3u3n - Revision history

OCA at 05:56, 13 July 2022

2022-07-13T05:56:19Z

←Older revision		Revision as of 05:56, 13 July 2022
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	<StructureSection load='3u3n' size='340' side='right'caption='[[3u3n]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3u3n' size='340' side='right'caption='[[3u3n]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u3n]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Horsefly Horsefly]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3U3N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u3n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Horsefly Horsefly]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U3N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u3u\|3u3u]], [[3u31\|3u31]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u3u\|3u3u]], [[3u31\|3u31]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3u3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3n OCA], [~~http~~://pdbe.org/3u3n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3u3n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3u3n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3u3n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3n OCA], [https://pdbe.org/3u3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u3n RCSB], [https://www.ebi.ac.uk/pdbsum/3u3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u3n ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:52, 14 August 2019

2019-08-14T17:52:29Z

←Older revision		Revision as of 17:52, 14 August 2019
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	==Crystal structure of tablysin-15==		==Crystal structure of tablysin-15==
-	<StructureSection load='3u3n' size='340' side='right' caption='[[3u3n]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='3u3n' size='340' side='right'caption='[[3u3n]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3u3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Horsefly Horsefly]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U3N FirstGlance]. <br>		<table><tr><td colspan='2'>[[3u3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Horsefly Horsefly]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U3N FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Horsefly]]		[[Category: Horsefly]]
		+	[[Category: Large Structures]]
	[[Category: Andersen, J F]]		[[Category: Andersen, J F]]
	[[Category: Alphavbeta3 integrin]]		[[Category: Alphavbeta3 integrin]]

OCA at 07:27, 11 August 2016

2016-08-11T07:27:41Z

←Older revision		Revision as of 07:27, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of tablysin-15==		==Crystal structure of tablysin-15==
	<StructureSection load='3u3n' size='340' side='right' caption='[[3u3n]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3u3n' size='340' side='right' caption='[[3u3n]], [[Resolution\|resolution]] 1.65Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u3u\|3u3u]], [[3u31\|3u31]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u3u\|3u3u]], [[3u31\|3u31]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u3n RCSB], [http://www.ebi.ac.uk/pdbsum/3u3n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3n OCA], [http://pdbe.org/3u3n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u3n RCSB], [http://www.ebi.ac.uk/pdbsum/3u3n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u3n ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3u3n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:50, 28 January 2015

2015-01-28T10:50:19Z

←Older revision		Revision as of 10:50, 28 January 2015
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	<StructureSection load='3u3n' size='340' side='right' caption='[[3u3n]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3u3n' size='340' side='right' caption='[[3u3n]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Tabanus_yao Tabanus yao~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U3N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Horsefly Horsefly]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U3N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u3u\|3u3u]], [[3u31\|3u31]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u3u\|3u3u]], [[3u31\|3u31]]</td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Tabanus yao~~]]	+	[[Category: Horsefly]]
	[[Category: Andersen, J F]]		[[Category: Andersen, J F]]
	[[Category: Alphavbeta3 integrin]]		[[Category: Alphavbeta3 integrin]]

OCA at 15:04, 9 December 2014

2014-12-09T15:04:22Z

←Older revision		Revision as of 15:04, 9 December 2014
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-	[[~~Image:~~3u3n.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of tablysin-15==
		+	<StructureSection load='3u3n' size='340' side='right' caption='[[3u3n]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3u3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tabanus_yao Tabanus yao]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U3N FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u3u\|3u3u]], [[3u31\|3u31]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u3n RCSB], [http://www.ebi.ac.uk/pdbsum/3u3n PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The antihemostatic/antiangiogenic protein tablysin-15 is a member of the cysteine-rich secretory, antigen 5 and pathogenesis-related 1 protein (CAP) superfamily and has been shown to bind the integrins alphaIIbbeta3 and alphaVbeta3 by means of an Arg-Gly-Asp (RGD) tripeptide sequence. Here we describe the X-ray crystal structure of tablysin-15 and show that the RGD motif is located in a novel structural context. The motif itself is contained in a type II beta-turn structure that is similar in its conformation to the RGD sequence of the cyclic pentapeptide cilengitide when bound to integrin alphaVbeta3. The CAP domain also contains a hydrophobic channel that appears to bind a fatty acid molecule in the crystal structure after purification from Escherichia coli. After delipidation of the protein, tablysin-15 was found to bind proinflammatory cysteinyl leukotrienes with submicromolar affinities. The structure of the leukotriene E4 (LTE4)-tablysin-15 complex shows that the ligand binds with the non-functionalized end of the fatty acid chain buried in the hydrophobic pocket, while the carboxylate end of the ligand binds forms hydrogen bond/salt bridge interactions with polar side chains at the channel entrance. Therefore, tablysin-15 functions as an inhibitor of integrin function and as an anti-inflammatory scavenger of eicosanoids.

