3u8d - Revision history

OCA at 06:02, 13 July 2022

2022-07-13T06:02:15Z

←Older revision		Revision as of 06:02, 13 July 2022
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	<StructureSection load='3u8d' size='340' side='right'caption='[[3u8d]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='3u8d' size='340' side='right'caption='[[3u8d]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u8d]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3U8D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U8D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=U8D:(3-{[3-(2-AMINO-2-OXOETHYL)-1-BENZYL-2-ETHYL-1H-INDOL-5-YL]OXY}PROPYL)PHOSPHONIC+ACID'>U8D</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=U8D:(3-{[3-(2-AMINO-2-OXOETHYL)-1-BENZYL-2-ETHYL-1H-INDOL-5-YL]OXY}PROPYL)PHOSPHONIC+ACID'>U8D</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u8b\|3u8b]], [[3u8h\|3u8h]], [[3u8i\|3u8i]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u8b\|3u8b]], [[3u8h\|3u8h]], [[3u8i\|3u8i]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLA2G2A, PLA2B, PLA2L, RASF-A ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLA2G2A, PLA2B, PLA2L, RASF-A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3u8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u8d OCA], [~~http~~://pdbe.org/3u8d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3u8d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3u8d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3u8d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u8d OCA], [https://pdbe.org/3u8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u8d RCSB], [https://www.ebi.ac.uk/pdbsum/3u8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PA2GA_HUMAN PA2GA_HUMAN]] Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.	+	[[https://www.uniprot.org/uniprot/PA2GA_HUMAN PA2GA_HUMAN]] Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Phospholipase A2\|Phospholipase A2]]	+	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:42, 17 July 2019

2019-07-17T11:42:39Z

←Older revision		Revision as of 11:42, 17 July 2019
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	==Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism==		==Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism==
-	<StructureSection load='3u8d' size='340' side='right' caption='[[3u8d]], [[Resolution\|resolution]] 1.81Å' scene=''>	+	<StructureSection load='3u8d' size='340' side='right'caption='[[3u8d]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3u8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[3u8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U8D FirstGlance]. <br>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bouveret, R]]		[[Category: Bouveret, R]]
	[[Category: Bryant, K J]]		[[Category: Bryant, K J]]

OCA at 20:53, 5 August 2016

2016-08-05T20:53:47Z

←Older revision		Revision as of 20:53, 5 August 2016
Line 1:		Line 1:
		+
	==Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism==		==Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism==
	<StructureSection load='3u8d' size='340' side='right' caption='[[3u8d]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='3u8d' size='340' side='right' caption='[[3u8d]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3u8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U8D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3u8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U8D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=U8D:(3-{[3-(2-AMINO-2-OXOETHYL)-1-BENZYL-2-ETHYL-1H-INDOL-5-YL]OXY}PROPYL)PHOSPHONIC+ACID'>U8D</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=U8D:(3-{[3-(2-AMINO-2-OXOETHYL)-1-BENZYL-2-ETHYL-1H-INDOL-5-YL]OXY}PROPYL)PHOSPHONIC+ACID'>U8D</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u8b\|3u8b]], [[3u8h\|3u8h]], [[3u8i\|3u8i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u8b\|3u8b]], [[3u8h\|3u8h]], [[3u8i\|3u8i]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLA2G2A, PLA2B, PLA2L, RASF-A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLA2G2A, PLA2B, PLA2L, RASF-A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u8d RCSB], [http://www.ebi.ac.uk/pdbsum/3u8d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u8d OCA], [http://pdbe.org/3u8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u8d RCSB], [http://www.ebi.ac.uk/pdbsum/3u8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3u8d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bouveret, R]]		[[Category: Bouveret, R]]
	[[Category: Bryant, K J]]		[[Category: Bryant, K J]]

OCA at 21:49, 25 December 2014

2014-12-25T21:49:48Z

←Older revision		Revision as of 21:49, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u8d RCSB], [http://www.ebi.ac.uk/pdbsum/3u8d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u8d RCSB], [http://www.ebi.ac.uk/pdbsum/3u8d PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PA2GA_HUMAN PA2GA_HUMAN]] Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:34, 21 December 2014

2014-12-21T07:34:50Z

←Older revision		Revision as of 07:34, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3u8d\| PDB=3u8d \| SCENE= }}~~	+	==Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism==
-	===Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism===	+	<StructureSection load='3u8d' size='340' side='right' caption='[[3u8d]], [[Resolution\|resolution]] 1.81Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23482564}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3u8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U8D FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=U8D:(3-{[3-(2-AMINO-2-OXOETHYL)-1-BENZYL-2-ETHYL-1H-INDOL-5-YL]OXY}PROPYL)PHOSPHONIC+ACID'>U8D</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3u8b\|3u8b]], [[3u8h\|3u8h]], [[3u8i\|3u8i]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLA2G2A, PLA2B, PLA2L, RASF-A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u8d RCSB], [http://www.ebi.ac.uk/pdbsum/3u8d PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human group IIA secreted phospholipase A2 (hGIIA) promotes tumor growth and inflammation and can act independently of its well described catalytic lipase activity via an alternative poorly understood signaling pathway. With six chemically diverse inhibitors we show that it is possible to selectively inhibit hGIIA signaling over catalysis, and x-ray crystal structures illustrate that signaling involves a pharmacologically distinct surface to the catalytic site. We demonstrate in rheumatoid fibroblast-like synoviocytes that non-catalytic signaling is associated with rapid internalization of the enzyme and colocalization with vimentin. Trafficking of exogenous hGIIA was monitored with immunofluorescence studies, which revealed that vimentin localization is disrupted by inhibitors of signaling that belong to a rare class of small molecule inhibitors that modulate protein-protein interactions. This study provides structural and pharmacological evidence for an association between vimentin, hGIIA, and arachidonic acid metabolism in synovial inflammation, avenues for selective interrogation of hGIIA signaling, and new strategies for therapeutic hGIIA inhibitor design.

-	~~==Function==~~	+	Selective Inhibition of Human Group IIA-secreted Phospholipase A2 (hGIIA) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid Synoviocytes.,Lee LK, Bryant KJ, Bouveret R, Lei PW, Duff AP, Harrop SJ, Huang EP, Harvey RP, Gelb MH, Gray PP, Curmi PM, Cunningham AM, Church WB, Scott KF J Biol Chem. 2013 May 24;288(21):15269-79. doi: 10.1074/jbc.M112.397893. Epub, 2013 Mar 12. PMID:23482564<ref>PMID:23482564</ref>
-	~~[[http://www.uniprot.org/uniprot/PA2GA_HUMAN PA2GA_HUMAN]] Thought to participate in the regulation~~ of ~~the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium~~-~~dependent hydrolysis~~ of ~~the 2-acyl groups~~ in 3-~~sn-phosphoglycerides~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3u8d]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3U8D OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023482564</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Phospholipase A2\|Phospholipase A2]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bouveret, R.]]	+	[[Category: Bouveret, R]]
-	[[Category: Bryant, K J.]]	+	[[Category: Bryant, K J]]
-	[[Category: Church, W B.]]	+	[[Category: Church, W B]]
-	[[Category: Cunningham, A M.]]	+	[[Category: Cunningham, A M]]
-	[[Category: Curmi, P M.]]	+	[[Category: Curmi, P M]]
-	[[Category: Duff, A P.]]	+	[[Category: Duff, A P]]
-	[[Category: Gelb, M H.]]	+	[[Category: Gelb, M H]]
-	[[Category: Gray, P P.]]	+	[[Category: Gray, P P]]
-	[[Category: Harrop, S J.]]	+	[[Category: Harrop, S J]]
-	[[Category: Harvey, R P.]]	+	[[Category: Harvey, R P]]
-	[[Category: Huang, E P.]]	+	[[Category: Huang, E P]]
-	[[Category: Lee, L K.]]	+	[[Category: Lee, L K]]
-	[[Category: Lei, P W.]]	+	[[Category: Lei, P W]]
-	[[Category: Scott, K F.]]	+	[[Category: Scott, K F]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Phospholipase a2 activity]]		[[Category: Phospholipase a2 activity]]
	[[Category: Secreted phospholipase a2]]		[[Category: Secreted phospholipase a2]]

OCA at 16:10, 19 June 2013

2013-06-19T16:10:34Z

←Older revision		Revision as of 16:10, 19 June 2013
Line 1:		Line 1:
-	[[Image:3u8d.jpg\|left\|200px]]
-
	{{STRUCTURE_3u8d\| PDB=3u8d \| SCENE= }}		{{STRUCTURE_3u8d\| PDB=3u8d \| SCENE= }}
-
	===Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism===		===Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism===
		+	{{ABSTRACT_PUBMED_23482564}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PA2GA_HUMAN PA2GA_HUMAN]] Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

	==About this Structure==		==About this Structure==
	[[3u8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8D OCA].		[[3u8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8D OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023482564</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bouveret, R.]]		[[Category: Bouveret, R.]]

