3qtf - Revision history

OCA at 10:50, 21 February 2024

2024-02-21T10:50:08Z

←Older revision		Revision as of 10:50, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3qtf' size='340' side='right'caption='[[3qtf]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='3qtf' size='340' side='right'caption='[[3qtf]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qtf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QTF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qtf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QTF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=05S:(6S)-6,15,15,18-TETRAMETHYL-17-OXO-2,3,4,5,6,7,14,15,16,17-DECAHYDRO-1H-8,12-(METHENO)[1,4,9]TRIAZACYCLOTETRADECINO[9,8-A]INDOLE-9-CARBOXAMIDE'>05S</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5703Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90A, HSP90AA1, HSPC1, HSPCA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=05S:(6S)-6,15,15,18-TETRAMETHYL-17-OXO-2,3,4,5,6,7,14,15,16,17-DECAHYDRO-1H-8,12-(METHENO)[1,4,9]TRIAZACYCLOTETRADECINO[9,8-A]INDOLE-9-CARBOXAMIDE'>05S</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtf OCA], [https://pdbe.org/3qtf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qtf RCSB], [https://www.ebi.ac.uk/pdbsum/3qtf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qtf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtf OCA], [https://pdbe.org/3qtf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qtf RCSB], [https://www.ebi.ac.uk/pdbsum/3qtf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qtf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	A novel series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. A basic nitrogen within the tether linking the aniline nitrogen atom to a tetrahydroindolone moiety allowed access to compounds with good physical properties. Important structure-activity relationship information was obtained from this series which led to the discovery of a soluble and stable compound which is potent in an Hsp90 binding and cell-proliferation assay.	+
-		+
-	Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.,Zapf CW, Bloom JD, McBean JL, Dushin RG, Nittoli T, Ingalls C, Sutherland AG, Sonye JP, Eid CN, Golas J, Liu H, Boschelli F, Hu Y, Vogan E, Levin JI Bioorg Med Chem Lett. 2011 Apr 15;21(8):2278-82. Epub 2011 Feb 28. PMID:21420297<ref>PMID:21420297</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3qtf" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 26:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bloom~~, J D~~]]	+	[[Category: Bloom JD]]
-	[[Category: Boschelli, F]]	+	[[Category: Boschelli F]]
-	[[Category: Dushin~~, R G~~]]	+	[[Category: Dushin RG]]
-	[[Category: Eid~~, C N~~]]	+	[[Category: Eid CN]]
-	[[Category: Golas, J]]	+	[[Category: Golas J]]
-	[[Category: Hu, Y]]	+	[[Category: Hu Y]]
-	[[Category: Ingalls, C]]	+	[[Category: Ingalls C]]
-	[[Category: Levin~~, J I~~]]	+	[[Category: Levin JI]]
-	[[Category: Liu, H]]	+	[[Category: Liu H]]
-	[[Category: McBean~~, J L~~]]	+	[[Category: McBean JL]]
-	[[Category: Nittoli, T]]	+	[[Category: Nittoli T]]
-	[[Category: Sonye~~, J P~~]]	+	[[Category: Sonye JP]]
-	[[Category: Sutherland~~, A G~~]]	+	[[Category: Sutherland AG]]
-	[[Category: Vogan~~, E M~~]]	+	[[Category: Vogan EM]]
-	[[Category: Zapf~~, C W]]~~	+	[[Category: Zapf CW]]
-	~~[[Category: Atp binding domain]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Chaperone-chaperone inhibitor complex]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Stress response~~]]	+

OCA at 06:23, 8 June 2022

2022-06-08T06:23:08Z

←Older revision		Revision as of 06:23, 8 June 2022
Line 1:		Line 1:

	==Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity==		==Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity==
-	<StructureSection load='3qtf' size='340' side='right' caption='[[3qtf]], [[Resolution\|resolution]] 1.57Å' scene=''>	+	<StructureSection load='3qtf' size='340' side='right'caption='[[3qtf]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qtf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QTF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qtf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QTF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=05S:(6S)-6,15,15,18-TETRAMETHYL-17-OXO-2,3,4,5,6,7,14,15,16,17-DECAHYDRO-1H-8,12-(METHENO)[1,4,9]TRIAZACYCLOTETRADECINO[9,8-A]INDOLE-9-CARBOXAMIDE'>05S</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=05S:(6S)-6,15,15,18-TETRAMETHYL-17-OXO-2,3,4,5,6,7,14,15,16,17-DECAHYDRO-1H-8,12-(METHENO)[1,4,9]TRIAZACYCLOTETRADECINO[9,8-A]INDOLE-9-CARBOXAMIDE'>05S</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90A, HSP90AA1, HSPC1, HSPCA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90A, HSP90AA1, HSPC1, HSPCA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtf OCA], [~~http~~://pdbe.org/3qtf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qtf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qtf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qtf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtf OCA], [https://pdbe.org/3qtf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qtf RCSB], [https://www.ebi.ac.uk/pdbsum/3qtf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qtf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bloom, J D]]		[[Category: Bloom, J D]]
	[[Category: Boschelli, F]]		[[Category: Boschelli, F]]

