3pbl - Revision history

OCA at 09:51, 6 September 2023

2023-09-06T09:51:03Z

←Older revision		Revision as of 09:51, 6 September 2023
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	<StructureSection load='3pbl' size='340' side='right'caption='[[3pbl]], [[Resolution\|resolution]] 2.89Å' scene=''>		<StructureSection load='3pbl' size='340' side='right'caption='[[3pbl]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PBL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PBL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.89Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DRD3~~, ~~E ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~<~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [https://pdbe.org/3pbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [https://www.ebi.ac.uk/pdbsum/3pbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pbl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [https://pdbe.org/3pbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [https://www.ebi.ac.uk/pdbsum/3pbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pbl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Hereditary essential tremor. Disease susceptibility is associated with variations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN] Hereditary essential tremor. Disease susceptibility is associated with variations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.<ref>PMID:19520868</ref>	+	[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.<ref>PMID:19520868</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 32:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Escherichia virus T4]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Lysozyme]]~~	+	[[Category: Cherezov V]]
-	~~[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]~~	+	[[Category: Chien EYT]]
-	[[Category: Cherezov, V]]	+	[[Category: Han GW]]
-	[[Category: Chien~~, E Y.T]]~~	+	[[Category: Katritch V]]
-	~~[[Category: GPCR, GPCR Network~~]]	+	[[Category: Liu W]]
-	[[Category: Han~~, G W~~]]	+	[[Category: Stevens RC]]
-	[[Category: Katritch, V]]	+	[[Category: Zhao Q]]
-	[[Category: Liu, W]]	+
-	[[Category: Stevens~~, R C~~]]	+
-	[[Category: Zhao, Q]]	+
-	~~[[Category: Accelerated technologies center for gene to 3d structure]]~~	+
-	~~[[Category: Atcg3d]]~~	+
-	~~[[Category: Chimera]]~~	+
-	~~[[Category: Dopamine]]~~	+
-	~~[[Category: Eticlopride]]~~	+
-	~~[[Category: G protein-coupled receptor]]~~	+
-	~~[[Category: Gpcr]]~~	+
-	~~[[Category: Gpcr network]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Neurotransmitter]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Signal transduction]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: T4l fusion]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 08:32, 25 May 2022

2022-05-25T08:32:55Z

←Older revision		Revision as of 08:32, 25 May 2022
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	==Structure of the human dopamine D3 receptor in complex with eticlopride==		==Structure of the human dopamine D3 receptor in complex with eticlopride==
-	<StructureSection load='3pbl' size='340' side='right' caption='[[3pbl]], [[Resolution\|resolution]] 2.89Å' scene=''>	+	<StructureSection load='3pbl' size='340' side='right'caption='[[3pbl]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PBL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PBL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=~~MAL~~:~~MALTOSE~~'>~~MAL~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DRD3, E ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DRD3, E ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [~~http~~://pdbe.org/3pbl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pbl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pbl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [https://pdbe.org/3pbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [https://www.ebi.ac.uk/pdbsum/3pbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pbl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Hereditary essential tremor. Disease susceptibility is associated with variations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Hereditary essential tremor. Disease susceptibility is associated with variations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.<ref>PMID:19520868</ref>	+	[[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.<ref>PMID:19520868</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[Dopamine ~~Receptors~~\|Dopamine ~~Receptors~~]]	+	*[[Dopamine receptor\|Dopamine receptor]]
		+	*[[Dopamine receptor 3D structures\|Dopamine receptor 3D structures]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
		+	*[[Neurotransmitters\|Neurotransmitters]]
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]		[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]

OCA at 00:48, 16 November 2017

2017-11-16T00:48:22Z

←Older revision		Revision as of 00:48, 16 November 2017
Line 25:		Line 25:
	==See Also==		==See Also==
	*[[Dopamine Receptors\|Dopamine Receptors]]		*[[Dopamine Receptors\|Dopamine Receptors]]
-	*[[Dopamine receptor\|Dopamine receptor]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	== References ==		== References ==

OCA at 19:34, 5 August 2016

2016-08-05T19:34:32Z

←Older revision		Revision as of 19:34, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the human dopamine D3 receptor in complex with eticlopride==		==Structure of the human dopamine D3 receptor in complex with eticlopride==
	<StructureSection load='3pbl' size='340' side='right' caption='[[3pbl]], [[Resolution\|resolution]] 2.89Å' scene=''>		<StructureSection load='3pbl' size='340' side='right' caption='[[3pbl]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterobacteria_phage_t4 Enterobacteria phage t4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PBL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PBL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DRD3, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~10665 Enterobacteria phage T4~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DRD3, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [http://www.ebi.ac.uk/pdbsum/3pbl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [http://pdbe.org/3pbl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [http://www.ebi.ac.uk/pdbsum/3pbl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pbl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3pbl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Dopamine Receptors\|Dopamine Receptors]]
	*[[Dopamine receptor\|Dopamine receptor]]		*[[Dopamine receptor\|Dopamine receptor]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
Line 28:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enterobacteria phage t4~~]]	+	[[Category: Human]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]		[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]

OCA at 06:26, 19 December 2014

2014-12-19T06:26:34Z

←Older revision		Revision as of 06:26, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3pbl~~\| ~~PDB~~=3pbl \| ~~SCENE~~= }}	+	==Structure of the human dopamine D3 receptor in complex with eticlopride==
-	===~~Structure~~ of the human dopamine D3 receptor in complex with eticlopride~~===~~	+	<StructureSection load='3pbl' size='340' side='right' caption='[[3pbl]], [[Resolution\|resolution]] 2.89Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21097933}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PBL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DRD3, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [http://www.ebi.ac.uk/pdbsum/3pbl PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Hereditary essential tremor. Disease susceptibility is associated with variations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.<ref>PMID:19520868</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dopamine modulates movement, cognition, and emotion through activation of dopamine G protein-coupled receptors in the brain. The crystal structure of the human dopamine D3 receptor (D3R) in complex with the small molecule D2R/D3R-specific antagonist eticlopride reveals important features of the ligand binding pocket and extracellular loops. On the intracellular side of the receptor, a locked conformation of the ionic lock and two distinctly different conformations of intracellular loop 2 are observed. Docking of R-22, a D3R-selective antagonist, reveals an extracellular extension of the eticlopride binding site that comprises a second binding pocket for the aryl amide of R-22, which differs between the highly homologous D2R and D3R. This difference provides direction to the design of D3R-selective agents for treating drug abuse and other neuropsychiatric indications.

-	~~==About this~~ Structure==	+	Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.,Chien EY, Liu W, Zhao Q, Katritch V, Han GW, Hanson MA, Shi L, Newman AH, Javitch JA, Cherezov V, Stevens RC Science. 2010 Nov 19;330(6007):1091-5. PMID:21097933<ref>PMID:21097933</ref>
-	~~[[3pbl]] is~~ a ~~2 chain structure with sequence from [http:~~/~~/en~~.~~wikipedia~~.~~org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA].~~	+

-	~~==See Also==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	*[[G protein-coupled receptor\|G protein-coupled receptor]]	+	</div>
-	*[[Hen Egg-White (HEW) Lysozyme\|Hen Egg-White (HEW) Lysozyme]]	+
-	*[[Human dopamine d3 receptor\|Human dopamine d3 receptor]]	+

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:021097933~~</~~ref~~><~~references group="xtra"~~/>	+	*[[Dopamine receptor\|Dopamine receptor]]
		+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Enterobacteria phage t4]]		[[Category: Enterobacteria phage t4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
-	[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]	+	[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]
-	[[Category: Cherezov, V.]]	+	[[Category: Cherezov, V]]
-	[[Category: Chien, E Y.T.]]	+	[[Category: Chien, E Y.T]]
-	[[Category: GPCR, GPCR Network.]]	+	[[Category: GPCR, GPCR Network]]
-	[[Category: Han, G W.]]	+	[[Category: Han, G W]]
-	[[Category: Katritch, V.]]	+	[[Category: Katritch, V]]
-	[[Category: Liu, W.]]	+	[[Category: Liu, W]]
-	[[Category: Stevens, R C.]]	+	[[Category: Stevens, R C]]
-	[[Category: Zhao, Q~~.]]~~	+	[[Category: Zhao, Q]]
-	~~[[Category: 7tm~~]]	+
	[[Category: Accelerated technologies center for gene to 3d structure]]		[[Category: Accelerated technologies center for gene to 3d structure]]
	[[Category: Atcg3d]]		[[Category: Atcg3d]]
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	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Neurotransmitter]]		[[Category: Neurotransmitter]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi-2~~]]	+
	[[Category: Psi-biology]]		[[Category: Psi-biology]]
	[[Category: Signal transduction]]		[[Category: Signal transduction]]

OCA at 09:40, 11 March 2013

2013-03-11T09:40:27Z

←Older revision		Revision as of 09:40, 11 March 2013
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-	[[Image:3pbl.png\|left\|200px]]
-
	{{STRUCTURE_3pbl\| PDB=3pbl \| SCENE= }}		{{STRUCTURE_3pbl\| PDB=3pbl \| SCENE= }}
-
	===Structure of the human dopamine D3 receptor in complex with eticlopride===		===Structure of the human dopamine D3 receptor in complex with eticlopride===
-
	{{ABSTRACT_PUBMED_21097933}}		{{ABSTRACT_PUBMED_21097933}}

OCA at 13:04, 20 October 2012

2012-10-20T13:04:16Z

←Older revision		Revision as of 13:04, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3pbl]] is a 2 chain structure ~~of [[Hen Egg-White (HEW) Lysozyme]]~~ with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria~~ phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA].	+	[[3pbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA].

	==See Also==		==See Also==
		+	*[[G protein-coupled receptor\|G protein-coupled receptor]]
	*[[Hen Egg-White (HEW) Lysozyme\|Hen Egg-White (HEW) Lysozyme]]		*[[Hen Egg-White (HEW) Lysozyme\|Hen Egg-White (HEW) Lysozyme]]
	*[[Human dopamine d3 receptor\|Human dopamine d3 receptor]]		*[[Human dopamine d3 receptor\|Human dopamine d3 receptor]]
Line 16:		Line 17:
	==Reference==		==Reference==
	<ref group="xtra">PMID:021097933</ref><references group="xtra"/>		<ref group="xtra">PMID:021097933</ref><references group="xtra"/>
-	[[Category: ~~Homo sapiens, enterobacteria~~ phage t4]]	+	[[Category: Enterobacteria phage t4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]		[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure.]]

OCA at 10:48, 26 July 2012

2012-07-26T10:48:37Z

←Older revision		Revision as of 10:48, 26 July 2012
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	[[Image:3pbl.png\|left\|200px]]		[[Image:3pbl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3pbl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3pbl\| PDB=3pbl \| SCENE= }}		{{STRUCTURE_3pbl\| PDB=3pbl \| SCENE= }}

	===Structure of the human dopamine D3 receptor in complex with eticlopride===		===Structure of the human dopamine D3 receptor in complex with eticlopride===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21097933}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21097933 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21097933}}		{{ABSTRACT_PUBMED_21097933}}

OCA: Protected "3pbl" [edit=sysop:move=sysop]

2012-05-09T08:11:20Z

Protected "3pbl" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:11, 9 May 2012

OCA at 08:11, 9 May 2012

2012-05-09T08:11:19Z

←Older revision		Revision as of 08:11, 9 May 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3pbl.png\|left\|200px]]		[[Image:3pbl.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~3PBL~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA].	+	[[3pbl]] is a 2 chain structure of [[Hen Egg-White (HEW) Lysozyme]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA].
		+
		+	==See Also==
		+	*[[Hen Egg-White (HEW) Lysozyme\|Hen Egg-White (HEW) Lysozyme]]
		+	*[[Human dopamine d3 receptor\|Human dopamine d3 receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21097933~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021097933</ref><references group="xtra"/>
	[[Category: Homo sapiens, enterobacteria phage t4]]		[[Category: Homo sapiens, enterobacteria phage t4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
Line 29:		Line 32:
	[[Category: Cherezov, V.]]		[[Category: Cherezov, V.]]
	[[Category: Chien, E Y.T.]]		[[Category: Chien, E Y.T.]]
		+	[[Category: GPCR, GPCR Network.]]
	[[Category: Han, G W.]]		[[Category: Han, G W.]]
	[[Category: Katritch, V.]]		[[Category: Katritch, V.]]
Line 42:		Line 46:
	[[Category: G protein-coupled receptor]]		[[Category: G protein-coupled receptor]]
	[[Category: Gpcr]]		[[Category: Gpcr]]
		+	[[Category: Gpcr network]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
Line 48:		Line 53:
	[[Category: Protein structure initiative]]		[[Category: Protein structure initiative]]
	[[Category: Psi-2]]		[[Category: Psi-2]]
		+	[[Category: Psi-biology]]
	[[Category: Signal transduction]]		[[Category: Signal transduction]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: T4l fusion]]		[[Category: T4l fusion]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:12:03 2010''