3rn8 - Revision history

OCA at 10:18, 22 June 2022

2022-06-22T10:18:04Z

←Older revision		Revision as of 10:18, 22 June 2022
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	==Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator==		==Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator==
-	<StructureSection load='3rn8' size='340' side='right' caption='[[3rn8]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3rn8' size='340' side='right'caption='[[3rn8]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rn8]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3RN8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rn8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RN8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=RN8:3,3-BENZENE-1,4-DIYLBIS(4-CYANO-5-ETHYLTHIOPHENE-2-CARBOXYLIC+ACID)'>RN8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=RN8:3,3-BENZENE-1,4-DIYLBIS(4-CYANO-5-ETHYLTHIOPHENE-2-CARBOXYLIC+ACID)'>RN8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lbc\|1lbc]], [[1lb9\|1lb9]], [[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[3rnn\|3rnn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lbc\|1lbc]], [[1lb9\|1lb9]], [[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[3rnn\|3rnn]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRIA2, GLUR2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRIA2, GLUR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3rn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rn8 OCA], [~~http~~://pdbe.org/3rn8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3rn8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3rn8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3rn8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rn8 OCA], [https://pdbe.org/3rn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rn8 RCSB], [https://www.ebi.ac.uk/pdbsum/3rn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rn8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref>	+	[[https://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 3rn8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3rn8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Timm, D E]]		[[Category: Timm, D E]]
	[[Category: Glutamate receptor potentiator complex]]		[[Category: Glutamate receptor potentiator complex]]

OCA at 22:01, 15 November 2017

2017-11-15T22:01:14Z

←Older revision		Revision as of 22:01, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3rn8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3rn8" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:19, 5 August 2016

2016-08-05T12:19:46Z

←Older revision		Revision as of 12:19, 5 August 2016
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		+
	==Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator==		==Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator==
	<StructureSection load='3rn8' size='340' side='right' caption='[[3rn8]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3rn8' size='340' side='right' caption='[[3rn8]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3rn8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RN8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3rn8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RN8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=RN8:3,3-BENZENE-1,4-DIYLBIS(4-CYANO-5-ETHYLTHIOPHENE-2-CARBOXYLIC+ACID)'>RN8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=RN8:3,3-BENZENE-1,4-DIYLBIS(4-CYANO-5-ETHYLTHIOPHENE-2-CARBOXYLIC+ACID)'>RN8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lbc\|1lbc]], [[1lb9\|1lb9]], [[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[3rnn\|3rnn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lbc\|1lbc]], [[1lb9\|1lb9]], [[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[3rnn\|3rnn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRIA2, GLUR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRIA2, GLUR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rn8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rn8 RCSB], [http://www.ebi.ac.uk/pdbsum/3rn8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rn8 OCA], [http://pdbe.org/3rn8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rn8 RCSB], [http://www.ebi.ac.uk/pdbsum/3rn8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rn8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3rn8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Timm, D E]]		[[Category: Timm, D E]]
	[[Category: Glutamate receptor potentiator complex]]		[[Category: Glutamate receptor potentiator complex]]

OCA at 02:23, 25 December 2014

2014-12-25T02:23:58Z

←Older revision		Revision as of 02:23, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rn8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rn8 RCSB], [http://www.ebi.ac.uk/pdbsum/3rn8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rn8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rn8 RCSB], [http://www.ebi.ac.uk/pdbsum/3rn8 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:08, 9 December 2014