OCA at 07:08, 17 October 2012

2012-10-17T07:08:37Z

←Older revision		Revision as of 07:08, 17 October 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3u8d.jpg\|left\|200px]]

-	~~The entry~~ 3u8d ~~is ON HOLD~~ ~~until Oct 12 2013~~	+	{{STRUCTURE_3u8d\| PDB=3u8d \| SCENE= }}

-	~~Authors: Lee, L.K., Bryant, K.J., Bouveret, R., Lei, P.-W., Duff, A.P., Harrop, S.J., Huang, E.P., Harvey, R.P., Gelb, M.H., Gray, P.P., Curmi, P.M., Cunningham, A.M., Church, W.B., Scott, K.F.~~	+	===Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism===

-	~~Description~~: ~~Functionally selective inhibition of Group IIA~~ phospholipase ~~A2 reveals a role for vimentin in regulating arachidonic acid metabolism~~	+
		+	==About this Structure==
		+	[[3u8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U8D OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Bouveret, R.]]
		+	[[Category: Bryant, K J.]]
		+	[[Category: Church, W B.]]
		+	[[Category: Cunningham, A M.]]
		+	[[Category: Curmi, P M.]]
		+	[[Category: Duff, A P.]]
		+	[[Category: Gelb, M H.]]
		+	[[Category: Gray, P P.]]
		+	[[Category: Harrop, S J.]]
		+	[[Category: Harvey, R P.]]
		+	[[Category: Huang, E P.]]
		+	[[Category: Lee, L K.]]
		+	[[Category: Lei, P W.]]
		+	[[Category: Scott, K F.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Phospholipase a2 activity]]
		+	[[Category: Secreted phospholipase a2]]

OCA at 04:38, 5 September 2012

2012-09-05T04:38:49Z

←Older revision		Revision as of 04:38, 5 September 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3u8d is ON HOLD until ~~Paper Publication~~	+	The entry 3u8d is ON HOLD until Oct 12 2013

	Authors: Lee, L.K., Bryant, K.J., Bouveret, R., Lei, P.-W., Duff, A.P., Harrop, S.J., Huang, E.P., Harvey, R.P., Gelb, M.H., Gray, P.P., Curmi, P.M., Cunningham, A.M., Church, W.B., Scott, K.F.		Authors: Lee, L.K., Bryant, K.J., Bouveret, R., Lei, P.-W., Duff, A.P., Harrop, S.J., Huang, E.P., Harvey, R.P., Gelb, M.H., Gray, P.P., Curmi, P.M., Cunningham, A.M., Church, W.B., Scott, K.F.

	Description: Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism		Description: Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism

OCA at 05:09, 27 June 2012

2012-06-27T05:09:51Z

←Older revision		Revision as of 05:09, 27 June 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3u8d is ON HOLD	+	The entry 3u8d is ON HOLD until Paper Publication

	Authors: Lee, L.K., Bryant, K.J., Bouveret, R., Lei, P.-W., Duff, A.P., Harrop, S.J., Huang, E.P., Harvey, R.P., Gelb, M.H., Gray, P.P., Curmi, P.M., Cunningham, A.M., Church, W.B., Scott, K.F.		Authors: Lee, L.K., Bryant, K.J., Bouveret, R., Lei, P.-W., Duff, A.P., Harrop, S.J., Huang, E.P., Harvey, R.P., Gelb, M.H., Gray, P.P., Curmi, P.M., Cunningham, A.M., Church, W.B., Scott, K.F.

	Description: Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism		Description: Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism

OCA at 11:14, 9 November 2011

2011-11-09T11:14:53Z

←Older revision		Revision as of 11:14, 9 November 2011
Line 3:		Line 3:
	The entry 3u8d is ON HOLD		The entry 3u8d is ON HOLD

-	Authors: Lee, L.K., Bryant, K.J., Bouveret, R., Lei, P-W., Duff, A.P., Harrop, S.J., Huang, E.P., Harvey, R.P., Gelb, M.H., Gray, P.P., Curmi, P.M., Cunningham, A.M., Church, W.B., Scott, K.F.	+	Authors: Lee, L.K., Bryant, K.J., Bouveret, R., Lei, P.-W., Duff, A.P., Harrop, S.J., Huang, E.P., Harvey, R.P., Gelb, M.H., Gray, P.P., Curmi, P.M., Cunningham, A.M., Church, W.B., Scott, K.F.

	Description: Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism		Description: Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in regulating arachidonic acid metabolism