3ts6 - Revision history

OCA at 08:17, 6 December 2023

2023-12-06T08:17:06Z

←Older revision		Revision as of 08:17, 6 December 2023
Line 3:		Line 3:
	<StructureSection load='3ts6' size='340' side='right'caption='[[3ts6]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='3ts6' size='340' side='right'caption='[[3ts6]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ts6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mpmv Mpmv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TS6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ts6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mason-Pfizer_monkey_virus Mason-Pfizer monkey virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TS6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=UMP:2~~-~~DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.84Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2d4n\|2d4n]]~~, [[2d4l\|2d4l]], [[2d4m\|2d4m]], [[3tp1\|3tp1]], [[3tpn\|3tpn]], [[3tps\|3tps]], [[3tpw\|3tpw]], [[3tpy\|3tpy]], [[3tq3\|3tq3]], [[3tq4\|3tq4]], [[3tq5\|3tq5]], [[3trl\|3trl]], [[3trn\|3trn]], [[3tsl\|3tsl]], [[3tta\|3tta]]<~~/div></td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">GAG~~-~~PRO ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5~~&id=11855 MPMV])</td></tr>~~	+
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ts6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ts6 OCA], [https://pdbe.org/3ts6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ts6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ts6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ts6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ts6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ts6 OCA], [https://pdbe.org/3ts6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ts6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ts6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ts6 ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/PRO_MPMV PRO_MPMV] Matrix protein. Nucleocapsid protein p14: Nucleocapsid protein. Capsid protein. The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell.[PROSITE-ProRule:PRU00275]<ref>PMID:9636364</ref> The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell.[PROSITE-ProRule:PRU00275]<ref>PMID:9636364</ref> Enhances the activity of the reverse transcriptase. May be part of the mature RT.<ref>PMID:22171253</ref>
-	~~Deoxyuridine 5'-triphosphate nucleotidohydrolase from Mason-Pfizer monkey retrovirus (M-PMV dUTPase) is a betaretroviral member of the dUTPase enzyme family~~. ~~In the mature M-PMV virion, this enzyme is present as the C-terminal domain of the fusion~~ protein ~~nucleocapsid-dUTPase~~. ~~The homotrimeric organization characteristic of dUTPases is retained in this bifunctional fusion~~ protein. ~~The fusion~~ protein ~~supposedly plays a role in adequate localization~~ of ~~dUTPase activity in~~ the ~~vicinity~~ of ~~nucleic acids during reverse transcription and integration~~. ~~Here~~, ~~the nucleocapsid~~-~~free dUTPase (48 426 Da) was cocrystallized with a dUTP substrate analogue using the hanging-drop vapour-diffusion method~~. ~~The obtained crystals belong~~ to the ~~primitive hexagonal space group P6(3), with unit-~~cell ~~parameters a = 60~~.~~6, b = 60.6, c = 63.6 angstroms, alpha = 90, beta = 90, gamma = 120 degrees. Native and PtCl4~~-~~derivative data sets were collected using synchrotron radiation to 1.75~~ and ~~2.3 angstroms, respectively. Phasing was successfully performed by isomorphous replacement combined with anomalous scattering.~~	+
-		+
-	~~Crystallization and preliminary X~~-~~ray studies~~ of ~~dUTPase~~ from ~~Mason-Pfizer monkey retrovirus~~.,~~Barabas O, Nemeth V, Vertessy BG Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):399~~-~~401~~. ~~Epub 2006 Mar 25~~. ~~PMID~~:~~16582495~~<ref>PMID:~~16582495~~</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database~~ of the U.~~S. National Library~~ of ~~Medicine~~.<br>	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3ts6" style="background-color~~:~~#fffaf0;">~~</~~div~~>	+

	==See Also==		==See Also==
Line 28:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mpmv]]~~	+	[[Category: Mason-Pfizer monkey virus]]
-	~~[[Category: DUTP diphosphatase~~]]	+	[[Category: Barabas O]]
-	[[Category: Barabas, O]]	+	[[Category: Nemeth V]]
-	[[Category: Nemeth, V]]	+	[[Category: Vertessy GB]]
-	[[Category: Vertessy~~, G B]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Jelly roll~~]]	+

