3qvg - Revision history

OCA at 12:00, 14 March 2024

2024-03-14T12:00:12Z

←Older revision		Revision as of 12:00, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3qvg' size='340' side='right'caption='[[3qvg]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3qvg' size='340' side='right'caption='[[3qvg]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qvg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qvg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVG FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3pc7\|3pc7]], [[3pc6\|3pc6]], [[3pc8\|3pc8]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.26Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">LIG3 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN]), Xrcc-1, Xrcc1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvg OCA], [https://pdbe.org/3qvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qvg RCSB], [https://www.ebi.ac.uk/pdbsum/3qvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvg OCA], [https://pdbe.org/3qvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qvg RCSB], [https://www.ebi.ac.uk/pdbsum/3qvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DNLI3_HUMAN DNLI3_HUMAN]] Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. ~~[[https://www.uniprot.org/uniprot/XRCC1_MOUSE XRCC1_MOUSE]] Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.~~	+	[https://www.uniprot.org/uniprot/DNLI3_HUMAN DNLI3_HUMAN] Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The ultimate step common to almost all DNA repair pathways is the ligation of the nicked intermediate to form contiguous double-stranded DNA. In the mammalian nucleotide and base excision repair pathways, the ligation step is carried out by ligase III-alpha. For efficient ligation, ligase III-alpha is constitutively bound to the scaffolding protein XRCC1 through interactions between the C-terminal BRCT domains of each protein. Although structural data for the individual domains has been available, no structure of the complex has been determined and several alternative proposals for this interaction have been advanced. Interpretation of the models is complicated by the formation of homodimers that, depending on the model, may either contribute to, or compete with heterodimer formation. We report here the structures of both homodimer complexes as well as the heterodimer complex. Structural characterization of the heterodimer formed from a longer XRCC1 BRCT domain construct, including residues comprising the interdomain linker region, revealed an expanded heterodimer interface with the ligase III-alpha BRCT domain. This enhanced linker-mediated binding interface plays a significant role in the determination of heterodimer/homodimer selectivity. These data provide fundamental insights into the structural basis of BRCT-mediated dimerization, and resolve questions related to the organization of this important repair complex.	+
-		+
-	The structural basis for partitioning of the XRCC1/DNA ligase III-alpha BRCT-mediated dimer complexes.,Cuneo MJ, Gabel SA, Krahn JM, Ricker MA, London RE Nucleic Acids Res. 2011 Sep 1;39(17):7816-27. Epub 2011 Jun 7. PMID:21652643<ref>PMID:21652643</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3qvg" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[DNA ligase 3D structures\|DNA ligase 3D structures]]		*[[DNA ligase 3D structures\|DNA ligase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Cuneo~~, M J~~]]	+	[[Category: Cuneo MJ]]
-	[[Category: Krahn~~, J M~~]]	+	[[Category: Krahn JM]]
-	[[Category: London~~, R E]]~~	+	[[Category: London RE]]
-	~~[[Category: Brct domain]]~~	+
-	~~[[Category: Dna binding protein-ligase complex]]~~	+
-	~~[[Category: Dna ligase iii-alpha]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Xrcc1~~]]	+

OCA at 05:37, 15 June 2022

2022-06-15T05:37:59Z

←Older revision		Revision as of 05:37, 15 June 2022
Line 1:		Line 1:

	==XRCC1 bound to DNA ligase==		==XRCC1 bound to DNA ligase==
-	<StructureSection load='3qvg' size='340' side='right' caption='[[3qvg]], [[Resolution\|resolution]] 2.26Å' scene=''>	+	<StructureSection load='3qvg' size='340' side='right'caption='[[3qvg]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qvg]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3QVG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qvg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QVG FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pc7\|3pc7]], [[3pc6\|3pc6]], [[3pc8\|3pc8]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pc7\|3pc7]], [[3pc6\|3pc6]], [[3pc8\|3pc8]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIG3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Xrcc-1, Xrcc1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIG3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Xrcc-1, Xrcc1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3qvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvg OCA], [~~http~~://pdbe.org/3qvg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3qvg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3qvg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvg OCA], [https://pdbe.org/3qvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qvg RCSB], [https://www.ebi.ac.uk/pdbsum/3qvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DNLI3_HUMAN DNLI3_HUMAN]] Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. [[~~http~~://www.uniprot.org/uniprot/XRCC1_MOUSE XRCC1_MOUSE]] Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.	+	[[https://www.uniprot.org/uniprot/DNLI3_HUMAN DNLI3_HUMAN]] Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. [[https://www.uniprot.org/uniprot/XRCC1_MOUSE XRCC1_MOUSE]] Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3qvg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3qvg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA ligase 3D structures\|DNA ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Cuneo, M J]]		[[Category: Cuneo, M J]]

OCA at 09:19, 8 November 2017

2017-11-08T09:19:34Z

←Older revision		Revision as of 09:19, 8 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3qvg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3qvg" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA ligase\|DNA ligase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:03, 4 August 2016

2016-08-04T10:03:44Z

←Older revision		Revision as of 10:03, 4 August 2016
Line 1:		Line 1:
		+
	==XRCC1 bound to DNA ligase==		==XRCC1 bound to DNA ligase==
	<StructureSection load='3qvg' size='340' side='right' caption='[[3qvg]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3qvg' size='340' side='right' caption='[[3qvg]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3qvg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3qvg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pc7\|3pc7]], [[3pc6\|3pc6]], [[3pc8\|3pc8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pc7\|3pc7]], [[3pc6\|3pc6]], [[3pc8\|3pc8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), Xrcc-1, Xrcc1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Xrcc-1, Xrcc1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qvg RCSB], [http://www.ebi.ac.uk/pdbsum/3qvg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvg OCA], [http://pdbe.org/3qvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qvg RCSB], [http://www.ebi.ac.uk/pdbsum/3qvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qvg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3qvg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Cuneo, M J]]		[[Category: Cuneo, M J]]
	[[Category: Krahn, J M]]		[[Category: Krahn, J M]]

OCA at 08:09, 25 December 2014

2014-12-25T08:09:34Z

←Older revision		Revision as of 08:09, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qvg RCSB], [http://www.ebi.ac.uk/pdbsum/3qvg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qvg RCSB], [http://www.ebi.ac.uk/pdbsum/3qvg PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DNLI3_HUMAN DNLI3_HUMAN]] Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. [[http://www.uniprot.org/uniprot/XRCC1_MOUSE XRCC1_MOUSE]] Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:14, 9 December 2014

2014-12-09T11:14:30Z

←Older revision		Revision as of 11:14, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3qvg.~~png~~\|~~left~~\|~~200px~~]]	+	==XRCC1 bound to DNA ligase==
		+	<StructureSection load='3qvg' size='340' side='right' caption='[[3qvg]], [[Resolution\|resolution]] 2.26Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3qvg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QVG FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pc7\|3pc7]], [[3pc6\|3pc6]], [[3pc8\|3pc8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Xrcc-1, Xrcc1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qvg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qvg RCSB], [http://www.ebi.ac.uk/pdbsum/3qvg PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ultimate step common to almost all DNA repair pathways is the ligation of the nicked intermediate to form contiguous double-stranded DNA. In the mammalian nucleotide and base excision repair pathways, the ligation step is carried out by ligase III-alpha. For efficient ligation, ligase III-alpha is constitutively bound to the scaffolding protein XRCC1 through interactions between the C-terminal BRCT domains of each protein. Although structural data for the individual domains has been available, no structure of the complex has been determined and several alternative proposals for this interaction have been advanced. Interpretation of the models is complicated by the formation of homodimers that, depending on the model, may either contribute to, or compete with heterodimer formation. We report here the structures of both homodimer complexes as well as the heterodimer complex. Structural characterization of the heterodimer formed from a longer XRCC1 BRCT domain construct, including residues comprising the interdomain linker region, revealed an expanded heterodimer interface with the ligase III-alpha BRCT domain. This enhanced linker-mediated binding interface plays a significant role in the determination of heterodimer/homodimer selectivity. These data provide fundamental insights into the structural basis of BRCT-mediated dimerization, and resolve questions related to the organization of this important repair complex.

