3qmj - Revision history

OCA at 11:51, 14 March 2024

2024-03-14T11:51:23Z

←Older revision		Revision as of 11:51, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3qmj' size='340' side='right'caption='[[3qmj]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3qmj' size='340' side='right'caption='[[3qmj]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qmj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mycmm Mycmm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QMJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qmj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_marinum_M Mycobacterium marinum M]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QMJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~echA8_6, MMAR_2759 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmj OCA], [https://pdbe.org/3qmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qmj RCSB], [https://www.ebi.ac.uk/pdbsum/3qmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmj OCA], [https://pdbe.org/3qmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qmj RCSB], [https://www.ebi.ac.uk/pdbsum/3qmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmj ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/B2HD64_MYCMM B2HD64_MYCMM]
-	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.	+
-		+
-	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: ~~S1472-9792(14)20565-8. doi:, 10.1016~~/~~j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3qmj" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Enoyl-CoA hydratase 3D structures\|Enoyl-CoA hydratase 3D structures]]		*[[Enoyl-CoA hydratase 3D structures\|Enoyl-CoA hydratase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycmm]]~~	+	[[Category: Mycobacterium marinum M]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Emerald biostructure]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Niaid]]~~	+
-	~~[[Category: Nih]]~~	+
-	~~[[Category: Sbri]]~~	+
-	~~[[Category: Ssgcid]]~~	+
-	~~[[Category: Uw~~]]	+

OCA at 06:14, 8 June 2022

2022-06-08T06:14:55Z

←Older revision		Revision as of 06:14, 8 June 2022
Line 1:		Line 1:

	==Crystal structure of Enoyl-CoA hydratase EchA8_6 from Mycobacterium marinum==		==Crystal structure of Enoyl-CoA hydratase EchA8_6 from Mycobacterium marinum==
-	<StructureSection load='3qmj' size='340' side='right' caption='[[3qmj]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3qmj' size='340' side='right'caption='[[3qmj]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qmj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QMJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qmj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QMJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA8_6, MMAR_2759 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA8_6, MMAR_2759 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmj OCA], [~~http~~://pdbe.org/3qmj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qmj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qmj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmj OCA], [https://pdbe.org/3qmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qmj RCSB], [https://www.ebi.ac.uk/pdbsum/3qmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmj ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 3qmj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3qmj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Enoyl-CoA hydratase 3D structures\|Enoyl-CoA hydratase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mycmm]]		[[Category: Mycmm]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 18:39, 1 February 2017

2017-02-01T18:39:39Z

←Older revision		Revision as of 18:39, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal structure of Enoyl-CoA hydratase EchA8_6 from Mycobacterium marinum==		==Crystal structure of Enoyl-CoA hydratase EchA8_6 from Mycobacterium marinum==
	<StructureSection load='3qmj' size='340' side='right' caption='[[3qmj]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3qmj' size='340' side='right' caption='[[3qmj]], [[Resolution\|resolution]] 2.20Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA8_6, MMAR_2759 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA8_6, MMAR_2759 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qmj RCSB], [http://www.ebi.ac.uk/pdbsum/3qmj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmj OCA], [http://pdbe.org/3qmj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qmj RCSB], [http://www.ebi.ac.uk/pdbsum/3qmj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmj ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
-		+	<div class="pdbe-citations 3qmj" style="background-color:#fffaf0;"></div>
-	==~~See Also==~~	+
-	*[[Enoyl-CoA hydratase\|Enoyl-~~CoA hydratase]]~~	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:41, 22 April 2015

2015-04-22T06:41:44Z

←Older revision		Revision as of 06:41, 22 April 2015
Line 2:		Line 2:
	<StructureSection load='3qmj' size='340' side='right' caption='[[3qmj]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3qmj' size='340' side='right' caption='[[3qmj]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qmj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_marinum Mycobacterium marinum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QMJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qmj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QMJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA8_6, MMAR_2759 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1781 Mycobacterium marinum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA8_6, MMAR_2759 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qmj RCSB], [http://www.ebi.ac.uk/pdbsum/3qmj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qmj RCSB], [http://www.ebi.ac.uk/pdbsum/3qmj PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.
		+
		+	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Enoyl-CoA hydratase\|Enoyl-CoA hydratase]]		*[[Enoyl-CoA hydratase\|Enoyl-CoA hydratase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium marinum~~]]	+	[[Category: Mycmm]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Emerald biostructure]]		[[Category: Emerald biostructure]]