2014-12-09T13:08:11Z

←Older revision		Revision as of 13:08, 9 December 2014
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-	[[~~Image:~~3rn8.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator==
		+	<StructureSection load='3rn8' size='340' side='right' caption='[[3rn8]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3rn8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RN8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=RN8:3,3-BENZENE-1,4-DIYLBIS(4-CYANO-5-ETHYLTHIOPHENE-2-CARBOXYLIC+ACID)'>RN8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lbc\|1lbc]], [[1lb9\|1lb9]], [[1ftj\|1ftj]], [[1ftk\|1ftk]], [[1ftl\|1ftl]], [[3rnn\|3rnn]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRIA2, GLUR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rn8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rn8 RCSB], [http://www.ebi.ac.uk/pdbsum/3rn8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	At the dimer interface of the extracellular ligand-binding domain of AMPA receptors a hydrophilic pocket is formed that is known to interact with two classes of positive allosteric modulators, represented by cyclothiazide and the ampakine CX614. Here we present structural and functional data on two new positive allosteric modulators of AMPA receptors, CMPDA and CMPDB. Crystallographic data show that these compounds bind within the modulator-binding pocket, and that substituents of each compound overlap with distinct moieties of cyclothiazide and CX614. The goals of the present study were to determine 1) the degree of modulation by CMPDA and CMPDB of AMPA receptor deactivation and desensitization; 2) whether these compounds are splice isoform-selective; and, 3) whether predictions of mechanism of action could be inferred by comparing molecular interactions between the ligand binding domain and each compound to those of cyclothiazide and CX614. CMPDB was found to be more isoform-selective than would be predicted from initial binding assays. Importantly, these new compounds are both more potent and more efficacious, and also may be more clinically relevant, than the previously described AMPA receptor modulators.

-	~~{{STRUCTURE_3rn8\| PDB=3rn8 \| SCENE= }}~~	+	Structural and Functional Analysis of Two New Positive Allosteric Modulators of GluA2 Desensitization and Deactivation.,Timm DM, Benveniste M, Weeks AM, Nisenbaum ES, Partin KM Mol Pharmacol. 2011 May 4. PMID:21543522<ref>PMID:21543522</ref>

-	~~===Crystal Structure~~ of ~~iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21543522}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3rn8]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3RN8 OCA].~~	+

	==See Also==		==See Also==
	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]		*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021543522<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Timm, D E.]]	+	[[Category: Timm, D E]]
	[[Category: Glutamate receptor potentiator complex]]		[[Category: Glutamate receptor potentiator complex]]
	[[Category: Ligand gated ion channel]]		[[Category: Ligand gated ion channel]]
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 11:36, 20 October 2012

2012-10-20T11:36:13Z

←Older revision		Revision as of 11:36, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3rn8]] is a 3 chain structure ~~of [[Ionotropic Glutamate Receptors]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN8 OCA].	+	[[3rn8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN8 OCA].

	==See Also==		==See Also==

OCA at 05:55, 26 July 2012

2012-07-26T05:55:45Z

←Older revision		Revision as of 05:55, 26 July 2012
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	[[Image:3rn8.png\|left\|200px]]		[[Image:3rn8.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3rn8\| PDB=3rn8 \| SCENE= }}		{{STRUCTURE_3rn8\| PDB=3rn8 \| SCENE= }}

	===Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator===		===Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21543522}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_21543522}}		{{ABSTRACT_PUBMED_21543522}}

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	==See Also==		==See Also==
-	*[[Ionotropic Glutamate Receptors]]	+	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]

	==Reference==		==Reference==

OCA at 10:34, 16 November 2011

2011-11-16T10:34:28Z

←Older revision		Revision as of 10:34, 16 November 2011
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-	[[Image:3rn8.~~jpg~~\|left\|200px]]	+	[[Image:3rn8.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	[[3rn8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN8 OCA].	+	[[3rn8]] is a 3 chain structure of [[Ionotropic Glutamate Receptors]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN8 OCA].
		+
		+	==See Also==
		+	*[[Ionotropic Glutamate Receptors]]

	==Reference==		==Reference==
Line 25:		Line 28:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Timm, D E.]]		[[Category: Timm, D E.]]
		+	[[Category: Glutamate receptor potentiator complex]]
		+	[[Category: Ligand gated ion channel]]
		+	[[Category: Membrane]]
		+	[[Category: Transport protein]]

OCA at 05:39, 25 May 2011

2011-05-25T05:39:34Z

←Older revision		Revision as of 05:39, 25 May 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3rn8.jpg\|left\|200px]]

-	The ~~entry 3rn8~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3rn8", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3rn8\| PDB=3rn8 \| SCENE= }}

-	~~Authors: Timm, D.E.~~	+	===Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator===

-	~~Description~~: ~~Crystal~~ Structure ~~of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21543522}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21543522 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21543522}}
		+
		+	==About this Structure==
		+	[[3rn8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RN8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021543522</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Timm, D E.]]

OCA: Protected "3rn8" [edit=sysop:move=sysop]

2011-05-04T06:33:20Z

Protected "3rn8" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:33, 4 May 2011