3twi - Revision history

OCA at 13:41, 14 March 2024

2024-03-14T13:41:47Z

←Older revision		Revision as of 13:41, 14 March 2024
Line 3:		Line 3:
	<StructureSection load='3twi' size='340' side='right'caption='[[3twi]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='3twi' size='340' side='right'caption='[[3twi]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3twi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var.~~ anthracis~~" (cohn 1872) smith et al. 1946~~] and [https://en.wikipedia.org/wiki/~~Petma Petma~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TWI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3twi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [https://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TWI FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[2r6q\|2r6q]]~~, [[~~3tyj~~\|~~3tyj~~]]~~</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>bclA, BA_1222, GBAA_1222 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1392~~ "~~Bacillus cereus var. anthracis~~" ~~(Cohn 1872) Smith et al. 1946]), VLR-B ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7757 PETMA])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3twi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twi OCA], [https://pdbe.org/3twi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3twi RCSB], [https://www.ebi.ac.uk/pdbsum/3twi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3twi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3twi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twi OCA], [https://pdbe.org/3twi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3twi RCSB], [https://www.ebi.ac.uk/pdbsum/3twi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3twi ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q81JD7_BACAN Q81JD7_BACAN]
-	Variable lymphocyte receptors (VLRs) are the adaptive immune receptors of jawless fish, which evolved adaptive immunity independent of other vertebrates. In lieu of the immunoglobulin fold-based T and B cell receptors, lymphocyte-like cells of jawless fish express VLRs (VLRA, VLRB, or VLRC) composed of leucine-rich repeats and are similar to toll-like receptors (TLRs) in structure, but antibodies (VLRB) and T cell receptors (VLRA and VLRC) in function. Here, we present the structural and biochemical characterization of VLR4, a VLRB, in complex with BclA, the immunodominant glycoprotein of Bacillus anthracis spores. Using a combination of crystallography, mutagenesis, and binding studies, we delineate the mode of antigen recognition and binding between VLR4 and BclA, examine commonalities in VLRB recognition of antigens, and demonstrate the potential of VLR4 as a diagnostic tool for the identification of B. anthracis spores.	+
-		+
-	Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores.,Kirchdoerfer RN, Herrin BR, Han BW, Turnbough CL Jr, Cooper MD, Wilson IA Structure. 2012 Mar 7;20(3):~~479-86. PMID:22405006<ref>PMID:22405006<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 3twi" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Variable lymphocyte receptor 3D structures\|Variable lymphocyte receptor 3D structures]]		*[[Variable lymphocyte receptor 3D structures\|Variable lymphocyte receptor 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus anthracis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Petma~~]]	+	[[Category: Petromyzon marinus]]
-	[[Category: Cooper~~, M D~~]]	+	[[Category: Cooper MD]]
-	[[Category: Han~~, B W~~]]	+	[[Category: Han BW]]
-	[[Category: Herrin~~, B R~~]]	+	[[Category: Herrin BR]]
-	[[Category: Kirchdoerfer~~, R N~~]]	+	[[Category: Kirchdoerfer RN]]
-	[[Category: Turnbough~~, C L~~]]	+	[[Category: Turnbough Jr CL]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Antigen-binding]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Leucine-rich repeat]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 05:48, 13 July 2022

2022-07-13T05:48:23Z

←Older revision		Revision as of 05:48, 13 July 2022
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	==Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores==		==Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores==
-	<StructureSection load='3twi' size='340' side='right' caption='[[3twi]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='3twi' size='340' side='right'caption='[[3twi]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3twi]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946] and [~~http~~://en.wikipedia.org/wiki/Petma Petma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3TWI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3twi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946] and [https://en.wikipedia.org/wiki/Petma Petma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TWI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r6q\|2r6q]], [[3tyj\|3tyj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2r6q\|2r6q]], [[3tyj\|3tyj]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bclA, BA_1222, GBAA_1222 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946]), VLR-B ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7757 PETMA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bclA, BA_1222, GBAA_1222 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946]), VLR-B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7757 PETMA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3twi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twi OCA], [~~http~~://pdbe.org/3twi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3twi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3twi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3twi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3twi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twi OCA], [https://pdbe.org/3twi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3twi RCSB], [https://www.ebi.ac.uk/pdbsum/3twi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3twi ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Variable lymphocyte receptor\|Variable lymphocyte receptor]]	+	*[[Variable lymphocyte receptor 3D structures\|Variable lymphocyte receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Petma]]		[[Category: Petma]]
	[[Category: Cooper, M D]]		[[Category: Cooper, M D]]

OCA at 10:54, 11 August 2016

2016-08-11T10:54:26Z

←Older revision		Revision as of 10:54, 11 August 2016
Line 1:		Line 1:
		+
	==Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores==		==Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores==
	<StructureSection load='3twi' size='340' side='right' caption='[[3twi]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='3twi' size='340' side='right' caption='[[3twi]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3twi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_anthracis Bacillus~~ anthracis] and [http://en.wikipedia.org/wiki/~~Petromyzon_marinus Petromyzon marinus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TWI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3twi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946] and [http://en.wikipedia.org/wiki/Petma Petma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TWI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r6q\|2r6q]], [[3tyj\|3tyj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r6q\|2r6q]], [[3tyj\|3tyj]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bclA, BA_1222, GBAA_1222 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis]), VLR-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7757 ~~Petromyzon marinus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bclA, BA_1222, GBAA_1222 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946]), VLR-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7757 PETMA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3twi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3twi RCSB], [http://www.ebi.ac.uk/pdbsum/3twi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3twi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twi OCA], [http://pdbe.org/3twi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3twi RCSB], [http://www.ebi.ac.uk/pdbsum/3twi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3twi ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3twi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus anthracis]]~~	+	[[Category: Petma]]
-	~~[[Category: Petromyzon marinus~~]]	+
	[[Category: Cooper, M D]]		[[Category: Cooper, M D]]
	[[Category: Han, B W]]		[[Category: Han, B W]]

OCA at 09:26, 4 January 2015

2015-01-04T09:26:54Z

←Older revision		Revision as of 09:26, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3twi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TWI FirstGlance]. <br>		<table><tr><td colspan='2'>[[3twi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TWI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r6q\|2r6q]], [[3tyj\|3tyj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r6q\|2r6q]], [[3tyj\|3tyj]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bclA, BA_1222, GBAA_1222 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis]), VLR-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7757 Petromyzon marinus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bclA, BA_1222, GBAA_1222 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis]), VLR-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7757 Petromyzon marinus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3twi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3twi RCSB], [http://www.ebi.ac.uk/pdbsum/3twi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3twi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3twi RCSB], [http://www.ebi.ac.uk/pdbsum/3twi PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores.,Kirchdoerfer RN, Herrin BR, Han BW, Turnbough CL Jr, Cooper MD, Wilson IA Structure. 2012 Mar 7;20(3):479-86. PMID:22405006<ref>PMID:22405006</ref>		Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores.,Kirchdoerfer RN, Herrin BR, Han BW, Turnbough CL Jr, Cooper MD, Wilson IA Structure. 2012 Mar 7;20(3):479-86. PMID:22405006<ref>PMID:22405006</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Variable lymphocyte receptor\|Variable lymphocyte receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 25:
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: Petromyzon marinus]]		[[Category: Petromyzon marinus]]
-	[[Category: Cooper, M D.]]	+	[[Category: Cooper, M D]]
-	[[Category: Han, B W.]]	+	[[Category: Han, B W]]
-	[[Category: Herrin, B R.]]	+	[[Category: Herrin, B R]]
-	[[Category: Kirchdoerfer, R N.]]	+	[[Category: Kirchdoerfer, R N]]
-	[[Category: Turnbough, C L.]]	+	[[Category: Turnbough, C L]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
	[[Category: Antigen-binding]]		[[Category: Antigen-binding]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Leucine-rich repeat]]		[[Category: Leucine-rich repeat]]
	[[Category: Secreted]]		[[Category: Secreted]]

OCA at 05:58, 5 June 2014

2014-06-05T05:58:50Z

←Older revision		Revision as of 05:58, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3twi.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores==
		+	<StructureSection load='3twi' size='340' side='right' caption='[[3twi]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3twi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TWI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2r6q\|2r6q]], [[3tyj\|3tyj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bclA, BA_1222, GBAA_1222 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis]), VLR-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7757 Petromyzon marinus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3twi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3twi RCSB], [http://www.ebi.ac.uk/pdbsum/3twi PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Variable lymphocyte receptors (VLRs) are the adaptive immune receptors of jawless fish, which evolved adaptive immunity independent of other vertebrates. In lieu of the immunoglobulin fold-based T and B cell receptors, lymphocyte-like cells of jawless fish express VLRs (VLRA, VLRB, or VLRC) composed of leucine-rich repeats and are similar to toll-like receptors (TLRs) in structure, but antibodies (VLRB) and T cell receptors (VLRA and VLRC) in function. Here, we present the structural and biochemical characterization of VLR4, a VLRB, in complex with BclA, the immunodominant glycoprotein of Bacillus anthracis spores. Using a combination of crystallography, mutagenesis, and binding studies, we delineate the mode of antigen recognition and binding between VLR4 and BclA, examine commonalities in VLRB recognition of antigens, and demonstrate the potential of VLR4 as a diagnostic tool for the identification of B. anthracis spores.

