3ose - Revision history

OCA at 10:36, 21 February 2024

2024-02-21T10:36:07Z

←Older revision		Revision as of 10:36, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3ose' size='340' side='right'caption='[[3ose]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3ose' size='340' side='right'caption='[[3ose]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ose]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OSE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ose]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OSE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3osm\|3osm]], [[3ost\|3ost]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>MARK1, KIAA1477, MARK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ose FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ose OCA], [https://pdbe.org/3ose PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ose RCSB], [https://www.ebi.ac.uk/pdbsum/3ose PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ose ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ose FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ose OCA], [https://pdbe.org/3ose PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ose RCSB], [https://www.ebi.ac.uk/pdbsum/3ose PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ose ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.	+	[https://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref> <ref>PMID:17573348</ref>	+	[https://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref> <ref>PMID:17573348</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Phospholipid-binding modules such as PH, C1, and C2 domains play crucial roles in location-dependent regulation of many protein kinases. Here, we identify the KA1 domain (kinase associated-1 domain), found at the C terminus of yeast septin-associated kinases (Kcc4p, Gin4p, and Hsl1p) and human MARK/PAR1 kinases, as a membrane association domain that binds acidic phospholipids. Membrane localization of isolated KA1 domains depends on phosphatidylserine. Using X-ray crystallography, we identified a structurally conserved binding site for anionic phospholipids in KA1 domains from Kcc4p and MARK1. Mutating this site impairs membrane association of both KA1 domains and intact proteins and reveals the importance of phosphatidylserine for bud neck localization of yeast Kcc4p. Our data suggest that KA1 domains contribute to "coincidence detection," allowing kinases to bind other regulators (such as septins) only at the membrane surface. These findings have important implications for understanding MARK/PAR1 kinases, which are implicated in Alzheimer's disease, cancer, and autism.	+
-		+
-	Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.,Moravcevic K, Mendrola JM, Schmitz KR, Wang YH, Slochower D, Janmey PA, Lemmon MA Cell. 2010 Dec 10;143(6):966-77. PMID:21145462<ref>PMID:21145462</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3ose" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 30:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Lemmon MA]]
-	[[Category: Lemmon~~, M A~~]]	+	[[Category: Moravcevic K]]
-	[[Category: Moravcevic, K]]	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Lipid binding protein]]~~	+
-	~~[[Category: Membrane association]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:55, 18 May 2022

2022-05-18T10:55:19Z

←Older revision		Revision as of 10:55, 18 May 2022
Line 1:		Line 1:

	==Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase==		==Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase==
-	<StructureSection load='3ose' size='340' side='right' caption='[[3ose]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3ose' size='340' side='right'caption='[[3ose]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ose]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OSE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3OSE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ose]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OSE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3osm\|3osm]], [[3ost\|3ost]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3osm\|3osm]], [[3ost\|3ost]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1, KIAA1477, MARK ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1, KIAA1477, MARK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ose FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ose OCA], [~~http~~://pdbe.org/3ose PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ose RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ose PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ose ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ose FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ose OCA], [https://pdbe.org/3ose PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ose RCSB], [https://www.ebi.ac.uk/pdbsum/3ose PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ose ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.	+	[[https://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref> <ref>PMID:17573348</ref>	+	[[https://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref> <ref>PMID:17573348</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:

	==See Also==		==See Also==
-	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]	+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Lemmon, M A]]		[[Category: Lemmon, M A]]

OCA at 15:26, 4 August 2016

2016-08-04T15:26:13Z

←Older revision		Revision as of 15:26, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase==		==Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase==
	<StructureSection load='3ose' size='340' side='right' caption='[[3ose]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3ose' size='340' side='right' caption='[[3ose]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ose]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OSE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ose]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OSE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3osm\|3osm]], [[3ost\|3ost]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3osm\|3osm]], [[3ost\|3ost]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1, KIAA1477, MARK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1, KIAA1477, MARK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ose FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ose OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ose RCSB], [http://www.ebi.ac.uk/pdbsum/3ose PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ose FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ose OCA], [http://pdbe.org/3ose PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ose RCSB], [http://www.ebi.ac.uk/pdbsum/3ose PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ose ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ose" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 28:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Lemmon, M A]]		[[Category: Lemmon, M A]]

OCA at 07:19, 19 December 2014

2014-12-19T07:19:35Z

←Older revision		Revision as of 07:19, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ose\| PDB=3ose \| SCENE= }}~~	+	==Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase==
-	===Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase===	+	<StructureSection load='3ose' size='340' side='right' caption='[[3ose]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21145462}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3ose]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OSE FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3osm\|3osm]], [[3ost\|3ost]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MARK1, KIAA1477, MARK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ose FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ose OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ose RCSB], [http://www.ebi.ac.uk/pdbsum/3ose PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.		[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref> <ref>PMID:17573348</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phospholipid-binding modules such as PH, C1, and C2 domains play crucial roles in location-dependent regulation of many protein kinases. Here, we identify the KA1 domain (kinase associated-1 domain), found at the C terminus of yeast septin-associated kinases (Kcc4p, Gin4p, and Hsl1p) and human MARK/PAR1 kinases, as a membrane association domain that binds acidic phospholipids. Membrane localization of isolated KA1 domains depends on phosphatidylserine. Using X-ray crystallography, we identified a structurally conserved binding site for anionic phospholipids in KA1 domains from Kcc4p and MARK1. Mutating this site impairs membrane association of both KA1 domains and intact proteins and reveals the importance of phosphatidylserine for bud neck localization of yeast Kcc4p. Our data suggest that KA1 domains contribute to "coincidence detection," allowing kinases to bind other regulators (such as septins) only at the membrane surface. These findings have important implications for understanding MARK/PAR1 kinases, which are implicated in Alzheimer's disease, cancer, and autism.

-	~~==Function==~~	+	Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.,Moravcevic K, Mendrola JM, Schmitz KR, Wang YH, Slochower D, Janmey PA, Lemmon MA Cell. 2010 Dec 10;143(6):966-77. PMID:21145462<ref>PMID:21145462</ref>
-	~~[[http:~~/~~/www~~.~~uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX~~, ~~MAP2~~, ~~MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2~~, ~~MAP4 and MAPT/TAU at KXGS motifs~~, ~~causing detachment from microtubules~~, ~~and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics~~, ~~possibly by phosphorylating and regulating DCX~~. ~~Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins~~ (~~DVL1, DVL2 and/or DVL3~~).~~<ref>~~PMID:~~11433294</ref>~~<ref>PMID:~~17573348~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ose]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3OSE OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:021145462</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Lemmon, M A.]]	+	[[Category: Lemmon, M A]]
-	[[Category: Moravcevic, K.]]	+	[[Category: Moravcevic, K]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Lipid binding protein]]		[[Category: Lipid binding protein]]
	[[Category: Membrane association]]		[[Category: Membrane association]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 21:25, 24 March 2013

2013-03-24T21:25:08Z

←Older revision		Revision as of 21:25, 24 March 2013
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-	[[Image:3ose.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ose", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ose\| PDB=3ose \| SCENE= }}		{{STRUCTURE_3ose\| PDB=3ose \| SCENE= }}
-
	===Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase===		===Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase===
		+	{{ABSTRACT_PUBMED_21145462}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites.

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21145462}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref><ref>PMID:17573348</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 21145462 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21145462}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21145462~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021145462</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Lemmon, M A.]]		[[Category: Lemmon, M A.]]
	[[Category: Moravcevic, K.]]		[[Category: Moravcevic, K.]]
		+	[[Category: Kinase]]
		+	[[Category: Lipid binding protein]]
		+	[[Category: Membrane association]]
		+	[[Category: Transferase]]

OCA: Protected "3ose" [edit=sysop:move=sysop]

2011-01-05T15:37:54Z

Protected "3ose" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:37, 5 January 2011

OCA at 15:37, 5 January 2011

2011-01-05T15:37:52Z

←Older revision		Revision as of 15:37, 5 January 2011
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-	~~{{Seed}}~~	+	[[Image:3ose.png\|left\|200px]]
-	[[Image:3ose.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	===Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase===		===Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21145462}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21145462 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21145462}}

	==About this Structure==		==About this Structure==
-	~~3OSE~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OSE OCA].	+	[[3ose]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OSE OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21145462</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Lemmon, M A.]]		[[Category: Lemmon, M A.]]
	[[Category: Moravcevic, K.]]		[[Category: Moravcevic, K.]]
-	[[Category: Kinase]]
-	[[Category: Lipid binding protein]]
-	[[Category: Membrane association]]
-	[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:57:29 2010''

OCA at 06:44, 22 December 2010

2010-12-22T06:44:53Z

←Older revision		Revision as of 06:44, 22 December 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ose.jpg\|left\|200px]]

-	The ~~entry 3ose~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ose", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ose\| PDB=3ose \| SCENE= }}

-	~~Authors: Moravcevic, K., Lemmon, M.A.~~	+	===Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase===

-	Description: Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 15 10~~:39:27 2010''	+	==About this Structure==
		+	3OSE is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OSE OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Lemmon, M A.]]
		+	[[Category: Moravcevic, K.]]
		+	[[Category: Kinase]]
		+	[[Category: Lipid binding protein]]
		+	[[Category: Membrane association]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:57:29 2010''

OCA: New page: '''Unreleased structure''' The entry 3ose is ON HOLD Authors: Moravcevic, K., Lemmon, M.A. Description: Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase ''Page seed...

2010-09-15T07:30:45Z

New page: '''Unreleased structure''' The entry 3ose is ON HOLD Authors: Moravcevic, K., Lemmon, M.A. Description: Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase ''Page seed...

New page

'''Unreleased structure'''

The entry 3ose is ON HOLD

Authors: Moravcevic, K., Lemmon, M.A.

Description: Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:39:27 2010''