3pkl - Revision history

OCA at 09:56, 6 September 2023

2023-09-06T09:56:06Z

←Older revision		Revision as of 09:56, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3pkl' size='340' side='right'caption='[[3pkl]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3pkl' size='340' side='right'caption='[[3pkl]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pkl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aspfl Aspfl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PKL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pkl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PKL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AZA:8~~-~~AZAXANTHINE'>AZA</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XE:XENON'>XE</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.749Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XE:XENON'>XE</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>[[3pjk\|3pjk]], [[3pk3\|3pk3]], [[3pk4\|3pk4]], [[3pk5\|3pk5]], [[3pk6\|3pk6]], [[3pk8\|3pk8]], [[3pkf\|3pkf]], [[3pkg\|3pkg]], [[3pkh\|3pkh]], [[3pkk\|3pkk]], [[3pks\|3pks]], [[3pkt\|3pkt]], [[3pku\|3pku]], [[3ple\|3ple]], [[3plg\|3plg]], [[3plh\|3plh]], [[3pli\|3pli]], [[3plj\|3plj]], [[3plm\|3plm]], [[2ic0\|2ic0]], [[2icq\|2icq]], [[2iba\|2iba]]</~~div~~><~~/td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~uaZ~~, ~~uox ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5059 ASPFL])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkl OCA], [https://pdbe.org/3pkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pkl RCSB], [https://www.ebi.ac.uk/pdbsum/3pkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pkl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkl OCA], [https://pdbe.org/3pkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pkl RCSB], [https://www.ebi.ac.uk/pdbsum/3pkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pkl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.	+	[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 21:

	==See Also==		==See Also==
-	*[[Urate ~~Oxidase~~\|Urate ~~Oxidase~~]]	+	*[[Urate oxidase 3D structures\|Urate oxidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aspfl]]~~	+	[[Category: Aspergillus flavus]]
-	~~[[Category: Factor independent urate hydroxylase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Abraini~~, J H~~]]	+	[[Category: Abraini JH]]
-	[[Category: ~~Marassio, G]]~~	+	[[Category: Colloc'h N]]
-	~~[[Category: Prange, T]]~~	+	[[Category: Marassio G]]
-	~~[[Category: H,~~ N ~~Colloc~~]]	+	[[Category: Prange T]]
-	[[Category: ~~Oxidase]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Peroxisome~~]]	+
-	[[Category: T~~-fold]]~~	+
-	~~[[Category: Tetramer]]~~	+
-	~~[[Category: Uric acid degradation~~]]	+

OCA at 08:43, 25 May 2022

2022-05-25T08:43:22Z

←Older revision		Revision as of 08:43, 25 May 2022
Line 1:		Line 1:

