3nw2 - Revision history

OCA at 16:52, 1 November 2023

2023-11-01T16:52:09Z

←Older revision		Revision as of 16:52, 1 November 2023
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	<StructureSection load='3nw2' size='340' side='right'caption='[[3nw2]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3nw2' size='340' side='right'caption='[[3nw2]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nw2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NW2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nw2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NW2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPW:2-[2-(4-METHOXYPYRIDIN-2-YL)ETHYL]-3H-IMIDAZO[4,5-B]PYRIDINE'>MPW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nod\|1nod]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPW:2-[2-(4-METHOXYPYRIDIN-2-YL)ETHYL]-3H-IMIDAZO[4,5-B]PYRIDINE'>MPW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw2 OCA], [https://pdbe.org/3nw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nw2 RCSB], [https://www.ebi.ac.uk/pdbsum/3nw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw2 OCA], [https://pdbe.org/3nw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nw2 RCSB], [https://www.ebi.ac.uk/pdbsum/3nw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>	+	[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Anezo, C]]	+	[[Category: Anezo C]]
-	[[Category: Boer, R]]	+	[[Category: Boer R]]
-	[[Category: Diederichs, K]]	+	[[Category: Diederichs K]]
-	[[Category: Fuchss, T]]	+	[[Category: Fuchss T]]
-	[[Category: Graedler, U]]	+	[[Category: Graedler U]]
-	[[Category: Hesslinger, C]]	+	[[Category: Hesslinger C]]
-	[[Category: Strub, A]]	+	[[Category: Strub A]]
-	[[Category: Ulrich~~, W R~~]]	+	[[Category: Ulrich WR]]
-	[[Category: Zaliani, A]]	+	[[Category: Zaliani A]]
-	~~[[Category: Calmodulin-binding]]~~	+
-	~~[[Category: Fad]]~~	+
-	~~[[Category: Fmn]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]	+

OCA at 07:10, 12 May 2022

2022-05-12T07:10:24Z

←Older revision		Revision as of 07:10, 12 May 2022
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	<StructureSection load='3nw2' size='340' side='right'caption='[[3nw2]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3nw2' size='340' side='right'caption='[[3nw2]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nw2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NW2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nw2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NW2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPW:2-[2-(4-METHOXYPYRIDIN-2-YL)ETHYL]-3H-IMIDAZO[4,5-B]PYRIDINE'>MPW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPW:2-[2-(4-METHOXYPYRIDIN-2-YL)ETHYL]-3H-IMIDAZO[4,5-B]PYRIDINE'>MPW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nod\|1nod]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nod\|1nod]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw2 OCA], [~~http~~://pdbe.org/3nw2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3nw2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3nw2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw2 OCA], [https://pdbe.org/3nw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nw2 RCSB], [https://www.ebi.ac.uk/pdbsum/3nw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>	+	[[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]	+	*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:08, 14 August 2019

2019-08-14T18:08:43Z

←Older revision		Revision as of 18:08, 14 August 2019
Line 1:		Line 1:

	==Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights==		==Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights==
-	<StructureSection load='3nw2' size='340' side='right' caption='[[3nw2]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3nw2' size='340' side='right'caption='[[3nw2]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3nw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NW2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3nw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NW2 FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3nw2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3nw2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Anezo, C]]		[[Category: Anezo, C]]

OCA at 08:36, 8 November 2017

2017-11-08T08:36:11Z

←Older revision		Revision as of 08:36, 8 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3nw2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3nw2" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:19, 4 August 2016

2016-08-04T09:19:37Z

←Older revision		Revision as of 09:19, 4 August 2016
Line 1:		Line 1:
		+
	==Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights==		==Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights==
	<StructureSection load='3nw2' size='340' side='right' caption='[[3nw2]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3nw2' size='340' side='right' caption='[[3nw2]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NW2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NW2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPW:2-[2-(4-METHOXYPYRIDIN-2-YL)ETHYL]-3H-IMIDAZO[4,5-B]PYRIDINE'>MPW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPW:2-[2-(4-METHOXYPYRIDIN-2-YL)ETHYL]-3H-IMIDAZO[4,5-B]PYRIDINE'>MPW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nod\|1nod]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nod\|1nod]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-~~oxide_synthase~~ Nitric-oxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nw2 RCSB], [http://www.ebi.ac.uk/pdbsum/3nw2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw2 OCA], [http://pdbe.org/3nw2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nw2 RCSB], [http://www.ebi.ac.uk/pdbsum/3nw2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3nw2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus]]~~	+	[[Category: Lk3 transgenic mice]]
-	~~[[Category: Nitric-oxide synthase~~]]	+
	[[Category: Anezo, C]]		[[Category: Anezo, C]]
	[[Category: Boer, R]]		[[Category: Boer, R]]

OCA at 08:09, 24 December 2014

2014-12-24T08:09:50Z

←Older revision		Revision as of 08:09, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nw2 RCSB], [http://www.ebi.ac.uk/pdbsum/3nw2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nw2 RCSB], [http://www.ebi.ac.uk/pdbsum/3nw2 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:26, 9 December 2014

2014-12-09T13:26:55Z

←Older revision		Revision as of 13:26, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3nw2.~~png~~\|~~left~~\|~~200px~~]]	+	==Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights==
		+	<StructureSection load='3nw2' size='340' side='right' caption='[[3nw2]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3nw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NW2 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPW:2-[2-(4-METHOXYPYRIDIN-2-YL)ETHYL]-3H-IMIDAZO[4,5-B]PYRIDINE'>MPW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nod\|1nod]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase Nitric-oxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nw2 RCSB], [http://www.ebi.ac.uk/pdbsum/3nw2 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inducible arginine oxidation and subsequent NO production by correspondent synthase (iNOS) are important cellular answers to proinflammatory signals. Prolonged NO production has been proved in higher organisms to cause stroke or septic shock. Several classes of potent NOS inhibitors have been reported, most of them targeting the arginine binding site of the oxygenase domain. Here we disclose the SAR and the rational design of potent and selective iNOS inhibitors which may be useful as anti-inflammatory drugs.

-	~~{{STRUCTURE_3nw2\| PDB=3nw2 \| SCENE= }}~~	+	Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.,Gradler U, Fuchss T, Ulrich WR, Boer R, Strub A, Hesslinger C, Anezo C, Diederichs K, Zaliani A Bioorg Med Chem Lett. 2011 Jul 15;21(14):4228-32. Epub 2011 May 30. PMID:21684157<ref>PMID:21684157</ref>

-	~~===Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21684157}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3nw2]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA].~~	+

	==See Also==		==See Also==
	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]		*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021684157<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Nitric-oxide synthase]]		[[Category: Nitric-oxide synthase]]
-	[[Category: Anezo, C.]]	+	[[Category: Anezo, C]]
-	[[Category: Boer, R.]]	+	[[Category: Boer, R]]
-	[[Category: Diederichs, K.]]	+	[[Category: Diederichs, K]]
-	[[Category: Fuchss, T.]]	+	[[Category: Fuchss, T]]
-	[[Category: Graedler, U.]]	+	[[Category: Graedler, U]]
-	[[Category: Hesslinger, C.]]	+	[[Category: Hesslinger, C]]
-	[[Category: Strub, A.]]	+	[[Category: Strub, A]]
-	[[Category: Ulrich, W R.]]	+	[[Category: Ulrich, W R]]
-	[[Category: Zaliani, A.]]	+	[[Category: Zaliani, A]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]
	[[Category: Fad]]		[[Category: Fad]]

OCA at 05:42, 20 October 2012

2012-10-20T05:42:05Z

←Older revision		Revision as of 05:42, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3nw2]] is a 2 chain structure ~~of [[Nitric Oxide Synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA].	+	[[3nw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA].

	==See Also==		==See Also==

OCA at 10:51, 25 July 2012

2012-07-25T10:51:56Z

←Older revision		Revision as of 10:51, 25 July 2012
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	[[Image:3nw2.png\|left\|200px]]		[[Image:3nw2.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3nw2\| PDB=3nw2 \| SCENE= }}		{{STRUCTURE_3nw2\| PDB=3nw2 \| SCENE= }}

	===Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights===		===Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21684157}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21684157 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21684157}}		{{ABSTRACT_PUBMED_21684157}}

	==About this Structure==		==About this Structure==
-	[[3nw2]] is a 2 chain structure of [[Nitric ~~oxide synthase~~]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA].	+	[[3nw2]] is a 2 chain structure of [[Nitric Oxide Synthase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA].

	==See Also==		==See Also==
-	*[[Nitric ~~oxide synthase~~]]	+	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]

	==Reference==		==Reference==

OCA at 05:57, 28 December 2011

2011-12-28T05:57:42Z

←Older revision		Revision as of 05:57, 28 December 2011
Line 1:		Line 1:
-	[[Image:3nw2.~~jpg~~\|left\|200px]]	+	[[Image:3nw2.png\|left\|200px]]

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	===Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights===		===Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21684157}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21684157 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21684157}}

	==About this Structure==		==About this Structure==
-	[[3nw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA].	+	[[3nw2]] is a 2 chain structure of [[Nitric oxide synthase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA].
		+
		+	==See Also==
		+	*[[Nitric oxide synthase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021684157</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Nitric-oxide synthase]]		[[Category: Nitric-oxide synthase]]