3nn7 - Revision history

OCA at 09:17, 6 September 2023

2023-09-06T09:17:52Z

←Older revision		Revision as of 09:17, 6 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3nn7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NN7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3nn7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NN7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BXA:BROMOACETIC+ACID'>BXA</scene>~~, ~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3ms3\|3ms3]], [[3msa\|3msa]], [[3msf\|3msf]], [[3msn\|3msn]], [[3n21\|3n21]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BXA:BROMOACETIC+ACID'>BXA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nn7 OCA], [https://pdbe.org/3nn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nn7 RCSB], [https://www.ebi.ac.uk/pdbsum/3nn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nn7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nn7 OCA], [https://pdbe.org/3nn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nn7 RCSB], [https://www.ebi.ac.uk/pdbsum/3nn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nn7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/THER_BACTH THER_BACTH]] Extracellular zinc metalloprotease.	+	[https://www.uniprot.org/uniprot/THER_BACTH THER_BACTH] Extracellular zinc metalloprotease.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 28:
	[[Category: Bacillus thermoproteolyticus]]		[[Category: Bacillus thermoproteolyticus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Thermolysin]]~~	+	[[Category: Behnen J]]
-	[[Category: Behnen, J]]	+	[[Category: Heine A]]
-	[[Category: Heine, A]]	+	[[Category: Klebe G]]
-	[[Category: Klebe, G]]	+
-	~~[[Category: 2-bromoacetate]]~~	+
-	~~[[Category: Fragment soaking]]~~	+
-	~~[[Category: Fragment-based lead discovery]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Metalloprotease]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 07:06, 12 May 2022

2022-05-12T07:06:26Z

←Older revision		Revision as of 07:06, 12 May 2022
Line 3:		Line 3:
	<StructureSection load='3nn7' size='340' side='right'caption='[[3nn7]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3nn7' size='340' side='right'caption='[[3nn7]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nn7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NN7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nn7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NN7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BXA:BROMOACETIC+ACID'>BXA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BXA:BROMOACETIC+ACID'>BXA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ms3\|3ms3]], [[3msa\|3msa]], [[3msf\|3msf]], [[3msn\|3msn]], [[3n21\|3n21]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ms3\|3ms3]], [[3msa\|3msa]], [[3msf\|3msf]], [[3msn\|3msn]], [[3n21\|3n21]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3nn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nn7 OCA], [~~http~~://pdbe.org/3nn7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3nn7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3nn7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3nn7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nn7 OCA], [https://pdbe.org/3nn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nn7 RCSB], [https://www.ebi.ac.uk/pdbsum/3nn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nn7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/THER_BACTH THER_BACTH]] Extracellular zinc metalloprotease.	+	[[https://www.uniprot.org/uniprot/THER_BACTH THER_BACTH]] Extracellular zinc metalloprotease.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Thermolysin\|Thermolysin]]	+	*[[Thermolysin 3D structures\|Thermolysin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:27, 17 July 2019

2019-07-17T11:27:53Z

←Older revision		Revision as of 11:27, 17 July 2019
Line 1:		Line 1:

	==Crystal structure of Thermolysin in complex with 2-bromoacetate==		==Crystal structure of Thermolysin in complex with 2-bromoacetate==
-	<StructureSection load='3nn7' size='340' side='right' caption='[[3nn7]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='3nn7' size='340' side='right'caption='[[3nn7]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3nn7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NN7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3nn7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NN7 FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus thermoproteolyticus]]		[[Category: Bacillus thermoproteolyticus]]
		+	[[Category: Large Structures]]
	[[Category: Thermolysin]]		[[Category: Thermolysin]]
	[[Category: Behnen, J]]		[[Category: Behnen, J]]

OCA at 10:10, 5 August 2016

2016-08-05T10:10:36Z

←Older revision		Revision as of 10:10, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Thermolysin in complex with 2-bromoacetate==		==Crystal structure of Thermolysin in complex with 2-bromoacetate==
	<StructureSection load='3nn7' size='340' side='right' caption='[[3nn7]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3nn7' size='340' side='right' caption='[[3nn7]], [[Resolution\|resolution]] 2.05Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ms3\|3ms3]], [[3msa\|3msa]], [[3msf\|3msf]], [[3msn\|3msn]], [[3n21\|3n21]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ms3\|3ms3]], [[3msa\|3msa]], [[3msf\|3msf]], [[3msn\|3msn]], [[3n21\|3n21]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nn7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nn7 RCSB], [http://www.ebi.ac.uk/pdbsum/3nn7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nn7 OCA], [http://pdbe.org/3nn7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nn7 RCSB], [http://www.ebi.ac.uk/pdbsum/3nn7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nn7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3nn7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 01:28, 25 December 2014

2014-12-25T01:28:48Z

←Older revision		Revision as of 01:28, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3nn7.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of Thermolysin in complex with 2-bromoacetate==
		+	<StructureSection load='3nn7' size='340' side='right' caption='[[3nn7]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3nn7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NN7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BXA:BROMOACETIC+ACID'>BXA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ms3\|3ms3]], [[3msa\|3msa]], [[3msf\|3msf]], [[3msn\|3msn]], [[3n21\|3n21]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nn7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nn7 RCSB], [http://www.ebi.ac.uk/pdbsum/3nn7 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/THER_BACTH THER_BACTH]] Extracellular zinc metalloprotease.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Small highly soluble probe molecules such as aniline, urea, N-methylurea, 2-bromoacetate, 1,2-propanediol, nitrous oxide, benzamidine, and phenol were soaked into crystals of various proteins to map their binding pockets and to detect hot spots of binding with respect to hydrophobic and hydrophilic properties. The selected probe molecules were first tested at the zinc protease thermolysin. They were then applied to a wider range of proteins such as protein kinase A, D-xylose isomerase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, endothiapepsin, and secreted aspartic protease 2. The crystal structures obtained clearly show that the probe molecules populate the protein binding pockets in an ordered fashion. The thus characterized, experimentally observed hot spots of binding were subjected to computational active site mapping using HotspotsX. This approach uses knowledge-based pair potentials to detect favorable binding positions for various atom types. Good agreement between the in silico hot spot predictions and the experimentally observed positions of the polar hydrogen bond forming functional groups and hydrophobic portions was obtained. Finally, we compared the observed poses of the small-molecule probes with those of much larger structurally related ligands. They coincide remarkably well with the larger ligands, considering their spatial orientation and the experienced interaction patterns. This observation confirms the fundamental hypothesis of fragment-based lead discovery: that binding poses, even of very small molecular probes, do not significantly deviate or move once a ligand is grown further into the binding site. This underscores the fact that these probes populate given hot spots and can be regarded as relevant seeds for further design.

-	~~{{STRUCTURE_3nn7\| PDB=3nn7 \| SCENE= }}~~	+	Experimental and Computational Active Site Mapping as a Starting Point to Fragment-Based Lead Discovery.,Behnen J, Koster H, Neudert G, Craan T, Heine A, Klebe G ChemMedChem. 2011 Dec 23. doi: 10.1002/cmdc.201100490. PMID:22213702<ref>PMID:22213702</ref>

-	~~===Crystal structure~~ of ~~Thermolysin in complex with 2-bromoacetate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22213702}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3nn7]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA].~~	+

	==See Also==		==See Also==
	*[[Thermolysin\|Thermolysin]]		*[[Thermolysin\|Thermolysin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022213702<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus thermoproteolyticus]]		[[Category: Bacillus thermoproteolyticus]]
	[[Category: Thermolysin]]		[[Category: Thermolysin]]
-	[[Category: Behnen, J.]]	+	[[Category: Behnen, J]]
-	[[Category: Heine, A.]]	+	[[Category: Heine, A]]
-	[[Category: Klebe, G.]]	+	[[Category: Klebe, G]]
	[[Category: 2-bromoacetate]]		[[Category: 2-bromoacetate]]
	[[Category: Fragment soaking]]		[[Category: Fragment soaking]]

OCA at 11:08, 20 October 2012

2012-10-20T11:08:55Z

←Older revision		Revision as of 11:08, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3nn7]] is a 1 chain structure ~~of [[Thermolysin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA].	+	[[3nn7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA].

	==See Also==		==See Also==

OCA at 04:23, 26 July 2012

2012-07-26T04:23:25Z

←Older revision		Revision as of 04:23, 26 July 2012
Line 1:		Line 1:
	[[Image:3nn7.png\|left\|200px]]		[[Image:3nn7.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3nn7\| PDB=3nn7 \| SCENE= }}		{{STRUCTURE_3nn7\| PDB=3nn7 \| SCENE= }}

	===Crystal structure of Thermolysin in complex with 2-bromoacetate===		===Crystal structure of Thermolysin in complex with 2-bromoacetate===

-
-	<!--
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	{{ABSTRACT_PUBMED_22213702}}		{{ABSTRACT_PUBMED_22213702}}

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	==See Also==		==See Also==
-	*[[Thermolysin]]	+	*[[Thermolysin\|Thermolysin]]

	==Reference==		==Reference==

OCA at 09:30, 18 January 2012

2012-01-18T09:30:14Z

←Older revision		Revision as of 09:30, 18 January 2012
Line 1:		Line 1:
-	[[Image:3nn7.~~jpg~~\|left\|200px]]	+	[[Image:3nn7.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal structure of Thermolysin in complex with 2-bromoacetate===		===Crystal structure of Thermolysin in complex with 2-bromoacetate===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22213702}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22213702 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22213702}}

	==About this Structure==		==About this Structure==
-	[[3nn7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA].	+	[[3nn7]] is a 1 chain structure of [[Thermolysin]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA].
		+
		+	==See Also==
		+	*[[Thermolysin]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022213702</ref><references group="xtra"/>
	[[Category: Bacillus thermoproteolyticus]]		[[Category: Bacillus thermoproteolyticus]]
	[[Category: Thermolysin]]		[[Category: Thermolysin]]
Line 19:		Line 31:
	[[Category: Heine, A.]]		[[Category: Heine, A.]]
	[[Category: Klebe, G.]]		[[Category: Klebe, G.]]
		+	[[Category: 2-bromoacetate]]
		+	[[Category: Fragment soaking]]
		+	[[Category: Fragment-based lead discovery]]
		+	[[Category: Hydrolase]]
		+	[[Category: Metal-binding]]
		+	[[Category: Metalloprotease]]
		+	[[Category: Protease]]
		+	[[Category: Secreted]]
		+	[[Category: Zymogen]]

OCA at 05:48, 25 May 2011

2011-05-25T05:48:21Z

←Older revision		Revision as of 05:48, 25 May 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3nn7.jpg\|left\|200px]]

-	The ~~entry 3nn7~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3nn7", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3nn7\| PDB=3nn7 \| SCENE= }}

-	~~Authors: Behnen, J., Heine, A., Klebe, G.~~	+	===Crystal structure of Thermolysin in complex with 2-bromoacetate===

-	~~Description: Crystal~~ structure ~~of Thermolysin in complex~~ with 2-~~bromoacetate~~	+
		+	==About this Structure==
		+	[[3nn7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NN7 OCA].
		+	[[Category: Bacillus thermoproteolyticus]]
		+	[[Category: Thermolysin]]
		+	[[Category: Behnen, J.]]
		+	[[Category: Heine, A.]]
		+	[[Category: Klebe, G.]]

OCA: Protected "3nn7" [edit=sysop:move=sysop]

2011-03-23T06:38:59Z

Protected "3nn7" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:38, 23 March 2011