OCA at 01:32, 5 August 2016

2016-08-05T01:32:13Z

←Older revision		Revision as of 01:32, 5 August 2016
Line 1:		Line 1:
		+
	==Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity==		==Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity==
	<StructureSection load='3qtf' size='340' side='right' caption='[[3qtf]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='3qtf' size='340' side='right' caption='[[3qtf]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qtf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QTF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qtf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QTF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=05S:(6S)-6,15,15,18-TETRAMETHYL-17-OXO-2,3,4,5,6,7,14,15,16,17-DECAHYDRO-1H-8,12-(METHENO)[1,4,9]TRIAZACYCLOTETRADECINO[9,8-A]INDOLE-9-CARBOXAMIDE'>05S</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=05S:(6S)-6,15,15,18-TETRAMETHYL-17-OXO-2,3,4,5,6,7,14,15,16,17-DECAHYDRO-1H-8,12-(METHENO)[1,4,9]TRIAZACYCLOTETRADECINO[9,8-A]INDOLE-9-CARBOXAMIDE'>05S</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90A, HSP90AA1, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90A, HSP90AA1, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qtf RCSB], [http://www.ebi.ac.uk/pdbsum/3qtf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtf OCA], [http://pdbe.org/3qtf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qtf RCSB], [http://www.ebi.ac.uk/pdbsum/3qtf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qtf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qtf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bloom, J D]]		[[Category: Bloom, J D]]
	[[Category: Boschelli, F]]		[[Category: Boschelli, F]]

OCA at 14:43, 25 December 2014

2014-12-25T14:43:59Z

←Older revision		Revision as of 14:43, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qtf RCSB], [http://www.ebi.ac.uk/pdbsum/3qtf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qtf RCSB], [http://www.ebi.ac.uk/pdbsum/3qtf PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:43, 9 December 2014

2014-12-09T12:43:52Z

←Older revision		Revision as of 12:43, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3qtf.~~png~~\|~~left~~\|~~200px~~]]	+	==Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity==
		+	<StructureSection load='3qtf' size='340' side='right' caption='[[3qtf]], [[Resolution\|resolution]] 1.57Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qtf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QTF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=05S:(6S)-6,15,15,18-TETRAMETHYL-17-OXO-2,3,4,5,6,7,14,15,16,17-DECAHYDRO-1H-8,12-(METHENO)[1,4,9]TRIAZACYCLOTETRADECINO[9,8-A]INDOLE-9-CARBOXAMIDE'>05S</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90A, HSP90AA1, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qtf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qtf RCSB], [http://www.ebi.ac.uk/pdbsum/3qtf PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. A basic nitrogen within the tether linking the aniline nitrogen atom to a tetrahydroindolone moiety allowed access to compounds with good physical properties. Important structure-activity relationship information was obtained from this series which led to the discovery of a soluble and stable compound which is potent in an Hsp90 binding and cell-proliferation assay.

-	~~{{STRUCTURE_3qtf\| PDB=3qtf \| SCENE= }}~~	+	Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.,Zapf CW, Bloom JD, McBean JL, Dushin RG, Nittoli T, Ingalls C, Sutherland AG, Sonye JP, Eid CN, Golas J, Liu H, Boschelli F, Hu Y, Vogan E, Levin JI Bioorg Med Chem Lett. 2011 Apr 15;21(8):2278-82. Epub 2011 Feb 28. PMID:21420297<ref>PMID:21420297</ref>

-	~~===Design and SAR~~ of ~~macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21420297}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qtf]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA].~~	+

	==See Also==		==See Also==
	*[[Heat Shock Proteins\|Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021420297<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bloom, J D.]]	+	[[Category: Bloom, J D]]
-	[[Category: Boschelli, F.]]	+	[[Category: Boschelli, F]]
-	[[Category: Dushin, R G.]]	+	[[Category: Dushin, R G]]
-	[[Category: Eid, C N.]]	+	[[Category: Eid, C N]]
-	[[Category: Golas, J.]]	+	[[Category: Golas, J]]
-	[[Category: Hu, Y.]]	+	[[Category: Hu, Y]]
-	[[Category: Ingalls, C.]]	+	[[Category: Ingalls, C]]
-	[[Category: Levin, J I.]]	+	[[Category: Levin, J I]]
-	[[Category: Liu, H.]]	+	[[Category: Liu, H]]
-	[[Category: McBean, J L.]]	+	[[Category: McBean, J L]]
-	[[Category: Nittoli, T.]]	+	[[Category: Nittoli, T]]
-	[[Category: Sonye, J P.]]	+	[[Category: Sonye, J P]]
-	[[Category: Sutherland, A G.]]	+	[[Category: Sutherland, A G]]
-	[[Category: Vogan, E M.]]	+	[[Category: Vogan, E M]]
-	[[Category: Zapf, C W.]]	+	[[Category: Zapf, C W]]
	[[Category: Atp binding domain]]		[[Category: Atp binding domain]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA at 17:57, 20 October 2012

2012-10-20T17:57:21Z

←Older revision		Revision as of 17:57, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3qtf]] is a 1 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA].	+	[[3qtf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA].

	==See Also==		==See Also==

OCA at 02:32, 27 July 2012

2012-07-27T02:32:21Z

←Older revision		Revision as of 02:32, 27 July 2012
Line 1:		Line 1:
	[[Image:3qtf.png\|left\|200px]]		[[Image:3qtf.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qtf", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qtf\| PDB=3qtf \| SCENE= }}		{{STRUCTURE_3qtf\| PDB=3qtf \| SCENE= }}

	===Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity===		===Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21420297}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21420297 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21420297}}		{{ABSTRACT_PUBMED_21420297}}

	==About this Structure==		==About this Structure==
-	[[3qtf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA].	+	[[3qtf]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA].
		+
		+	==See Also==
		+	*[[Heat Shock Proteins\|Heat Shock Proteins]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21420297~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021420297</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bloom, J D.]]		[[Category: Bloom, J D.]]
Line 39:		Line 31:
	[[Category: Vogan, E M.]]		[[Category: Vogan, E M.]]
	[[Category: Zapf, C W.]]		[[Category: Zapf, C W.]]
		+	[[Category: Atp binding domain]]
		+	[[Category: Atp-binding]]
		+	[[Category: Chaperone]]
		+	[[Category: Chaperone-chaperone inhibitor complex]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Stress response]]

OCA at 10:05, 21 April 2011

2011-04-21T10:05:59Z

←Older revision		Revision as of 10:05, 21 April 2011
Line 1:		Line 1:
-	[[Image:3qtf.~~jpg~~\|left\|200px]]	+	[[Image:3qtf.png\|left\|200px]]

	<!--		<!--

OCA at 09:03, 6 April 2011

2011-04-06T09:03:31Z

←Older revision		Revision as of 09:03, 6 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qtf.jpg\|left\|200px]]

-	The ~~entry 3qtf~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qtf", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qtf\| PDB=3qtf \| SCENE= }}

-	~~Authors: Zapf, C.W., Bloom, J.D., McBean, J.L., Dushin, R.G., Nittoli, T., Ingalls, C., Sutherland, A.G., Sonye, J.P., Eid, C.N., Golas, J., Liu, H., Boschelli, F., Hu, Y., Vogan, E.M., Levin, J.I.~~	+	===Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity===

-	~~Description~~: ~~Design and SAR of macrocyclic Hsp90 inhibitors~~ with ~~increased metabolic stability and potent cell~~-~~proliferation activity~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21420297}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21420297 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21420297}}
		+
		+	==About this Structure==
		+	[[3qtf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QTF OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21420297</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Bloom, J D.]]
		+	[[Category: Boschelli, F.]]
		+	[[Category: Dushin, R G.]]
		+	[[Category: Eid, C N.]]
		+	[[Category: Golas, J.]]
		+	[[Category: Hu, Y.]]
		+	[[Category: Ingalls, C.]]
		+	[[Category: Levin, J I.]]
		+	[[Category: Liu, H.]]
		+	[[Category: McBean, J L.]]
		+	[[Category: Nittoli, T.]]
		+	[[Category: Sonye, J P.]]
		+	[[Category: Sutherland, A G.]]
		+	[[Category: Vogan, E M.]]
		+	[[Category: Zapf, C W.]]

OCA: Protected "3qtf" [edit=sysop:move=sysop]

2011-03-02T06:44:12Z

Protected "3qtf" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:44, 2 March 2011