3q3g - Revision history

OCA at 05:50, 8 June 2022

2022-06-08T05:50:23Z

←Older revision		Revision as of 05:50, 8 June 2022
Line 1:		Line 1:

	==Crystal Structure of A-domain in complex with antibody==		==Crystal Structure of A-domain in complex with antibody==
-	<StructureSection load='3q3g' size='340' side='right' caption='[[3q3g]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='3q3g' size='340' side='right'caption='[[3q3g]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q3g]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3Q3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q3g]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q3G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITGAM, CD11B, CR3A ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITGAM, CD11B, CR3A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3q3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3g OCA], [~~http~~://pdbe.org/3q3g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3q3g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3q3g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3q3g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3g OCA], [https://pdbe.org/3q3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q3g RCSB], [https://www.ebi.ac.uk/pdbsum/3q3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q3g ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[~~http~~://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.	+	[[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[https://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.	+	[[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Integrin\|Integrin]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
-	*[[3D structures of antibody\|3D structures of antibody]]	+	*[[Integrin 3D structures\|Integrin 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Arnaout, M A]]		[[Category: Arnaout, M A]]

OCA at 23:51, 4 August 2016

2016-08-04T23:51:33Z

←Older revision		Revision as of 23:51, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of A-domain in complex with antibody==		==Crystal Structure of A-domain in complex with antibody==
	<StructureSection load='3q3g' size='340' side='right' caption='[[3q3g]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3q3g' size='340' side='right' caption='[[3q3g]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3q3g]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3q3g]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q3G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITGAM, CD11B, CR3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITGAM, CD11B, CR3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q3g RCSB], [http://www.ebi.ac.uk/pdbsum/3q3g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3g OCA], [http://pdbe.org/3q3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q3g RCSB], [http://www.ebi.ac.uk/pdbsum/3q3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q3g ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3q3g" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Antibody\|Antibody]]
	*[[Integrin\|Integrin]]		*[[Integrin\|Integrin]]
		+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Arnaout, M A]]		[[Category: Arnaout, M A]]

OCA at 11:11, 19 December 2014

2014-12-19T11:11:16Z

←Older revision		Revision as of 11:11, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3q3g\| PDB=3q3g \| SCENE= }}~~	+	==Crystal Structure of A-domain in complex with antibody==
-	===Crystal Structure of A-domain in complex with antibody===	+	<StructureSection load='3q3g' size='340' side='right' caption='[[3q3g]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22095715}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3q3g]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q3G FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ITGAM, CD11B, CR3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q3g RCSB], [http://www.ebi.ac.uk/pdbsum/3q3g PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.		[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.		[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A central feature of integrin interaction with physiologic ligands is the monodentate binding of a ligand carboxylate to a Mg(2+) ion hexacoordinated at the metal ion-dependent adhesion site (MIDAS) in the integrin A domain. This interaction stabilizes the A domain in the high-affinity state, which is distinguished from the default low-affinity state by tertiary changes in the domain that culminate in cell adhesion. Small molecule ligand-mimetic integrin antagonists act as partial agonists, eliciting similar activating conformational changes in the A domain, which has contributed to paradoxical adhesion and increased patient mortality in large clinical trials. As with other ligand-mimetic integrin antagonists, the function-blocking mAb 107 binds MIDAS of integrin CD11b/CD18 A domain (CD11bA), but in contrast, it favors the inhibitory Ca(2+) ion over the Mg(2+) ion at MIDAS. We determined the crystal structures of the Fab fragment of mAb 107 complexed to the low- and high-affinity states of CD11bA. Favored binding of the Ca(2+) ion at MIDAS is caused by the unusual symmetric bidentate ligation of a Fab-derived ligand Asp to a heptacoordinated MIDAS Ca(2+) ion. Binding of the Fab fragment of mAb 107 to CD11bA did not trigger the activating tertiary changes in the domain or in the full-length integrin. These data show that the denticity of the ligand Asp/Glu can modify the divalent cation selectivity at MIDAS and hence integrin function. Stabilizing the Ca(2+) ion at MIDAS by bidentate ligation to a ligand Asp/Glu may provide one approach for designing pure integrin antagonists.

-	~~==About this Structure==~~	+	Stable Coordination of the Inhibitory Ca2+ Ion at the Metal Ion-Dependent Adhesion Site in Integrin CD11b/CD18 by an Antibody-Derived Ligand Aspartate: Implications for Integrin Regulation and Structure-Based Drug Design.,Mahalingam B, Ajroud K, Alonso JL, Anand S, Adair BD, Horenstein AL, Malavasi F, Xiong JP, Arnaout MA J Immunol. 2011 Nov 16. PMID:22095715<ref>PMID:22095715</ref>
-	~~[[3q3g]] is a 12 chain structure with sequence from [http~~:~~//en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]~~ and ~~[http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3Q3G OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	*[[Integrin\|Integrin]]
-	==~~Reference~~==	+	== References ==
-	~~<ref group="xtra">PMID:022095715</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Arnaout, M A.]]	+	[[Category: Arnaout, M A]]
-	[[Category: Mahalingam, B.]]	+	[[Category: Mahalingam, B]]
-	[[Category: Xiong, J P.]]	+	[[Category: Xiong, J P]]
	[[Category: Immune system-cell adhesion complex]]		[[Category: Immune system-cell adhesion complex]]

OCA at 05:15, 25 March 2013

2013-03-25T05:15:42Z

←Older revision		Revision as of 05:15, 25 March 2013
Line 1:		Line 1:
-	[[Image:3q3g.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3q3g", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3q3g\| PDB=3q3g \| SCENE= }}		{{STRUCTURE_3q3g\| PDB=3q3g \| SCENE= }}
-
	===Crystal Structure of A-domain in complex with antibody===		===Crystal Structure of A-domain in complex with antibody===
		+	{{ABSTRACT_PUBMED_22095715}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22095715}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 22095715~~ is the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_22095715}}~~	+

	==About this Structure==		==About this Structure==
	[[3q3g]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3G OCA].		[[3q3g]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3G OCA].
		+
		+	==See Also==
		+	*[[Antibody\|Antibody]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022095715</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022095715</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 08:08, 7 December 2011

2011-12-07T08:08:58Z

←Older revision		Revision as of 08:08, 7 December 2011
Line 1:		Line 1:
-	[[Image:3q3g.~~jpg~~\|left\|200px]]	+	[[Image:3q3g.png\|left\|200px]]

	<!--		<!--

OCA at 06:22, 30 November 2011

2011-11-30T06:22:13Z

←Older revision		Revision as of 06:22, 30 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3q3g.jpg\|left\|200px]]

-	The ~~entry 3q3g~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3q3g", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3q3g\| PDB=3q3g \| SCENE= }}

-	~~Authors: Mahalingam, B., Xiong, J.P., Arnaout, M.~~A.	+	===Crystal Structure of A-domain in complex with antibody===

-	~~Description~~: ~~Crystal~~ Structure of A-~~domain in~~ complex ~~with antibody~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22095715}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22095715 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22095715}}
		+
		+	==About this Structure==
		+	[[3q3g]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3G OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022095715</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Mus musculus]]
		+	[[Category: Arnaout, M A.]]
		+	[[Category: Mahalingam, B.]]
		+	[[Category: Xiong, J P.]]
		+	[[Category: Immune system-cell adhesion complex]]

OCA at 06:43, 23 March 2011

2011-03-23T06:43:00Z

←Older revision		Revision as of 06:43, 23 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3q3g is ON HOLD	+	The entry 3q3g is ON HOLD until Paper Publication

	Authors: Mahalingam, B., Xiong, J.P., Arnaout, M.A.		Authors: Mahalingam, B., Xiong, J.P., Arnaout, M.A.

	Description: Crystal Structure of A-domain in complex with antibody		Description: Crystal Structure of A-domain in complex with antibody

OCA at 06:03, 9 March 2011

2011-03-09T06:03:15Z

←Older revision		Revision as of 06:03, 9 March 2011
Line 3:		Line 3:
	The entry 3q3g is ON HOLD		The entry 3q3g is ON HOLD

-	Authors: Mahalingam, B~~., Ajroud, K., Anand, S~~., Xiong, J.P., Arnaout, M.A.	+	Authors: Mahalingam, B., Xiong, J.P., Arnaout, M.A.

	Description: Crystal Structure of A-domain in complex with antibody		Description: Crystal Structure of A-domain in complex with antibody

OCA at 04:50, 12 January 2011

2011-01-12T04:50:26Z

←Older revision		Revision as of 04:50, 12 January 2011
Line 3:		Line 3:
	The entry 3q3g is ON HOLD		The entry 3q3g is ON HOLD

-	Authors: Mahalingam B, Ajroud K, Anand S, Xiong J.P, Arnaout M.A	+	Authors: Mahalingam, B., Ajroud, K., Anand, S., Xiong, J.P., Arnaout, M.A.

-	Description: Crystal Structure of A-domain of in complex with antibody	+	Description: Crystal Structure of A-domain in complex with antibody

OCA: Protected "3q3g" [edit=sysop:move=sysop]

2010-12-29T18:18:09Z

Protected "3q3g" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:18, 29 December 2010