3nea - Revision history

OCA at 09:13, 6 September 2023

2023-09-06T09:13:54Z

←Older revision		Revision as of 09:13, 6 September 2023
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	<StructureSection load='3nea' size='340' side='right'caption='[[3nea]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='3nea' size='340' side='right'caption='[[3nea]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nea]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"francisella_tularensis_subsp~~.~~_nearctica"_olsufjev_1970 "francisella~~ tularensis subsp. ~~nearctica" olsufjev 1970~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NEA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nea]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis Francisella tularensis subsp. tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NEA FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>FTT_0680c, pth ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~119856~~ "~~Francisella tularensis subsp. nearctica~~" ~~Olsufjev 1970])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase]~~, ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nea OCA], [https://pdbe.org/3nea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nea RCSB], [https://www.ebi.ac.uk/pdbsum/3nea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nea ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nea OCA], [https://pdbe.org/3nea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nea RCSB], [https://www.ebi.ac.uk/pdbsum/3nea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nea ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PTH_FRATT PTH_FRATT]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).	+	[https://www.uniprot.org/uniprot/PTH_FRATT PTH_FRATT] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Francisella tularensis subsp. ~~nearctica olsufjev 1970]]~~	+	[[Category: Francisella tularensis subsp. tularensis]]
-	~~[[Category: Aminoacyl-tRNA hydrolase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Branstrom~~, A A~~]]	+	[[Category: Branstrom AA]]
-	[[Category: Chirgadze~~, N Y~~]]	+	[[Category: Chirgadze NY]]
-	[[Category: Gothe~~, S A~~]]	+	[[Category: Gothe SA]]
-	[[Category: Lam, R]]	+	[[Category: Lam R]]
-	[[Category: Lipman~~, R S~~]]	+	[[Category: Lipman RS]]
-	[[Category: McGrath~~, T E~~]]	+	[[Category: McGrath TE]]
-	[[Category: Peddi~~, S R~~]]	+	[[Category: Peddi SR]]
-	[[Category: Razumova, E]]	+	[[Category: Razumova E]]
-	[[Category: Romanov, V]]	+	[[Category: Romanov V]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Peptidyl-trna~~]]	+

OCA at 07:00, 12 May 2022

2022-05-12T07:00:11Z

←Older revision		Revision as of 07:00, 12 May 2022
Line 1:		Line 1:

	==Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis==		==Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis==
-	<StructureSection load='3nea' size='340' side='right' caption='[[3nea]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='3nea' size='340' side='right'caption='[[3nea]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nea]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"francisella_tularensis_subsp._nearctica"_olsufjev_1970 "francisella tularensis subsp. nearctica" olsufjev 1970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NEA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nea]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"francisella_tularensis_subsp._nearctica"_olsufjev_1970 "francisella tularensis subsp. nearctica" olsufjev 1970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NEA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTT_0680c, pth ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119856 "Francisella tularensis subsp. nearctica" Olsufjev 1970])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTT_0680c, pth ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119856 "Francisella tularensis subsp. nearctica" Olsufjev 1970])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nea OCA], [~~http~~://pdbe.org/3nea PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3nea RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3nea PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3nea ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nea OCA], [https://pdbe.org/3nea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nea RCSB], [https://www.ebi.ac.uk/pdbsum/3nea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nea ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTH_FRATT PTH_FRATT]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).	+	[[https://www.uniprot.org/uniprot/PTH_FRATT PTH_FRATT]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3nea" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3nea" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Peptidyl-tRNA hydrolase\|Peptidyl-tRNA hydrolase]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	[[Category: Francisella tularensis subsp. nearctica olsufjev 1970]]		[[Category: Francisella tularensis subsp. nearctica olsufjev 1970]]
	[[Category: Aminoacyl-tRNA hydrolase]]		[[Category: Aminoacyl-tRNA hydrolase]]
		+	[[Category: Large Structures]]
	[[Category: Branstrom, A A]]		[[Category: Branstrom, A A]]
	[[Category: Chirgadze, N Y]]		[[Category: Chirgadze, N Y]]

OCA at 08:28, 8 November 2017

2017-11-08T08:28:27Z

←Older revision		Revision as of 08:28, 8 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3nea" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3nea" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Peptidyl-tRNA hydrolase\|Peptidyl-tRNA hydrolase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:21, 4 August 2016

2016-08-04T07:21:57Z

←Older revision		Revision as of 07:21, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis==		==Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis==
	<StructureSection load='3nea' size='340' side='right' caption='[[3nea]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='3nea' size='340' side='right' caption='[[3nea]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nea]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Francisella_tularensis_subsp~~.~~_tularensis Francisella~~ tularensis subsp. ~~tularensis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NEA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nea]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"francisella_tularensis_subsp._nearctica"_olsufjev_1970 "francisella tularensis subsp. nearctica" olsufjev 1970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NEA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTT_0680c, pth ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119856 Francisella tularensis subsp. ~~tularensis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTT_0680c, pth ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119856 "Francisella tularensis subsp. nearctica" Olsufjev 1970])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nea OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nea RCSB], [http://www.ebi.ac.uk/pdbsum/3nea PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nea OCA], [http://pdbe.org/3nea PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nea RCSB], [http://www.ebi.ac.uk/pdbsum/3nea PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nea ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3nea" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Francisella tularensis subsp. nearctica olsufjev 1970]]
	[[Category: Aminoacyl-tRNA hydrolase]]		[[Category: Aminoacyl-tRNA hydrolase]]
-	[[Category: Francisella tularensis subsp. tularensis]]
	[[Category: Branstrom, A A]]		[[Category: Branstrom, A A]]
	[[Category: Chirgadze, N Y]]		[[Category: Chirgadze, N Y]]

OCA at 06:47, 24 December 2014

2014-12-24T06:47:22Z

←Older revision		Revision as of 06:47, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nea OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nea RCSB], [http://www.ebi.ac.uk/pdbsum/3nea PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nea OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nea RCSB], [http://www.ebi.ac.uk/pdbsum/3nea PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTH_FRATT PTH_FRATT]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:49, 18 December 2014

2014-12-18T14:49:56Z

←Older revision		Revision as of 14:49, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3nea\| PDB=3nea \| SCENE= }}~~	+	==Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis==
-	===Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis===	+	<StructureSection load='3nea' size='340' side='right' caption='[[3nea]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21505237}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3nea]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis Francisella tularensis subsp. tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NEA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTT_0680c, pth ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119856 Francisella tularensis subsp. tularensis])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nea OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nea RCSB], [http://www.ebi.ac.uk/pdbsum/3nea PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The rational design of novel antibiotics for bacteria involves the identification of inhibitors for enzymes involved in essential biochemical pathways in cells. In this study, the cloning, expression, purification, crystallization and structure of the enzyme peptidyl-tRNA hydrolase from Francisella tularensis, the causative agent of tularemia, was performed. The structure of F. tularensis peptidyl-tRNA hydrolase is comparable to those of other bacterial peptidyl-tRNA hydrolases, with most residues in the active site conserved amongst the family. The resultant reagents, structural data and analyses provide essential information for the structure-based design of novel inhibitors for this class of proteins.

-	~~==Function==~~	+	Structure of Francisella tularensis peptidyl-tRNA hydrolase.,Clarke TE, Romanov V, Lam R, Gothe SA, Peddi SR, Razumova EB, Lipman RS, Branstrom AA, Chirgadze NY Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt, 4):446-9. Epub 2011 Mar 26. PMID:21505237<ref>PMID:21505237</ref>
-	~~[[http://www.uniprot.org/uniprot/PTH_FRATT PTH_FRATT]] The natural substrate for this enzyme may be~~ peptidyl-~~tRNAs which drop off the ribosome during protein synthesis~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3nea]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Francisella_tularensis_subsp~~.~~_tularensis Francisella tularensis subsp. tularensis]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:021505237</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Peptidyl-tRNA hydrolase\|Peptidyl-tRNA hydrolase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Aminoacyl-tRNA hydrolase]]		[[Category: Aminoacyl-tRNA hydrolase]]
	[[Category: Francisella tularensis subsp. tularensis]]		[[Category: Francisella tularensis subsp. tularensis]]
-	[[Category: Branstrom, A A.]]	+	[[Category: Branstrom, A A]]
-	[[Category: Chirgadze, N Y.]]	+	[[Category: Chirgadze, N Y]]
-	[[Category: Gothe, S A.]]	+	[[Category: Gothe, S A]]
-	[[Category: Lam, R.]]	+	[[Category: Lam, R]]
-	[[Category: Lipman, R S.]]	+	[[Category: Lipman, R S]]
-	[[Category: McGrath, T E.]]	+	[[Category: McGrath, T E]]
-	[[Category: Peddi, S R.]]	+	[[Category: Peddi, S R]]
-	[[Category: Razumova, E.]]	+	[[Category: Razumova, E]]
-	[[Category: Romanov, V.]]	+	[[Category: Romanov, V]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Peptidyl-trna]]		[[Category: Peptidyl-trna]]

OCA at 11:46, 24 April 2013

2013-04-24T11:46:05Z

←Older revision		Revision as of 11:46, 24 April 2013
Line 1:		Line 1:
-	[[Image:3nea.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3nea", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3nea\| PDB=3nea \| SCENE= }}		{{STRUCTURE_3nea\| PDB=3nea \| SCENE= }}
-
	===Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis===		===Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis===
		+	{{ABSTRACT_PUBMED_21505237}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/PTH_FRATT PTH_FRATT]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21505237}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 21505237 is the PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_21505237}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021505237</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021505237</ref><references group="xtra"/><references/>
	[[Category: Aminoacyl-tRNA hydrolase]]		[[Category: Aminoacyl-tRNA hydrolase]]
	[[Category: Francisella tularensis subsp. tularensis]]		[[Category: Francisella tularensis subsp. tularensis]]

OCA at 06:15, 15 June 2011

2011-06-15T06:15:27Z

←Older revision		Revision as of 06:15, 15 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3nea.jpg\|left\|200px]]

-	The ~~entry 3nea~~ is ~~ON HOLD~~ ~~until Jun 09 2012~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3nea", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3nea\| PDB=3nea \| SCENE= }}

-	~~Authors: Lam, R., McGrath, T.E., Romanov, V., Gothe, S.A., Peddi, S.R., Razumova, E., Lipman, R.S., Branstrom, A.A., Chirgadze, N.Y.~~	+	===Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis===

-	~~Description~~: ~~Crystal~~ Structure ~~of Peptidyl~~-tRNA hydrolase ~~from~~ Francisella tularensis	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21505237}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21505237 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21505237}}
		+
		+	==About this Structure==
		+	[[3nea]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis Francisella tularensis subsp. tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021505237</ref><references group="xtra"/>
		+	[[Category: Aminoacyl-tRNA hydrolase]]
		+	[[Category: Francisella tularensis subsp. tularensis]]
		+	[[Category: Branstrom, A A.]]
		+	[[Category: Chirgadze, N Y.]]
		+	[[Category: Gothe, S A.]]
		+	[[Category: Lam, R.]]
		+	[[Category: Lipman, R S.]]
		+	[[Category: McGrath, T E.]]
		+	[[Category: Peddi, S R.]]
		+	[[Category: Razumova, E.]]
		+	[[Category: Romanov, V.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Peptidyl-trna]]

OCA: Protected "3nea" [edit=sysop:move=sysop]

2011-06-08T04:43:28Z

Protected "3nea" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:43, 8 June 2011

OCA at 04:43, 8 June 2011

2011-06-08T04:43:27Z

←Older revision		Revision as of 04:43, 8 June 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3nea is ON HOLD until Jun 08 2012	+	The entry 3nea is ON HOLD until Jun 09 2012

	Authors: Lam, R., McGrath, T.E., Romanov, V., Gothe, S.A., Peddi, S.R., Razumova, E., Lipman, R.S., Branstrom, A.A., Chirgadze, N.Y.		Authors: Lam, R., McGrath, T.E., Romanov, V., Gothe, S.A., Peddi, S.R., Razumova, E., Lipman, R.S., Branstrom, A.A., Chirgadze, N.Y.

	Description: Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis		Description: Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:42:45 2010''