OCA at 17:10, 6 July 2022

2022-07-06T17:10:39Z

←Older revision		Revision as of 17:10, 6 July 2022
Line 1:		Line 1:

	==Crystal structure of M-PMV DUTPASE relaxed end-product (dUMP) complex==		==Crystal structure of M-PMV DUTPASE relaxed end-product (dUMP) complex==
-	<StructureSection load='3ts6' size='340' side='right' caption='[[3ts6]], [[Resolution\|resolution]] 1.84Å' scene=''>	+	<StructureSection load='3ts6' size='340' side='right'caption='[[3ts6]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ts6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mpmv Mpmv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TS6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ts6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mpmv Mpmv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TS6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d4n\|2d4n]], [[2d4l\|2d4l]], [[2d4m\|2d4m]], [[3tp1\|3tp1]], [[3tpn\|3tpn]], [[3tps\|3tps]], [[3tpw\|3tpw]], [[3tpy\|3tpy]], [[3tq3\|3tq3]], [[3tq4\|3tq4]], [[3tq5\|3tq5]], [[3trl\|3trl]], [[3trn\|3trn]], [[3tsl\|3tsl]], [[3tta\|3tta]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2d4n\|2d4n]], [[2d4l\|2d4l]], [[2d4m\|2d4m]], [[3tp1\|3tp1]], [[3tpn\|3tpn]], [[3tps\|3tps]], [[3tpw\|3tpw]], [[3tpy\|3tpy]], [[3tq3\|3tq3]], [[3tq4\|3tq4]], [[3tq5\|3tq5]], [[3trl\|3trl]], [[3trn\|3trn]], [[3tsl\|3tsl]], [[3tta\|3tta]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAG-PRO ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11855 MPMV])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAG-PRO ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11855 MPMV])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ts6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ts6 OCA], [~~http~~://pdbe.org/3ts6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ts6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ts6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ts6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ts6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ts6 OCA], [https://pdbe.org/3ts6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ts6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ts6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ts6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3ts6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ts6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DUTPase 3D structures\|DUTPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mpmv]]		[[Category: Mpmv]]
	[[Category: DUTP diphosphatase]]		[[Category: DUTP diphosphatase]]

OCA at 09:56, 8 November 2017

2017-11-08T09:56:10Z

←Older revision		Revision as of 09:56, 8 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 3ts6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3ts6" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase\|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:54, 10 December 2016

2016-12-10T18:54:39Z

←Older revision		Revision as of 18:54, 10 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of M-PMV DUTPASE relaxed end-product (dUMP) complex==		==Crystal structure of M-PMV DUTPASE relaxed end-product (dUMP) complex==
	<StructureSection load='3ts6' size='340' side='right' caption='[[3ts6]], [[Resolution\|resolution]] 1.84Å' scene=''>		<StructureSection load='3ts6' size='340' side='right' caption='[[3ts6]], [[Resolution\|resolution]] 1.84Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ts6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mason-pfizer_monkey_virus Mason-pfizer monkey virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TS6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ts6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mpmv Mpmv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TS6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d4n\|2d4n]], [[2d4l\|2d4l]], [[2d4m\|2d4m]], [[3tp1\|3tp1]], [[3tpn\|3tpn]], [[3tps\|3tps]], [[3tpw\|3tpw]], [[3tpy\|3tpy]], [[3tq3\|3tq3]], [[3tq4\|3tq4]], [[3tq5\|3tq5]], [[3trl\|3trl]], [[3trn\|3trn]], [[3tsl\|3tsl]], [[3tta\|3tta]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d4n\|2d4n]], [[2d4l\|2d4l]], [[2d4m\|2d4m]], [[3tp1\|3tp1]], [[3tpn\|3tpn]], [[3tps\|3tps]], [[3tpw\|3tpw]], [[3tpy\|3tpy]], [[3tq3\|3tq3]], [[3tq4\|3tq4]], [[3tq5\|3tq5]], [[3trl\|3trl]], [[3trn\|3trn]], [[3tsl\|3tsl]], [[3tta\|3tta]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAG-PRO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11855 ~~Mason-Pfizer monkey virus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAG-PRO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11855 MPMV])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ts6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ts6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ts6 RCSB], [http://www.ebi.ac.uk/pdbsum/3ts6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ts6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ts6 OCA], [http://pdbe.org/3ts6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ts6 RCSB], [http://www.ebi.ac.uk/pdbsum/3ts6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ts6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ts6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mason-pfizer monkey virus~~]]	+	[[Category: Mpmv]]
	[[Category: DUTP diphosphatase]]		[[Category: DUTP diphosphatase]]
	[[Category: Barabas, O]]		[[Category: Barabas, O]]

