3t5u - Revision history

OCA at 13:18, 14 March 2024

2024-03-14T13:18:09Z

←Older revision		Revision as of 13:18, 14 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3t5u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T5U FirstGlance]. <br>		<table><tr><td colspan='2'>[[3t5u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T5U FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=A09:N~~-~~HYDROXYBENZENESULFONAMIDE'>A09</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1ca2\|1ca2]], [[2wej\|2wej]], [[3t5z\|3t5z]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A09:N-HYDROXYBENZENESULFONAMIDE'>A09</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5u OCA], [https://pdbe.org/3t5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t5u RCSB], [https://www.ebi.ac.uk/pdbsum/3t5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5u OCA], [https://pdbe.org/3t5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t5u RCSB], [https://www.ebi.ac.uk/pdbsum/3t5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5u ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	N-substituted benzenesulfonamides, incorporating the N-amino-, N-hydroxy- and N-methoxy-moieties at the sulfonamide zinc binding group, have been investigated as CAIs by means of inhibition and structural studies, unraveling interesting aspects related to their inhibition mechanism.	+
-		+
-	Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II.,Di Fiore A, Maresca A, Alterio V, Supuran CT, De Simone G Chem Commun (Camb). 2011 Nov 14;47(42):11636-8. Epub 2011 Sep 26. PMID:21952494<ref>PMID:21952494</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3t5u" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 29:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alterio, V]]	+	[[Category: Alterio V]]
-	[[Category: ~~Fiore, A Di~~]]	+	[[Category: De Simone G]]
-	[[Category: ~~Maresca,~~ A]]	+	[[Category: Di Fiore A]]
-	[[Category: ~~Simone, G De~~]]	+	[[Category: Maresca A]]
-	[[Category: Supuran~~, C T]]~~	+	[[Category: Supuran CT]]
-	~~[[Category: Lyase-lyase inhibitor complex]]~~	+
-	~~[[Category: Protein-inhibitor complex~~]]	+

OCA at 16:44, 6 July 2022

2022-07-06T16:44:18Z

←Older revision		Revision as of 16:44, 6 July 2022
Line 1:		Line 1:

	==Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide==		==Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide==
-	<StructureSection load='3t5u' size='340' side='right' caption='[[3t5u]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='3t5u' size='340' side='right'caption='[[3t5u]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3t5u]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3T5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3t5u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T5U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A09:N-HYDROXYBENZENESULFONAMIDE'>A09</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A09:N-HYDROXYBENZENESULFONAMIDE'>A09</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ca2\|1ca2]], [[2wej\|2wej]], [[3t5z\|3t5z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ca2\|1ca2]], [[2wej\|2wej]], [[3t5z\|3t5z]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3t5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5u OCA], [~~http~~://pdbe.org/3t5u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3t5u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3t5u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5u OCA], [https://pdbe.org/3t5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t5u RCSB], [https://www.ebi.ac.uk/pdbsum/3t5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5u ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[Carbonic anhydrase\|Carbonic anhydrase]]	+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 31:
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Alterio, V]]		[[Category: Alterio, V]]
	[[Category: Fiore, A Di]]		[[Category: Fiore, A Di]]

OCA at 05:13, 5 August 2016

2016-08-05T05:13:50Z

←Older revision		Revision as of 05:13, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide==		==Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide==
	<StructureSection load='3t5u' size='340' side='right' caption='[[3t5u]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3t5u' size='340' side='right' caption='[[3t5u]], [[Resolution\|resolution]] 1.75Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ca2\|1ca2]], [[2wej\|2wej]], [[3t5z\|3t5z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ca2\|1ca2]], [[2wej\|2wej]], [[3t5z\|3t5z]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t5u RCSB], [http://www.ebi.ac.uk/pdbsum/3t5u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5u OCA], [http://pdbe.org/3t5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3t5u RCSB], [http://www.ebi.ac.uk/pdbsum/3t5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5u ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3t5u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:37, 21 December 2014

2014-12-21T07:37:32Z

←Older revision		Revision as of 07:37, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3t5u\| PDB=3t5u \| SCENE= }}~~	+	==Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide==
-	===Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide===	+	<StructureSection load='3t5u' size='340' side='right' caption='[[3t5u]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21952494}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3t5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T5U FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A09:N-HYDROXYBENZENESULFONAMIDE'>A09</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ca2\|1ca2]], [[2wej\|2wej]], [[3t5z\|3t5z]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t5u RCSB], [http://www.ebi.ac.uk/pdbsum/3t5u PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N-substituted benzenesulfonamides, incorporating the N-amino-, N-hydroxy- and N-methoxy-moieties at the sulfonamide zinc binding group, have been investigated as CAIs by means of inhibition and structural studies, unraveling interesting aspects related to their inhibition mechanism.

-	~~==Disease==~~	+	Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II.,Di Fiore A, Maresca A, Alterio V, Supuran CT, De Simone G Chem Commun (Camb). 2011 Nov 14;47(42):11636-8. Epub 2011 Sep 26. PMID:21952494<ref>PMID:21952494</ref>
-	~~[[http~~:~~//www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are~~ the ~~cause~~ of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-~~Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due~~ to ~~defective resorption of immature bone~~. ~~The disorder occurs in two forms: a severe autosomal recessive form occurring in utero~~, ~~infancy~~, ~~or childhood~~, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, ~~cerebral calcification~~ (~~marble brain disease~~) ~~and in some cases with mental retardation~~.~~<ref>PMID~~:~~1928091</ref><ref>~~PMID:~~1542674</ref><ref>PMID:8834238</ref><ref>PMID:9143915</ref>~~<ref>PMID:~~15300855~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration~~ of ~~carbon dioxide~~. ~~Can hydrate cyanamide to urea~~. ~~Involved in the regulation~~ of ~~fluid secretion into the anterior chamber of the eye~~.<~~ref~~>~~PMID:10550681~~</~~ref~~>~~<ref>PMID:11831900</ref>~~	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[3t5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5U OCA].	+

	==See Also==		==See Also==
	*[[Carbonic anhydrase\|Carbonic anhydrase]]		*[[Carbonic anhydrase\|Carbonic anhydrase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021952494</ref><ref group="xtra">PMID:003151019</ref><ref group="xtra">PMID:019882701</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Alterio, V.]]	+	[[Category: Alterio, V]]
-	[[Category: Fiore, A Di.]]	+	[[Category: Fiore, A Di]]
-	[[Category: Maresca, A.]]	+	[[Category: Maresca, A]]
-	[[Category: Simone, G De.]]	+	[[Category: Simone, G De]]
-	[[Category: Supuran, C T.]]	+	[[Category: Supuran, C T]]
	[[Category: Lyase-lyase inhibitor complex]]		[[Category: Lyase-lyase inhibitor complex]]
	[[Category: Protein-inhibitor complex]]		[[Category: Protein-inhibitor complex]]

OCA at 11:56, 24 March 2013

2013-03-24T11:56:10Z

←Older revision		Revision as of 11:56, 24 March 2013
Line 1:		Line 1:
-	[[Image:3t5u.jpg\|left\|200px]]
-
	{{STRUCTURE_3t5u\| PDB=3t5u \| SCENE= }}		{{STRUCTURE_3t5u\| PDB=3t5u \| SCENE= }}
-
	===Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide===		===Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide===
-
	{{ABSTRACT_PUBMED_21952494}}		{{ABSTRACT_PUBMED_21952494}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref><ref>PMID:1542674</ref><ref>PMID:8834238</ref><ref>PMID:9143915</ref><ref>PMID:15300855</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref><ref>PMID:11831900</ref>

	==About this Structure==		==About this Structure==
	[[3t5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5U OCA].		[[3t5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5U OCA].
		+
		+	==See Also==
		+	*[[Carbonic anhydrase\|Carbonic anhydrase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021952494</ref><ref group="xtra">PMID:003151019</ref><ref group="xtra">PMID:019882701</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021952494</ref><ref group="xtra">PMID:003151019</ref><ref group="xtra">PMID:019882701</ref><references group="xtra"/><references/>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 07:52, 20 June 2012

2012-06-20T07:52:05Z

←Older revision		Revision as of 07:52, 20 June 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3t5u.jpg\|left\|200px]]

-	~~The entry~~ 3t5u ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3t5u\| PDB=3t5u \| SCENE= }}

-	~~Authors: Di Fiore, A., Maresca, A., Alterio, V., Supuran, C.T., De Simone, G.~~	+	===Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide===

-	~~Description: Crystal~~ structure ~~of the human carbonic anhydrase II in complex~~ with N-~~hydroxy benzenesulfonamide~~	+	{{ABSTRACT_PUBMED_21952494}}
		+
		+	==About this Structure==
		+	[[3t5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5U OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021952494</ref><ref group="xtra">PMID:003151019</ref><ref group="xtra">PMID:019882701</ref><references group="xtra"/>
		+	[[Category: Carbonate dehydratase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Alterio, V.]]
		+	[[Category: Fiore, A Di.]]
		+	[[Category: Maresca, A.]]
		+	[[Category: Simone, G De.]]
		+	[[Category: Supuran, C T.]]
		+	[[Category: Lyase-lyase inhibitor complex]]
		+	[[Category: Protein-inhibitor complex]]

OCA at 06:02, 14 September 2011

2011-09-14T06:02:02Z

←Older revision		Revision as of 06:02, 14 September 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3t5u is ON HOLD	+	The entry 3t5u is ON HOLD until Paper Publication

	Authors: Di Fiore, A., Maresca, A., Alterio, V., Supuran, C.T., De Simone, G.		Authors: Di Fiore, A., Maresca, A., Alterio, V., Supuran, C.T., De Simone, G.

	Description: Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide		Description: Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide

OCA at 05:34, 10 August 2011

2011-08-10T05:34:47Z

←Older revision		Revision as of 05:34, 10 August 2011
Line 3:		Line 3:
	The entry 3t5u is ON HOLD		The entry 3t5u is ON HOLD

-	Authors: Di Fiore, A., Maresca, A., Alterio, V., Supuran, C. T., De Simone, G.	+	Authors: Di Fiore, A., Maresca, A., Alterio, V., Supuran, C.T., De Simone, G.

	Description: Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide		Description: Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide

OCA: Protected "3t5u" [edit=sysop:move=sysop]

2011-08-03T08:28:16Z

Protected "3t5u" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:28, 3 August 2011

OCA: New page: '''Unreleased structure''' The entry 3t5u is ON HOLD Authors: Di Fiore, A., Maresca, A., Alterio, V., Supuran, C. T., De Simone, G. Description: Crystal structure of the human carbonic...

2011-08-03T08:28:15Z

New page: '''Unreleased structure''' The entry 3t5u is ON HOLD Authors: Di Fiore, A., Maresca, A., Alterio, V., Supuran, C. T., De Simone, G. Description: Crystal structure of the human carbonic...

New page

'''Unreleased structure'''

The entry 3t5u is ON HOLD

Authors: Di Fiore, A., Maresca, A., Alterio, V., Supuran, C. T., De Simone, G.

Description: Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide