3r1v - Revision history

OCA at 05:45, 15 June 2022

2022-06-15T05:45:26Z

←Older revision		Revision as of 05:45, 15 June 2022
Line 1:		Line 1:

	==Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound==		==Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound==
-	<StructureSection load='3r1v' size='340' side='right' caption='[[3r1v]], [[Resolution\|resolution]] 2.19Å' scene=''>	+	<StructureSection load='3r1v' size='340' side='right'caption='[[3r1v]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3r1v]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3R1V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3r1v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R1V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZB:4-{(E)-[4-(PROPAN-2-YL)PHENYL]DIAZENYL}PHENOL'>AZB</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZB:4-{(E)-[4-(PROPAN-2-YL)PHENYL]DIAZENYL}PHENOL'>AZB</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r1o\|3r1o]], [[3r1p\|3r1p]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3r1o\|3r1o]], [[3r1p\|3r1p]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OBP7, AgamOBP7, AGAP001556, agCG57323 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OBP7, AgamOBP7, AGAP001556, agCG57323 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3r1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1v OCA], [~~http~~://pdbe.org/3r1v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3r1v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3r1v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3r1v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1v OCA], [https://pdbe.org/3r1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r1v RCSB], [https://www.ebi.ac.uk/pdbsum/3r1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r1v ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Odorant binding protein\|Odorant binding protein]]
	*[[Odorant binding protein 3D structures\|Odorant binding protein 3D structures]]		*[[Odorant binding protein 3D structures\|Odorant binding protein 3D structures]]
	== References ==		== References ==
Line 27:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Anoga]]		[[Category: Anoga]]
		+	[[Category: Large Structures]]
	[[Category: Cambillau, C]]		[[Category: Cambillau, C]]
	[[Category: Field, L]]		[[Category: Field, L]]

OCA at 12:50, 11 August 2016

2016-08-11T12:50:05Z

←Older revision		Revision as of 12:50, 11 August 2016
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		+
	==Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound==		==Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound==
	<StructureSection load='3r1v' size='340' side='right' caption='[[3r1v]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='3r1v' size='340' side='right' caption='[[3r1v]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3r1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Anopheles_gambiae Anopheles gambiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R1V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3r1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R1V FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZB:4-{(E)-[4-(PROPAN-2-YL)PHENYL]DIAZENYL}PHENOL'>AZB</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZB:4-{(E)-[4-(PROPAN-2-YL)PHENYL]DIAZENYL}PHENOL'>AZB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r1o\|3r1o]], [[3r1p\|3r1p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r1o\|3r1o]], [[3r1p\|3r1p]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OBP7, AgamOBP7, AGAP001556, agCG57323 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ~~Anopheles gambiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OBP7, AgamOBP7, AGAP001556, agCG57323 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r1v RCSB], [http://www.ebi.ac.uk/pdbsum/3r1v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1v OCA], [http://pdbe.org/3r1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3r1v RCSB], [http://www.ebi.ac.uk/pdbsum/3r1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3r1v ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3r1v" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Odorant binding protein\|Odorant binding protein]]		*[[Odorant binding protein\|Odorant binding protein]]
		+	*[[Odorant binding protein 3D structures\|Odorant binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Anopheles gambiae~~]]	+	[[Category: Anoga]]
	[[Category: Cambillau, C]]		[[Category: Cambillau, C]]
	[[Category: Field, L]]		[[Category: Field, L]]

OCA at 08:34, 18 December 2014

2014-12-18T08:34:29Z

←Older revision		Revision as of 08:34, 18 December 2014
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-	~~{{STRUCTURE_3r1v\| PDB=3r1v \| SCENE= }}~~	+	==Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound==
-	===Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound===	+	<StructureSection load='3r1v' size='340' side='right' caption='[[3r1v]], [[Resolution\|resolution]] 2.19Å' scene=''>
-	{~~{ABSTRACT_PUBMED_22019737}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3r1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R1V FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZB:4-{(E)-[4-(PROPAN-2-YL)PHENYL]DIAZENYL}PHENOL'>AZB</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r1o\|3r1o]], [[3r1p\|3r1p]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OBP7, AgamOBP7, AGAP001556, agCG57323 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 Anopheles gambiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r1v RCSB], [http://www.ebi.ac.uk/pdbsum/3r1v PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Anopheles gambiae (Agam) targets human and animals by using its olfactory system, leading to the spread of Plasmodium falciparum, the malaria vector. Odorant binding proteins (OBPs) participate to the first event in odorant recognition and constitute an interesting target for insect control. OBPs interact with olfactory receptors to which they deliver the odorant molecule. We have undertaken a large-scale study of proteins belonging to the olfactory system of Agam with in mind of designing strong olfactory repellants. Here, we report the expression, three-dimensional structures and binding properties of AgamOBP07, a member of a new structural class of OBPs, characterized by the occurrence of eight cysteines. We showed that AgamOBP07 possesses seven alpha-helices and four disulfide bridges, instead of six alpha-helices and three disulfide bridges in classical OBPs. The extra seventh helix is located at the surface of the protein, locked by the fourth disulfide bridge, and forms a wall of the internal cavity. The binding site of the protein is mainly hydrophobic, elongated and open and is able to accommodate elongated ligands, linear or polycyclic, as suggested also by binding experiments. An elongated electron density was observed in the internal cavity of the purified protein, belonging to a serendipitous ligand. The structure of AgamOBP07 in complex with an azo-bicyclic model compound reveals that a large conformational change in the protein has reshaped its binding site, provoking helix 4 unfolding and doubling of the cavity volume.