-	~~<!--~~	+	Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores.,Kirchdoerfer RN, Herrin BR, Han BW, Turnbough CL Jr, Cooper MD, Wilson IA Structure. 2012 Mar 7;20(3):479-86. PMID:22405006<ref>PMID:22405006</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3twi"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3twi\| PDB=3twi \| SCENE= }}~~	+

-	~~===Variable Lymphocyte Receptor Recognition~~ of the ~~Immunodominant Glycoprotein of Bacillus anthracis Spores===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22405006}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22405006 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22405006}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3twi]] is a 6 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022405006<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: Petromyzon marinus]]		[[Category: Petromyzon marinus]]

OCA at 06:46, 28 March 2012

2012-03-28T06:46:54Z

←Older revision		Revision as of 06:46, 28 March 2012
Line 11:		Line 11:
	===Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores===		===Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22405006}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22405006 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22405006}}

	==About this Structure==		==About this Structure==
	[[3twi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA].		[[3twi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022405006</ref><references group="xtra"/>
	[[Category: Bacillus anthracis]]		[[Category: Bacillus anthracis]]
	[[Category: Petromyzon marinus]]		[[Category: Petromyzon marinus]]

OCA at 06:44, 14 March 2012

2012-03-14T06:44:04Z

←Older revision		Revision as of 06:44, 14 March 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3twi.jpg\|left\|200px]]

-	The ~~entry 3twi~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3twi", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3twi\| PDB=3twi \| SCENE= }}

-	~~Authors: Kirchdoerfer, R.N., Herrin, B.R., Han, B.W., Turnbough, C.L., Cooper, M.D., Wilson, I.A.~~	+	===Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores===

-	~~Description~~: ~~Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of~~ Bacillus anthracis ~~Spores~~	+
		+	==About this Structure==
		+	[[3twi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] and [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWI OCA].
		+	[[Category: Bacillus anthracis]]
		+	[[Category: Petromyzon marinus]]
		+	[[Category: Cooper, M D.]]
		+	[[Category: Han, B W.]]
		+	[[Category: Herrin, B R.]]
		+	[[Category: Kirchdoerfer, R N.]]
		+	[[Category: Turnbough, C L.]]
		+	[[Category: Wilson, I A.]]
		+	[[Category: Antigen-binding]]
		+	[[Category: Immune system]]
		+	[[Category: Leucine-rich repeat]]
		+	[[Category: Secreted]]

OCA at 08:44, 30 October 2011

2011-10-30T08:44:48Z

←Older revision		Revision as of 08:44, 30 October 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3twi is ON HOLD	+	The entry 3twi is ON HOLD until Paper Publication

	Authors: Kirchdoerfer, R.N., Herrin, B.R., Han, B.W., Turnbough, C.L., Cooper, M.D., Wilson, I.A.		Authors: Kirchdoerfer, R.N., Herrin, B.R., Han, B.W., Turnbough, C.L., Cooper, M.D., Wilson, I.A.

	Description: Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores		Description: Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores

OCA: Protected "3twi" [edit=sysop:move=sysop]

2011-09-28T05:19:18Z

Protected "3twi" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:19, 28 September 2011

OCA: New page: '''Unreleased structure''' The entry 3twi is ON HOLD Authors: Kirchdoerfer, R.N., Herrin, B.R., Han, B.W., Turnbough, C.L., Cooper, M.D., Wilson, I.A. Description: Variable Lymphocyte ...

2011-09-28T05:19:17Z

New page: '''Unreleased structure''' The entry 3twi is ON HOLD Authors: Kirchdoerfer, R.N., Herrin, B.R., Han, B.W., Turnbough, C.L., Cooper, M.D., Wilson, I.A. Description: Variable Lymphocyte ...

New page

'''Unreleased structure'''

The entry 3twi is ON HOLD

Authors: Kirchdoerfer, R.N., Herrin, B.R., Han, B.W., Turnbough, C.L., Cooper, M.D., Wilson, I.A.

Description: Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores