound protein 2]]	+	*[[Growth factor receptor-bound protein\|Growth factor receptor-bound protein]]

	==Reference==		==Reference==

OCA at 14:14, 20 October 2012

2012-10-20T14:14:31Z

←Older revision		Revision as of 14:14, 20 October 2012
Line 1:		Line 1:
-	[[Image:3n7y.~~jpg~~\|left\|200px]]	+	[[Image:3n7y.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3n7y", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3n7y\| PDB=3n7y \| SCENE= }}		{{STRUCTURE_3n7y\| PDB=3n7y \| SCENE= }}

	===Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV===		===Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21116482}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21116482 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21116482}}		{{ABSTRACT_PUBMED_21116482}}

	==About this Structure==		==About this Structure==
	[[3n7y]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7Y OCA].		[[3n7y]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7Y OCA].
		+
		+	==See Also==
		+	*[[Growth factor receptor-bound protein 2\|Growth factor receptor-bound protein 2]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21116482~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021116482</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Clements, J H.]]		[[Category: Clements, J H.]]
	[[Category: Martin, S F.]]		[[Category: Martin, S F.]]
	[[Category: Whiddon, B B.]]		[[Category: Whiddon, B B.]]
		+	[[Category: Golgi apparatus]]
		+	[[Category: Host-virus interaction]]
		+	[[Category: Ligand preorganization]]
		+	[[Category: Macrocycle]]
		+	[[Category: Macrocyclic ligand]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protein binding-peptide complex]]

OCA: Protected "3n7y" [edit=sysop:move=sysop]

2011-01-12T05:14:53Z

Protected "3n7y" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:14, 12 January 2011

OCA at 05:14, 12 January 2011

2011-01-12T05:14:51Z

←Older revision		Revision as of 05:14, 12 January 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3n7y.jpg\|left\|200px]]

-	The ~~entry 3n7y~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3n7y", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3n7y\| PDB=3n7y \| SCENE= }}

-	~~Authors: Whiddon, B.B., Clements, J.H., Martin, S.F.~~	+	===Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV===

-	Description: Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Nov 24 13~~:53:~~56 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21116482}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21116482 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21116482}}
		+
		+	==About this Structure==
		+	[[3n7y]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7Y OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21116482</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Clements, J H.]]
		+	[[Category: Martin, S F.]]
		+	[[Category: Whiddon, B B.]]

OCA at 10:42, 24 November 2010

2010-11-24T10:42:25Z

←Older revision		Revision as of 10:42, 24 November 2010
Line 3:		Line 3:
	The entry 3n7y is ON HOLD		The entry 3n7y is ON HOLD

-	Authors: Whiddon, ~~Benjamin~~ B., Clements, ~~John~~ H., Martin, ~~Stephen~~ F.	+	Authors: Whiddon, B.B., Clements, J.H., Martin, S.F.

	Description: Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV		Description: Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jun 10 10~~:58:27 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 13:53:56 2010''