3p2t - Revision history

OCA at 17:01, 1 November 2023

2023-11-01T17:01:31Z

←Older revision		Revision as of 17:01, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3p2t' size='340' side='right'caption='[[3p2t]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3p2t' size='340' side='right'caption='[[3p2t]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p2t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P2T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p2t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P2T FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.699Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~LILRB4, ILT3, LIR5 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2t OCA], [https://pdbe.org/3p2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p2t RCSB], [https://www.ebi.ac.uk/pdbsum/3p2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p2t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2t OCA], [https://pdbe.org/3p2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p2t RCSB], [https://www.ebi.ac.uk/pdbsum/3p2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p2t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LIRB4_HUMAN LIRB4_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:11875462</ref> <ref>PMID:9151699</ref>	+	[https://www.uniprot.org/uniprot/LIRB4_HUMAN LIRB4_HUMAN] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:11875462</ref> <ref>PMID:9151699</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	[[Category: Cheng, H]]	+	[[Category: Cheng H]]
-	[[Category: Gao~~, G F~~]]	+	[[Category: Gao GF]]
-	[[Category: Nam, G]]	+	[[Category: Nam G]]
-	[[Category: Willcox~~, B E~~]]	+	[[Category: Willcox BE]]
-	[[Category: Zhang~~, J H]]~~	+	[[Category: Zhang JH]]
-	~~[[Category: Disulfide]]~~	+
-	~~[[Category: Ig]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Inhibitory receptor]]~~	+
-	~~[[Category: Lilr~~]]	+

OCA at 11:16, 18 May 2022

2022-05-18T11:16:09Z

←Older revision		Revision as of 11:16, 18 May 2022
Line 1:		Line 1:

	==Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)==		==Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)==
-	<StructureSection load='3p2t' size='340' side='right' caption='[[3p2t]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3p2t' size='340' side='right'caption='[[3p2t]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p2t]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3P2T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p2t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P2T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LILRB4, ILT3, LIR5 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LILRB4, ILT3, LIR5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3p2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2t OCA], [~~http~~://pdbe.org/3p2t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3p2t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3p2t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3p2t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2t OCA], [https://pdbe.org/3p2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p2t RCSB], [https://www.ebi.ac.uk/pdbsum/3p2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p2t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LIRB4_HUMAN LIRB4_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:11875462</ref> <ref>PMID:9151699</ref>	+	[[https://www.uniprot.org/uniprot/LIRB4_HUMAN LIRB4_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:11875462</ref> <ref>PMID:9151699</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3p2t" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3p2t" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Leukocyte immunoglobulin-like receptor\|Leukocyte immunoglobulin-like receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Cheng, H]]		[[Category: Cheng, H]]

OCA at 15:22, 5 August 2016

2016-08-05T15:22:08Z

←Older revision		Revision as of 15:22, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)==		==Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)==
	<StructureSection load='3p2t' size='340' side='right' caption='[[3p2t]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3p2t' size='340' side='right' caption='[[3p2t]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3p2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P2T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3p2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P2T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LILRB4, ILT3, LIR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LILRB4, ILT3, LIR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p2t RCSB], [http://www.ebi.ac.uk/pdbsum/3p2t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2t OCA], [http://pdbe.org/3p2t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p2t RCSB], [http://www.ebi.ac.uk/pdbsum/3p2t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p2t ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LIRB4_HUMAN LIRB4_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:11875462</ref> <ref>PMID:9151699</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3p2t" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Cheng, H]]		[[Category: Cheng, H]]

OCA at 23:17, 3 January 2015

2015-01-03T23:17:33Z

←Older revision		Revision as of 23:17, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3p2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P2T FirstGlance]. <br>		<table><tr><td colspan='2'>[[3p2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P2T FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LILRB4, ILT3, LIR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LILRB4, ILT3, LIR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p2t RCSB], [http://www.ebi.ac.uk/pdbsum/3p2t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p2t RCSB], [http://www.ebi.ac.uk/pdbsum/3p2t PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance.,Cheng H, Mohammed F, Nam G, Chen Y, Qi J, Garner LI, Allen RL, Yan J, Willcox BE, Gao GF J Biol Chem. 2011 May 20;286(20):18013-25. Epub 2011 Mar 30. PMID:21454581<ref>PMID:21454581</ref>		Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance.,Cheng H, Mohammed F, Nam G, Chen Y, Qi J, Garner LI, Allen RL, Yan J, Willcox BE, Gao GF J Biol Chem. 2011 May 20;286(20):18013-25. Epub 2011 Mar 30. PMID:21454581<ref>PMID:21454581</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, Y.]]	+	[[Category: Chen, Y]]
-	[[Category: Cheng, H.]]	+	[[Category: Cheng, H]]
-	[[Category: Gao, G F.]]	+	[[Category: Gao, G F]]
-	[[Category: Nam, G.]]	+	[[Category: Nam, G]]
-	[[Category: Willcox, B E.]]	+	[[Category: Willcox, B E]]
-	[[Category: Zhang, J H.]]	+	[[Category: Zhang, J H]]
	[[Category: Disulfide]]		[[Category: Disulfide]]
	[[Category: Ig]]		[[Category: Ig]]

OCA at 05:30, 4 June 2014

2014-06-04T05:30:16Z

←Older revision		Revision as of 05:30, 4 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3p2t.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)==
		+	<StructureSection load='3p2t' size='340' side='right' caption='[[3p2t]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3p2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P2T FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LILRB4, ILT3, LIR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p2t RCSB], [http://www.ebi.ac.uk/pdbsum/3p2t PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The myeloid inhibitory receptor LILRB4 (also called ILT3, LIR-5, CD85k), a member of the leukocyte immunoglobulin-like receptors (LILRs/LIRs), is an important mediator of immune tolerance. Up-regulated on tolerogenic dendritic cells, it has been shown to modulate immune responses via induction of T cell anergy and differentiation of CD8(+) T suppressor cells and may play a role in establishing immune tolerance in cancer. Consequently, characterizing the molecular mechanisms involved in LILRB4 function and in particular its structure and ligands is a key aim but has remained elusive to date. Here we describe the production, crystallization, and structure of the LILRB4 ectodomain to 1.7 A using an expression strategy involving engineering of an additional disulfide bond in the D2 domain to enhance protein stability. LILRB4 comprises two immunoglobulin domains similar in structure to other LILRs; however, the D2 domain, which is most closely related to the D4 domains of other family members, contains 3(10) helices not previously observed. At the D1-D2 interface, reduced interdomain contacts resulted in an obtuse interdomain angle of approximately 107 degrees . Comparison with MHC class I binding Group 1 LILRs suggests LILRB4 is both conformationally and electrostatically unsuited to MHC ligation, consistent with LILRB4 status as a Group 2 LILR likely to bind novel non-MHC class I ligands. Finally, examination of the LILRB4 surface highlighted distinctive surface patches on the D1 domain and D1D2 hinge region, which may be involved in ligand binding. These findings will facilitate our attempts to precisely define the role of LILRB4 in the regulation of immune tolerance.

-	<!--	+	Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance.,Cheng H, Mohammed F, Nam G, Chen Y, Qi J, Garner LI, Allen RL, Yan J, Willcox BE, Gao GF J Biol Chem. 2011 May 20;286(20):18013-25. Epub 2011 Mar 30. PMID:21454581<ref>PMID:21454581</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3p2t"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3p2t\| PDB=3p2t \| SCENE= }}~~	+

-	~~===Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3~~/~~LIR-5/CD85k)===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21454581}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21454581 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21454581}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3p2t]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021454581<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, Y.]]		[[Category: Chen, Y.]]

OCA at 06:33, 24 August 2011

2011-08-24T06:33:52Z

←Older revision		Revision as of 06:33, 24 August 2011
Line 1:		Line 1:
-	[[Image:3p2t.~~jpg~~\|left\|200px]]	+	[[Image:3p2t.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)===		===Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21454581}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21454581 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21454581}}

	==About this Structure==		==About this Structure==
	[[3p2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA].		[[3p2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021454581</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, Y.]]		[[Category: Chen, Y.]]
Line 21:		Line 30:
	[[Category: Willcox, B E.]]		[[Category: Willcox, B E.]]
	[[Category: Zhang, J H.]]		[[Category: Zhang, J H.]]
		+	[[Category: Disulfide]]
		+	[[Category: Ig]]
		+	[[Category: Immune system]]
		+	[[Category: Inhibitory receptor]]
		+	[[Category: Lilr]]

OCA: Protected "3p2t" [edit=sysop:move=sysop]

2011-03-30T08:15:06Z

Protected "3p2t" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:15, 30 March 2011

OCA at 08:15, 30 March 2011

2011-03-30T08:15:03Z

←Older revision		Revision as of 08:15, 30 March 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3p2t.jpg\|left\|200px]]

-	The ~~entry 3p2t~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3p2t", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3p2t\| PDB=3p2t \| SCENE= }}

-	~~Authors: Chen, Y., Kol, N., Cheng, H., Zhang, J.H., Willcox, B.E., Gao, G.F.~~	+	===Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)===

-	Description: Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Nov 3 10~~:04:~~53 2010''~~	+	==About this Structure==
		+	[[3p2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2T OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Chen, Y.]]
		+	[[Category: Cheng, H.]]
		+	[[Category: Gao, G F.]]
		+	[[Category: Nam, G.]]
		+	[[Category: Willcox, B E.]]
		+	[[Category: Zhang, J H.]]

OCA at 06:54, 3 November 2010

2010-11-03T06:54:14Z

←Older revision		Revision as of 06:54, 3 November 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3p2t is ON HOLD	+	The entry 3p2t is ON HOLD until Paper Publication

	Authors: Chen, Y., Kol, N., Cheng, H., Zhang, J.H., Willcox, B.E., Gao, G.F.		Authors: Chen, Y., Kol, N., Cheng, H., Zhang, J.H., Willcox, B.E., Gao, G.F.
Line 7:		Line 7:
	Description: Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)		Description: Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 13~~ 10:33:16 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 10:04:53 2010''

OCA: New page: '''Unreleased structure''' The entry 3p2t is ON HOLD Authors: Chen, Y., Kol, N., Cheng, H., Zhang, J.H., Willcox, B.E., Gao, G.F. Description: Crystal Structure of Leukocyte Ig-like Re...

2010-10-13T07:23:27Z

New page: '''Unreleased structure''' The entry 3p2t is ON HOLD Authors: Chen, Y., Kol, N., Cheng, H., Zhang, J.H., Willcox, B.E., Gao, G.F. Description: Crystal Structure of Leukocyte Ig-like Re...

New page

'''Unreleased structure'''

The entry 3p2t is ON HOLD

Authors: Chen, Y., Kol, N., Cheng, H., Zhang, J.H., Willcox, B.E., Gao, G.F.

Description: Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k)

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 13 10:33:16 2010''