3uda - Revision history

OCA at 08:38, 20 March 2024

2024-03-20T08:38:31Z

←Older revision		Revision as of 08:38, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3uda' size='340' side='right'caption='[[3uda]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='3uda' size='340' side='right'caption='[[3uda]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uda]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UDA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uda]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UDA FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~"><~~scene name~~='~~pdbligand~~=~~PO4~~:~~PHOSPHATE+ION'~~>~~PO4~~</~~scene~~>, <scene name='pdbligand=IDY:METHYL+2-O-SULFO-ALPHA-L-IDOPYRANOSIDURONIC+ACID'>IDY</scene>, <scene name='pdbligand=SUS:2-DEOXY-3,6-DI-O-SULFO-2-(SULFOAMINO)-ALPHA-D-GLUCOPYRANOSE'>SUS</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ud7\|3ud7]], [[3ud8\|3ud8]], [[3ud9\|3ud9]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDY:METHYL+2-O-SULFO-ALPHA-L-IDOPYRANOSIDURONIC+ACID'>IDY</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SUS:2-DEOXY-3,6-DI-O-SULFO-2-(SULFOAMINO)-ALPHA-D-GLUCOPYRANOSE'>SUS</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uda OCA], [https://pdbe.org/3uda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uda RCSB], [https://www.ebi.ac.uk/pdbsum/3uda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uda ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uda OCA], [https://pdbe.org/3uda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uda RCSB], [https://www.ebi.ac.uk/pdbsum/3uda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uda ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>	+	[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Several biological processes involve glycans, yet understanding their ligand specificities is impeded by their inherent diversity and difficult acquisition. Generating broad synthetic sugar libraries for bioevaluations is a powerful tool in unraveling glycan structural information. In the case of the widely distributed heparan sulfate (HS), however, the 48 theoretical possibilities for its repeating disaccharide call for synthetic approaches that should minimize the effort in an undoubtedly huge undertaking. Here we employed a divergent strategy to afford all 48 HS-based disaccharides from just two orthogonally protected disaccharide precursors. Different combinations and sequence of transformation steps were applied with many downstream intermediates leading up to multiple target products. With the full disaccharide library in hand, affinity screening with fibroblast growth factor-1 (FGF-1) revealed that four of the synthetic sugars bind to FGF-1. The molecular details of the interaction were further clarified through X-ray analysis of the sugar-protein cocrystals. The capability of comprehensive sugar libraries in providing key insights in glycan-ligand interaction is, thus, highlighted.	+
-		+
-	Divergent synthesis of 48 heparan sulfate-based disaccharides and probing the specific sugar-fibroblast growth factor-1 interaction.,Hu YP, Zhong YQ, Chen ZG, Chen CY, Shi Z, Zulueta MM, Ku CC, Lee PY, Wang CC, Hung SC J Am Chem Soc. 2012 Dec 26;134(51):20722-7. doi: 10.1021/ja3090065. Epub 2012 Dec, 14. PMID:23240683<ref>PMID:23240683</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3uda" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 27:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hung, S C]]	+	[[Category: Hung S-C]]
-	[[Category: Shi, Z]]	+	[[Category: Shi Z]]
-	~~[[Category: Heparin/heparan sulfate binding]]~~	+
-	~~[[Category: Hormone~~]]	+

OCA at 06:08, 13 July 2022

2022-07-13T06:08:33Z

←Older revision		Revision as of 06:08, 13 July 2022
Line 1:		Line 1:

