3nwt - Revision history

OCA at 10:01, 14 February 2024

2024-02-14T10:01:47Z

←Older revision		Revision as of 10:01, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='3nwt' size='340' side='right'caption='[[3nwt]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3nwt' size='340' side='right'caption='[[3nwt]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NWT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NWT FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3nws\|3nws]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">CDC13, YDL220C ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwt OCA], [https://pdbe.org/3nwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nwt RCSB], [https://www.ebi.ac.uk/pdbsum/3nwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nwt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwt OCA], [https://pdbe.org/3nwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nwt RCSB], [https://www.ebi.ac.uk/pdbsum/3nwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nwt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>	+	[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The essential yeast protein Cdc13 facilitates chromosome end replication by recruiting telomerase to telomeres, and together with its interacting partners Stn1 and Ten1, it protects chromosome ends from nucleolytic attack, thus contributing to genome integrity. Although Cdc13 has been studied extensively, the precise role of its N-terminal domain (Cdc13N) in telomere length regulation remains unclear. Here we present a structural, biochemical, and functional characterization of Cdc13N. The structure reveals that this domain comprises an oligonucleotide/oligosaccharide binding (OB) fold and is involved in Cdc13 dimerization. Biochemical data show that Cdc13N weakly binds long, single-stranded, telomeric DNA in a fashion that is directly dependent on domain oligomerization. When introduced into full-length Cdc13 in vivo, point mutations that prevented Cdc13N dimerization or DNA binding caused telomere shortening or lengthening, respectively. The multiple DNA binding domains and dimeric nature of Cdc13 offer unique insights into how it coordinates the recruitment and regulation of telomerase access to the telomeres.	+
-		+
-	Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation.,Mitchell MT, Smith JS, Mason M, Harper S, Speicher DW, Johnson FB, Skordalakes E Mol Cell Biol. 2010 Nov;30(22):5325-34. Epub 2010 Sep 13. PMID:20837709<ref>PMID:20837709</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3nwt" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Harper, S]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Johnson~~, F B~~]]	+	[[Category: Harper S]]
-	[[Category: Mason, M]]	+	[[Category: Johnson FB]]
-	[[Category: Mitchell~~, M T~~]]	+	[[Category: Mason M]]
-	[[Category: Skordalakes, E]]	+	[[Category: Mitchell MT]]
-	[[Category: Smith~~, J S~~]]	+	[[Category: Skordalakes E]]
-	[[Category: Speicher~~, D W]]~~	+	[[Category: Smith JS]]
-	~~[[Category: Cell cycle]]~~	+	[[Category: Speicher DW]]
-	~~[[Category: Oligonucleotide/oligosaccharide binding fold - ob fold]]~~	+
-	~~[[Category: Single stranded telomeric dna binding~~]]	+

OCA at 07:11, 12 May 2022

2022-05-12T07:11:07Z

←Older revision		Revision as of 07:11, 12 May 2022
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	<StructureSection load='3nwt' size='340' side='right'caption='[[3nwt]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3nwt' size='340' side='right'caption='[[3nwt]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nwt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NWT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NWT FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nws\|3nws]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nws\|3nws]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDC13, YDL220C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDC13, YDL220C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwt OCA], [~~http~~://pdbe.org/3nwt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3nwt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3nwt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3nwt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwt OCA], [https://pdbe.org/3nwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nwt RCSB], [https://www.ebi.ac.uk/pdbsum/3nwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nwt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>	+	[[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:29, 17 July 2019

2019-07-17T11:29:26Z

←Older revision		Revision as of 11:29, 17 July 2019
Line 1:		Line 1:

	==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13==		==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13==
-	<StructureSection load='3nwt' size='340' side='right' caption='[[3nwt]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='3nwt' size='340' side='right'caption='[[3nwt]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3nwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NWT FirstGlance]. <br>		<table><tr><td colspan='2'>[[3nwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NWT FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Harper, S]]		[[Category: Harper, S]]
	[[Category: Johnson, F B]]		[[Category: Johnson, F B]]

OCA at 22:02, 5 August 2016

2016-08-05T22:02:09Z

←Older revision		Revision as of 22:02, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13==		==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13==
	<StructureSection load='3nwt' size='340' side='right' caption='[[3nwt]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3nwt' size='340' side='right' caption='[[3nwt]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NWT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NWT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nws\|3nws]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nws\|3nws]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDC13, YDL220C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDC13, YDL220C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nwt RCSB], [http://www.ebi.ac.uk/pdbsum/3nwt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwt OCA], [http://pdbe.org/3nwt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nwt RCSB], [http://www.ebi.ac.uk/pdbsum/3nwt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nwt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3nwt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Harper, S]]		[[Category: Harper, S]]
	[[Category: Johnson, F B]]		[[Category: Johnson, F B]]

OCA at 06:12, 25 December 2014

2014-12-25T06:12:50Z

←Older revision		Revision as of 06:12, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nwt RCSB], [http://www.ebi.ac.uk/pdbsum/3nwt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nwt RCSB], [http://www.ebi.ac.uk/pdbsum/3nwt PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:18, 19 December 2014

2014-12-19T07:18:54Z

←Older revision		Revision as of 07:18, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3nwt\| PDB=3nwt \| SCENE= }}~~	+	==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13==
-	===Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13===	+	<StructureSection load='3nwt' size='340' side='right' caption='[[3nwt]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20837709}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3nwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NWT FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nws\|3nws]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDC13, YDL220C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nwt RCSB], [http://www.ebi.ac.uk/pdbsum/3nwt PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The essential yeast protein Cdc13 facilitates chromosome end replication by recruiting telomerase to telomeres, and together with its interacting partners Stn1 and Ten1, it protects chromosome ends from nucleolytic attack, thus contributing to genome integrity. Although Cdc13 has been studied extensively, the precise role of its N-terminal domain (Cdc13N) in telomere length regulation remains unclear. Here we present a structural, biochemical, and functional characterization of Cdc13N. The structure reveals that this domain comprises an oligonucleotide/oligosaccharide binding (OB) fold and is involved in Cdc13 dimerization. Biochemical data show that Cdc13N weakly binds long, single-stranded, telomeric DNA in a fashion that is directly dependent on domain oligomerization. When introduced into full-length Cdc13 in vivo, point mutations that prevented Cdc13N dimerization or DNA binding caused telomere shortening or lengthening, respectively. The multiple DNA binding domains and dimeric nature of Cdc13 offer unique insights into how it coordinates the recruitment and regulation of telomerase access to the telomeres.

-	~~==Function==~~	+	Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation.,Mitchell MT, Smith JS, Mason M, Harper S, Speicher DW, Johnson FB, Skordalakes E Mol Cell Biol. 2010 Nov;30(22):5325-34. Epub 2010 Sep 13. PMID:20837709<ref>PMID:20837709</ref>
-	~~[[http://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single~~-~~stranded telomeric~~ DNA-binding ~~protein that regulates~~ telomere ~~replication. Has a role in both positive and negative~~ regulation. ~~Promotes [TG(1-3)] strand lengthening via interaction with EST1~~. ~~Promotes [C~~(~~1-3~~)~~A] strand re~~-~~synthesis by DNA polymerase alpha via interaction with POL1~~. ~~Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity~~.~~<ref>~~PMID:~~11230149</ref> <ref>PMID:11390652</ref>~~ <ref>PMID:~~10898792~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3nwt]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020837709</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Harper, S.]]	+	[[Category: Harper, S]]
-	[[Category: Johnson, F B.]]	+	[[Category: Johnson, F B]]
-	[[Category: Mason, M.]]	+	[[Category: Mason, M]]
-	[[Category: Mitchell, M T.]]	+	[[Category: Mitchell, M T]]
-	[[Category: Skordalakes, E.]]	+	[[Category: Skordalakes, E]]
-	[[Category: Smith, J S.]]	+	[[Category: Smith, J S]]
-	[[Category: Speicher, D W.]]	+	[[Category: Speicher, D W]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Oligonucleotide/oligosaccharide binding fold - ob fold]]		[[Category: Oligonucleotide/oligosaccharide binding fold - ob fold]]
	[[Category: Single stranded telomeric dna binding]]		[[Category: Single stranded telomeric dna binding]]

OCA at 12:01, 24 April 2013

2013-04-24T12:01:04Z

←Older revision		Revision as of 12:01, 24 April 2013
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-	[[Image:3nwt.png\|left\|200px]]
-
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	{{STRUCTURE_3nwt\| PDB=3nwt \| SCENE= }}		{{STRUCTURE_3nwt\| PDB=3nwt \| SCENE= }}
-
	===Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13===		===Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13===
		+	{{ABSTRACT_PUBMED_20837709}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20837709}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 20837709 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20837709}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20837709~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020837709</ref><references group="xtra"/><references/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Harper, S.]]		[[Category: Harper, S.]]
Line 31:		Line 19:
	[[Category: Smith, J S.]]		[[Category: Smith, J S.]]
	[[Category: Speicher, D W.]]		[[Category: Speicher, D W.]]
		+	[[Category: Cell cycle]]
		+	[[Category: Oligonucleotide/oligosaccharide binding fold - ob fold]]
		+	[[Category: Single stranded telomeric dna binding]]

OCA: Protected "3nwt" [edit=sysop:move=sysop]

2011-01-19T05:34:45Z

Protected "3nwt" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:34, 19 January 2011

OCA at 05:34, 19 January 2011

2011-01-19T05:34:44Z

←Older revision		Revision as of 05:34, 19 January 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3nwt.png\|left\|200px]]
-	[[Image:3nwt.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	===Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13===		===Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20837709}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20837709 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20837709}}

	==About this Structure==		==About this Structure==
-	~~3NWT~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA].	+	[[3nwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20837709</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Harper, S.]]		[[Category: Harper, S.]]
Line 23:		Line 31:
	[[Category: Smith, J S.]]		[[Category: Smith, J S.]]
	[[Category: Speicher, D W.]]		[[Category: Speicher, D W.]]
-	[[Category: Cell cycle]]
-	[[Category: Oligonucleotide/oligosaccharide binding fold - ob fold]]
-	[[Category: Single stranded telomeric dna binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:48:06 2010''

OCA at 11:39, 22 September 2010

2010-09-22T11:39:07Z

←Older revision		Revision as of 11:39, 22 September 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3nwt.jpg\|left\|200px]]

-	The ~~entry 3nwt~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3nwt", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3nwt\| PDB=3nwt \| SCENE= }}

-	~~Authors: Mitchell, M.T., Smith, J.S., Mason, M., Harper, S., Speicher, D.W., Johnson, F.B., Skordalakes, E.~~	+	===Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13===

-	Description: CDC13N Crystal Structure

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 4 08~~:50:28 2010''	+	==About this Structure==
		+	3NWT is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA].
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Harper, S.]]
		+	[[Category: Johnson, F B.]]
		+	[[Category: Mason, M.]]
		+	[[Category: Mitchell, M T.]]
		+	[[Category: Skordalakes, E.]]
		+	[[Category: Smith, J S.]]
		+	[[Category: Speicher, D W.]]
		+	[[Category: Cell cycle]]
		+	[[Category: Oligonucleotide/oligosaccharide binding fold - ob fold]]
		+	[[Category: Single stranded telomeric dna binding]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:48:06 2010''