3pxg - Revision history

OCA at 17:08, 1 November 2023

2023-11-01T17:08:55Z

←Older revision		Revision as of 17:08, 1 November 2023
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	<StructureSection load='3pxg' size='340' side='right'caption='[[3pxg]], [[Resolution\|resolution]] 3.65Å' scene=''>		<StructureSection load='3pxg' size='340' side='right'caption='[[3pxg]], [[Resolution\|resolution]] 3.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pxg]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pxg]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PXG FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2y1q\|2y1q]]~~, [[~~2y1r~~\|~~2y1r~~]]~~, [[3pxi\|3pxi]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.654Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pxg OCA], [https://pdbe.org/3pxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pxg RCSB], [https://www.ebi.ac.uk/pdbsum/3pxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pxg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pxg OCA], [https://pdbe.org/3pxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pxg RCSB], [https://www.ebi.ac.uk/pdbsum/3pxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pxg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU]] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref> [[https://www.uniprot.org/uniprot/CLPC_BACSU CLPC_BACSU]] Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK.	+	[https://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Mei~~, Z Q~~]]	+	[[Category: Mei ZQ]]
-	[[Category: Shi~~, Y G~~]]	+	[[Category: Shi YG]]
-	[[Category: Wang, F]]	+	[[Category: Wang F]]
-	[[Category: Wang~~, J W]]~~	+	[[Category: Wang JW]]
-	~~[[Category: Aaa+ protein]]~~	+
-	~~[[Category: Clpb]]~~	+
-	~~[[Category: Clpc]]~~	+
-	~~[[Category: Clpx]]~~	+
-	~~[[Category: Hsp100/clp]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Proteolysis~~]]	+

OCA at 09:00, 25 May 2022

2022-05-25T09:00:28Z

←Older revision		Revision as of 09:00, 25 May 2022
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	==Structure of MecA121 and ClpC1-485 complex==		==Structure of MecA121 and ClpC1-485 complex==
-	<StructureSection load='3pxg' size='340' side='right' caption='[[3pxg]], [[Resolution\|resolution]] 3.65Å' scene=''>	+	<StructureSection load='3pxg' size='340' side='right'caption='[[3pxg]], [[Resolution\|resolution]] 3.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pxg]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3PXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pxg]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PXG FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y1q\|2y1q]], [[2y1r\|2y1r]], [[3pxi\|3pxi]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2y1q\|2y1q]], [[2y1r\|2y1r]], [[3pxi\|3pxi]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3pxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pxg OCA], [~~http~~://pdbe.org/3pxg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3pxg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3pxg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3pxg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pxg OCA], [https://pdbe.org/3pxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pxg RCSB], [https://www.ebi.ac.uk/pdbsum/3pxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pxg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU]] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref> [[~~http~~://www.uniprot.org/uniprot/CLPC_BACSU CLPC_BACSU]] Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK.	+	[[https://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU]] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref> [[https://www.uniprot.org/uniprot/CLPC_BACSU CLPC_BACSU]] Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Vibrio subtilis ehrenberg 1835]]		[[Category: Vibrio subtilis ehrenberg 1835]]
		+	[[Category: Large Structures]]
	[[Category: Mei, Z Q]]		[[Category: Mei, Z Q]]
	[[Category: Shi, Y G]]		[[Category: Shi, Y G]]

OCA at 10:14, 13 February 2019

2019-02-13T10:14:08Z

←Older revision		Revision as of 10:14, 13 February 2019
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	<StructureSection load='3pxg' size='340' side='right' caption='[[3pxg]], [[Resolution\|resolution]] 3.65Å' scene=''>		<StructureSection load='3pxg' size='340' side='right' caption='[[3pxg]], [[Resolution\|resolution]] 3.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pxg]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pxg]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PXG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y1q\|2y1q]], [[2y1r\|2y1r]], [[3pxi\|3pxi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y1q\|2y1q]], [[2y1r\|2y1r]], [[3pxi\|3pxi]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pxg OCA], [http://pdbe.org/3pxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pxg RCSB], [http://www.ebi.ac.uk/pdbsum/3pxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pxg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pxg OCA], [http://pdbe.org/3pxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pxg RCSB], [http://www.ebi.ac.uk/pdbsum/3pxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pxg ProSAT]</span></td></tr>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Mei, Z Q]]		[[Category: Mei, Z Q]]
	[[Category: Shi, Y G]]		[[Category: Shi, Y G]]