	==Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex==		==Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex==
-	<StructureSection load='3uda' size='340' side='right' caption='[[3uda]], [[Resolution\|resolution]] 2.51Å' scene=''>	+	<StructureSection load='3uda' size='340' side='right'caption='[[3uda]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uda]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UDA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uda]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UDA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~IDY~~:~~METHYL~~+~~2-O-SULFO-ALPHA-L-IDOPYRANOSIDURONIC+ACID~~'>~~IDY~~</scene>, <scene name='pdbligand=~~PO4~~:~~PHOSPHATE~~+~~ION~~'>~~PO4~~</scene>, <scene name='pdbligand=SUS:2-DEOXY-3,6-DI-O-SULFO-2-(SULFOAMINO)-ALPHA-D-GLUCOPYRANOSE'>SUS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=IDY:METHYL+2-O-SULFO-ALPHA-L-IDOPYRANOSIDURONIC+ACID'>IDY</scene>, <scene name='pdbligand=SUS:2-DEOXY-3,6-DI-O-SULFO-2-(SULFOAMINO)-ALPHA-D-GLUCOPYRANOSE'>SUS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ud7\|3ud7]], [[3ud8\|3ud8]], [[3ud9\|3ud9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ud7\|3ud7]], [[3ud8\|3ud8]], [[3ud9\|3ud9]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3uda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uda OCA], [~~http~~://pdbe.org/3uda PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3uda RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3uda PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3uda ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uda OCA], [https://pdbe.org/3uda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uda RCSB], [https://www.ebi.ac.uk/pdbsum/3uda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uda ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>	+	[[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Fibroblast growth factor\|Fibroblast growth factor]]	+	*[[Fibroblast growth factor 3D structures\|Fibroblast growth factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hung, S C]]		[[Category: Hung, S C]]
	[[Category: Shi, Z]]		[[Category: Shi, Z]]
	[[Category: Heparin/heparan sulfate binding]]		[[Category: Heparin/heparan sulfate binding]]
	[[Category: Hormone]]		[[Category: Hormone]]

OCA at 12:30, 5 August 2016

2016-08-05T12:30:57Z

←Older revision		Revision as of 12:30, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex==		==Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex==
	<StructureSection load='3uda' size='340' side='right' caption='[[3uda]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='3uda' size='340' side='right' caption='[[3uda]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uda]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UDA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uda]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UDA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IDY:METHYL+2-O-SULFO-ALPHA-L-IDOPYRANOSIDURONIC+ACID'>IDY</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SUS:2-DEOXY-3,6-DI-O-SULFO-2-(SULFOAMINO)-ALPHA-D-GLUCOPYRANOSE'>SUS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IDY:METHYL+2-O-SULFO-ALPHA-L-IDOPYRANOSIDURONIC+ACID'>IDY</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SUS:2-DEOXY-3,6-DI-O-SULFO-2-(SULFOAMINO)-ALPHA-D-GLUCOPYRANOSE'>SUS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ud7\|3ud7]], [[3ud8\|3ud8]], [[3ud9\|3ud9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ud7\|3ud7]], [[3ud8\|3ud8]], [[3ud9\|3ud9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uda RCSB], [http://www.ebi.ac.uk/pdbsum/3uda PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uda OCA], [http://pdbe.org/3uda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uda RCSB], [http://www.ebi.ac.uk/pdbsum/3uda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uda ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3uda" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hung, S C]]		[[Category: Hung, S C]]
	[[Category: Shi, Z]]		[[Category: Shi, Z]]
	[[Category: Heparin/heparan sulfate binding]]		[[Category: Heparin/heparan sulfate binding]]
	[[Category: Hormone]]		[[Category: Hormone]]

OCA at 18:52, 25 December 2014

2014-12-25T18:52:06Z

←Older revision		Revision as of 18:52, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uda RCSB], [http://www.ebi.ac.uk/pdbsum/3uda PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uda RCSB], [http://www.ebi.ac.uk/pdbsum/3uda PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:22, 9 December 2014

2014-12-09T17:22:24Z

←Older revision		Revision as of 17:22, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3uda.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex==
		+	<StructureSection load='3uda' size='340' side='right' caption='[[3uda]], [[Resolution\|resolution]] 2.51Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3uda]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UDA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IDY:METHYL+2-O-SULFO-ALPHA-L-IDOPYRANOSIDURONIC+ACID'>IDY</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SUS:2-DEOXY-3,6-DI-O-SULFO-2-(SULFOAMINO)-ALPHA-D-GLUCOPYRANOSE'>SUS</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ud7\|3ud7]], [[3ud8\|3ud8]], [[3ud9\|3ud9]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uda RCSB], [http://www.ebi.ac.uk/pdbsum/3uda PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Several biological processes involve glycans, yet understanding their ligand specificities is impeded by their inherent diversity and difficult acquisition. Generating broad synthetic sugar libraries for bioevaluations is a powerful tool in unraveling glycan structural information. In the case of the widely distributed heparan sulfate (HS), however, the 48 theoretical possibilities for its repeating disaccharide call for synthetic approaches that should minimize the effort in an undoubtedly huge undertaking. Here we employed a divergent strategy to afford all 48 HS-based disaccharides from just two orthogonally protected disaccharide precursors. Different combinations and sequence of transformation steps were applied with many downstream intermediates leading up to multiple target products. With the full disaccharide library in hand, affinity screening with fibroblast growth factor-1 (FGF-1) revealed that four of the synthetic sugars bind to FGF-1. The molecular details of the interaction were further clarified through X-ray analysis of the sugar-protein cocrystals. The capability of comprehensive sugar libraries in providing key insights in glycan-ligand interaction is, thus, highlighted.

-	~~{{STRUCTURE_3uda\| PDB=3uda \| SCENE= }}~~	+	Divergent synthesis of 48 heparan sulfate-based disaccharides and probing the specific sugar-fibroblast growth factor-1 interaction.,Hu YP, Zhong YQ, Chen ZG, Chen CY, Shi Z, Zulueta MM, Ku CC, Lee PY, Wang CC, Hung SC J Am Chem Soc. 2012 Dec 26;134(51):20722-7. doi: 10.1021/ja3090065. Epub 2012 Dec, 14. PMID:23240683<ref>PMID:23240683</ref>

-	~~===Crystal Structure Analysis~~ of ~~FGF1-Disaccharide(NI24) complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23240683}}~~	+	==See Also==
-		+	*[[Fibroblast growth factor\|Fibroblast growth factor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3uda~~]] ~~is a 3 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDA OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hung, S C.]]	+	[[Category: Hung, S C]]
-	[[Category: Shi, Z.]]	+	[[Category: Shi, Z]]
	[[Category: Heparin/heparan sulfate binding]]		[[Category: Heparin/heparan sulfate binding]]
	[[Category: Hormone]]		[[Category: Hormone]]

OCA at 08:49, 16 January 2013

2013-01-16T08:49:03Z

←Older revision		Revision as of 08:49, 16 January 2013
Line 1:		Line 1:
-	[[Image:3uda.~~jpg~~\|left\|200px]]	+	[[Image:3uda.png\|left\|200px]]

	{{STRUCTURE_3uda\| PDB=3uda \| SCENE= }}		{{STRUCTURE_3uda\| PDB=3uda \| SCENE= }}
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	===Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex===		===Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex===

		+	{{ABSTRACT_PUBMED_23240683}}

	==About this Structure==		==About this Structure==

OCA at 14:35, 28 November 2012

2012-11-28T14:35:16Z

←Older revision		Revision as of 14:35, 28 November 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3uda.jpg\|left\|200px]]

-	~~The entry~~ 3uda ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3uda\| PDB=3uda \| SCENE= }}

-	~~Authors: Hung, S.~~-~~C., Shi, Z.~~	+	===Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex===

-	~~Description: Crystal~~ Structure ~~Analysis of FGF1~~-~~Disaccharide(NI24) complex~~	+
		+	==About this Structure==
		+	[[3uda]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UDA OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Hung, S C.]]
		+	[[Category: Shi, Z.]]
		+	[[Category: Heparin/heparan sulfate binding]]
		+	[[Category: Hormone]]

OCA at 06:40, 28 December 2011

2011-12-28T06:40:07Z

←Older revision		Revision as of 06:40, 28 December 2011
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3uda is ON HOLD	+	The entry 3uda is ON HOLD until Paper Publication

	Authors: Hung, S.-C., Shi, Z.		Authors: Hung, S.-C., Shi, Z.

	Description: Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex		Description: Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex

OCA at 11:52, 16 November 2011

2011-11-16T11:52:17Z

←Older revision		Revision as of 11:52, 16 November 2011
Line 3:		Line 3:
	The entry 3uda is ON HOLD		The entry 3uda is ON HOLD

-	Authors: Hung, ~~Shang~~-~~Cheng~~ , Shi ~~Zhonghao~~	+	Authors: Hung, S.-C., Shi, Z.

	Description: Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex		Description: Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex

OCA: Protected "3uda" [edit=sysop:move=sysop]

2011-11-02T08:02:28Z

Protected "3uda" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:02, 2 November 2011