3rgq - Revision history

OCA at 10:54, 21 February 2024

2024-02-21T10:54:13Z

←Older revision		Revision as of 10:54, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3rgq' size='340' side='right'caption='[[3rgq]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3rgq' size='340' side='right'caption='[[3rgq]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RGQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RGQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5P5:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIBUTANOATE'>5P5</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rgo\|3rgo]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5P5:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIBUTANOATE'>5P5</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plip, Ptpmt1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgq OCA], [https://pdbe.org/3rgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rgq RCSB], [https://www.ebi.ac.uk/pdbsum/3rgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rgq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgq OCA], [https://pdbe.org/3rgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rgq RCSB], [https://www.ebi.ac.uk/pdbsum/3rgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rgq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PTPM1_MOUSE PTPM1_MOUSE]] Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).	+	[https://www.uniprot.org/uniprot/PTPM1_MOUSE PTPM1_MOUSE] Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. We recently reported that PTPMT1 dephosphorylates phosphatidylglycerol phosphate, an essential intermediate of cardiolipin biosynthesis. To gain further insights into the molecular basis of PTPMT1 function, we determined the crystal structures of the phosphatase domain of PTPMT1. PTPMT1 exhibits a canonical protein tyrosine phosphatase domain fold, resembling many dual-specificity phosphatases such as phosphatase and tensin homolog and vaccinia H1-related phosphatase. We also determined the structure of the catalytically inactive phosphatase in complex with a surrogate substrate, phosphatidylinositol 5-phosphate, which sheds light on the substrate recognition and specificity of PTPMT1. Comparison of the apo and substrate-bound structures of PTPMT1 suggests that it undergoes significant conformational change during catalysis, and we further demonstrated that an evolutionarily conserved EEYE loop is important for its activity.	+
-		+
-	Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.,Xiao J, Engel JL, Zhang J, Chen MJ, Manning G, Dixon JE Proc Natl Acad Sci U S A. 2011 Jul 5. PMID:21730175<ref>PMID:21730175</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3rgq" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Phosphoinositide phosphatase\|Phosphoinositide phosphatase]]		*[[Phosphoinositide phosphatase\|Phosphoinositide phosphatase]]
	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]		*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Engel~~, J L~~]]	+	[[Category: Engel JL]]
-	[[Category: Xiao, J]]	+	[[Category: Xiao J]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 06:02, 15 June 2022

2022-06-15T06:02:41Z

←Older revision		Revision as of 06:02, 15 June 2022
Line 1:		Line 1:

	==Crystal Structure of PTPMT1 in complex with PI(5)P==		==Crystal Structure of PTPMT1 in complex with PI(5)P==
-	<StructureSection load='3rgq' size='340' side='right' caption='[[3rgq]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='3rgq' size='340' side='right'caption='[[3rgq]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rgq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RGQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RGQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5P5:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIBUTANOATE'>5P5</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5P5:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIBUTANOATE'>5P5</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rgo\|3rgo]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rgo\|3rgo]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plip, Ptpmt1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plip, Ptpmt1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgq OCA], [~~http~~://pdbe.org/3rgq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rgq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rgq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rgq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgq OCA], [https://pdbe.org/3rgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rgq RCSB], [https://www.ebi.ac.uk/pdbsum/3rgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rgq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTPM1_MOUSE PTPM1_MOUSE]] Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).	+	[[https://www.uniprot.org/uniprot/PTPM1_MOUSE PTPM1_MOUSE]] Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3rgq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3rgq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphoinositide phosphatase\|Phosphoinositide phosphatase]]
		+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Engel, J L]]		[[Category: Engel, J L]]
	[[Category: Xiao, J]]		[[Category: Xiao, J]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 09:25, 8 November 2017

2017-11-08T09:25:52Z

←Older revision		Revision as of 09:25, 8 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3rgq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3rgq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phosphoinositide phosphatase\|Phosphoinositide phosphatase]]
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:17, 10 December 2016

2016-12-10T11:17:50Z

←Older revision		Revision as of 11:17, 10 December 2016
Line 1:		Line 1:
		+
	==Crystal Structure of PTPMT1 in complex with PI(5)P==		==Crystal Structure of PTPMT1 in complex with PI(5)P==
	<StructureSection load='3rgq' size='340' side='right' caption='[[3rgq]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='3rgq' size='340' side='right' caption='[[3rgq]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RGQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RGQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5P5:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIBUTANOATE'>5P5</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5P5:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIBUTANOATE'>5P5</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rgo\|3rgo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rgo\|3rgo]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plip, Ptpmt1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plip, Ptpmt1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rgq RCSB], [http://www.ebi.ac.uk/pdbsum/3rgq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgq OCA], [http://pdbe.org/3rgq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rgq RCSB], [http://www.ebi.ac.uk/pdbsum/3rgq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rgq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTPM1_MOUSE PTPM1_MOUSE]] Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3rgq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Phosphoinositide phosphatase\|Phosphoinositide phosphatase]]
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
Line 23:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Engel, J L]]		[[Category: Engel, J L]]
	[[Category: Xiao, J]]		[[Category: Xiao, J]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 12:27, 9 December 2014

