3sgo - Revision history

OCA at 09:50, 1 March 2024

2024-03-01T09:50:26Z

←Older revision		Revision as of 09:50, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3sgo' size='340' side='right'caption='[[3sgo]], [[Resolution\|resolution]] 2.56Å' scene=''>		<StructureSection load='3sgo' size='340' side='right'caption='[[3sgo]], [[Resolution\|resolution]] 2.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sgo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SGO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sgo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SGO FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[3sgm\|3sgm]]~~, [[~~3sgn~~\|~~3sgn~~]]~~, [[3sgp\|3sgp]], [[3sgr\|3sgr]], [[3sgs\|3sgs]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.557Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgo OCA], [https://pdbe.org/3sgo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sgo RCSB], [https://www.ebi.ac.uk/pdbsum/3sgo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgo OCA], [https://pdbe.org/3sgo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sgo RCSB], [https://www.ebi.ac.uk/pdbsum/3sgo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	+	[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Amyloid diseases, including Alzheimer's, Parkinson's, and the prion conditions, are each associated with a particular protein in fibrillar form. These amyloid fibrils were long suspected to be the disease agents, but evidence suggests that smaller, often transient and polymorphic oligomers are the toxic entities. Here, we identify a segment of the amyloid-forming protein alphaB crystallin, which forms an oligomeric complex exhibiting properties of other amyloid oligomers: beta-sheet-rich structure, cytotoxicity, and recognition by an oligomer-specific antibody. The x-ray-derived atomic structure of the oligomer reveals a cylindrical barrel, formed from six antiparallel protein strands, that we term a cylindrin. The cylindrin structure is compatible with a sequence segment from the beta-amyloid protein of Alzheimer's disease. Cylindrins offer models for the hitherto elusive structures of amyloid oligomers.	+
-		+
-	Atomic view of a toxic amyloid small oligomer.,Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D Science. 2012 Mar 9;335(6073):1228-31. PMID:22403391<ref>PMID:22403391</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3sgo" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cascio, D]]	+	[[Category: Cascio D]]
-	[[Category: Eisenberg, D]]	+	[[Category: Eisenberg D]]
-	[[Category: Laganowsky, A]]	+	[[Category: Laganowsky A]]
-	[[Category: Sawaya~~, M R]]~~	+	[[Category: Sawaya MR]]
-	~~[[Category: Amyloid]]~~	+
-	~~[[Category: Amyloid oligomer]]~~	+
-	~~[[Category: Beta cylindrin]]~~	+
-	~~[[Category: Protein fibril~~]]	+

OCA at 07:55, 29 June 2022

2022-06-29T07:55:26Z

←Older revision		Revision as of 07:55, 29 June 2022
Line 1:		Line 1:

	==Amyloid-related segment of alphaB-crystallin residues 90-100==		==Amyloid-related segment of alphaB-crystallin residues 90-100==
-	<StructureSection load='3sgo' size='340' side='right' caption='[[3sgo]], [[Resolution\|resolution]] 2.56Å' scene=''>	+	<StructureSection load='3sgo' size='340' side='right'caption='[[3sgo]], [[Resolution\|resolution]] 2.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3sgo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3SGO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3sgo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SGO FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sgm\|3sgm]], [[3sgn\|3sgn]], [[3sgp\|3sgp]], [[3sgr\|3sgr]], [[3sgs\|3sgs]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sgm\|3sgm]], [[3sgn\|3sgn]], [[3sgp\|3sgp]], [[3sgr\|3sgr]], [[3sgs\|3sgs]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3sgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgo OCA], [~~http~~://pdbe.org/3sgo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3sgo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3sgo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgo OCA], [https://pdbe.org/3sgo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sgo RCSB], [https://www.ebi.ac.uk/pdbsum/3sgo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	+	[[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]

OCA at 14:01, 11 August 2016

2016-08-11T14:01:30Z

←Older revision		Revision as of 14:01, 11 August 2016
Line 1:		Line 1:
		+
	==Amyloid-related segment of alphaB-crystallin residues 90-100==		==Amyloid-related segment of alphaB-crystallin residues 90-100==
	<StructureSection load='3sgo' size='340' side='right' caption='[[3sgo]], [[Resolution\|resolution]] 2.56Å' scene=''>		<StructureSection load='3sgo' size='340' side='right' caption='[[3sgo]], [[Resolution\|resolution]] 2.56Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3sgo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SGO FirstGlance]. <br>		<table><tr><td colspan='2'>[[3sgo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SGO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sgm\|3sgm]], [[3sgn\|3sgn]], [[3sgp\|3sgp]], [[3sgr\|3sgr]], [[3sgs\|3sgs]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sgm\|3sgm]], [[3sgn\|3sgn]], [[3sgp\|3sgp]], [[3sgr\|3sgr]], [[3sgs\|3sgs]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sgo RCSB], [http://www.ebi.ac.uk/pdbsum/3sgo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgo OCA], [http://pdbe.org/3sgo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sgo RCSB], [http://www.ebi.ac.uk/pdbsum/3sgo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3sgo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:03, 4 January 2015

2015-01-04T11:03:25Z

←Older revision		Revision as of 11:03, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3sgo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SGO FirstGlance]. <br>		<table><tr><td colspan='2'>[[3sgo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SGO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sgm\|3sgm]], [[3sgn\|3sgn]], [[3sgp\|3sgp]], [[3sgr\|3sgr]], [[3sgs\|3sgs]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sgm\|3sgm]], [[3sgn\|3sgn]], [[3sgp\|3sgp]], [[3sgr\|3sgr]], [[3sgs\|3sgs]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sgo RCSB], [http://www.ebi.ac.uk/pdbsum/3sgo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sgo RCSB], [http://www.ebi.ac.uk/pdbsum/3sgo PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
Line 16:		Line 16:
	Atomic view of a toxic amyloid small oligomer.,Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D Science. 2012 Mar 9;335(6073):1228-31. PMID:22403391<ref>PMID:22403391</ref>		Atomic view of a toxic amyloid small oligomer.,Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D Science. 2012 Mar 9;335(6073):1228-31. PMID:22403391<ref>PMID:22403391</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cascio, D.]]	+	[[Category: Cascio, D]]
-	[[Category: Eisenberg, D.]]	+	[[Category: Eisenberg, D]]
-	[[Category: Laganowsky, A.]]	+	[[Category: Laganowsky, A]]
-	[[Category: Sawaya, M R.]]	+	[[Category: Sawaya, M R]]
	[[Category: Amyloid]]		[[Category: Amyloid]]
	[[Category: Amyloid oligomer]]		[[Category: Amyloid oligomer]]
	[[Category: Beta cylindrin]]		[[Category: Beta cylindrin]]
	[[Category: Protein fibril]]		[[Category: Protein fibril]]

OCA at 05:28, 5 June 2014

2014-06-05T05:28:13Z

←Older revision		Revision as of 05:28, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3sgo.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Amyloid-related segment of alphaB-crystallin residues 90-100==
		+	<StructureSection load='3sgo' size='340' side='right' caption='[[3sgo]], [[Resolution\|resolution]] 2.56Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3sgo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SGO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3sgm\|3sgm]], [[3sgn\|3sgn]], [[3sgp\|3sgp]], [[3sgr\|3sgr]], [[3sgs\|3sgs]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sgo RCSB], [http://www.ebi.ac.uk/pdbsum/3sgo PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Amyloid diseases, including Alzheimer's, Parkinson's, and the prion conditions, are each associated with a particular protein in fibrillar form. These amyloid fibrils were long suspected to be the disease agents, but evidence suggests that smaller, often transient and polymorphic oligomers are the toxic entities. Here, we identify a segment of the amyloid-forming protein alphaB crystallin, which forms an oligomeric complex exhibiting properties of other amyloid oligomers: beta-sheet-rich structure, cytotoxicity, and recognition by an oligomer-specific antibody. The x-ray-derived atomic structure of the oligomer reveals a cylindrical barrel, formed from six antiparallel protein strands, that we term a cylindrin. The cylindrin structure is compatible with a sequence segment from the beta-amyloid protein of Alzheimer's disease. Cylindrins offer models for the hitherto elusive structures of amyloid oligomers.

-	~~<!--~~	+	Atomic view of a toxic amyloid small oligomer.,Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D Science. 2012 Mar 9;335(6073):1228-31. PMID:22403391<ref>PMID:22403391</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3sgo"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3sgo\| PDB=3sgo \| SCENE= }}~~	+

-	~~===Amyloid-related segment~~ of ~~alphaB-crystallin residues 90-100===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22403391}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22403391 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22403391}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3sgo]] is a 1 chain structure. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3SGO OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022403391<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cascio, D.]]		[[Category: Cascio, D.]]
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]

OCA at 07:38, 21 March 2012

2012-03-21T07:38:07Z

←Older revision		Revision as of 07:38, 21 March 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3sgo.jpg\|left\|200px]]

-	The ~~entry 3sgo~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3sgo", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3sgo\| PDB=3sgo \| SCENE= }}

-	~~Authors: Laganowsky, A., Sawaya, M.R., Cascio, D., Eisenberg, D.~~	+	===Amyloid-related segment of alphaB-crystallin residues 90-100===

-	~~Description~~: ~~Amyloid~~-~~related segment of alphaB~~-~~crystallin residues 90~~-~~100~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22403391}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22403391 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22403391}}
		+
		+	==About this Structure==
		+	[[3sgo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGO OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022403391</ref><references group="xtra"/>
		+	[[Category: Cascio, D.]]
		+	[[Category: Eisenberg, D.]]
		+	[[Category: Laganowsky, A.]]
		+	[[Category: Sawaya, M R.]]
		+	[[Category: Amyloid]]
		+	[[Category: Amyloid oligomer]]
		+	[[Category: Beta cylindrin]]
		+	[[Category: Protein fibril]]

OCA at 18:25, 6 July 2011

2011-07-06T18:25:40Z

←Older revision		Revision as of 18:25, 6 July 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3sgo is ON HOLD	+	The entry 3sgo is ON HOLD until Paper Publication

-	Authors: Laganowsky, ~~Arthur~~, Sawaya, ~~Michael~~ R., Cascio, ~~Duilio~~, Eisenberg, ~~David~~	+	Authors: Laganowsky, A., Sawaya, M.R., Cascio, D., Eisenberg, D.

	Description: Amyloid-related segment of alphaB-crystallin residues 90-100		Description: Amyloid-related segment of alphaB-crystallin residues 90-100

OCA: Protected "3sgo" [edit=sysop:move=sysop]

2011-06-22T16:24:06Z

Protected "3sgo" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:24, 22 June 2011

OCA: New page: '''Unreleased structure''' The entry 3sgo is ON HOLD Authors: Laganowsky, Arthur, Sawaya, Michael R., Cascio, Duilio, Eisenberg, David Description: Amyloid-related segment of alphaB-cr...

2011-06-22T16:24:06Z

New page: '''Unreleased structure''' The entry 3sgo is ON HOLD Authors: Laganowsky, Arthur, Sawaya, Michael R., Cascio, Duilio, Eisenberg, David Description: Amyloid-related segment of alphaB-cr...

New page

'''Unreleased structure'''

The entry 3sgo is ON HOLD

Authors: Laganowsky, Arthur, Sawaya, Michael R., Cascio, Duilio, Eisenberg, David

Description: Amyloid-related segment of alphaB-crystallin residues 90-100