3ng8 - Revision history

OCA at 09:14, 6 September 2023

2023-09-06T09:14:48Z

←Older revision		Revision as of 09:14, 6 September 2023
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	<StructureSection load='3ng8' size='340' side='right'caption='[[3ng8]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='3ng8' size='340' side='right'caption='[[3ng8]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ng8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ng8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NG8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2qt7\|2qt7]], [[3n0i\|3n0i]], [[3n4w\|3n4w]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">ICA3, ICA512, PTPRN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ng8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ng8 OCA], [https://pdbe.org/3ng8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ng8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ng8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ng8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ng8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ng8 OCA], [https://pdbe.org/3ng8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ng8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ng8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ng8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN]] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>	+	[https://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ermacora~~, M R~~]]	+	[[Category: Ermacora MR]]
-	[[Category: Jakoncic, J]]	+	[[Category: Jakoncic J]]
-	[[Category: Poskus, E]]	+	[[Category: Poskus E]]
-	[[Category: Primo~~, M E]]~~	+	[[Category: Primo ME]]
-	~~[[Category: Autoimmunity]]~~	+
-	~~[[Category: Diabetes]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Ia-2]]~~	+
-	~~[[Category: Ica-512]]~~	+
-	~~[[Category: Protein-tyrosine phosphatase]]~~	+
-	~~[[Category: Proteolysis]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transmembrane protein~~]]	+

OCA at 07:01, 12 May 2022

2022-05-12T07:01:15Z

←Older revision		Revision as of 07:01, 12 May 2022
Line 1:		Line 1:

	==Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5==		==Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5==
-	<StructureSection load='3ng8' size='340' side='right' caption='[[3ng8]], [[Resolution\|resolution]] 1.35Å' scene=''>	+	<StructureSection load='3ng8' size='340' side='right'caption='[[3ng8]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ng8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ng8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NG8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qt7\|2qt7]], [[3n0i\|3n0i]], [[3n4w\|3n4w]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2qt7\|2qt7]], [[3n0i\|3n0i]], [[3n4w\|3n4w]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ICA3, ICA512, PTPRN ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ICA3, ICA512, PTPRN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ng8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ng8 OCA], [~~http~~://pdbe.org/3ng8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ng8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ng8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ng8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ng8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ng8 OCA], [https://pdbe.org/3ng8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ng8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ng8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ng8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN]] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>	+	[[https://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN]] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ermacora, M R]]		[[Category: Ermacora, M R]]
	[[Category: Jakoncic, J]]		[[Category: Jakoncic, J]]

OCA at 10:40, 5 August 2016

2016-08-05T10:40:49Z

←Older revision		Revision as of 10:40, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5==		==Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5==
	<StructureSection load='3ng8' size='340' side='right' caption='[[3ng8]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='3ng8' size='340' side='right' caption='[[3ng8]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ng8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ng8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NG8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qt7\|2qt7]], [[3n0i\|3n0i]], [[3n4w\|3n4w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qt7\|2qt7]], [[3n0i\|3n0i]], [[3n4w\|3n4w]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ICA3, ICA512, PTPRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ICA3, ICA512, PTPRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ng8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ng8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ng8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ng8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ng8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ng8 OCA], [http://pdbe.org/3ng8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ng8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ng8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ng8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ng8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ermacora, M R]]		[[Category: Ermacora, M R]]
	[[Category: Jakoncic, J]]		[[Category: Jakoncic, J]]

OCA at 01:41, 25 December 2014

2014-12-25T01:41:00Z

←Older revision		Revision as of 01:41, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ng8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ng8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ng8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ng8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ng8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ng8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ng8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ng8 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN]] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:40, 18 December 2014

2014-12-18T16:40:48Z

←Older revision		Revision as of 16:40, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ng8\| PDB=3ng8 \| SCENE= }}~~	+	==Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5==
-	===Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5===	+	<StructureSection load='3ng8' size='340' side='right' caption='[[3ng8]], [[Resolution\|resolution]] 1.35Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18048354}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ng8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NG8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qt7\|2qt7]], [[3n0i\|3n0i]], [[3n4w\|3n4w]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ICA3, ICA512, PTPRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ng8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ng8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ng8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ng8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	IA-2 (insulinoma-associated protein 2) is a protein-tyrosine phosphatase receptor located in secretory granules of neuroendocrine cells. Initially, it attracted attention due to its involvement in the autoimmune response associated to diabetes. Later it was found that upon exocytosis, the cytoplasmic domain of IA-2 is cleaved and relocated to the nucleus, where it enhances the transcription of the insulin gene. A concerted functioning of the whole receptor is to be expected. However, very little is known about the structure and function of the transmembrane and extracellular domains of IA-2. To address this issue, we solved the x-ray structure of the mature ectodomain of IA-2 (meIA-2) to 1.30A resolution. The fold of meIA-2 is related to the SEA (sea urchin sperm protein, enterokinase, agrin)) domains of mucins, suggesting its participation in adhesive contacts to the extracellular matrix and providing clues on how this kind of molecule may associate and form homo- and heterodimers. Moreover, we discovered that meIA-2 is self-proteolyzed in vitro by reactive oxygen species, suggesting the possibility of a new shedding mechanism that might be significant in normal function or pathological processes. Knowledge of meIA-2 structure should facilitate the search of its possible ligands and molecular interactions.

-	~~==Function==~~	+	Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2.,Primo ME, Klinke S, Sica MP, Goldbaum FA, Jakoncic J, Poskus E, Ermacora MR J Biol Chem. 2008 Feb 22;283(8):4674-81. Epub 2007 Nov 29. PMID:18048354<ref>PMID:18048354</ref>
-	~~[[http://www~~.~~uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN]] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules~~, ~~such as their biogenesis~~, ~~trafficking or regulated exocytosis or may have a general role in neuroendocrine functions~~. ~~Seems to lack intrinsic enzyme activity~~. ~~May play a role in the regulation of secretory granules via its interaction with SNTB2~~.~~<ref>~~PMID:~~8144912</ref>~~ <ref>PMID:~~8641276~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ng8]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:018048354</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ermacora, M R.]]	+	[[Category: Ermacora, M R]]
-	[[Category: Jakoncic, J.]]	+	[[Category: Jakoncic, J]]
-	[[Category: Poskus, E.]]	+	[[Category: Poskus, E]]
-	[[Category: Primo, M E.]]	+	[[Category: Primo, M E]]
	[[Category: Autoimmunity]]		[[Category: Autoimmunity]]
	[[Category: Diabetes]]		[[Category: Diabetes]]

OCA at 14:11, 10 July 2013

2013-07-10T14:11:30Z

←Older revision		Revision as of 14:11, 10 July 2013
Line 1:		Line 1:
-	[[Image:3ng8.png\|left\|200px]]
-
	{{STRUCTURE_3ng8\| PDB=3ng8 \| SCENE= }}		{{STRUCTURE_3ng8\| PDB=3ng8 \| SCENE= }}
-
	===Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5===		===Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5===
		+	{{ABSTRACT_PUBMED_18048354}}

-	~~{{ABSTRACT_PUBMED_18048354}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN]] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018048354</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018048354</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ermacora, M R.]]		[[Category: Ermacora, M R.]]

OCA at 11:14, 20 October 2012

2012-10-20T11:14:57Z

←Older revision		Revision as of 11:14, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ng8]] is a 2 chain structure ~~of [[Tyrosine phosphatase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA].	+	[[3ng8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA].

	==See Also==		==See Also==

OCA: Protected "3ng8" [edit=sysop:move=sysop]

2012-07-26T04:42:55Z

Protected "3ng8" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:42, 26 July 2012

OCA at 04:42, 26 July 2012

2012-07-26T04:42:53Z

←Older revision		Revision as of 04:42, 26 July 2012
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-	~~{{Seed}}~~	+	[[Image:3ng8.png\|left\|200px]]
-	[[Image:3ng8.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ng8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ng8\| PDB=3ng8 \| SCENE= }}		{{STRUCTURE_3ng8\| PDB=3ng8 \| SCENE= }}

	===Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5===		===Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5===

		+	{{ABSTRACT_PUBMED_18048354}}

	==About this Structure==		==About this Structure==
-	~~3NG8~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA].	+	[[3ng8]] is a 2 chain structure of [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA].
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18048354~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018048354</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ermacora, M R.]]		[[Category: Ermacora, M R.]]
Line 33:		Line 30:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transmembrane protein]]		[[Category: Transmembrane protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:41:52 2010''

OCA at 05:29, 15 December 2010

2010-12-15T05:29:33Z

←Older revision		Revision as of 05:29, 15 December 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ng8.jpg\|left\|200px]]

-	The ~~entry 3ng8~~ is ~~ON HOLD~~ ~~until Dec 11 2011~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ng8", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ng8\| PDB=3ng8 \| SCENE= }}

-	~~Authors: Primo, M.E., Jakoncic, J., Poskus, E., Ermacora, M.R~~.	+	===Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5===

-	Description: Crystal structure of an abridged SER TO ALA MUTANT OF THE MATURE ECTODOMAIN of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at PH 8.5

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 4~~ 08:48:28 2010''	+	==About this Structure==
		+	3NG8 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:18048354</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Ermacora, M R.]]
		+	[[Category: Jakoncic, J.]]
		+	[[Category: Poskus, E.]]
		+	[[Category: Primo, M E.]]
		+	[[Category: Autoimmunity]]
		+	[[Category: Diabetes]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Ia-2]]
		+	[[Category: Ica-512]]
		+	[[Category: Protein-tyrosine phosphatase]]
		+	[[Category: Proteolysis]]
		+	[[Category: Receptor]]
		+	[[Category: Transferase]]
		+	[[Category: Transmembrane protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:41:52 2010''