3u3c - Revision history

OCA: Redirecting to 4r32

2014-09-24T10:12:10Z

Redirecting to 4r32

←Older revision		Revision as of 10:12, 24 September 2014
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-	~~{{STRUCTURE_3u3c\| PDB=3u3c \| SCENE= }}~~	+	#REDIRECT [[4r32]] This PDB entry is obsolete and replaced by 4r32
-	~~===Structural Basis for the interaction of Pyk2 PAT domain with paxillin LD motifs===~~	+
-		+
-	~~==Disease==~~	+
-	[[~~http://www.uniprot.org/uniprot/FAK2_HUMAN FAK2_HUMAN~~]] ~~Note=Aberrant PTK2B/PYK2 expression may play a role in cancer cell proliferation, migration and invasion, in tumor formation and metastasis. Elevated PTK2B/PYK2 expression~~ is ~~seen in gliomas, hepatocellular carcinoma, lung cancer~~ and ~~breast cancer.<ref>PMID:18339875</ref><ref>PMID:18765415</ref><ref>PMID:19648005</ref><ref>PMID:21533080</ref><ref>PMID:20001213</ref><ref>PMID:19428251</ref><ref>PMID:19244237</ref>~~	+
-		+
-	~~==Function==~~	+
-	[[http://www.uniprot.org/uniprot/FAK2_HUMAN FAK2_HUMAN]] Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2.<ref>PMID:7544443</ref><ref>PMID:8849729</ref><ref>PMID:8670418</ref><ref>PMID:10022920</ref><ref>PMID:12771146</ref><ref>PMID:12893833</ref><ref>PMID:14585963</ref><ref>PMID:15050747</ref><ref>PMID:15166227</ref><ref>PMID:17634955</ref><ref>PMID:18339875</ref><ref>PMID:18765415</ref><ref>PMID:18086875</ref><ref>PMID:18587400</ref><ref>PMID:19207108</ref><ref>PMID:19648005</ref><ref>PMID:19086031</ref><ref>PMID:20521079</ref><ref>PMID:19880522</ref><ref>PMID:20381867</ref><ref>PMID:21357692</ref><ref>PMID:21533080</ref><ref>PMID:20001213</ref><ref>PMID:19428251</ref><ref>PMID:19244237</ref> [[http://www.uniprot.org/uniprot/PAXI_HUMAN PAXI_HUMAN]] Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).	+
-		+
-	~~==About this Structure==~~	+
-	[[3u3c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3C OCA].	+
-		+
-	~~==Reference==~~	+
-	~~<references group="xtra"/><references/>~~	+
-	~~[[Category: Homo sapiens]]~~	+
-	~~[[Category: Non-specific protein-tyrosine kinase]]~~	+
-	~~[[Category: Guibao, C C.]]~~	+
-	~~[[Category: Miller, D J.]]~~	+
-	~~[[Category: Vanarotti, M.]]~~	+
-	~~[[Category: Zheng, J J.]]~~	+
-	~~[[Category: 4-helix bundle]]~~	+
-	~~[[Category: Focal adhesion]]~~	+
-	~~[[Category: Paxillin]]~~	+
-	~~[[Category: Transferase-signaling protein complex]]~~	+
-	~~[[Category: Tyrosine kinase]]~~	+

OCA at 03:18, 25 March 2013

2013-03-25T03:18:14Z

←Older revision		Revision as of 03:18, 25 March 2013
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-	[[Image:3u3c.jpg\|left\|200px]]
-
	{{STRUCTURE_3u3c\| PDB=3u3c \| SCENE= }}		{{STRUCTURE_3u3c\| PDB=3u3c \| SCENE= }}
-
	===Structural Basis for the interaction of Pyk2 PAT domain with paxillin LD motifs===		===Structural Basis for the interaction of Pyk2 PAT domain with paxillin LD motifs===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/FAK2_HUMAN FAK2_HUMAN]] Note=Aberrant PTK2B/PYK2 expression may play a role in cancer cell proliferation, migration and invasion, in tumor formation and metastasis. Elevated PTK2B/PYK2 expression is seen in gliomas, hepatocellular carcinoma, lung cancer and breast cancer.<ref>PMID:18339875</ref><ref>PMID:18765415</ref><ref>PMID:19648005</ref><ref>PMID:21533080</ref><ref>PMID:20001213</ref><ref>PMID:19428251</ref><ref>PMID:19244237</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/FAK2_HUMAN FAK2_HUMAN]] Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2.<ref>PMID:7544443</ref><ref>PMID:8849729</ref><ref>PMID:8670418</ref><ref>PMID:10022920</ref><ref>PMID:12771146</ref><ref>PMID:12893833</ref><ref>PMID:14585963</ref><ref>PMID:15050747</ref><ref>PMID:15166227</ref><ref>PMID:17634955</ref><ref>PMID:18339875</ref><ref>PMID:18765415</ref><ref>PMID:18086875</ref><ref>PMID:18587400</ref><ref>PMID:19207108</ref><ref>PMID:19648005</ref><ref>PMID:19086031</ref><ref>PMID:20521079</ref><ref>PMID:19880522</ref><ref>PMID:20381867</ref><ref>PMID:21357692</ref><ref>PMID:21533080</ref><ref>PMID:20001213</ref><ref>PMID:19428251</ref><ref>PMID:19244237</ref> [[http://www.uniprot.org/uniprot/PAXI_HUMAN PAXI_HUMAN]] Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

	==About this Structure==		==About this Structure==
	[[3u3c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3C OCA].		[[3u3c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3C OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific protein-tyrosine kinase]]		[[Category: Non-specific protein-tyrosine kinase]]

OCA at 07:41, 24 October 2012

2012-10-24T07:41:40Z

←Older revision		Revision as of 07:41, 24 October 2012
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-	~~'''Unreleased structure'''~~	+	[[Image:3u3c.jpg\|left\|200px]]

-	~~The entry~~ 3u3c ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3u3c\| PDB=3u3c \| SCENE= }}

-	~~Authors: Vanarotti, M., Miller, D.J., Guibao, C.C., Zheng, J.J.~~	+	===Structural Basis for the interaction of Pyk2 PAT domain with paxillin LD motifs===

-	~~Description: Structural Basis for the interaction of Pyk2 PAT domain~~ with ~~paxillin LD motifs~~	+
		+	==About this Structure==
		+	[[3u3c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3C OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Non-specific protein-tyrosine kinase]]
		+	[[Category: Guibao, C C.]]
		+	[[Category: Miller, D J.]]
		+	[[Category: Vanarotti, M.]]
		+	[[Category: Zheng, J J.]]
		+	[[Category: 4-helix bundle]]
		+	[[Category: Focal adhesion]]
		+	[[Category: Paxillin]]
		+	[[Category: Transferase-signaling protein complex]]
		+	[[Category: Tyrosine kinase]]

OCA at 18:33, 23 November 2011

2011-11-23T18:33:42Z

←Older revision		Revision as of 18:33, 23 November 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3u3c is ON HOLD	+	The entry 3u3c is ON HOLD until Paper Publication

	Authors: Vanarotti, M., Miller, D.J., Guibao, C.C., Zheng, J.J.		Authors: Vanarotti, M., Miller, D.J., Guibao, C.C., Zheng, J.J.

	Description: Structural Basis for the interaction of Pyk2 PAT domain with paxillin LD motifs		Description: Structural Basis for the interaction of Pyk2 PAT domain with paxillin LD motifs

OCA: Protected "3u3c" [edit=sysop:move=sysop]

2011-10-30T08:49:34Z

Protected "3u3c" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:49, 30 October 2011

OCA: New page: '''Unreleased structure''' The entry 3u3c is ON HOLD Authors: Vanarotti, M., Miller, D.J., Guibao, C.C., Zheng, J.J. Description: Structural Basis for the interaction of Pyk2 PAT domai...

2011-10-30T08:49:34Z

New page: '''Unreleased structure''' The entry 3u3c is ON HOLD Authors: Vanarotti, M., Miller, D.J., Guibao, C.C., Zheng, J.J. Description: Structural Basis for the interaction of Pyk2 PAT domai...

New page

'''Unreleased structure'''

The entry 3u3c is ON HOLD

Authors: Vanarotti, M., Miller, D.J., Guibao, C.C., Zheng, J.J.

Description: Structural Basis for the interaction of Pyk2 PAT domain with paxillin LD motifs