OCA at 14:17, 9 December 2014

2014-12-09T14:17:02Z

←Older revision		Revision as of 14:17, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3ts6.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of M-PMV DUTPASE relaxed end-product (dUMP) complex==
		+	<StructureSection load='3ts6' size='340' side='right' caption='[[3ts6]], [[Resolution\|resolution]] 1.84Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ts6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mason-pfizer_monkey_virus Mason-pfizer monkey virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TS6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d4n\|2d4n]], [[2d4l\|2d4l]], [[2d4m\|2d4m]], [[3tp1\|3tp1]], [[3tpn\|3tpn]], [[3tps\|3tps]], [[3tpw\|3tpw]], [[3tpy\|3tpy]], [[3tq3\|3tq3]], [[3tq4\|3tq4]], [[3tq5\|3tq5]], [[3trl\|3trl]], [[3trn\|3trn]], [[3tsl\|3tsl]], [[3tta\|3tta]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GAG-PRO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11855 Mason-Pfizer monkey virus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ts6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ts6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ts6 RCSB], [http://www.ebi.ac.uk/pdbsum/3ts6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Deoxyuridine 5'-triphosphate nucleotidohydrolase from Mason-Pfizer monkey retrovirus (M-PMV dUTPase) is a betaretroviral member of the dUTPase enzyme family. In the mature M-PMV virion, this enzyme is present as the C-terminal domain of the fusion protein nucleocapsid-dUTPase. The homotrimeric organization characteristic of dUTPases is retained in this bifunctional fusion protein. The fusion protein supposedly plays a role in adequate localization of dUTPase activity in the vicinity of nucleic acids during reverse transcription and integration. Here, the nucleocapsid-free dUTPase (48 426 Da) was cocrystallized with a dUTP substrate analogue using the hanging-drop vapour-diffusion method. The obtained crystals belong to the primitive hexagonal space group P6(3), with unit-cell parameters a = 60.6, b = 60.6, c = 63.6 angstroms, alpha = 90, beta = 90, gamma = 120 degrees. Native and PtCl4-derivative data sets were collected using synchrotron radiation to 1.75 and 2.3 angstroms, respectively. Phasing was successfully performed by isomorphous replacement combined with anomalous scattering.

-	~~{{STRUCTURE_3ts6\| PDB=3ts6 \| SCENE= }}~~	+	Crystallization and preliminary X-ray studies of dUTPase from Mason-Pfizer monkey retrovirus.,Barabas O, Nemeth V, Vertessy BG Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):399-401. Epub 2006 Mar 25. PMID:16582495<ref>PMID:16582495</ref>

-	~~===Crystal structure~~ of ~~M-PMV DUTPASE relaxed end-product (dUMP) complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16582495}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ts6]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mason-pfizer_monkey_virus Mason-pfizer monkey virus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA].~~	+

	==See Also==		==See Also==
	*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase\|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]		*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase\|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016582495<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mason-pfizer monkey virus]]		[[Category: Mason-pfizer monkey virus]]
	[[Category: DUTP diphosphatase]]		[[Category: DUTP diphosphatase]]
-	[[Category: Barabas, O.]]	+	[[Category: Barabas, O]]
-	[[Category: Nemeth, V.]]	+	[[Category: Nemeth, V]]
-	[[Category: Vertessy, G B.]]	+	[[Category: Vertessy, G B]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Jelly roll]]		[[Category: Jelly roll]]

OCA at 18:40, 20 October 2012

2012-10-20T18:40:48Z

←Older revision		Revision as of 18:40, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ts6]] is a 1 chain structure ~~of [[Deoxyuridine 5'-triphosphate nucleotidohydrolase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mason-pfizer_monkey_virus Mason-pfizer monkey virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA].	+	[[3ts6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mason-pfizer_monkey_virus Mason-pfizer monkey virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA].

	==See Also==		==See Also==

OCA at 04:52, 27 July 2012

2012-07-27T04:52:03Z

←Older revision		Revision as of 04:52, 27 July 2012
Line 1:		Line 1:
	[[Image:3ts6.png\|left\|200px]]		[[Image:3ts6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ts6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ts6\| PDB=3ts6 \| SCENE= }}		{{STRUCTURE_3ts6\| PDB=3ts6 \| SCENE= }}

	===Crystal structure of M-PMV DUTPASE relaxed end-product (dUMP) complex===		===Crystal structure of M-PMV DUTPASE relaxed end-product (dUMP) complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16582495}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16582495 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16582495}}		{{ABSTRACT_PUBMED_16582495}}

	==About this Structure==		==About this Structure==
-	[[3ts6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mason-pfizer_monkey_virus Mason-pfizer monkey virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA].	+	[[3ts6]] is a 1 chain structure of [[Deoxyuridine 5'-triphosphate nucleotidohydrolase]] with sequence from [http://en.wikipedia.org/wiki/Mason-pfizer_monkey_virus Mason-pfizer monkey virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA].
		+
		+	==See Also==
		+	*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase\|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]

	==Reference==		==Reference==

OCA at 09:51, 30 October 2011

2011-10-30T09:51:59Z

←Older revision		Revision as of 09:51, 30 October 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3ts6.png\|left\|200px]]

-	The ~~entry 3ts6~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ts6", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ts6\| PDB=3ts6 \| SCENE= }}

-	~~Authors: Nemeth, V., Barabas, O., Vertessy, G.B.~~	+	===Crystal structure of M-PMV DUTPASE relaxed end-product (dUMP) complex===

-	~~Description: Crystal structure of M~~-~~PMV DUTPASE relaxed end~~-~~product~~ (~~dUMP~~) ~~complex~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_16582495}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16582495 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16582495}}
		+
		+	==About this Structure==
		+	[[3ts6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mason-pfizer_monkey_virus Mason-pfizer monkey virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TS6 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:016582495</ref><references group="xtra"/>
		+	[[Category: Mason-pfizer monkey virus]]
		+	[[Category: DUTP diphosphatase]]
		+	[[Category: Barabas, O.]]
		+	[[Category: Nemeth, V.]]
		+	[[Category: Vertessy, G B.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Jelly roll]]

OCA: Protected "3ts6" [edit=sysop:move=sysop]

2011-09-21T05:33:37Z

Protected "3ts6" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:33, 21 September 2011

OCA: New page: '''Unreleased structure''' The entry 3ts6 is ON HOLD Authors: Nemeth, V., Barabas, O., Vertessy, G.B. Description: Crystal structure of M-PMV DUTPASE relaxed end-product (dUMP) complex

2011-09-21T05:33:36Z

New page: '''Unreleased structure''' The entry 3ts6 is ON HOLD Authors: Nemeth, V., Barabas, O., Vertessy, G.B. Description: Crystal structure of M-PMV DUTPASE relaxed end-product (dUMP) complex

New page

'''Unreleased structure'''

The entry 3ts6 is ON HOLD

Authors: Nemeth, V., Barabas, O., Vertessy, G.B.

Description: Crystal structure of M-PMV DUTPASE relaxed end-product (dUMP) complex