3s5b - Revision history

OCA at 08:36, 20 March 2024

2024-03-20T08:36:40Z

←Older revision		Revision as of 08:36, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3s5b' size='340' side='right'caption='[[3s5b]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3s5b' size='340' side='right'caption='[[3s5b]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s5b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Caeel Caeel~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S5B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s5b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S5B FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.796Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~cps-6 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5b OCA], [https://pdbe.org/3s5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s5b RCSB], [https://www.ebi.ac.uk/pdbsum/3s5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5b OCA], [https://pdbe.org/3s5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s5b RCSB], [https://www.ebi.ac.uk/pdbsum/3s5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NUCG_CAEEL NUCG_CAEEL]] Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation.	+	[https://www.uniprot.org/uniprot/NUCG_CAEEL NUCG_CAEEL] Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Endonuclease G (EndoG) is a mitochondrial protein that traverses to the nucleus and participates in chromosomal DNA degradation during apoptosis in yeast, worms, flies, and mammals. However, it remains unclear how EndoG binds and digests DNA. Here we show that the Caenorhabditis elegans CPS-6, a homolog of EndoG, is a homodimeric Mg(2+)-dependent nuclease, binding preferentially to G-tract DNA in the optimum low salt buffer at pH 7. The crystal structure of CPS-6 was determined at 1.8 A resolution, revealing a mixed alphabeta topology with the two betabetaalpha-metal finger nuclease motifs located distantly at the two sides of the dimeric enzyme. A structural model of the CPS-6-DNA complex suggested a positively charged DNA-binding groove near the Mg(2+)-bound active site. Mutations of four aromatic and basic residues: Phe(122), Arg(146), Arg(156), and Phe(166), in the protein-DNA interface significantly reduced the DNA binding and cleavage activity of CPS-6, confirming that these residues are critical for CPS-6-DNA interactions. In vivo transformation rescue experiments further showed that the reduced DNase activity of CPS-6 mutants was positively correlated with its diminished cell killing activity in C. elegans. Taken together, these biochemical, structural, mutagenesis, and in vivo data reveal a molecular basis of how CPS-6 binds and hydrolyzes DNA to promote cell death.	+
-		+
-	Structural insights into apoptotic DNA degradation by CED-3 protease suppressor-6 (CPS-6) from Caenorhabditis elegans.,Lin JL, Nakagawa A, Lin CL, Hsiao YY, Yang WZ, Wang YT, Doudeva LG, Skeen-Gaar RR, Xue D, Yuan HS J Biol Chem. 2012 Mar 2;287(10):7110-20. Epub 2012 Jan 5. PMID:22223640<ref>PMID:22223640</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3s5b" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caeel~~]]	+	[[Category: Caenorhabditis elegans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lin~~, J L.J~~]]	+	[[Category: Lin JLJ]]
-	[[Category: Yuan~~, H S]]~~	+	[[Category: Yuan HS]]
-	~~[[Category: Beta-beta-alpha-metal finger nuclease]]~~	+
-	~~[[Category: Dna fragmentation]]~~	+
-	~~[[Category: Dnase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mitochondria]]~~	+
-	~~[[Category: Nuclease]]~~	+
-	~~[[Category: Protein-dna interaction~~]]	+

OCA at 10:38, 22 June 2022

2022-06-22T10:38:46Z

←Older revision		Revision as of 10:38, 22 June 2022
Line 1:		Line 1:

	==Crystal Structure of CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans==		==Crystal Structure of CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans==
-	<StructureSection load='3s5b' size='340' side='right' caption='[[3s5b]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3s5b' size='340' side='right'caption='[[3s5b]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s5b]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3S5B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s5b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S5B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cps-6 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cps-6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3s5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5b OCA], [~~http~~://pdbe.org/3s5b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3s5b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3s5b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5b OCA], [https://pdbe.org/3s5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s5b RCSB], [https://www.ebi.ac.uk/pdbsum/3s5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NUCG_CAEEL NUCG_CAEEL]] Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation.	+	[[https://www.uniprot.org/uniprot/NUCG_CAEEL NUCG_CAEEL]] Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Caeel]]		[[Category: Caeel]]
		+	[[Category: Large Structures]]
	[[Category: Lin, J L.J]]		[[Category: Lin, J L.J]]
	[[Category: Yuan, H S]]		[[Category: Yuan, H S]]

OCA at 09:24, 4 August 2016

2016-08-04T09:24:55Z

←Older revision		Revision as of 09:24, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans==		==Crystal Structure of CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans==
	<StructureSection load='3s5b' size='340' side='right' caption='[[3s5b]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3s5b' size='340' side='right' caption='[[3s5b]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3s5b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Caenorhabditis_elegans Caenorhabditis elegans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S5B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3s5b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S5B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cps-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 ~~Caenorhabditis elegans~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cps-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s5b RCSB], [http://www.ebi.ac.uk/pdbsum/3s5b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5b OCA], [http://pdbe.org/3s5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3s5b RCSB], [http://www.ebi.ac.uk/pdbsum/3s5b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3s5b" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caenorhabditis elegans~~]]	+	[[Category: Caeel]]
	[[Category: Lin, J L.J]]		[[Category: Lin, J L.J]]
	[[Category: Yuan, H S]]		[[Category: Yuan, H S]]

OCA at 08:13, 24 December 2014

2014-12-24T08:13:05Z

←Older revision		Revision as of 08:13, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s5b RCSB], [http://www.ebi.ac.uk/pdbsum/3s5b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s5b RCSB], [http://www.ebi.ac.uk/pdbsum/3s5b PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NUCG_CAEEL NUCG_CAEEL]] Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:57, 19 December 2014