OCA at 18:07, 4 August 2016

2016-08-04T18:07:48Z

←Older revision		Revision as of 18:07, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of MecA121 and ClpC1-485 complex==		==Structure of MecA121 and ClpC1-485 complex==
	<StructureSection load='3pxg' size='340' side='right' caption='[[3pxg]], [[Resolution\|resolution]] 3.65Å' scene=''>		<StructureSection load='3pxg' size='340' side='right' caption='[[3pxg]], [[Resolution\|resolution]] 3.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3pxg]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3pxg]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PXG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y1q\|2y1q]], [[2y1r\|2y1r]], [[3pxi\|3pxi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y1q\|2y1q]], [[2y1r\|2y1r]], [[3pxi\|3pxi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pxg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pxg RCSB], [http://www.ebi.ac.uk/pdbsum/3pxg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pxg OCA], [http://pdbe.org/3pxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pxg RCSB], [http://www.ebi.ac.uk/pdbsum/3pxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pxg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3pxg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Mei, Z Q]]		[[Category: Mei, Z Q]]
	[[Category: Shi, Y G]]		[[Category: Shi, Y G]]

OCA at 18:01, 24 December 2014

2014-12-24T18:01:47Z

←Older revision		Revision as of 18:01, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3pxg\| PDB=3pxg \| SCENE= }}~~	+	==Structure of MecA121 and ClpC1-485 complex==
-	===Structure of MecA121 and ClpC1-485 complex===	+	<StructureSection load='3pxg' size='340' side='right' caption='[[3pxg]], [[Resolution\|resolution]] 3.65Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21368759}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3pxg]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PXG FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y1q\|2y1q]], [[2y1r\|2y1r]], [[3pxi\|3pxi]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pxg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pxg RCSB], [http://www.ebi.ac.uk/pdbsum/3pxg PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU]] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref> [[http://www.uniprot.org/uniprot/CLPC_BACSU CLPC_BACSU]] Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK.		[[http://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU]] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref> [[http://www.uniprot.org/uniprot/CLPC_BACSU CLPC_BACSU]] Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Regulated proteolysis by ATP-dependent proteases is universal in all living cells. Bacterial ClpC, a member of the Clp/Hsp100 family of AAA+ proteins (ATPases associated with diverse cellular activities) with two nucleotide-binding domains (D1 and D2), requires the adaptor protein MecA for activation and substrate targeting. The activated, hexameric MecA-ClpC molecular machine harnesses the energy of ATP binding and hydrolysis to unfold specific substrate proteins and translocate the unfolded polypeptide to the ClpP protease for degradation. Here we report three related crystal structures: a heterodimer between MecA and the amino domain of ClpC, a heterododecamer between MecA and D2-deleted ClpC, and a hexameric complex between MecA and full-length ClpC. In conjunction with biochemical analyses, these structures reveal the organizational principles behind the hexameric MecA-ClpC complex, explain the molecular mechanisms for MecA-mediated ClpC activation and provide mechanistic insights into the function of the MecA-ClpC molecular machine. These findings have implications for related Clp/Hsp100 molecular machines.