2014-12-09T12:27:07Z

←Older revision		Revision as of 12:27, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3rgq.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of PTPMT1 in complex with PI(5)P==
		+	<StructureSection load='3rgq' size='340' side='right' caption='[[3rgq]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3rgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RGQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5P5:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIBUTANOATE'>5P5</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rgo\|3rgo]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plip, Ptpmt1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rgq RCSB], [http://www.ebi.ac.uk/pdbsum/3rgq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. We recently reported that PTPMT1 dephosphorylates phosphatidylglycerol phosphate, an essential intermediate of cardiolipin biosynthesis. To gain further insights into the molecular basis of PTPMT1 function, we determined the crystal structures of the phosphatase domain of PTPMT1. PTPMT1 exhibits a canonical protein tyrosine phosphatase domain fold, resembling many dual-specificity phosphatases such as phosphatase and tensin homolog and vaccinia H1-related phosphatase. We also determined the structure of the catalytically inactive phosphatase in complex with a surrogate substrate, phosphatidylinositol 5-phosphate, which sheds light on the substrate recognition and specificity of PTPMT1. Comparison of the apo and substrate-bound structures of PTPMT1 suggests that it undergoes significant conformational change during catalysis, and we further demonstrated that an evolutionarily conserved EEYE loop is important for its activity.

-	~~{{STRUCTURE_3rgq\| PDB=3rgq \| SCENE= }}~~	+	Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.,Xiao J, Engel JL, Zhang J, Chen MJ, Manning G, Dixon JE Proc Natl Acad Sci U S A. 2011 Jul 5. PMID:21730175<ref>PMID:21730175</ref>

-	~~===Crystal Structure~~ of ~~PTPMT1 in complex with PI(5)P===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21730175}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3rgq]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA].~~	+

	==See Also==		==See Also==
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021730175<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Engel, J L.]]	+	[[Category: Engel, J L]]
-	[[Category: Xiao, J.]]	+	[[Category: Xiao, J]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 09:53, 20 October 2012

2012-10-20T09:53:40Z

←Older revision		Revision as of 09:53, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3rgq]] is a 1 chain structure ~~of [[Tyrosine phosphatase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA].	+	[[3rgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA].

	==See Also==		==See Also==

OCA at 11:29, 14 August 2012

2012-08-14T11:29:52Z

←Older revision		Revision as of 11:29, 14 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3rgq]] is a 1 chain structure of ~~[[Proten tyrosine phosphatase]] and~~ [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA].	+	[[3rgq]] is a 1 chain structure of [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA].

	==See Also==		==See Also==
-	*[[Proten tyrosine phosphatase\|Proten tyrosine phosphatase]]
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]

OCA at 00:17, 26 July 2012

2012-07-26T00:17:39Z

←Older revision		Revision as of 00:17, 26 July 2012
Line 1:		Line 1:
	[[Image:3rgq.png\|left\|200px]]		[[Image:3rgq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3rgq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3rgq\| PDB=3rgq \| SCENE= }}		{{STRUCTURE_3rgq\| PDB=3rgq \| SCENE= }}

	===Crystal Structure of PTPMT1 in complex with PI(5)P===		===Crystal Structure of PTPMT1 in complex with PI(5)P===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21730175}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21730175 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21730175}}		{{ABSTRACT_PUBMED_21730175}}

	==About this Structure==		==About this Structure==
-	[[3rgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA].	+	[[3rgq]] is a 1 chain structure of [[Proten tyrosine phosphatase]] and [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA].
		+
		+	==See Also==
		+	*[[Proten tyrosine phosphatase\|Proten tyrosine phosphatase]]
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]

	==Reference==		==Reference==

OCA at 05:27, 20 July 2011

2011-07-20T05:27:36Z

←Older revision		Revision as of 05:27, 20 July 2011
Line 1:		Line 1:
-	[[Image:3rgq.~~jpg~~\|left\|200px]]	+	[[Image:3rgq.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal Structure of PTPMT1 in complex with PI(5)P===		===Crystal Structure of PTPMT1 in complex with PI(5)P===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21730175}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21730175 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21730175}}

	==About this Structure==		==About this Structure==
	[[3rgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA].		[[3rgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021730175</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Engel, J L.]]		[[Category: Engel, J L.]]
	[[Category: Xiao, J.]]		[[Category: Xiao, J.]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 19:01, 6 July 2011

2011-07-06T19:01:46Z

←Older revision		Revision as of 19:01, 6 July 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3rgq.jpg\|left\|200px]]

-	The ~~entry 3rgq~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rgq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rgq\| PDB=3rgq \| SCENE= }}

-	~~Authors: Xiao, J., Engel, J.L.~~	+	===Crystal Structure of PTPMT1 in complex with PI(5)P===

-	~~Description: Crystal~~ Structure ~~of PTPMT1 in complex~~ with ~~PI(5)P~~	+
		+	==About this Structure==
		+	[[3rgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGQ OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Engel, J L.]]
		+	[[Category: Xiao, J.]]
		+	[[Category: Hydrolase]]