3ope - Revision history

OCA at 11:18, 21 February 2024

2024-02-21T11:18:03Z

←Older revision		Revision as of 11:18, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3ope' size='340' side='right'caption='[[3ope]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3ope' size='340' side='right'caption='[[3ope]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ope]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OPE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ope]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OPE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SAM:S~~-~~ADENOSYLMETHIONINE'>SAM</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ASH1L, KIAA1420, KMT2H ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ope OCA], [https://pdbe.org/3ope PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ope RCSB], [https://www.ebi.ac.uk/pdbsum/3ope PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ope ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ope OCA], [https://pdbe.org/3ope PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ope RCSB], [https://www.ebi.ac.uk/pdbsum/3ope PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ope ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ASH1L_HUMAN ASH1L_HUMAN]] Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).<ref>PMID:21239497</ref>	+	[https://www.uniprot.org/uniprot/ASH1L_HUMAN ASH1L_HUMAN] Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).<ref>PMID:21239497</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Absent, small, or homeotic disc1 (Ash1) is a trithorax group histone methyltransferase that is involved in gene activation. Although there are many known histone methyltransferases, their regulatory mechanisms are poorly understood. Here, we present the crystal structure of the human ASH1L catalytic domain, showing its substrate binding pocket blocked by a loop from the post-SET domain. In this configuration, the loop limits substrate access to the active site. Mutagenesis of the loop stimulates ASH1L histone methyltransferase activity, suggesting that ASH1L activity may be regulated through the loop from the post-SET domain. In addition, we show that human ASH1L specifically methylates histone H3 Lys-36. Our data implicate that there may be a regulatory mechanism of ASH1L histone methyltransferases.	+
-		+
-	Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism.,An S, Yeo KJ, Jeon YH, Song JJ J Biol Chem. 2011 Mar 11;286(10):8369-74. Epub 2011 Jan 14. PMID:21239497<ref>PMID:21239497</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3ope" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Histone-lysine N-methyltransferase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: An, S]]	+	[[Category: An S]]
-	[[Category: Song, J]]	+	[[Category: Song J]]
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Set]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:52, 18 May 2022

2022-05-18T10:52:00Z

←Older revision		Revision as of 10:52, 18 May 2022
Line 3:		Line 3:
	<StructureSection load='3ope' size='340' side='right'caption='[[3ope]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3ope' size='340' side='right'caption='[[3ope]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ope]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3OPE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ope]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OPE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ASH1L, KIAA1420, KMT2H ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ASH1L, KIAA1420, KMT2H ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ope OCA], [~~http~~://pdbe.org/3ope PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ope RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ope PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ope ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ope OCA], [https://pdbe.org/3ope PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ope RCSB], [https://www.ebi.ac.uk/pdbsum/3ope PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ope ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ASH1L_HUMAN ASH1L_HUMAN]] Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).<ref>PMID:21239497</ref>	+	[[https://www.uniprot.org/uniprot/ASH1L_HUMAN ASH1L_HUMAN]] Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).<ref>PMID:21239497</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:33, 11 December 2019

2019-12-11T15:33:29Z

←Older revision		Revision as of 15:33, 11 December 2019
Line 1:		Line 1:

	==Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase==		==Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase==
-	<StructureSection load='3ope' size='340' side='right' caption='[[3ope]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='3ope' size='340' side='right'caption='[[3ope]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ope]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OPE FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ope]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OPE FirstGlance]. <br>
Line 26:		Line 26:
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: An, S]]		[[Category: An, S]]
	[[Category: Song, J]]		[[Category: Song, J]]

OCA at 21:54, 4 August 2016

2016-08-04T21:54:50Z

←Older revision		Revision as of 21:54, 4 August 2016
Line 1:		Line 1:
		+
	==Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase==		==Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase==
	<StructureSection load='3ope' size='340' side='right' caption='[[3ope]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3ope' size='340' side='right' caption='[[3ope]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ope]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OPE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ope]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OPE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ASH1L, KIAA1420, KMT2H ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ASH1L, KIAA1420, KMT2H ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ope OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ope RCSB], [http://www.ebi.ac.uk/pdbsum/3ope PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ope OCA], [http://pdbe.org/3ope PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ope RCSB], [http://www.ebi.ac.uk/pdbsum/3ope PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ope ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ope" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: An, S]]		[[Category: An, S]]
	[[Category: Song, J]]		[[Category: Song, J]]

OCA at 20:01, 24 December 2014

2014-12-24T20:01:21Z

←Older revision		Revision as of 20:01, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ope OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ope RCSB], [http://www.ebi.ac.uk/pdbsum/3ope PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ope OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ope RCSB], [http://www.ebi.ac.uk/pdbsum/3ope PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ASH1L_HUMAN ASH1L_HUMAN]] Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).<ref>PMID:21239497</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:01, 19 December 2014

2014-12-19T07:01:15Z

←Older revision		Revision as of 07:01, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ope\| PDB=3ope \| SCENE= }}~~	+	==Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase==
-	===Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase===	+	<StructureSection load='3ope' size='340' side='right' caption='[[3ope]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21239497}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ope]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OPE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ASH1L, KIAA1420, KMT2H ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ope FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ope OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ope RCSB], [http://www.ebi.ac.uk/pdbsum/3ope PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Absent, small, or homeotic disc1 (Ash1) is a trithorax group histone methyltransferase that is involved in gene activation. Although there are many known histone methyltransferases, their regulatory mechanisms are poorly understood. Here, we present the crystal structure of the human ASH1L catalytic domain, showing its substrate binding pocket blocked by a loop from the post-SET domain. In this configuration, the loop limits substrate access to the active site. Mutagenesis of the loop stimulates ASH1L histone methyltransferase activity, suggesting that ASH1L activity may be regulated through the loop from the post-SET domain. In addition, we show that human ASH1L specifically methylates histone H3 Lys-36. Our data implicate that there may be a regulatory mechanism of ASH1L histone methyltransferases.

-	~~==Function==~~	+	Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism.,An S, Yeo KJ, Jeon YH, Song JJ J Biol Chem. 2011 Mar 11;286(10):8369-74. Epub 2011 Jan 14. PMID:21239497<ref>PMID:21239497</ref>
-	~~[[http://www.uniprot.org/uniprot/ASH1L_HUMAN ASH1L_HUMAN]] Histone methyltransferase specifically methylating 'Lys-36'~~ of histone H3 (~~H3K36me~~).<ref>PMID:21239497</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ope]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021239497</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: An, S.]]	+	[[Category: An, S]]
-	[[Category: Song, J.]]	+	[[Category: Song, J]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Set]]		[[Category: Set]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 06:23, 14 August 2013

2013-08-14T06:23:41Z

←Older revision		Revision as of 06:23, 14 August 2013
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	{{STRUCTURE_3ope\| PDB=3ope \| SCENE= }}		{{STRUCTURE_3ope\| PDB=3ope \| SCENE= }}
	===Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase===		===Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase===
-	{{~~ABSTRACT_PUBMED_021239497~~}}	+	{{ABSTRACT_PUBMED_21239497}}

	==Function==		==Function==
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	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:021239497</ref><references group="xtra"/><references/>
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 08:11, 2 May 2013

2013-05-02T08:11:48Z

←Older revision		Revision as of 08:11, 2 May 2013
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-	[[Image:3ope.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ope", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ope\| PDB=3ope \| SCENE= }}		{{STRUCTURE_3ope\| PDB=3ope \| SCENE= }}
-
	===Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase===		===Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase===
		+	{{ABSTRACT_PUBMED_021239497}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ASH1L_HUMAN ASH1L_HUMAN]] Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).<ref>PMID:21239497</ref>

	==About this Structure==		==About this Structure==
	[[3ope]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA].		[[3ope]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Histone-lysine N-methyltransferase]]		[[Category: Histone-lysine N-methyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: An, S.]]		[[Category: An, S.]]
	[[Category: Song, J.]]		[[Category: Song, J.]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Nucleus]]
		+	[[Category: Set]]
		+	[[Category: Transferase]]

OCA: Protected "3ope" [edit=sysop:move=sysop]

2011-01-12T05:17:10Z

Protected "3ope" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:17, 12 January 2011

OCA at 05:17, 12 January 2011

2011-01-12T05:17:09Z

←Older revision		Revision as of 05:17, 12 January 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3ope.jpg\|left\|200px]]

-	The ~~entry 3ope~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ope", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ope\| PDB=3ope \| SCENE= }}

-	~~Authors: An, S., Song, J.~~	+	===Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase===

-	Description: Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Sep 29 07~~:56:~~46 2010''~~	+	==About this Structure==
		+	[[3ope]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA].
		+	[[Category: Histone-lysine N-methyltransferase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: An, S.]]
		+	[[Category: Song, J.]]