3qht - Revision history

OCA at 11:46, 14 March 2024

2024-03-14T11:46:01Z

←Older revision		Revision as of 11:46, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3qht' size='340' side='right'caption='[[3qht]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3qht' size='340' side='right'caption='[[3qht]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qht]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~] and [https://en.wikipedia.org/wiki/~~Synthetic_construct_sequences~~ Synthetic construct ~~sequences~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QHT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qht]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QHT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SMT3, YDR510W, D9719.15 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qht OCA], [https://pdbe.org/3qht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qht RCSB], [https://www.ebi.ac.uk/pdbsum/3qht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qht ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qht OCA], [https://pdbe.org/3qht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qht RCSB], [https://www.ebi.ac.uk/pdbsum/3qht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qht ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations.	+	[https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST] Not known; suppressor of MIF2 mutations.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Discriminating closely related molecules remains a major challenge in the engineering of binding proteins and inhibitors. Here we report the development of highly selective inhibitors of small ubiquitin-related modifier (SUMO) family proteins. SUMOylation is involved in the regulation of diverse cellular processes. Functional differences between two major SUMO isoforms in humans, SUMO1 and SUMO2/3, are thought to arise from distinct interactions mediated by each isoform with other proteins containing SUMO-interacting motifs (SIMs). However, the roles of such isoform-specific interactions are largely uncharacterized due in part to the difficulty in generating high-affinity, isoform-specific inhibitors of SUMO/SIM interactions. We first determined the crystal structure of a "monobody," a designed binding protein based on the fibronectin type III scaffold, bound to the yeast homolog of SUMO. This structure illustrated a mechanism by which monobodies bind to the highly conserved SIM-binding site while discriminating individual SUMO isoforms. Based on this structure, we designed a SUMO-targeted library from which we obtained monobodies that bound to the SIM-binding site of human SUMO1 with K(d) values of approximately 100 nM but bound to SUMO2 400 times more weakly. The monobodies inhibited SUMO1/SIM interactions and, unexpectedly, also inhibited SUMO1 conjugation. These high-affinity and isoform-specific inhibitors will enhance mechanistic and cellular investigations of SUMO biology.	+
-		+
-	Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design.,Gilbreth RN, Truong K, Madu I, Koide A, Wojcik JB, Li NS, Piccirilli JA, Chen Y, Koide S Proc Natl Acad Sci U S A. 2011 May 10;108(19):7751-6. Epub 2011 Apr 25. PMID:21518904<ref>PMID:21518904</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3qht" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[SUMO 3D Structures\|SUMO 3D Structures]]		*[[SUMO 3D Structures\|SUMO 3D Structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Synthetic construct sequences~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Gilbreth, R N~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Koide, S~~]]	+	[[Category: Gilbreth RN]]
-	[[Category: ~~De novo protein]]~~	+	[[Category: Koide S]]
-	~~[[Category: Fibronectin type iii]]~~	+
-	~~[[Category: Smt3]]~~	+
-	~~[[Category: Yeast small ubiquitin-like modifier~~]]	+

OCA at 06:09, 8 June 2022

2022-06-08T06:09:24Z

←Older revision		Revision as of 06:09, 8 June 2022
Line 1:		Line 1:

	==Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO==		==Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO==
-	<StructureSection load='3qht' size='340' side='right' caption='[[3qht]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3qht' size='340' side='right'caption='[[3qht]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qht]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824] and [~~http~~://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QHT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qht]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824] and [https://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QHT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMT3, YDR510W, D9719.15 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMT3, YDR510W, D9719.15 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qht OCA], [~~http~~://pdbe.org/3qht PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qht RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qht PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qht ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qht OCA], [https://pdbe.org/3qht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qht RCSB], [https://www.ebi.ac.uk/pdbsum/3qht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qht ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations.	+	[[https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3qht" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3qht" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[SUMO 3D Structures\|SUMO 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Synthetic construct sequences]]		[[Category: Synthetic construct sequences]]
	[[Category: Gilbreth, R N]]		[[Category: Gilbreth, R N]]

OCA at 09:15, 8 November 2017

2017-11-08T09:15:14Z

←Older revision		Revision as of 09:15, 8 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 3qht" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3qht" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[SUMO\|SUMO]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:07, 5 August 2016

2016-08-05T02:07:18Z

←Older revision		Revision as of 02:07, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO==		==Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO==
	<StructureSection load='3qht' size='340' side='right' caption='[[3qht]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3qht' size='340' side='right' caption='[[3qht]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qht]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~] and [http://en.wikipedia.org/wiki/~~Synthetic_construct~~ Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QHT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qht]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QHT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMT3, YDR510W, D9719.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMT3, YDR510W, D9719.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qht OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qht RCSB], [http://www.ebi.ac.uk/pdbsum/3qht PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qht OCA], [http://pdbe.org/3qht PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qht RCSB], [http://www.ebi.ac.uk/pdbsum/3qht PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qht ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qht" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[SUMO\|SUMO]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
-	[[Category: Synthetic construct]]	+	[[Category: Synthetic construct sequences]]
	[[Category: Gilbreth, R N]]		[[Category: Gilbreth, R N]]
	[[Category: Koide, S]]		[[Category: Koide, S]]

OCA at 14:56, 25 December 2014

2014-12-25T14:56:23Z

←Older revision		Revision as of 14:56, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qht OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qht RCSB], [http://www.ebi.ac.uk/pdbsum/3qht PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qht OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qht RCSB], [http://www.ebi.ac.uk/pdbsum/3qht PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:51, 19 December 2014

