3tbd - Revision history

OCA at 10:00, 21 December 2022

2022-12-21T10:00:43Z

←Older revision		Revision as of 10:00, 21 December 2022
Line 3:		Line 3:
	<StructureSection load='3tbd' size='340' side='right'caption='[[3tbd]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3tbd' size='340' side='right'caption='[[3tbd]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL~~</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4~~</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">NTNG2, KIAA1857, LMNT2, UNQ9381/PRO34206 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbd OCA], [https://pdbe.org/3tbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbd RCSB], [https://www.ebi.ac.uk/pdbsum/3tbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbd OCA], [https://pdbe.org/3tbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbd RCSB], [https://www.ebi.ac.uk/pdbsum/3tbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NTNG2_HUMAN NTNG2_HUMAN]] Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.<ref>PMID:21946559</ref>	+	[https://www.uniprot.org/uniprot/NTNG2_HUMAN NTNG2_HUMAN] Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.<ref>PMID:21946559</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brasch, J]]	+	[[Category: Brasch J]]
-	[[Category: Liu, Q]]	+	[[Category: Liu Q]]
-	[[Category: Shapiro, L]]	+	[[Category: Shapiro L]]
-	~~[[Category: Axonal]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Domain vi]]~~	+
-	~~[[Category: Laminin n-terminal domain]]~~	+
-	~~[[Category: Le-domain]]~~	+
-	~~[[Category: Lrrc4]]~~	+
-	~~[[Category: Nervous system]]~~	+
-	~~[[Category: Netrin]]~~	+
-	~~[[Category: Netrin g ligand 2]]~~	+
-	~~[[Category: Netrin-g]]~~	+
-	~~[[Category: Neuronal cell adhesion molecule]]~~	+
-	~~[[Category: Neuronal synapse]]~~	+
-	~~[[Category: Ngl-2~~]]	+

OCA at 16:51, 6 July 2022

2022-07-06T16:51:01Z

←Older revision		Revision as of 16:51, 6 July 2022
Line 1:		Line 1:

	==Crystal Structure of domain VI and LE1 of human Netrin-G2==		==Crystal Structure of domain VI and LE1 of human Netrin-G2==
-	<StructureSection load='3tbd' size='340' side='right' caption='[[3tbd]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3tbd' size='340' side='right'caption='[[3tbd]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tbd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TBD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NTNG2, KIAA1857, LMNT2, UNQ9381/PRO34206 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NTNG2, KIAA1857, LMNT2, UNQ9381/PRO34206 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3tbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbd OCA], [~~http~~://pdbe.org/3tbd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3tbd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3tbd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbd OCA], [https://pdbe.org/3tbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbd RCSB], [https://www.ebi.ac.uk/pdbsum/3tbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NTNG2_HUMAN NTNG2_HUMAN]] Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.<ref>PMID:21946559</ref>	+	[[https://www.uniprot.org/uniprot/NTNG2_HUMAN NTNG2_HUMAN]] Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.<ref>PMID:21946559</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Brasch, J]]		[[Category: Brasch, J]]
	[[Category: Liu, Q]]		[[Category: Liu, Q]]

OCA at 13:47, 4 August 2016

2016-08-04T13:47:11Z

←Older revision		Revision as of 13:47, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of domain VI and LE1 of human Netrin-G2==		==Crystal Structure of domain VI and LE1 of human Netrin-G2==
	<StructureSection load='3tbd' size='340' side='right' caption='[[3tbd]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3tbd' size='340' side='right' caption='[[3tbd]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3tbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3tbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NTNG2, KIAA1857, LMNT2, UNQ9381/PRO34206 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NTNG2, KIAA1857, LMNT2, UNQ9381/PRO34206 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbd RCSB], [http://www.ebi.ac.uk/pdbsum/3tbd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbd OCA], [http://pdbe.org/3tbd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tbd RCSB], [http://www.ebi.ac.uk/pdbsum/3tbd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3tbd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Netrin\|Netrin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Brasch, J]]		[[Category: Brasch, J]]
	[[Category: Liu, Q]]		[[Category: Liu, Q]]

OCA at 15:14, 24 December 2014

2014-12-24T15:14:56Z

←Older revision		Revision as of 15:14, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3tbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBD FirstGlance]. <br>		<table><tr><td colspan='2'>[[3tbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NTNG2, KIAA1857, LMNT2, UNQ9381/PRO34206 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NTNG2, KIAA1857, LMNT2, UNQ9381/PRO34206 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbd RCSB], [http://www.ebi.ac.uk/pdbsum/3tbd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbd RCSB], [http://www.ebi.ac.uk/pdbsum/3tbd PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NTNG2_HUMAN NTNG2_HUMAN]] Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.<ref>PMID:21946559</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 15:
	Crystal structure of the ligand binding domain of netrin g2.,Brasch J, Harrison OJ, Ahlsen G, Liu Q, Shapiro L J Mol Biol. 2011 Dec 16;414(5):723-34. Epub 2011 Oct 25. PMID:22041449<ref>PMID:22041449</ref>		Crystal structure of the ligand binding domain of netrin g2.,Brasch J, Harrison OJ, Ahlsen G, Liu Q, Shapiro L J Mol Biol. 2011 Dec 16;414(5):723-34. Epub 2011 Oct 25. PMID:22041449<ref>PMID:22041449</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Brasch, J.]]	+	[[Category: Brasch, J]]
-	[[Category: Liu, Q.]]	+	[[Category: Liu, Q]]
-	[[Category: Shapiro, L.]]	+	[[Category: Shapiro, L]]
	[[Category: Axonal]]		[[Category: Axonal]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 06:07, 5 June 2014

2014-06-05T06:07:23Z

←Older revision		Revision as of 06:07, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3tbd.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of domain VI and LE1 of human Netrin-G2==
		+	<StructureSection load='3tbd' size='340' side='right' caption='[[3tbd]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3tbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NTNG2, KIAA1857, LMNT2, UNQ9381/PRO34206 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbd RCSB], [http://www.ebi.ac.uk/pdbsum/3tbd PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Netrin G proteins represent a small family of synaptic cell adhesion molecules related to netrins and to the polymerization domains of laminins. Two netrin G proteins are encoded in vertebrate genomes, netrins G1 and G2, which are known to bind the leucine-rich repeat proteins netrin G ligand (NGL)-1 and NGL-2, respectively. Netrin G proteins share a common multi-domain architecture comprising a laminin N-terminal (LN) domain followed by three laminin epidermal growth factor-like (LE) domains and a C' region containing a glycosylphosphatidylinositol anchor. Here, we use deletion analysis to show that the LN domain region of netrin Gs contains the binding site for NGLs to which they bind with 1:1 stoichiometry and sub-micromolar affinity. Netrin Gs are alternatively spliced in their LE domain regions, but the binding region, the LN domain, is identical in all splice forms. We determined the crystal structure for a fragment comprising the LN domain and domain LE1 of netrin G2 by sulfur single-wavelength anomalous diffraction phasing and refined it to 1.8 A resolution. The structure reveals an overall architecture similar to that of laminin alpha chain LN domains but includes significant differences including a Ca(2+) binding site in the LN domain. These results reveal the minimal binding unit for interaction of netrin Gs with NGLs, define structural features specific to netrin Gs, and suggest that netrin G alternative splicing is not involved in NGL recognition.

-	~~<!--~~	+	Crystal structure of the ligand binding domain of netrin g2.,Brasch J, Harrison OJ, Ahlsen G, Liu Q, Shapiro L J Mol Biol. 2011 Dec 16;414(5):723-34. Epub 2011 Oct 25. PMID:22041449<ref>PMID:22041449</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3tbd"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3tbd\| PDB=3tbd \| SCENE= }}~~	+

-	~~===Crystal Structure~~ of ~~domain VI and LE1 of human Netrin-G2===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22041449}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22041449 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22041449}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3tbd]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022041449<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brasch, J.]]		[[Category: Brasch, J.]]

OCA at 05:39, 11 January 2012

2012-01-11T05:39:17Z

←Older revision		Revision as of 05:39, 11 January 2012
Line 1:		Line 1:
-	[[Image:3tbd.~~jpg~~\|left\|200px]]	+	[[Image:3tbd.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal Structure of domain VI and LE1 of human Netrin-G2===		===Crystal Structure of domain VI and LE1 of human Netrin-G2===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22041449}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22041449 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22041449}}

	==About this Structure==		==About this Structure==
	[[3tbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA].		[[3tbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022041449</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brasch, J.]]		[[Category: Brasch, J.]]

OCA at 08:36, 2 November 2011

2011-11-02T08:36:45Z

←Older revision		Revision as of 08:36, 2 November 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3tbd.jpg\|left\|200px]]

-	The ~~entry 3tbd~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3tbd", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3tbd\| PDB=3tbd \| SCENE= }}

-	~~Authors: Brasch, J., Liu, Q., Shapiro, L.~~	+	===Crystal Structure of domain VI and LE1 of human Netrin-G2===

-	~~Description: Crystal~~ Structure of domain ~~VI and LE1 of human~~ Netrin-G2	+
		+	==About this Structure==
		+	[[3tbd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBD OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Brasch, J.]]
		+	[[Category: Liu, Q.]]
		+	[[Category: Shapiro, L.]]
		+	[[Category: Axonal]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Domain vi]]
		+	[[Category: Laminin n-terminal domain]]
		+	[[Category: Le-domain]]
		+	[[Category: Lrrc4]]
		+	[[Category: Nervous system]]
		+	[[Category: Netrin]]
		+	[[Category: Netrin g ligand 2]]
		+	[[Category: Netrin-g]]
		+	[[Category: Neuronal cell adhesion molecule]]
		+	[[Category: Neuronal synapse]]
		+	[[Category: Ngl-2]]

OCA at 06:02, 14 September 2011

2011-09-14T06:02:54Z

←Older revision		Revision as of 06:02, 14 September 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3tbd is ON HOLD	+	The entry 3tbd is ON HOLD until Paper Publication

	Authors: Brasch, J., Liu, Q., Shapiro, L.		Authors: Brasch, J., Liu, Q., Shapiro, L.

	Description: Crystal Structure of domain VI and LE1 of human Netrin-G2		Description: Crystal Structure of domain VI and LE1 of human Netrin-G2

OCA at 07:10, 24 August 2011

2011-08-24T07:10:02Z

←Older revision		Revision as of 07:10, 24 August 2011
Line 3:		Line 3:
	The entry 3tbd is ON HOLD		The entry 3tbd is ON HOLD

-	Authors: ~~Julia~~ Brasch, ~~Qun~~ Liu, ~~Lawrence~~ Shapiro	+	Authors: Brasch, J., Liu, Q., Shapiro, L.

	Description: Crystal Structure of domain VI and LE1 of human Netrin-G2		Description: Crystal Structure of domain VI and LE1 of human Netrin-G2

OCA: Protected "3tbd" [edit=sysop:move=sysop]

2011-08-17T05:55:55Z

Protected "3tbd" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:55, 17 August 2011