3np5 - Revision history

OCA at 09:18, 6 September 2023

2023-09-06T09:18:45Z

←Older revision		Revision as of 09:18, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3np5' size='340' side='right'caption='[[3np5]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3np5' size='340' side='right'caption='[[3np5]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3np5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3np5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NP5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2qt7\|2qt7]], [[3n0i\|3n0i]], [[3ng8\|3ng8]], [[3n4w\|3n4w]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">ICA3, ICA512, PTPRN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3np5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3np5 OCA], [https://pdbe.org/3np5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3np5 RCSB], [https://www.ebi.ac.uk/pdbsum/3np5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3np5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3np5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3np5 OCA], [https://pdbe.org/3np5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3np5 RCSB], [https://www.ebi.ac.uk/pdbsum/3np5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3np5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN]] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>	+	[https://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	IA-2 (insulinoma-associated protein 2) is a protein-tyrosine phosphatase receptor located in secretory granules of neuroendocrine cells. Initially, it attracted attention due to its involvement in the autoimmune response associated to diabetes. Later it was found that upon exocytosis, the cytoplasmic domain of IA-2 is cleaved and relocated to the nucleus, where it enhances the transcription of the insulin gene. A concerted functioning of the whole receptor is to be expected. However, very little is known about the structure and function of the transmembrane and extracellular domains of IA-2. To address this issue, we solved the x-ray structure of the mature ectodomain of IA-2 (meIA-2) to 1.30A resolution. The fold of meIA-2 is related to the SEA (sea urchin sperm protein, enterokinase, agrin)) domains of mucins, suggesting its participation in adhesive contacts to the extracellular matrix and providing clues on how this kind of molecule may associate and form homo- and heterodimers. Moreover, we discovered that meIA-2 is self-proteolyzed in vitro by reactive oxygen species, suggesting the possibility of a new shedding mechanism that might be significant in normal function or pathological processes. Knowledge of meIA-2 structure should facilitate the search of its possible ligands and molecular interactions.	+
-		+
-	Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2.,Primo ME, Klinke S, Sica MP, Goldbaum FA, Jakoncic J, Poskus E, Ermacora MR J Biol Chem. 2008 Feb 22;283(8):4674-81. Epub 2007 Nov 29. PMID:18048354<ref>PMID:18048354</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3np5" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 27:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ermacora~~, M R~~]]	+	[[Category: Ermacora MR]]
-	[[Category: Jakoncic, J]]	+	[[Category: Jakoncic J]]
-	[[Category: Poskus, E]]	+	[[Category: Poskus E]]
-	[[Category: Primo~~, M E]]~~	+	[[Category: Primo ME]]
-	~~[[Category: Autoimmunity]]~~	+
-	~~[[Category: Diabetes]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Ia-2]]~~	+
-	~~[[Category: Ica-512]]~~	+
-	~~[[Category: Protein-tyrosine phosphatase]]~~	+
-	~~[[Category: Proteolysis]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Transmembrane protein~~]]	+

OCA at 07:07, 12 May 2022

2022-05-12T07:07:18Z

←Older revision		Revision as of 07:07, 12 May 2022
Line 1:		Line 1:

	==Crystal structure of an abridged form of the mature ectodomain of the human receptor-type protein tyrosine phosphatase ICA512/IA-2 AT pH 4.5==		==Crystal structure of an abridged form of the mature ectodomain of the human receptor-type protein tyrosine phosphatase ICA512/IA-2 AT pH 4.5==
-	<StructureSection load='3np5' size='340' side='right' caption='[[3np5]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3np5' size='340' side='right'caption='[[3np5]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3np5]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3np5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NP5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qt7\|2qt7]], [[3n0i\|3n0i]], [[3ng8\|3ng8]], [[3n4w\|3n4w]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2qt7\|2qt7]], [[3n0i\|3n0i]], [[3ng8\|3ng8]], [[3n4w\|3n4w]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ICA3, ICA512, PTPRN ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ICA3, ICA512, PTPRN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3np5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3np5 OCA], [~~http~~://pdbe.org/3np5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3np5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3np5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3np5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3np5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3np5 OCA], [https://pdbe.org/3np5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3np5 RCSB], [https://www.ebi.ac.uk/pdbsum/3np5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3np5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN]] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>	+	[[https://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN]] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ermacora, M R]]		[[Category: Ermacora, M R]]
	[[Category: Jakoncic, J]]		[[Category: Jakoncic, J]]

