3seb - Revision history

OCA at 06:44, 3 April 2024

2024-04-03T06:44:43Z

←Older revision		Revision as of 06:44, 3 April 2024
Line 1:		Line 1:

	==STAPHYLOCOCCAL ENTEROTOXIN B==		==STAPHYLOCOCCAL ENTEROTOXIN B==
-	<StructureSection load='3seb' size='340' side='right' caption='[[3seb]], [[Resolution\|resolution]] 1.48Å' scene=''>	+	<StructureSection load='3seb' size='340' side='right'caption='[[3seb]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3seb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SEB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3seb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SEB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3seb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3seb OCA], [~~http~~://pdbe.org/3seb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3seb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3seb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3seb ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.48Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3seb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3seb OCA], [https://pdbe.org/3seb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3seb RCSB], [https://www.ebi.ac.uk/pdbsum/3seb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3seb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ETXB_STAAU ETXB_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.	+	[https://www.uniprot.org/uniprot/ETXB_STAAU ETXB_STAAU] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3seb ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3seb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Staphylococcal enterotoxin B is a member of a family of toxins known as superantigens that activate a large number of T-cells (up to 20%) by cross-linking MHC class II molecules with T-cell receptors in a Vbeta-restricted fashion. The crystal structure of staphylococcal enterotoxin B presented here has been determined at 1.5 A resolution, the highest resolution so far for a superantigen. The final model contains 1948 protein atoms and 177 water molecules and has excellent geometry with root-mean-square (rms) deviation of 0.007 A and 1.73 degrees in bond lengths and bond angles, respectively. The overall fold is similar to that of other microbial superantigens, but as it lacks the zinc-binding site found in other members of this family, such as staphylococcal enterotoxin A, C2 and D, this enterotoxin possesses only one MHC class II binding site. Comparison of the crystal structure of free SEB and in complex with an MHC class II molecule revealed no major changes in the MHC-binding site upon complex formation. However, a number of water molecules found in the free SEB may be displaced in the complex or contribute further to its stability. Detailed analysis of the TcR-binding site of SEB, SEA and SEC2 shows significant differences which may account for the ability of each superantigen to bind specific Vbeta sequences.
-
-	Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors.,Papageorgiou AC, Tranter HS, Acharya KR J Mol Biol. 1998 Mar 20;277(1):61-79. PMID:9514739<ref>PMID:9514739</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3seb" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Acharya~~, K R~~]]	+	[[Category: Acharya KR]]
-	[[Category: Papageorgiou~~, A C]]~~	+	[[Category: Papageorgiou AC]]
-	~~[[Category: Enterotoxin]]~~	+
-	~~[[Category: Superantigen]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 10:39, 13 February 2019

2019-02-13T10:39:59Z

←Older revision		Revision as of 10:39, 13 February 2019
Line 1:		Line 1:
		+
	==STAPHYLOCOCCAL ENTEROTOXIN B==		==STAPHYLOCOCCAL ENTEROTOXIN B==
	<StructureSection load='3seb' size='340' side='right' caption='[[3seb]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='3seb' size='340' side='right' caption='[[3seb]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3seb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3seb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SEB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3seb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3seb OCA], [http://pdbe.org/3seb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3seb RCSB], [http://www.ebi.ac.uk/pdbsum/3seb PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3seb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3seb OCA], [http://pdbe.org/3seb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3seb RCSB], [http://www.ebi.ac.uk/pdbsum/3seb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3seb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/se/3seb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/se/3seb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:34, 8 February 2016

2016-02-08T20:34:54Z

←Older revision		Revision as of 20:34, 8 February 2016
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3seb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3seb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SEB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3seb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3seb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3seb RCSB], [http://www.ebi.ac.uk/pdbsum/3seb PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3seb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3seb OCA], [http://pdbe.org/3seb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3seb RCSB], [http://www.ebi.ac.uk/pdbsum/3seb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3seb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3seb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:58, 25 December 2014

2014-12-25T01:58:47Z

←Older revision		Revision as of 01:58, 25 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3seb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3seb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3seb RCSB], [http://www.ebi.ac.uk/pdbsum/3seb PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3seb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3seb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3seb RCSB], [http://www.ebi.ac.uk/pdbsum/3seb PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ETXB_STAAU ETXB_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:17, 21 December 2014

2014-12-21T07:17:27Z

←Older revision		Revision as of 07:17, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3seb~~\| ~~PDB~~=3seb \| ~~SCENE~~= }}	+	==STAPHYLOCOCCAL ENTEROTOXIN B==
-	===~~STAPHYLOCOCCAL ENTEROTOXIN B~~===	+	<StructureSection load='3seb' size='340' side='right' caption='[[3seb]], [[Resolution\|resolution]] 1.48Å' scene=''>
-	~~{{ABSTRACT_PUBMED_9514739}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3seb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SEB FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3seb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3seb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3seb RCSB], [http://www.ebi.ac.uk/pdbsum/3seb PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/se/3seb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Staphylococcal enterotoxin B is a member of a family of toxins known as superantigens that activate a large number of T-cells (up to 20%) by cross-linking MHC class II molecules with T-cell receptors in a Vbeta-restricted fashion. The crystal structure of staphylococcal enterotoxin B presented here has been determined at 1.5 A resolution, the highest resolution so far for a superantigen. The final model contains 1948 protein atoms and 177 water molecules and has excellent geometry with root-mean-square (rms) deviation of 0.007 A and 1.73 degrees in bond lengths and bond angles, respectively. The overall fold is similar to that of other microbial superantigens, but as it lacks the zinc-binding site found in other members of this family, such as staphylococcal enterotoxin A, C2 and D, this enterotoxin possesses only one MHC class II binding site. Comparison of the crystal structure of free SEB and in complex with an MHC class II molecule revealed no major changes in the MHC-binding site upon complex formation. However, a number of water molecules found in the free SEB may be displaced in the complex or contribute further to its stability. Detailed analysis of the TcR-binding site of SEB, SEA and SEC2 shows significant differences which may account for the ability of each superantigen to bind specific Vbeta sequences.

-	~~==Function==~~	+	Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors.,Papageorgiou AC, Tranter HS, Acharya KR J Mol Biol. 1998 Mar 20;277(1):61-79. PMID:9514739<ref>PMID:9514739</ref>
-	~~[[http://www.uniprot.org/uniprot/ETXB_STAAU ETXB_STAAU]] Staphylococcal enterotoxins cause the intoxication~~ staphylococcal ~~food poisoning syndrome~~. ~~The illness characterized~~ by ~~high fever~~, ~~hypotension~~, ~~diarrhea~~, ~~shock, and in some cases death~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3seb]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3SEB OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:009514739</ref><ref group="xtra">PMID:011917145</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Acharya, K R.]]	+	[[Category: Acharya, K R]]
-	[[Category: Papageorgiou, A C.]]	+	[[Category: Papageorgiou, A C]]
	[[Category: Enterotoxin]]		[[Category: Enterotoxin]]
	[[Category: Superantigen]]		[[Category: Superantigen]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA: Protected "3seb" [edit=sysop:move=sysop]

2013-05-16T07:53:26Z

Protected "3seb" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:53, 16 May 2013

OCA at 07:53, 16 May 2013

2013-05-16T07:53:24Z

←Older revision		Revision as of 07:53, 16 May 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3seb.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3seb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3seb\| PDB=3seb \| SCENE= }}		{{STRUCTURE_3seb\| PDB=3seb \| SCENE= }}
-
	===STAPHYLOCOCCAL ENTEROTOXIN B===		===STAPHYLOCOCCAL ENTEROTOXIN B===
		+	{{ABSTRACT_PUBMED_9514739}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/ETXB_STAAU ETXB_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_9514739}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 9514739 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_9514739}}~~	+

	==About this Structure==		==About this Structure==
-	~~3SEB~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEB OCA].	+	[[3seb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEB OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9514739~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009514739</ref><ref group="xtra">PMID:011917145</ref><references group="xtra"/><references/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]
Line 30:		Line 17:
	[[Category: Superantigen]]		[[Category: Superantigen]]
	[[Category: Toxin]]		[[Category: Toxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:54:45 2009''

OCA at 00:54, 17 February 2009

2009-02-17T00:54:46Z

←Older revision		Revision as of 00:54, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3SEB is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEB OCA].	+	3SEB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SEB OCA].

	==Reference==		==Reference==
-	Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors., Papageorgiou AC, Tranter HS, Acharya KR, J Mol Biol. 1998 Mar 20;277(1):61-79. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/9514739 9514739]~~	+	<ref group="xtra">PMID:9514739</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]
Line 32:		Line 31:
	[[Category: Toxin]]		[[Category: Toxin]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 3 13~~:06:45 ~~2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:54:45 2009''

OCA at 10:06, 3 July 2008

2008-07-03T10:06:45Z

←Older revision		Revision as of 10:06, 3 July 2008
Line 1:		Line 1:
-	[[Image:3seb.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:3seb.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_3seb\| PDB=3seb \| SCENE= }}		{{STRUCTURE_3seb\| PDB=3seb \| SCENE= }}

-	~~'''~~STAPHYLOCOCCAL ENTEROTOXIN B~~'''~~	+	===STAPHYLOCOCCAL ENTEROTOXIN B===


-	~~==Overview==~~	+	<!--
-	~~Staphylococcal enterotoxin B is a member of a family of toxins known as superantigens that activate a large number of T~~-~~cells (up to 20%) by cross~~-~~linking MHC class II molecules with T-cell receptors in a Vbeta-restricted fashion.~~ The ~~crystal structure of staphylococcal enterotoxin B presented here has been determined at 1.5 A resolution~~, the ~~highest resolution so far for a superantigen. The final model contains 1948 protein atoms and 177 water molecules and has excellent geometry with root-mean-square~~ (~~rms) deviation of 0~~.~~007 A and 1~~.~~73 degrees in bond lengths and bond angles~~, ~~respectively. The overall fold~~ is ~~similar to that of other microbial superantigens, but as it lacks~~ the zinc-binding site found in other members of this family, such as staphylococcal enterotoxin A, C2 and D, this enterotoxin possesses only one MHC class II binding site. Comparison of the crystal structure of free SEB and in complex with an MHC class II molecule revealed no major changes in the MHC-binding site upon complex formation. However, a number ~~of water molecules found in the free SEB may be displaced in the complex or contribute further to its stability~~. ~~Detailed analysis of the TcR~~-~~binding site of SEB, SEA and SEC2 shows significant differences which may account for the ability of each superantigen to bind specific Vbeta sequences.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_9514739}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 9514739 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_9514739}}

	==About this Structure==		==About this Structure==
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	[[Category: Superantigen]]		[[Category: Superantigen]]
	[[Category: Toxin]]		[[Category: Toxin]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:12:53 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:06:45 2008''

OCA at 19:12, 4 May 2008

2008-05-04T19:12:54Z

←Older revision		Revision as of 19:12, 4 May 2008
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	[[Image:3seb.gif\|left\|200px]]		[[Image:3seb.gif\|left\|200px]]

-	{{Structure	+	<!--
-	\|PDB~~= 3seb \|SIZE=350\|CAPTION= <~~scene ~~name='initialview01'>3seb</scene>~~, ~~resolution 1~~.~~48Å~~	+	The line below this paragraph, containing "STRUCTURE_3seb", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	\|~~LIGAND~~=	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	\|~~ACTIVITY~~=	+	or leave the SCENE parameter empty for the default display.
-	~~\|GENE=~~	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_3seb\| PDB=3seb \| SCENE= }}
-	~~\|RELATEDENTRY=~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3seb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3seb OCA], [http://www.ebi.ac.uk/pdbsum/3seb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3seb RCSB]</span>	+
-	}}	+

	'''STAPHYLOCOCCAL ENTEROTOXIN B'''		'''STAPHYLOCOCCAL ENTEROTOXIN B'''
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	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]
	[[Category: Papageorgiou, A C.]]		[[Category: Papageorgiou, A C.]]
-	[[Category: ~~enterotoxin~~]]	+	[[Category: Enterotoxin]]
-	[[Category: ~~superantigen~~]]	+	[[Category: Superantigen]]
-	[[Category: ~~toxin~~]]	+	[[Category: Toxin]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:12:53 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:36:03 2008''	+