	==Urate oxidase under 0.8 MPa / 8 bars pressure of xenon==		==Urate oxidase under 0.8 MPa / 8 bars pressure of xenon==
-	<StructureSection load='3pkl' size='340' side='right' caption='[[3pkl]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='3pkl' size='340' side='right'caption='[[3pkl]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pkl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PKL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pkl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PKL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XE:XENON'>XE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XE:XENON'>XE</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pjk\|3pjk]], [[3pk3\|3pk3]], [[3pk4\|3pk4]], [[3pk5\|3pk5]], [[3pk6\|3pk6]], [[3pk8\|3pk8]], [[3pkf\|3pkf]], [[3pkg\|3pkg]], [[3pkh\|3pkh]], [[3pkk\|3pkk]], [[3pks\|3pks]], [[3pkt\|3pkt]], [[3pku\|3pku]], [[3ple\|3ple]], [[3plg\|3plg]], [[3plh\|3plh]], [[3pli\|3pli]], [[3plj\|3plj]], [[3plm\|3plm]], [[2ic0\|2ic0]], [[2icq\|2icq]], [[2iba\|2iba]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pjk\|3pjk]], [[3pk3\|3pk3]], [[3pk4\|3pk4]], [[3pk5\|3pk5]], [[3pk6\|3pk6]], [[3pk8\|3pk8]], [[3pkf\|3pkf]], [[3pkg\|3pkg]], [[3pkh\|3pkh]], [[3pkk\|3pkk]], [[3pks\|3pks]], [[3pkt\|3pkt]], [[3pku\|3pku]], [[3ple\|3ple]], [[3plg\|3plg]], [[3plh\|3plh]], [[3pli\|3pli]], [[3plj\|3plj]], [[3plm\|3plm]], [[2ic0\|2ic0]], [[2icq\|2icq]], [[2iba\|2iba]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uaZ, uox ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5059 ASPFL])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uaZ, uox ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5059 ASPFL])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkl OCA], [~~http~~://pdbe.org/3pkl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pkl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pkl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pkl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkl OCA], [https://pdbe.org/3pkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pkl RCSB], [https://www.ebi.ac.uk/pdbsum/3pkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pkl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.	+	[[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 3pkl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pkl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Urate Oxidase\|Urate Oxidase]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 31:
	[[Category: Aspfl]]		[[Category: Aspfl]]
	[[Category: Factor independent urate hydroxylase]]		[[Category: Factor independent urate hydroxylase]]
		+	[[Category: Large Structures]]
	[[Category: Abraini, J H]]		[[Category: Abraini, J H]]
	[[Category: Marassio, G]]		[[Category: Marassio, G]]

OCA at 09:01, 8 November 2017

2017-11-08T09:01:36Z

←Older revision		Revision as of 09:01, 8 November 2017
Line 22:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 3pkl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3pkl" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Urate Oxidase\|Urate Oxidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:51, 4 August 2016

2016-08-04T14:51:59Z

←Older revision		Revision as of 14:51, 4 August 2016
Line 1:		Line 1:
		+
	==Urate oxidase under 0.8 MPa / 8 bars pressure of xenon==		==Urate oxidase under 0.8 MPa / 8 bars pressure of xenon==
	<StructureSection load='3pkl' size='340' side='right' caption='[[3pkl]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3pkl' size='340' side='right' caption='[[3pkl]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pkl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aspergillus_flavus Aspergillus flavus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PKL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pkl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PKL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XE:XENON'>XE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XE:XENON'>XE</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pjk\|3pjk]], [[3pk3\|3pk3]], [[3pk4\|3pk4]], [[3pk5\|3pk5]], [[3pk6\|3pk6]], [[3pk8\|3pk8]], [[3pkf\|3pkf]], [[3pkg\|3pkg]], [[3pkh\|3pkh]], [[3pkk\|3pkk]], [[3pks\|3pks]], [[3pkt\|3pkt]], [[3pku\|3pku]], [[3ple\|3ple]], [[3plg\|3plg]], [[3plh\|3plh]], [[3pli\|3pli]], [[3plj\|3plj]], [[3plm\|3plm]], [[2ic0\|2ic0]], [[2icq\|2icq]], [[2iba\|2iba]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pjk\|3pjk]], [[3pk3\|3pk3]], [[3pk4\|3pk4]], [[3pk5\|3pk5]], [[3pk6\|3pk6]], [[3pk8\|3pk8]], [[3pkf\|3pkf]], [[3pkg\|3pkg]], [[3pkh\|3pkh]], [[3pkk\|3pkk]], [[3pks\|3pks]], [[3pkt\|3pkt]], [[3pku\|3pku]], [[3ple\|3ple]], [[3plg\|3plg]], [[3plh\|3plh]], [[3pli\|3pli]], [[3plj\|3plj]], [[3plm\|3plm]], [[2ic0\|2ic0]], [[2icq\|2icq]], [[2iba\|2iba]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uaZ, uox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5059 ~~Aspergillus flavus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uaZ, uox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5059 ASPFL])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Urate_oxidase Urate oxidase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pkl RCSB], [http://www.ebi.ac.uk/pdbsum/3pkl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkl OCA], [http://pdbe.org/3pkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pkl RCSB], [http://www.ebi.ac.uk/pdbsum/3pkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pkl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3pkl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aspergillus flavus~~]]	+	[[Category: Aspfl]]
-	[[Category: ~~Urate oxidase~~]]	+	[[Category: Factor independent urate hydroxylase]]
	[[Category: Abraini, J H]]		[[Category: Abraini, J H]]
	[[Category: Marassio, G]]		[[Category: Marassio, G]]

OCA at 10:16, 25 December 2014

2014-12-25T10:16:35Z

←Older revision		Revision as of 10:16, 25 December 2014
Line 10:		Line 10:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pkl RCSB], [http://www.ebi.ac.uk/pdbsum/3pkl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pkl RCSB], [http://www.ebi.ac.uk/pdbsum/3pkl PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:12, 9 December 2014

2014-12-09T11:12:12Z

←Older revision		Revision as of 11:12, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3pkl.~~png~~\|~~left~~\|~~200px~~]]	+	==Urate oxidase under 0.8 MPa / 8 bars pressure of xenon==
		+	<StructureSection load='3pkl' size='340' side='right' caption='[[3pkl]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3pkl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PKL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XE:XENON'>XE</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pjk\|3pjk]], [[3pk3\|3pk3]], [[3pk4\|3pk4]], [[3pk5\|3pk5]], [[3pk6\|3pk6]], [[3pk8\|3pk8]], [[3pkf\|3pkf]], [[3pkg\|3pkg]], [[3pkh\|3pkh]], [[3pkk\|3pkk]], [[3pks\|3pks]], [[3pkt\|3pkt]], [[3pku\|3pku]], [[3ple\|3ple]], [[3plg\|3plg]], [[3plh\|3plh]], [[3pli\|3pli]], [[3plj\|3plj]], [[3plm\|3plm]], [[2ic0\|2ic0]], [[2icq\|2icq]], [[2iba\|2iba]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uaZ, uox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5059 Aspergillus flavus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Urate_oxidase Urate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pkl RCSB], [http://www.ebi.ac.uk/pdbsum/3pkl PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The remarkably safe anesthetics xenon (Xe) and, to lesser extent, nitrous oxide (N(2)O) possess neuroprotective properties in preclinical studies. To investigate the mechanisms of pharmacological action of these gases, which are still poorly known, we performed both crystallography under a large range of gas pressure and biochemical studies on urate oxidase, a prototype of globular gas-binding proteins whose activity is modulated by inert gases. We show that Xe and N(2)O bind to, compete for, and expand the volume of a hydrophobic cavity located just behind the active site of urate oxidase and further inhibit urate oxidase enzymatic activity. By demonstrating a significant relationship between the binding and biochemical effects of Xe and N(2)O, given alone or in combination, these data from structure to function highlight the mechanisms by which chemically and metabolically inert gases can alter protein function and produce their pharmacological effects. Interestingly, the effects of a Xe:N(2)O equimolar mixture were found to be equivalent to those of Xe alone, thereby suggesting that gas mixtures containing Xe and N(2)O could be an alternative and efficient neuroprotective strategy to Xe alone, whose widespread clinical use is limited due to the cost of production and availability of this gas.-Marassio, G., Prange, T., David, H. N., Sopkova-de Oliveira Santos, J., Gabison, L., Delcroix, N., Abraini, J. H., Colloc'h, N. Pressure-response analysis of anesthetic gases xenon and nitrous oxide on urate oxidase: a crystallographic study.

-	~~{{STRUCTURE_3pkl\| PDB=3pkl \| SCENE= }}~~	+	Pressure-response analysis of anesthetic gases xenon and nitrous oxide on urate oxidase: a crystallographic study.,Marassio G, Prange T, David HN, Sopkova-de Oliveira Santos J, Gabison L, Delcroix N, Abraini JH, Colloc'h N FASEB J. 2011 Mar 18. PMID:21421845<ref>PMID:21421845</ref>

-	~~===Urate oxidase under 0.8 MPa~~ / ~~8 bars pressure~~ of ~~xenon===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21421845}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3pkl]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aspergillus_flavus Aspergillus flavus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA].~~	+

	==See Also==		==See Also==
	*[[Urate Oxidase\|Urate Oxidase]]		*[[Urate Oxidase\|Urate Oxidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021421845<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aspergillus flavus]]		[[Category: Aspergillus flavus]]
	[[Category: Urate oxidase]]		[[Category: Urate oxidase]]
-	[[Category: Abraini, J H.]]	+	[[Category: Abraini, J H]]
-	[[Category: Marassio, G.]]	+	[[Category: Marassio, G]]
-	[[Category: Prange, T.]]	+	[[Category: Prange, T]]
-	[[Category: H, N Colloc.]]	+	[[Category: H, N Colloc]]
	[[Category: Oxidase]]		[[Category: Oxidase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 15:32, 20 October 2012

2012-10-20T15:32:01Z

←Older revision		Revision as of 15:32, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3pkl]] is a 1 chain structure ~~of [[Urate Oxidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA].	+	[[3pkl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA].

	==See Also==		==See Also==

OCA at 18:40, 26 July 2012

2012-07-26T18:40:36Z

←Older revision		Revision as of 18:40, 26 July 2012
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	[[Image:3pkl.png\|left\|200px]]		[[Image:3pkl.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_3pkl\| PDB=3pkl \| SCENE= }}		{{STRUCTURE_3pkl\| PDB=3pkl \| SCENE= }}

	===Urate oxidase under 0.8 MPa / 8 bars pressure of xenon===		===Urate oxidase under 0.8 MPa / 8 bars pressure of xenon===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21421845}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21421845 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21421845}}		{{ABSTRACT_PUBMED_21421845}}

	==About this Structure==		==About this Structure==
-	[[3pkl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA].	+	[[3pkl]] is a 1 chain structure of [[Urate Oxidase]] with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA].
		+
		+	==See Also==
		+	*[[Urate Oxidase\|Urate Oxidase]]

	==Reference==		==Reference==

OCA at 08:01, 13 July 2011

2011-07-13T08:01:31Z

←Older revision		Revision as of 08:01, 13 July 2011
Line 1:		Line 1:
-	[[Image:3pkl.~~jpg~~\|left\|200px]]	+	[[Image:3pkl.png\|left\|200px]]

	<!--		<!--
Line 22:		Line 22:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21421845~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021421845</ref><references group="xtra"/>
	[[Category: Aspergillus flavus]]		[[Category: Aspergillus flavus]]
	[[Category: Urate oxidase]]		[[Category: Urate oxidase]]
Line 29:		Line 29:
	[[Category: Prange, T.]]		[[Category: Prange, T.]]
	[[Category: H, N Colloc.]]		[[Category: H, N Colloc.]]
		+	[[Category: Oxidase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Peroxisome]]
		+	[[Category: T-fold]]
		+	[[Category: Tetramer]]
		+	[[Category: Uric acid degradation]]

OCA at 08:56, 6 April 2011

2011-04-06T08:56:57Z

←Older revision		Revision as of 08:56, 6 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3pkl.jpg\|left\|200px]]

-	The ~~entry 3pkl~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3pkl", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3pkl\| PDB=3pkl \| SCENE= }}

-	~~Authors: Marassio, G., Colloc'h, N., Prange, T., Abraini, J.H~~.	+	===Urate oxidase under 0.8 MPa / 8 bars pressure of xenon===

-	~~Description~~: Urate oxidase ~~under 0~~.~~8 MPa / 8 bars pressure of xenon~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21421845}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21421845 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21421845}}
		+
		+	==About this Structure==
		+	[[3pkl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21421845</ref><references group="xtra"/>
		+	[[Category: Aspergillus flavus]]
		+	[[Category: Urate oxidase]]
		+	[[Category: Abraini, J H.]]
		+	[[Category: Marassio, G.]]
		+	[[Category: Prange, T.]]
		+	[[Category: H, N Colloc.]]