2014-12-19T10:57:02Z

←Older revision		Revision as of 10:57, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3s5b\| PDB=3s5b \| SCENE= }}~~	+	==Crystal Structure of CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans==
-	===Crystal Structure of CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans===	+	<StructureSection load='3s5b' size='340' side='right' caption='[[3s5b]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22223640}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3s5b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S5B FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cps-6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s5b RCSB], [http://www.ebi.ac.uk/pdbsum/3s5b PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Endonuclease G (EndoG) is a mitochondrial protein that traverses to the nucleus and participates in chromosomal DNA degradation during apoptosis in yeast, worms, flies, and mammals. However, it remains unclear how EndoG binds and digests DNA. Here we show that the Caenorhabditis elegans CPS-6, a homolog of EndoG, is a homodimeric Mg(2+)-dependent nuclease, binding preferentially to G-tract DNA in the optimum low salt buffer at pH 7. The crystal structure of CPS-6 was determined at 1.8 A resolution, revealing a mixed alphabeta topology with the two betabetaalpha-metal finger nuclease motifs located distantly at the two sides of the dimeric enzyme. A structural model of the CPS-6-DNA complex suggested a positively charged DNA-binding groove near the Mg(2+)-bound active site. Mutations of four aromatic and basic residues: Phe(122), Arg(146), Arg(156), and Phe(166), in the protein-DNA interface significantly reduced the DNA binding and cleavage activity of CPS-6, confirming that these residues are critical for CPS-6-DNA interactions. In vivo transformation rescue experiments further showed that the reduced DNase activity of CPS-6 mutants was positively correlated with its diminished cell killing activity in C. elegans. Taken together, these biochemical, structural, mutagenesis, and in vivo data reveal a molecular basis of how CPS-6 binds and hydrolyzes DNA to promote cell death.

-	~~==Function==~~	+	Structural insights into apoptotic DNA degradation by CED-3 protease suppressor-6 (CPS-6) from Caenorhabditis elegans.,Lin JL, Nakagawa A, Lin CL, Hsiao YY, Yang WZ, Wang YT, Doudeva LG, Skeen-Gaar RR, Xue D, Yuan HS J Biol Chem. 2012 Mar 2;287(10):7110-20. Epub 2012 Jan 5. PMID:22223640<ref>PMID:22223640</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/NUCG_CAEEL NUCG_CAEEL]] Endonuclease important for programmed cell death~~; ~~it mediates apoptotic DNA fragmentation~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3s5b]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3S5B OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022223640</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
-	[[Category: Lin, J L.J.]]	+	[[Category: Lin, J L.J]]
-	[[Category: Yuan, H S.]]	+	[[Category: Yuan, H S]]
	[[Category: Beta-beta-alpha-metal finger nuclease]]		[[Category: Beta-beta-alpha-metal finger nuclease]]
	[[Category: Dna fragmentation]]		[[Category: Dna fragmentation]]

OCA at 09:12, 19 June 2013

2013-06-19T09:12:08Z

←Older revision		Revision as of 09:12, 19 June 2013
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-	[[Image:3s5b.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3s5b", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_3s5b\| PDB=3s5b \| SCENE= }}		{{STRUCTURE_3s5b\| PDB=3s5b \| SCENE= }}
-
	===Crystal Structure of CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans===		===Crystal Structure of CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans===
		+	{{ABSTRACT_PUBMED_22223640}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/NUCG_CAEEL NUCG_CAEEL]] Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation.

	==About this Structure==		==About this Structure==
	[[3s5b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5B OCA].		[[3s5b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5B OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022223640</ref><references group="xtra"/><references/>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
	[[Category: Lin, J L.J.]]		[[Category: Lin, J L.J.]]

OCA at 06:26, 11 January 2012

2012-01-11T06:26:44Z

←Older revision		Revision as of 06:26, 11 January 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3s5b.png\|left\|200px]]

-	The ~~entry 3s5b~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3s5b", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3s5b\| PDB=3s5b \| SCENE= }}

-	~~Authors: Yuan, H.S., Lin, L.J.~~	+	===Crystal Structure of CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans===

-	~~Description: Crystal~~ Structure ~~of Endonuclease G~~ from Caenorhabditis elegans	+
		+	==About this Structure==
		+	[[3s5b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5B OCA].
		+	[[Category: Caenorhabditis elegans]]
		+	[[Category: Lin, J L.J.]]
		+	[[Category: Yuan, H S.]]
		+	[[Category: Beta-beta-alpha-metal finger nuclease]]
		+	[[Category: Dna fragmentation]]
		+	[[Category: Dnase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mitochondria]]
		+	[[Category: Nuclease]]
		+	[[Category: Protein-dna interaction]]

OCA at 05:27, 10 August 2011

2011-08-10T05:27:43Z

←Older revision		Revision as of 05:27, 10 August 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3s5b is ON HOLD	+	The entry 3s5b is ON HOLD until Paper Publication

	Authors: Yuan, H.S., Lin, L.J.		Authors: Yuan, H.S., Lin, L.J.

	Description: Crystal Structure of Endonuclease G from Caenorhabditis elegans		Description: Crystal Structure of Endonuclease G from Caenorhabditis elegans

OCA at 04:53, 8 June 2011

2011-06-08T04:53:10Z

←Older revision		Revision as of 04:53, 8 June 2011
Line 3:		Line 3:
	The entry 3s5b is ON HOLD		The entry 3s5b is ON HOLD

-	Authors: Yuan, H. S. , Lin, L.J.	+	Authors: Yuan, H.S., Lin, L.J.

	Description: Crystal Structure of Endonuclease G from Caenorhabditis elegans		Description: Crystal Structure of Endonuclease G from Caenorhabditis elegans

OCA: Protected "3s5b" [edit=sysop:move=sysop]

2011-06-01T05:26:51Z

Protected "3s5b" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:26, 1 June 2011