3pg9 - Revision history

OCA at 17:06, 1 November 2023

2023-11-01T17:06:09Z

←Older revision		Revision as of 17:06, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3pg9' size='340' side='right'caption='[[3pg9]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3pg9' size='340' side='right'caption='[[3pg9]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pg9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43589 Atcc 43589~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PG9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pg9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PG9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TYR:TYROSINE'>TYR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3pg8\|3pg8]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TYR:TYROSINE'>TYR</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">aroF ([https~~:~~//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/3-deoxy-7-phosphoheptulonate_synthase 3-deoxy-7-phosphoheptulonate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.54 2.5.1.54] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg9 OCA], [https://pdbe.org/3pg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pg9 RCSB], [https://www.ebi.ac.uk/pdbsum/3pg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pg9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg9 OCA], [https://pdbe.org/3pg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pg9 RCSB], [https://www.ebi.ac.uk/pdbsum/3pg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pg9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AROF_THEMA AROF_THEMA]] Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).	+	[https://www.uniprot.org/uniprot/AROF_THEMA AROF_THEMA] Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
-	[[Category: Atcc 43589]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cross, P J]]
-	[[Category: Dobson, R C.J]]
-	[[Category: Parker, E J]]
-	[[Category: Patchett, M L]]
-	[[Category: Act domain]]
-	[[Category: Allosteric regulation]]
-	[[Category: Aromatic biosynthesis]]
-	[[Category: Dah7p]]
-	[[Category: Ferredoxin-like domain]]
-	[[Category: Shikimate pathway]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
-	[[Category: ~~Tim barrel~~]]	+	[[Category: Cross PJ]]
-	[[Category: ~~Transferase~~]]	+	[[Category: Dobson RCJ]]
-	[[Category: ~~Transferase-transferase inhibitor complex~~]]	+	[[Category: Parker EJ]]
-	[[Category: ~~Tyr-bound~~]]	+	[[Category: Patchett ML]]

OCA at 08:38, 25 May 2022

2022-05-25T08:38:21Z

←Older revision		Revision as of 08:38, 25 May 2022
Line 1:		Line 1:

	==Thermotoga maritima DAH7P synthase in complex with inhibitor==		==Thermotoga maritima DAH7P synthase in complex with inhibitor==
-	<StructureSection load='3pg9' size='340' side='right' caption='[[3pg9]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='3pg9' size='340' side='right'caption='[[3pg9]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pg9]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PG9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pg9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PG9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TYR:TYROSINE'>TYR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TYR:TYROSINE'>TYR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pg8\|3pg8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pg8\|3pg8]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroF ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/3-deoxy-7-phosphoheptulonate_synthase 3-deoxy-7-phosphoheptulonate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.54 2.5.1.54] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-deoxy-7-phosphoheptulonate_synthase 3-deoxy-7-phosphoheptulonate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.54 2.5.1.54] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg9 OCA], [~~http~~://pdbe.org/3pg9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pg9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pg9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pg9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg9 OCA], [https://pdbe.org/3pg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pg9 RCSB], [https://www.ebi.ac.uk/pdbsum/3pg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pg9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AROF_THEMA AROF_THEMA]] Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).	+	[[https://www.uniprot.org/uniprot/AROF_THEMA AROF_THEMA]] Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[DAHP synthase\|DAHP synthase]]	+	*[[DAHP synthase 3D structures\|DAHP synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 30:
	[[Category: 3-deoxy-7-phosphoheptulonate synthase]]		[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
	[[Category: Atcc 43589]]		[[Category: Atcc 43589]]
		+	[[Category: Large Structures]]
	[[Category: Cross, P J]]		[[Category: Cross, P J]]
	[[Category: Dobson, R C.J]]		[[Category: Dobson, R C.J]]

OCA at 20:51, 5 August 2016

2016-08-05T20:51:07Z

←Older revision		Revision as of 20:51, 5 August 2016
Line 1:		Line 1:
		+
	==Thermotoga maritima DAH7P synthase in complex with inhibitor==		==Thermotoga maritima DAH7P synthase in complex with inhibitor==
	<StructureSection load='3pg9' size='340' side='right' caption='[[3pg9]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3pg9' size='340' side='right' caption='[[3pg9]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pg9]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermotoga_maritima Thermotoga maritima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PG9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pg9]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PG9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TYR:TYROSINE'>TYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TYR:TYROSINE'>TYR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pg8\|3pg8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pg8\|3pg8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ~~Thermotoga maritima~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-7-phosphoheptulonate_synthase 3-deoxy-7-phosphoheptulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.54 2.5.1.54] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-7-phosphoheptulonate_synthase 3-deoxy-7-phosphoheptulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.54 2.5.1.54] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pg9 RCSB], [http://www.ebi.ac.uk/pdbsum/3pg9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg9 OCA], [http://pdbe.org/3pg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pg9 RCSB], [http://www.ebi.ac.uk/pdbsum/3pg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pg9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3pg9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Aldolase~~\|~~Aldolase~~]]	+	*[[DAHP synthase\|DAHP synthase]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: 3-deoxy-7-phosphoheptulonate synthase]]		[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
-	[[Category: ~~Thermotoga maritima~~]]	+	[[Category: Atcc 43589]]
	[[Category: Cross, P J]]		[[Category: Cross, P J]]
	[[Category: Dobson, R C.J]]		[[Category: Dobson, R C.J]]
Line 38:		Line 40:
	[[Category: Ferredoxin-like domain]]		[[Category: Ferredoxin-like domain]]
	[[Category: Shikimate pathway]]		[[Category: Shikimate pathway]]
		+	[[Category: Thermotoga maritima]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]
	[[Category: Tyr-bound]]		[[Category: Tyr-bound]]

OCA at 21:48, 25 December 2014

2014-12-25T21:48:39Z

←Older revision		Revision as of 21:48, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pg9 RCSB], [http://www.ebi.ac.uk/pdbsum/3pg9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pg9 RCSB], [http://www.ebi.ac.uk/pdbsum/3pg9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AROF_THEMA AROF_THEMA]] Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:44, 9 December 2014

2014-12-09T13:44:49Z

←Older revision		Revision as of 13:44, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3pg9.~~png~~\|~~left~~\|~~200px~~]]	+	==Thermotoga maritima DAH7P synthase in complex with inhibitor==
		+	<StructureSection load='3pg9' size='340' side='right' caption='[[3pg9]], [[Resolution\|resolution]] 2.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3pg9]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PG9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TYR:TYROSINE'>TYR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pg8\|3pg8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-7-phosphoheptulonate_synthase 3-deoxy-7-phosphoheptulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.54 2.5.1.54] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pg9 RCSB], [http://www.ebi.ac.uk/pdbsum/3pg9 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The first step of the shikimate pathway for aromatic amino acid biosynthesis is catalyzed by 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS). Thermotoga maritima DAH7PS (TmaDAH7PS) is tetrameric, with monomer units comprised of a core catalytic (beta/alpha)(8) barrel and an N-terminal domain. This enzyme is inhibited strongly by tyrosine and to a lesser extent by the presence of phenylalanine. A truncated mutant of TmaDAH7PS lacking the N-terminal domain was catalytically more active and completely insensitive to tyrosine and phenylalanine, consistent with a role for this domain in allosteric inhibition. The structure of this protein was determined to 2.0 A. In contrast to the wild-type enzyme, this enzyme is dimeric. Wild-type TmaDAH7PS was co-crystallized with tyrosine, and the structure of this complex was determined to a resolution of 2.35 A. Tyrosine was found to bind at the interface between two regulatory N-terminal domains, formed from diagonally located monomers of the tetramer, revealing a major reorganization of the regulatory domain with respect to the barrel relative to unliganded enzyme. This significant conformational rearrangement observed in the crystal structures was also clearly evident from small angle X-ray scattering measurements recorded in the presence and absence of tyrosine. The closed conformation adopted by the protein on tyrosine binding impedes substrate entry into the neighboring barrel, revealing an unusual tyrosine-controlled gating mechanism for allosteric control of this enzyme.