-	~~{{STRUCTURE_3u3n\| PDB=3u3n \| SCENE= }}~~	+	Structure of a protein having inhibitory disintegrin and leukotriene scavenging functions contained in a single domain.,Xu X, Francischetti IM, Lai R, Ribeiro JM, Andersen JF J Biol Chem. 2012 Feb 6. PMID:22311975<ref>PMID:22311975</ref>

-	~~===Crystal structure~~ of ~~tablysin-15===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22311975}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3u3n]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Tabanus_yao Tabanus yao]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022311975<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Tabanus yao]]		[[Category: Tabanus yao]]
-	[[Category: Andersen, J F.]]	+	[[Category: Andersen, J F]]
	[[Category: Alphavbeta3 integrin]]		[[Category: Alphavbeta3 integrin]]
	[[Category: Binding protein]]		[[Category: Binding protein]]

OCA at 05:56, 17 October 2012

2012-10-17T05:56:16Z

←Older revision		Revision as of 05:56, 17 October 2012
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	[[Image:3u3n.png\|left\|200px]]		[[Image:3u3n.png\|left\|200px]]

-	<!--
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3u3n\| PDB=3u3n \| SCENE= }}		{{STRUCTURE_3u3n\| PDB=3u3n \| SCENE= }}

	===Crystal structure of tablysin-15===		===Crystal structure of tablysin-15===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22311975}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22311975 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_22311975}}		{{ABSTRACT_PUBMED_22311975}}

OCA at 05:02, 23 May 2012

2012-05-23T05:02:09Z

←Older revision		Revision as of 05:02, 23 May 2012
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-	[[Image:3u3n.~~jpg~~\|left\|200px]]	+	[[Image:3u3n.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of tablysin-15===		===Crystal structure of tablysin-15===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22311975}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22311975 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22311975}}

	==About this Structure==		==About this Structure==
	[[3u3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tabanus_yao Tabanus yao]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA].		[[3u3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tabanus_yao Tabanus yao]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022311975</ref><references group="xtra"/>
	[[Category: Tabanus yao]]		[[Category: Tabanus yao]]
	[[Category: Andersen, J F.]]		[[Category: Andersen, J F.]]

OCA at 06:53, 15 February 2012

2012-02-15T06:53:24Z

←Older revision		Revision as of 06:53, 15 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3u3n.jpg\|left\|200px]]

-	The ~~entry 3u3n~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3u3n", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3u3n\| PDB=3u3n \| SCENE= }}

-	~~Authors: Andersen, J.F.~~	+	===Crystal structure of tablysin-15===

-	~~Description: Crystal~~ structure ~~of tablysin~~-15	+
		+	==About this Structure==
		+	[[3u3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tabanus_yao Tabanus yao]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA].
		+	[[Category: Tabanus yao]]
		+	[[Category: Andersen, J F.]]
		+	[[Category: Alphavbeta3 integrin]]
		+	[[Category: Binding protein]]
		+	[[Category: Cap domain]]
		+	[[Category: Protein binding]]
		+	[[Category: Salivary gland]]

OCA at 11:49, 16 November 2011

2011-11-16T11:49:19Z

←Older revision		Revision as of 11:49, 16 November 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3u3n is ON HOLD	+	The entry 3u3n is ON HOLD until Paper Publication

	Authors: Andersen, J.F.		Authors: Andersen, J.F.

	Description: Crystal structure of tablysin-15		Description: Crystal structure of tablysin-15

OCA: Protected "3u3n" [edit=sysop:move=sysop]

2011-10-30T08:49:52Z

Protected "3u3n" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:49, 30 October 2011