OCA at 10:15, 19 December 2014

2014-12-19T10:15:20Z

←Older revision		Revision as of 10:15, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3qmj\| PDB=3qmj \| SCENE= }}~~	+	==Crystal structure of Enoyl-CoA hydratase EchA8_6 from Mycobacterium marinum==
-	===Crystal structure of Enoyl-CoA hydratase EchA8_6 from Mycobacterium marinum===	+	<StructureSection load='3qmj' size='340' side='right' caption='[[3qmj]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qmj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QMJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">echA8_6, MMAR_2759 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1781 Mycobacterium marinum])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qmj RCSB], [http://www.ebi.ac.uk/pdbsum/3qmj PDBsum]</span></td></tr>
		+	</table>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~3qmj~~]] ~~is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMJ OCA].~~	+	*[[Enoyl-CoA hydratase\|Enoyl-CoA hydratase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium marinum]]		[[Category: Mycobacterium marinum]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Emerald biostructure]]		[[Category: Emerald biostructure]]
	[[Category: Lyase]]		[[Category: Lyase]]
Line 11:		Line 19:
	[[Category: Nih]]		[[Category: Nih]]
	[[Category: Sbri]]		[[Category: Sbri]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]
	[[Category: Uw]]		[[Category: Uw]]

OCA at 08:13, 8 May 2013

2013-05-08T08:13:58Z

←Older revision		Revision as of 08:13, 8 May 2013
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-	[[Image:3qmj.png\|left\|200px]]
-
-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_3qmj\| PDB=3qmj \| SCENE= }}		{{STRUCTURE_3qmj\| PDB=3qmj \| SCENE= }}
-
	===Crystal structure of Enoyl-CoA hydratase EchA8_6 from Mycobacterium marinum===		===Crystal structure of Enoyl-CoA hydratase EchA8_6 from Mycobacterium marinum===
-

	==About this Structure==		==About this Structure==
Line 16:		Line 6:
	[[Category: Mycobacterium marinum]]		[[Category: Mycobacterium marinum]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: Emerald biostructure]]
		+	[[Category: Lyase]]
		+	[[Category: Niaid]]
		+	[[Category: Nih]]
		+	[[Category: Sbri]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Ssgcid]]
		+	[[Category: Structural genomic]]
		+	[[Category: Uw]]

OCA at 07:24, 16 March 2011

2011-03-16T07:24:49Z

←Older revision		Revision as of 07:24, 16 March 2011
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-	[[Image:3qmj.~~jpg~~\|left\|200px]]	+	[[Image:3qmj.png\|left\|200px]]

	<!--		<!--

OCA at 06:36, 9 March 2011

2011-03-09T06:36:09Z

←Older revision		Revision as of 06:36, 9 March 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3qmj.jpg\|left\|200px]]

-	The ~~entry 3qmj~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qmj", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qmj\| PDB=3qmj \| SCENE= }}

-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	===Crystal structure of Enoyl-CoA hydratase EchA8_6 from Mycobacterium marinum===

-	~~Description: Crystal~~ structure ~~of Enoyl-CoA hydratase EchA8_6~~ from Mycobacterium marinum	+
		+	==About this Structure==
		+	[[3qmj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_marinum Mycobacterium marinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMJ OCA].
		+	[[Category: Mycobacterium marinum]]
		+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]

OCA: Protected "3qmj" [edit=sysop:move=sysop]

2011-02-16T05:22:17Z

Protected "3qmj" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:22, 16 February 2011

OCA: New page: '''Unreleased structure''' The entry 3qmj is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal structure of Enoyl-CoA hydratase E...

2011-02-16T05:22:16Z

New page: '''Unreleased structure''' The entry 3qmj is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal structure of Enoyl-CoA hydratase E...

New page

'''Unreleased structure'''

The entry 3qmj is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: Crystal structure of Enoyl-CoA hydratase EchA8_6 from Mycobacterium marinum