-	~~{{STRUCTURE_3pg9\| PDB=3pg9 \| SCENE= }}~~	+	Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis.,Cross PJ, Dobson RC, Patchett ML, Parker EJ J Biol Chem. 2011 Mar 25;286(12):10216-24. Epub 2011 Jan 30. PMID:21282100<ref>PMID:21282100</ref>

-	~~===Thermotoga maritima DAH7P synthase in complex with inhibitor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21282100}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3pg9]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermotoga_maritima Thermotoga maritima]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA].~~	+

	==See Also==		==See Also==
	*[[Aldolase\|Aldolase]]		*[[Aldolase\|Aldolase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021282100<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: 3-deoxy-7-phosphoheptulonate synthase]]		[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
-	[[Category: Cross, P J.]]	+	[[Category: Cross, P J]]
-	[[Category: Dobson, R C.J.]]	+	[[Category: Dobson, R C.J]]
-	[[Category: Parker, E J.]]	+	[[Category: Parker, E J]]
-	[[Category: Patchett, M L.]]	+	[[Category: Patchett, M L]]
	[[Category: Act domain]]		[[Category: Act domain]]
	[[Category: Allosteric regulation]]		[[Category: Allosteric regulation]]
Line 27:		Line 36:
	[[Category: Ferredoxin-like domain]]		[[Category: Ferredoxin-like domain]]
	[[Category: Shikimate pathway]]		[[Category: Shikimate pathway]]
-	[[Category: Thermotoga maritima]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]
	[[Category: Tyr-bound]]		[[Category: Tyr-bound]]

OCA at 22:02, 20 October 2012

2012-10-20T22:02:41Z

←Older revision		Revision as of 22:02, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3pg9]] is a 8 chain structure ~~of [[Aldolase]]~~ with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA].	+	[[3pg9]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA].

	==See Also==		==See Also==

OCA at 05:04, 22 August 2012

2012-08-22T05:04:46Z

←Older revision		Revision as of 05:04, 22 August 2012
Line 5:		Line 5:
	===Thermotoga maritima DAH7P synthase in complex with inhibitor===		===Thermotoga maritima DAH7P synthase in complex with inhibitor===

		+	{{ABSTRACT_PUBMED_21282100}}

	==About this Structure==		==About this Structure==
Line 11:		Line 12:
	==See Also==		==See Also==
	*[[Aldolase\|Aldolase]]		*[[Aldolase\|Aldolase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021282100</ref><references group="xtra"/>
	[[Category: 3-deoxy-7-phosphoheptulonate synthase]]		[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]

OCA at 15:04, 27 July 2012

2012-07-27T15:04:14Z

←Older revision		Revision as of 15:04, 27 July 2012
Line 1:		Line 1:
-	[[Image:3pg9.~~jpg~~\|left\|200px]]	+	[[Image:3pg9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3pg9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3pg9\| PDB=3pg9 \| SCENE= }}		{{STRUCTURE_3pg9\| PDB=3pg9 \| SCENE= }}

Line 13:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3pg9]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA].	+	[[3pg9]] is a 8 chain structure of [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA].
		+
		+	==See Also==
		+	*[[Aldolase\|Aldolase]]
	[[Category: 3-deoxy-7-phosphoheptulonate synthase]]		[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
Line 20:		Line 17:
	[[Category: Parker, E J.]]		[[Category: Parker, E J.]]
	[[Category: Patchett, M L.]]		[[Category: Patchett, M L.]]
		+	[[Category: Act domain]]
		+	[[Category: Allosteric regulation]]
		+	[[Category: Aromatic biosynthesis]]
		+	[[Category: Dah7p]]
		+	[[Category: Ferredoxin-like domain]]
		+	[[Category: Shikimate pathway]]
		+	[[Category: Thermotoga maritima]]
		+	[[Category: Tim barrel]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]
		+	[[Category: Tyr-bound]]

OCA: Protected "3pg9" [edit=sysop:move=sysop]

2011-01-26T13:04:40Z

Protected "3pg9" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:04, 26 January 2011

OCA at 13:04, 26 January 2011

2011-01-26T13:04:37Z

←Older revision		Revision as of 13:04, 26 January 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3pg9.jpg\|left\|200px]]

-	The ~~entry 3pg9~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3pg9", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3pg9\| PDB=3pg9 \| SCENE= }}

-	~~Authors: Cross, P.J., Dobson, R.C.J., Patchett, M.L., Parker, E.J.~~	+	===Thermotoga maritima DAH7P synthase in complex with inhibitor===

-	Description: Thermotoga maritima DAH7P synthase in complex with inhibitor

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Dec 8 11~~:31:~~49 2010''~~	+	==About this Structure==
		+	[[3pg9]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG9 OCA].
		+	[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
		+	[[Category: Thermotoga maritima]]
		+	[[Category: Cross, P J.]]
		+	[[Category: Dobson, R C.J.]]
		+	[[Category: Parker, E J.]]
		+	[[Category: Patchett, M L.]]