-	~~==About this~~ Structure==	+	Structure and mechanism of the hexameric MecA-ClpC molecular machine.,Wang F, Mei Z, Qi Y, Yan C, Hu Q, Wang J, Shi Y Nature. 2011 Mar 2. PMID:21368759<ref>PMID:21368759</ref>
-	~~[[3pxg]] is a 12 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:021368759</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Mei, Z Q.]]	+	[[Category: Mei, Z Q]]
-	[[Category: Shi, Y G.]]	+	[[Category: Shi, Y G]]
-	[[Category: Wang, F.]]	+	[[Category: Wang, F]]
-	[[Category: Wang, J W.]]	+	[[Category: Wang, J W]]
	[[Category: Aaa+ protein]]		[[Category: Aaa+ protein]]
	[[Category: Clpb]]		[[Category: Clpb]]

OCA at 06:57, 16 October 2013

2013-10-16T06:57:49Z

←Older revision		Revision as of 06:57, 16 October 2013
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-	[[Image:3pxg.png\|left\|200px]]
-
-	<!--
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	{{STRUCTURE_3pxg\| PDB=3pxg \| SCENE= }}		{{STRUCTURE_3pxg\| PDB=3pxg \| SCENE= }}
-
	===Structure of MecA121 and ClpC1-485 complex===		===Structure of MecA121 and ClpC1-485 complex===
		+	{{ABSTRACT_PUBMED_21368759}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU]] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref> [[http://www.uniprot.org/uniprot/CLPC_BACSU CLPC_BACSU]] Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK.

	==About this Structure==		==About this Structure==
	[[3pxg]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA].		[[3pxg]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021368759</ref><references group="xtra"/><references/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Mei, Z Q.]]		[[Category: Mei, Z Q.]]

OCA at 06:18, 11 April 2012

2012-04-11T06:18:30Z

←Older revision		Revision as of 06:18, 11 April 2012
Line 1:		Line 1:
-	[[Image:3pxg.~~jpg~~\|left\|200px]]	+	[[Image:3pxg.png\|left\|200px]]

	<!--		<!--
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	[[Category: Wang, F.]]		[[Category: Wang, F.]]
	[[Category: Wang, J W.]]		[[Category: Wang, J W.]]
		+	[[Category: Aaa+ protein]]
		+	[[Category: Clpb]]
		+	[[Category: Clpc]]
		+	[[Category: Clpx]]
		+	[[Category: Hsp100/clp]]
		+	[[Category: Protein binding]]
		+	[[Category: Proteolysis]]

OCA at 08:34, 16 March 2011

2011-03-16T08:34:46Z

←Older revision		Revision as of 08:34, 16 March 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3pxg.jpg\|left\|200px]]

-	The ~~entry 3pxg~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3pxg", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3pxg\| PDB=3pxg \| SCENE= }}

-	~~Authors: Wang, F., Mei, Z.Q., Wang, J.W., Shi, Y.G.~~	+	===Structure of MecA121 and ClpC1-485 complex===

-	~~Description:~~ Structure ~~of MecA121 and ClpC1~~-~~485 complex~~	+
		+	==About this Structure==
		+	[[3pxg]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PXG OCA].
		+	[[Category: Bacillus subtilis]]
		+	[[Category: Mei, Z Q.]]
		+	[[Category: Shi, Y G.]]
		+	[[Category: Wang, F.]]
		+	[[Category: Wang, J W.]]

OCA at 15:55, 5 January 2011

2011-01-05T15:55:00Z

←Older revision		Revision as of 15:55, 5 January 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3pxg is ON HOLD	+	The entry 3pxg is ON HOLD until Paper Publication

	Authors: Wang, F., Mei, Z.Q., Wang, J.W., Shi, Y.G.		Authors: Wang, F., Mei, Z.Q., Wang, J.W., Shi, Y.G.

	Description: Structure of MecA121 and ClpC1-485 complex		Description: Structure of MecA121 and ClpC1-485 complex

OCA: Protected "3pxg" [edit=sysop:move=sysop]

2010-12-29T18:15:53Z

Protected "3pxg" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:15, 29 December 2010