2014-12-19T10:51:05Z

←Older revision		Revision as of 10:51, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3qht\| PDB=3qht \| SCENE= }}~~	+	==Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO==
-	===Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO===	+	<StructureSection load='3qht' size='340' side='right' caption='[[3qht]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21518904}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qht]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QHT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SMT3, YDR510W, D9719.15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qht OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qht RCSB], [http://www.ebi.ac.uk/pdbsum/3qht PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Discriminating closely related molecules remains a major challenge in the engineering of binding proteins and inhibitors. Here we report the development of highly selective inhibitors of small ubiquitin-related modifier (SUMO) family proteins. SUMOylation is involved in the regulation of diverse cellular processes. Functional differences between two major SUMO isoforms in humans, SUMO1 and SUMO2/3, are thought to arise from distinct interactions mediated by each isoform with other proteins containing SUMO-interacting motifs (SIMs). However, the roles of such isoform-specific interactions are largely uncharacterized due in part to the difficulty in generating high-affinity, isoform-specific inhibitors of SUMO/SIM interactions. We first determined the crystal structure of a "monobody," a designed binding protein based on the fibronectin type III scaffold, bound to the yeast homolog of SUMO. This structure illustrated a mechanism by which monobodies bind to the highly conserved SIM-binding site while discriminating individual SUMO isoforms. Based on this structure, we designed a SUMO-targeted library from which we obtained monobodies that bound to the SIM-binding site of human SUMO1 with K(d) values of approximately 100 nM but bound to SUMO2 400 times more weakly. The monobodies inhibited SUMO1/SIM interactions and, unexpectedly, also inhibited SUMO1 conjugation. These high-affinity and isoform-specific inhibitors will enhance mechanistic and cellular investigations of SUMO biology.

-	~~==Function==~~	+	Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design.,Gilbreth RN, Truong K, Madu I, Koide A, Wojcik JB, Li NS, Piccirilli JA, Chen Y, Koide S Proc Natl Acad Sci U S A. 2011 May 10;108(19):7751-6. Epub 2011 Apr 25. PMID:21518904<ref>PMID:21518904</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known~~; ~~suppressor of MIF2 mutations~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3qht]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en~~.~~wikipedia.org~~/~~wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHT OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021518904</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Synthetic construct]]		[[Category: Synthetic construct]]
-	[[Category: Gilbreth, R N.]]	+	[[Category: Gilbreth, R N]]
-	[[Category: Koide, S.]]	+	[[Category: Koide, S]]
	[[Category: De novo protein]]		[[Category: De novo protein]]
	[[Category: Fibronectin type iii]]		[[Category: Fibronectin type iii]]
	[[Category: Smt3]]		[[Category: Smt3]]
	[[Category: Yeast small ubiquitin-like modifier]]		[[Category: Yeast small ubiquitin-like modifier]]

OCA at 08:16, 8 May 2013

2013-05-08T08:16:48Z

←Older revision		Revision as of 08:16, 8 May 2013
Line 1:		Line 1:
-	[[Image:3qht.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qht", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qht\| PDB=3qht \| SCENE= }}		{{STRUCTURE_3qht\| PDB=3qht \| SCENE= }}
-
	===Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO===		===Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO===
		+	{{ABSTRACT_PUBMED_21518904}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST]] Not known; suppressor of MIF2 mutations.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21518904}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 21518904 is the PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_21518904}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021518904</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021518904</ref><references group="xtra"/><references/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Synthetic construct]]		[[Category: Synthetic construct]]
	[[Category: Gilbreth, R N.]]		[[Category: Gilbreth, R N.]]
	[[Category: Koide, S.]]		[[Category: Koide, S.]]
		+	[[Category: De novo protein]]
		+	[[Category: Fibronectin type iii]]
		+	[[Category: Smt3]]
		+	[[Category: Yeast small ubiquitin-like modifier]]

OCA at 05:58, 25 May 2011

2011-05-25T05:58:31Z

←Older revision		Revision as of 05:58, 25 May 2011
Line 1:		Line 1:
-	[[Image:3qht.~~jpg~~\|left\|200px]]	+	[[Image:3qht.png\|left\|200px]]

	<!--		<!--

OCA at 04:43, 12 May 2011

2011-05-12T04:43:05Z

←Older revision		Revision as of 04:43, 12 May 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3qht.jpg\|left\|200px]]

-	The ~~entry 3qht~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qht", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qht\| PDB=3qht \| SCENE= }}

-	~~Authors: Koide, S., Gilbreth, R.N.~~	+	===Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO===

-	~~Description~~: ~~Crystal Structure of~~ the ~~Monobody ySMB~~-~~1 bound to yeast SUMO~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21518904}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21518904 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21518904}}
		+
		+	==About this Structure==
		+	[[3qht]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QHT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021518904</ref><references group="xtra"/>
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Gilbreth, R N.]]
		+	[[Category: Koide, S.]]

OCA at 06:39, 2 March 2011

2011-03-02T06:39:16Z

←Older revision		Revision as of 06:39, 2 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3qht is ON HOLD	+	The entry 3qht is ON HOLD until Paper Publication

	Authors: Koide, S., Gilbreth, R.N.		Authors: Koide, S., Gilbreth, R.N.

	Description: Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO		Description: Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO