3qr9 - Revision history

OCA at 10:49, 21 February 2024

2024-02-21T10:49:16Z

←Older revision		Revision as of 10:49, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3qr9' size='340' side='right'caption='[[3qr9]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='3qr9' size='340' side='right'caption='[[3qr9]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QR9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.87Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[3qqs\|3qqs]]~~, [[~~2bpq~~\|~~2bpq]], [[1zvw\|1zvw]], [[3qs8\|3qs8]], [[3qsa\|3qsa~~]]~~</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>MT2248, MTCY190.03c, trpD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1773~~ "~~Bacillus tuberculosis~~" ~~(Zopf 1883) Klein 1884])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/Anthranilate_phosphoribosyltransferase Anthranilate phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.18 2.4.2.18] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr9 OCA], [https://pdbe.org/3qr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qr9 RCSB], [https://www.ebi.ac.uk/pdbsum/3qr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qr9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr9 OCA], [https://pdbe.org/3qr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qr9 RCSB], [https://www.ebi.ac.uk/pdbsum/3qr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qr9 ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/TRPD_MYCTU TRPD_MYCTU]
-	Anthranilate phosphoribosyltransferase (AnPRT, EC 2.4.2.18) is a homodimeric enzyme that catalyzes the reaction between 5'-phosphoribosyl-1'-pyrophosphate (PRPP) and anthranilate, as part of the tryptophan biosynthesis pathway. Here we present the results of the first chemical screen for inhibitors against Mycobacterium tuberculosis (Mtb) AnPRT, along with crystal structures of Mtb-AnPRT in complex with PRPP and several inhibitors. Previous work revealed that PRPP is bound at the base of a deep cleft in Mtb-AnPRT, and predicted two anthranilate binding sites along the tunnel leading to the PRPP binding site. Unexpectedly, the inhibitors presented here almost exclusively bound at the entrance of the tunnel, in the presumed non-catalytic anthranilate binding site, previously hypothesized to have a role in substrate capture. The potencies of the inhibitors were measured, yielding Ki values from 1.5 - 119 muM, with the strongest inhibition displayed by a bi-anthranilate compound that makes hydrogen bond and salt bridge contacts with Mtb-AnPRT via its carboxyl groups. Our results reveal how the substrate capture mechanism of AnPRT can be exploited to inhibit the enzyme's activity and provide a scaffold for the design of improved Mtb-AnPRT inhibitors that may ultimately form the basis of new anti-tuberculosis drugs with a novel mode of action.	+
-		+
-	Substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition.,Castell A, Short FL, Evans GL, Cookson TV, Bulloch EM, Joseph DD, Lee CE, Parker EJ, Baker EN, Lott JS Biochemistry. 2013 Jan 30. PMID:~~23363292<ref>PMID:23363292<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3qr9" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]		*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Anthranilate phosphoribosyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Castell, A~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: ~~Lott, J S~~]]	+	[[Category: Castell A]]
-	[[Category: ~~Short, F L~~]]	+	[[Category: Lott JS]]
-	[[Category: ~~Structural genomic]]~~	+	[[Category: Short FL]]
-	~~[[Category: Anthranilic acid]]~~	+
-	~~[[Category: Magnesium]]~~	+
-	~~[[Category: Magnesium binding]]~~	+
-	~~[[Category: Phosphoribosyl pyrophosphate]]~~	+
-	~~[[Category: Tbsgc]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Tryptophan~~]]	+

OCA at 06:20, 8 June 2022

2022-06-08T06:20:40Z

←Older revision		Revision as of 06:20, 8 June 2022
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	==Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)==		==Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)==
-	<StructureSection load='3qr9' size='340' side='right' caption='[[3qr9]], [[Resolution\|resolution]] 1.87Å' scene=''>	+	<StructureSection load='3qr9' size='340' side='right'caption='[[3qr9]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qr9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QR9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qqs\|3qqs]], [[2bpq\|2bpq]], [[1zvw\|1zvw]], [[3qs8\|3qs8]], [[3qsa\|3qsa]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qqs\|3qqs]], [[2bpq\|2bpq]], [[1zvw\|1zvw]], [[3qs8\|3qs8]], [[3qsa\|3qsa]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT2248, MTCY190.03c, trpD ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT2248, MTCY190.03c, trpD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Anthranilate_phosphoribosyltransferase Anthranilate phosphoribosyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.18 2.4.2.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Anthranilate_phosphoribosyltransferase Anthranilate phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.18 2.4.2.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr9 OCA], [~~http~~://pdbe.org/3qr9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qr9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qr9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qr9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr9 OCA], [https://pdbe.org/3qr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qr9 RCSB], [https://www.ebi.ac.uk/pdbsum/3qr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qr9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
-	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]	+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Anthranilate phosphoribosyltransferase]]		[[Category: Anthranilate phosphoribosyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Castell, A]]		[[Category: Castell, A]]
	[[Category: Lott, J S]]		[[Category: Lott, J S]]

OCA at 23:21, 4 August 2016

2016-08-04T23:21:01Z

←Older revision		Revision as of 23:21, 4 August 2016
Line 1:		Line 1:
		+
	==Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)==		==Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)==
	<StructureSection load='3qr9' size='340' side='right' caption='[[3qr9]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='3qr9' size='340' side='right' caption='[[3qr9]], [[Resolution\|resolution]] 1.87Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT2248, MTCY190.03c, trpD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT2248, MTCY190.03c, trpD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Anthranilate_phosphoribosyltransferase Anthranilate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.18 2.4.2.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Anthranilate_phosphoribosyltransferase Anthranilate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.18 2.4.2.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qr9 RCSB], [http://www.ebi.ac.uk/pdbsum/3qr9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr9 OCA], [http://pdbe.org/3qr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qr9 RCSB], [http://www.ebi.ac.uk/pdbsum/3qr9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qr9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qr9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:26, 21 December 2014

2014-12-21T18:26:27Z

←Older revision		Revision as of 18:26, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3qr9\| PDB=3qr9 \| SCENE= }}~~	+	==Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)==
-	===Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)===	+	<StructureSection load='3qr9' size='340' side='right' caption='[[3qr9]], [[Resolution\|resolution]] 1.87Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23363292}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QR9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qqs\|3qqs]], [[2bpq\|2bpq]], [[1zvw\|1zvw]], [[3qs8\|3qs8]], [[3qsa\|3qsa]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT2248, MTCY190.03c, trpD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Anthranilate_phosphoribosyltransferase Anthranilate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.18 2.4.2.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qr9 RCSB], [http://www.ebi.ac.uk/pdbsum/3qr9 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Anthranilate phosphoribosyltransferase (AnPRT, EC 2.4.2.18) is a homodimeric enzyme that catalyzes the reaction between 5'-phosphoribosyl-1'-pyrophosphate (PRPP) and anthranilate, as part of the tryptophan biosynthesis pathway. Here we present the results of the first chemical screen for inhibitors against Mycobacterium tuberculosis (Mtb) AnPRT, along with crystal structures of Mtb-AnPRT in complex with PRPP and several inhibitors. Previous work revealed that PRPP is bound at the base of a deep cleft in Mtb-AnPRT, and predicted two anthranilate binding sites along the tunnel leading to the PRPP binding site. Unexpectedly, the inhibitors presented here almost exclusively bound at the entrance of the tunnel, in the presumed non-catalytic anthranilate binding site, previously hypothesized to have a role in substrate capture. The potencies of the inhibitors were measured, yielding Ki values from 1.5 - 119 muM, with the strongest inhibition displayed by a bi-anthranilate compound that makes hydrogen bond and salt bridge contacts with Mtb-AnPRT via its carboxyl groups. Our results reveal how the substrate capture mechanism of AnPRT can be exploited to inhibit the enzyme's activity and provide a scaffold for the design of improved Mtb-AnPRT inhibitors that may ultimately form the basis of new anti-tuberculosis drugs with a novel mode of action.

-	~~==About this Structure==~~	+	Substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition.,Castell A, Short FL, Evans GL, Cookson TV, Bulloch EM, Joseph DD, Lee CE, Parker EJ, Baker EN, Lott JS Biochemistry. 2013 Jan 30. PMID:23363292<ref>PMID:23363292</ref>
-	~~[[3qr9]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3QR9 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]		*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023363292</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
-	~~[[Category: Anthranilate phosphoribosyltransferase]]~~	+	</StructureSection>
-	~~[[Category: Castell, A.]]~~	+
-	~~[[Category: Lott, J S.]]~~	+
-	~~[[Category: Short, F L.]]~~	+
-	~~[[Category: TBSGC, TB Structural Genomics Consortium.]]~~	+
	[[Category: Anthranilate phosphoribosyltransferase]]		[[Category: Anthranilate phosphoribosyltransferase]]
		+	[[Category: Castell, A]]
		+	[[Category: Lott, J S]]
		+	[[Category: Short, F L]]
		+	[[Category: Structural genomic]]
	[[Category: Anthranilic acid]]		[[Category: Anthranilic acid]]
	[[Category: Magnesium]]		[[Category: Magnesium]]
	[[Category: Magnesium binding]]		[[Category: Magnesium binding]]
	[[Category: Phosphoribosyl pyrophosphate]]		[[Category: Phosphoribosyl pyrophosphate]]
-	[[Category: Structural genomic]]
-	[[Category: Tb structural genomics consortium]]
	[[Category: Tbsgc]]		[[Category: Tbsgc]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Tryptophan]]		[[Category: Tryptophan]]

OCA at 08:36, 27 November 2013

2013-11-27T08:36:26Z

←Older revision		Revision as of 08:36, 27 November 2013
Line 4:		Line 4:

	==About this Structure==		==About this Structure==
-	[[3qr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR9 OCA].	+	[[3qr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR9 OCA].

	==See Also==		==See Also==
	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]		*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023363292</ref><references group="xtra"/><references/>
	[[Category: Anthranilate phosphoribosyltransferase]]		[[Category: Anthranilate phosphoribosyltransferase]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Castell, A.]]		[[Category: Castell, A.]]
	[[Category: Lott, J S.]]		[[Category: Lott, J S.]]

OCA at 21:44, 10 April 2013

2013-04-10T21:44:49Z

←Older revision		Revision as of 21:44, 10 April 2013
Line 1:		Line 1:
-	[[Image:3qr9.png\|left\|200px]]
-
	{{STRUCTURE_3qr9\| PDB=3qr9 \| SCENE= }}		{{STRUCTURE_3qr9\| PDB=3qr9 \| SCENE= }}
-
	===Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)===		===Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)===
-
	{{ABSTRACT_PUBMED_23363292}}		{{ABSTRACT_PUBMED_23363292}}

OCA at 12:43, 20 February 2013

2013-02-20T12:43:11Z

←Older revision		Revision as of 12:43, 20 February 2013
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-	[[Image:3qr9.~~jpg~~\|left\|200px]]	+	[[Image:3qr9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qr9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qr9\| PDB=3qr9 \| SCENE= }}		{{STRUCTURE_3qr9\| PDB=3qr9 \| SCENE= }}

	===Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)===		===Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)===

		+	{{ABSTRACT_PUBMED_23363292}}

	==About this Structure==		==About this Structure==
	[[3qr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR9 OCA].		[[3qr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR9 OCA].
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
	[[Category: Anthranilate phosphoribosyltransferase]]		[[Category: Anthranilate phosphoribosyltransferase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA at 06:34, 15 June 2011

2011-06-15T06:34:50Z

←Older revision		Revision as of 06:34, 15 June 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3qr9.jpg\|left\|200px]]

-	The ~~entry 3qr9~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qr9", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qr9\| PDB=3qr9 \| SCENE= }}

-	~~Authors: Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium~~ (~~TBSGC~~)	+	===Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)===

-	~~Description~~: Anthranilate phosphoribosyltransferase ~~(trpD) from~~ Mycobacterium tuberculosis ~~(apo structure)~~	+
		+	==About this Structure==
		+	[[3qr9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR9 OCA].
		+	[[Category: Anthranilate phosphoribosyltransferase]]
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Castell, A.]]
		+	[[Category: Lott, J S.]]
		+	[[Category: Short, F L.]]
		+	[[Category: TBSGC, TB Structural Genomics Consortium.]]
		+	[[Category: Anthranilate phosphoribosyltransferase]]
		+	[[Category: Anthranilic acid]]
		+	[[Category: Magnesium]]
		+	[[Category: Magnesium binding]]
		+	[[Category: Phosphoribosyl pyrophosphate]]
		+	[[Category: Structural genomic]]
		+	[[Category: Tb structural genomics consortium]]
		+	[[Category: Tbsgc]]
		+	[[Category: Transferase]]
		+	[[Category: Tryptophan]]

OCA at 06:41, 2 March 2011

2011-03-02T06:41:59Z

←Older revision		Revision as of 06:41, 2 March 2011
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	Authors: Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)		Authors: Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)

-	Description: ~~ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE~~ (~~TRPD~~) ~~FROM MYCOBACTERIUM TUBERCULOSIS~~ (~~APO STRUCTURE~~)	+	Description: Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)

OCA: Protected "3qr9" [edit=sysop:move=sysop]

2011-02-23T09:41:23Z

Protected "3qr9" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:41, 23 February 2011