-	~~==About this~~ Structure==	+	The Crystal Structure of Odorant Binding Protein 7 from Anopheles gambiae Exhibits an Outstanding Adaptability of Its Binding Site.,Lagarde A, Spinelli S, Tegoni M, He X, Field L, Zhou JJ, Cambillau C J Mol Biol. 2011 Oct 12. PMID:22019737<ref>PMID:22019737</ref>
-	~~[[3r1v]] is a 2 chain structure with sequence~~ from ~~[http://en.wikipedia.org/wiki/Anopheles_gambiae~~ Anopheles gambiae]. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3R1V OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Odorant binding protein\|Odorant binding protein]]		*[[Odorant binding protein\|Odorant binding protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022019737<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Anopheles gambiae]]		[[Category: Anopheles gambiae]]
-	[[Category: Cambillau, C.]]	+	[[Category: Cambillau, C]]
-	[[Category: Field, L.]]	+	[[Category: Field, L]]
-	[[Category: He, X.]]	+	[[Category: He, X]]
-	[[Category: Lagarde, A.]]	+	[[Category: Lagarde, A]]
-	[[Category: Spinelli, S.]]	+	[[Category: Spinelli, S]]
-	[[Category: Tegoni, M.]]	+	[[Category: Tegoni, M]]
-	[[Category: Zhou, J J.]]	+	[[Category: Zhou, J J]]
	[[Category: All helical protein]]		[[Category: All helical protein]]
	[[Category: Mosquito antenna]]		[[Category: Mosquito antenna]]
	[[Category: Odorant molecules binding]]		[[Category: Odorant molecules binding]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 10:28, 11 March 2013

2013-03-11T10:28:32Z

←Older revision		Revision as of 10:28, 11 March 2013
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-	[[Image:3r1v.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3r1v", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3r1v\| PDB=3r1v \| SCENE= }}		{{STRUCTURE_3r1v\| PDB=3r1v \| SCENE= }}
-
	===Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound===		===Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22019737}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22019737 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22019737}}		{{ABSTRACT_PUBMED_22019737}}

	==About this Structure==		==About this Structure==
	[[3r1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1V OCA].		[[3r1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1V OCA].
		+
		+	==See Also==
		+	*[[Odorant binding protein\|Odorant binding protein]]

	==Reference==		==Reference==

OCA at 10:47, 9 November 2011

2011-11-09T10:47:42Z

←Older revision		Revision as of 10:47, 9 November 2011
Line 11:		Line 11:
	===Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound===		===Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22019737}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22019737 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22019737}}

	==About this Structure==		==About this Structure==
	[[3r1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1V OCA].		[[3r1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1V OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022019737</ref><references group="xtra"/>
	[[Category: Anopheles gambiae]]		[[Category: Anopheles gambiae]]
	[[Category: Cambillau, C.]]		[[Category: Cambillau, C.]]

OCA at 10:19, 30 October 2011

2011-10-30T10:19:13Z

←Older revision		Revision as of 10:19, 30 October 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3r1v.png\|left\|200px]]

-	The ~~entry 3r1v~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3r1v", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3r1v\| PDB=3r1v \| SCENE= }}

-	~~Authors: Lagarde~~, ~~A., Spinelli, S., Tegoni, M., Field, L., He, X., Zhou, J.J., Cambillau, C.~~	+	===Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound===

-	~~Description~~: ~~Odorant Binding Protein 7~~ from Anopheles gambiae ~~with Four Disulfide Bridges~~, ~~in complex with an azo compound~~	+
		+	==About this Structure==
		+	[[3r1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1V OCA].
		+	[[Category: Anopheles gambiae]]
		+	[[Category: Cambillau, C.]]
		+	[[Category: Field, L.]]
		+	[[Category: He, X.]]
		+	[[Category: Lagarde, A.]]
		+	[[Category: Spinelli, S.]]
		+	[[Category: Tegoni, M.]]
		+	[[Category: Zhou, J J.]]
		+	[[Category: All helical protein]]
		+	[[Category: Mosquito antenna]]
		+	[[Category: Odorant molecules binding]]
		+	[[Category: Transport protein]]

OCA: Protected "3r1v" [edit=sysop:move=sysop]

2011-03-23T06:49:11Z

Protected "3r1v" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:49, 23 March 2011

OCA: New page: '''Unreleased structure''' The entry 3r1v is ON HOLD until Paper Publication Authors: Lagarde, A., Spinelli, S., Tegoni, M., Field, L., He, X., Zhou, J.J., Cambillau, C. Description: O...

2011-03-23T06:49:10Z

New page: '''Unreleased structure''' The entry 3r1v is ON HOLD until Paper Publication Authors: Lagarde, A., Spinelli, S., Tegoni, M., Field, L., He, X., Zhou, J.J., Cambillau, C. Description: O...

New page

'''Unreleased structure'''

The entry 3r1v is ON HOLD until Paper Publication

Authors: Lagarde, A., Spinelli, S., Tegoni, M., Field, L., He, X., Zhou, J.J., Cambillau, C.

Description: Odorant Binding Protein 7 from Anopheles gambiae with Four Disulfide Bridges, in complex with an azo compound