OCA at 20:27, 5 August 2016

2016-08-05T20:27:04Z

←Older revision		Revision as of 20:27, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of an abridged form of the mature ectodomain of the human receptor-type protein tyrosine phosphatase ICA512/IA-2 AT pH 4.5==		==Crystal structure of an abridged form of the mature ectodomain of the human receptor-type protein tyrosine phosphatase ICA512/IA-2 AT pH 4.5==
	<StructureSection load='3np5' size='340' side='right' caption='[[3np5]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3np5' size='340' side='right' caption='[[3np5]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3np5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3np5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NP5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qt7\|2qt7]], [[3n0i\|3n0i]], [[3ng8\|3ng8]], [[3n4w\|3n4w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qt7\|2qt7]], [[3n0i\|3n0i]], [[3ng8\|3ng8]], [[3n4w\|3n4w]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ICA3, ICA512, PTPRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ICA3, ICA512, PTPRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3np5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3np5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3np5 RCSB], [http://www.ebi.ac.uk/pdbsum/3np5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3np5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3np5 OCA], [http://pdbe.org/3np5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3np5 RCSB], [http://www.ebi.ac.uk/pdbsum/3np5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3np5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3np5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ermacora, M R]]		[[Category: Ermacora, M R]]
	[[Category: Jakoncic, J]]		[[Category: Jakoncic, J]]

OCA at 05:36, 25 December 2014

2014-12-25T05:36:31Z

←Older revision		Revision as of 05:36, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3np5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3np5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3np5 RCSB], [http://www.ebi.ac.uk/pdbsum/3np5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3np5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3np5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3np5 RCSB], [http://www.ebi.ac.uk/pdbsum/3np5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN]] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:18, 9 December 2014

2014-12-09T13:18:59Z

←Older revision		Revision as of 13:18, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3np5.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of an abridged form of the mature ectodomain of the human receptor-type protein tyrosine phosphatase ICA512/IA-2 AT pH 4.5==
		+	<StructureSection load='3np5' size='340' side='right' caption='[[3np5]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3np5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NP5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qt7\|2qt7]], [[3n0i\|3n0i]], [[3ng8\|3ng8]], [[3n4w\|3n4w]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ICA3, ICA512, PTPRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3np5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3np5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3np5 RCSB], [http://www.ebi.ac.uk/pdbsum/3np5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	IA-2 (insulinoma-associated protein 2) is a protein-tyrosine phosphatase receptor located in secretory granules of neuroendocrine cells. Initially, it attracted attention due to its involvement in the autoimmune response associated to diabetes. Later it was found that upon exocytosis, the cytoplasmic domain of IA-2 is cleaved and relocated to the nucleus, where it enhances the transcription of the insulin gene. A concerted functioning of the whole receptor is to be expected. However, very little is known about the structure and function of the transmembrane and extracellular domains of IA-2. To address this issue, we solved the x-ray structure of the mature ectodomain of IA-2 (meIA-2) to 1.30A resolution. The fold of meIA-2 is related to the SEA (sea urchin sperm protein, enterokinase, agrin)) domains of mucins, suggesting its participation in adhesive contacts to the extracellular matrix and providing clues on how this kind of molecule may associate and form homo- and heterodimers. Moreover, we discovered that meIA-2 is self-proteolyzed in vitro by reactive oxygen species, suggesting the possibility of a new shedding mechanism that might be significant in normal function or pathological processes. Knowledge of meIA-2 structure should facilitate the search of its possible ligands and molecular interactions.

-	~~{{STRUCTURE_3np5\| PDB=3np5 \| SCENE= }}~~	+	Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2.,Primo ME, Klinke S, Sica MP, Goldbaum FA, Jakoncic J, Poskus E, Ermacora MR J Biol Chem. 2008 Feb 22;283(8):4674-81. Epub 2007 Nov 29. PMID:18048354<ref>PMID:18048354</ref>

-	~~===Crystal structure of an abridged form~~ of the ~~mature ectodomain~~ of ~~the human receptor-type protein tyrosine phosphatase ICA512/IA-2 AT pH 4~~.~~5===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18048354}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3np5]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP5 OCA].~~	+

	==See Also==		==See Also==
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018048354<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ermacora, M R.]]	+	[[Category: Ermacora, M R]]
-	[[Category: Jakoncic, J.]]	+	[[Category: Jakoncic, J]]
-	[[Category: Poskus, E.]]	+	[[Category: Poskus, E]]
-	[[Category: Primo, M E.]]	+	[[Category: Primo, M E]]
	[[Category: Autoimmunity]]		[[Category: Autoimmunity]]
	[[Category: Diabetes]]		[[Category: Diabetes]]

OCA at 13:13, 20 October 2012

2012-10-20T13:13:41Z

←Older revision		Revision as of 13:13, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3np5]] is a 4 chain structure ~~of [[Tyrosine phosphatase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP5 OCA].	+	[[3np5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP5 OCA].

	==See Also==		==See Also==

OCA at 11:17, 26 July 2012

2012-07-26T11:17:45Z

←Older revision		Revision as of 11:17, 26 July 2012
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	[[Image:3np5.png\|left\|200px]]		[[Image:3np5.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_3np5\| PDB=3np5 \| SCENE= }}		{{STRUCTURE_3np5\| PDB=3np5 \| SCENE= }}

	===Crystal structure of an abridged form of the mature ectodomain of the human receptor-type protein tyrosine phosphatase ICA512/IA-2 AT pH 4.5===		===Crystal structure of an abridged form of the mature ectodomain of the human receptor-type protein tyrosine phosphatase ICA512/IA-2 AT pH 4.5===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18048354}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18048354 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_18048354}}		{{ABSTRACT_PUBMED_18048354}}

OCA at 06:59, 18 April 2012

2012-04-18T06:59:59Z

←Older revision		Revision as of 06:59, 18 April 2012
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-	[[Image:3np5.~~jpg~~\|left\|200px]]	+	[[Image:3np5.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of an abridged form of the mature ectodomain of the human receptor-type protein tyrosine phosphatase ICA512/IA-2 AT pH 4.5===		===Crystal structure of an abridged form of the mature ectodomain of the human receptor-type protein tyrosine phosphatase ICA512/IA-2 AT pH 4.5===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18048354}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18048354 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18048354}}

	==About this Structure==		==About this Structure==
-	[[3np5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP5 OCA].	+	[[3np5]] is a 4 chain structure of [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP5 OCA].
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18048354~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018048354</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ermacora, M R.]]		[[Category: Ermacora, M R.]]
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	[[Category: Poskus, E.]]		[[Category: Poskus, E.]]
	[[Category: Primo, M E.]]		[[Category: Primo, M E.]]
		+	[[Category: Autoimmunity]]
		+	[[Category: Diabetes]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Hydrolase]]
		+	[[Category: Ia-2]]
		+	[[Category: Ica-512]]
		+	[[Category: Protein-tyrosine phosphatase]]
		+	[[Category: Proteolysis]]
		+	[[Category: Receptor]]
		+	[[Category: Transmembrane protein]]

OCA at 05:26, 12 January 2011

2011-01-12T05:26:05Z

←Older revision		Revision as of 05:26, 12 January 2011
Line 22:		Line 22:
	[[Category: Poskus, E.]]		[[Category: Poskus, E.]]
	[[Category: Primo, M E.]]		[[Category: Primo, M E.]]
-	[[Category: Autoimmunity]]
-	[[Category: Diabetes]]
-	[[Category: Glycoprotein]]
-	[[Category: Hydrolase]]
-	[[Category: Ia-2]]
-	[[Category: Ica-512]]
-	[[Category: Protein-tyrosine phosphatase]]
-	[[Category: Proteolysis]]
-	[[Category: Receptor]]
-	[[Category: Transmembrane protein]]

OCA: Protected "3np5" [edit=sysop:move=sysop]

2010-12-29T18:36:39Z

Protected "3np5" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:36, 29 December 2010