-	~~{{STRUCTURE_3qvg\| PDB=3qvg \| SCENE= }}~~	+	The structural basis for partitioning of the XRCC1/DNA ligase III-alpha BRCT-mediated dimer complexes.,Cuneo MJ, Gabel SA, Krahn JM, Ricker MA, London RE Nucleic Acids Res. 2011 Sep 1;39(17):7816-27. Epub 2011 Jun 7. PMID:21652643<ref>PMID:21652643</ref>

-	~~===XRCC1 bound to DNA ligase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21652643}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3qvg]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA].~~	+

	==See Also==		==See Also==
	*[[DNA ligase\|DNA ligase]]		*[[DNA ligase\|DNA ligase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021652643<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Cuneo, M J.]]	+	[[Category: Cuneo, M J]]
-	[[Category: Krahn, J M.]]	+	[[Category: Krahn, J M]]
-	[[Category: London, R E.]]	+	[[Category: London, R E]]
	[[Category: Brct domain]]		[[Category: Brct domain]]
	[[Category: Dna binding protein-ligase complex]]		[[Category: Dna binding protein-ligase complex]]

OCA at 14:29, 20 October 2012

2012-10-20T14:29:52Z

←Older revision		Revision as of 14:29, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3qvg]] is a 4 chain structure ~~of [[DNA ligase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA].	+	[[3qvg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA].

	==See Also==		==See Also==

OCA at 15:20, 26 July 2012

2012-07-26T15:20:07Z

←Older revision		Revision as of 15:20, 26 July 2012
Line 1:		Line 1:
	[[Image:3qvg.png\|left\|200px]]		[[Image:3qvg.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3qvg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3qvg\| PDB=3qvg \| SCENE= }}		{{STRUCTURE_3qvg\| PDB=3qvg \| SCENE= }}

	===XRCC1 bound to DNA ligase===		===XRCC1 bound to DNA ligase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21652643}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21652643 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21652643}}		{{ABSTRACT_PUBMED_21652643}}

	==About this Structure==		==About this Structure==
-	[[3qvg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA].	+	[[3qvg]] is a 4 chain structure of [[DNA ligase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA].
		+
		+	==See Also==
		+	*[[DNA ligase\|DNA ligase]]

	==Reference==		==Reference==

OCA at 07:31, 2 November 2011

2011-11-02T07:31:41Z

←Older revision		Revision as of 07:31, 2 November 2011
Line 1:		Line 1:
-	[[Image:3qvg.~~jpg~~\|left\|200px]]	+	[[Image:3qvg.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===XRCC1 bound to DNA ligase===		===XRCC1 bound to DNA ligase===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21652643}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21652643 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21652643}}

	==About this Structure==		==About this Structure==
	[[3qvg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA].		[[3qvg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021652643</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 06:34, 15 June 2011

2011-06-15T06:34:41Z

←Older revision		Revision as of 06:34, 15 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3qvg.jpg\|left\|200px]]

-	The ~~entry 3qvg~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3qvg", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3qvg\| PDB=3qvg \| SCENE= }}

-	~~Authors: Cuneo, M.J., Krahn, J.M., London, R.E.~~	+	===XRCC1 bound to DNA ligase===

-	~~Description~~: ~~XRCC1 bound to DNA~~ ligase	+
		+	==About this Structure==
		+	[[3qvg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QVG OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Mus musculus]]
		+	[[Category: Cuneo, M J.]]
		+	[[Category: Krahn, J M.]]
		+	[[Category: London, R E.]]
		+	[[Category: Brct domain]]
		+	[[Category: Dna binding protein-ligase complex]]
		+	[[Category: Dna ligase iii-alpha]]
		+	[[Category: Dna repair]]
		+	[[Category: Xrcc1]]