3ux9 - Revision history

OCA at 08:14, 20 July 2022

2022-07-20T08:14:28Z

←Older revision		Revision as of 08:14, 20 July 2022
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	==Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus==		==Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus==
-	<StructureSection load='3ux9' size='340' side='right' caption='[[3ux9]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3ux9' size='340' side='right'caption='[[3ux9]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ux9]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UX9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UX9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ux9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UX9 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFNA1, IFNA13 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFNA1, IFNA13 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ux9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ux9 OCA], [~~http~~://pdbe.org/3ux9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ux9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ux9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ux9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ux9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ux9 OCA], [https://pdbe.org/3ux9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ux9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ux9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ux9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IFNA1_HUMAN IFNA1_HUMAN]] Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<ref>PMID:1634550</ref>	+	[[https://www.uniprot.org/uniprot/IFNA1_HUMAN IFNA1_HUMAN]] Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<ref>PMID:1634550</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Liang, M F]]		[[Category: Liang, M F]]
	[[Category: Liang, W]]		[[Category: Liang, W]]

OCA at 13:01, 11 August 2016

2016-08-11T13:01:31Z

←Older revision		Revision as of 13:01, 11 August 2016
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		+
	==Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus==		==Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus==
	<StructureSection load='3ux9' size='340' side='right' caption='[[3ux9]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3ux9' size='340' side='right' caption='[[3ux9]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ux9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UX9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ux9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UX9 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFNA1, IFNA13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFNA1, IFNA13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ux9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ux9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ux9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ux9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ux9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ux9 OCA], [http://pdbe.org/3ux9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ux9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ux9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ux9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IFNA1_HUMAN IFNA1_HUMAN]] Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<ref>PMID:1634550</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ux9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Liang, M F]]		[[Category: Liang, M F]]
	[[Category: Liang, W]]		[[Category: Liang, W]]

OCA at 09:57, 4 January 2015

2015-01-04T09:57:11Z

←Older revision		Revision as of 09:57, 4 January 2015
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-	[[~~Image:~~3ux9.~~jpg~~\|~~left\|200px~~]]	+	==Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus==
		+	<StructureSection load='3ux9' size='340' side='right' caption='[[3ux9]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ux9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UX9 FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IFNA1, IFNA13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ux9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ux9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ux9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ux9 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Increasing evidences suggest that the type I interferon alpha (IFNalpha) plays a critical role in the etiopathogenesis of systemic lupus erythematosus (SLE), which makes it a promising therapeutic target for the treatment of the disease. By screening a large size non-immune human antibody library, we have developed a human single-chain antibody (ScFv) AIFNalpha1bScFv01 and corresponding whole antibody AIFNalpha1bIgG01 to human interferon alpha1b (IFNalpha1b) with high specificity and high affinity. The IgG antibody could down-regulate the expression of ISG15 and IFIT-1 induced by either recombinant IFNalpha1b or naive IFNalpha from SLE patients' sera, and reduced total serum IgG and IgM antibodies level in a pristane-primed lupus-like mouse model. The crystal structure of AIFNalpha1bScFv01-IFNalpha1b complex solved to 2.8 A resolution revealed that both Pro26-Gln40 region in loop AB and Glu147-Arg150 region in helix E of IFNalpha1b contribute to binding with AIFNalpha1bScFv01. Four residues of above two regions (Leu30, Asp32, Asp35 and Arg150) are critical for the formation of antigen-antibody complexes. AIFNalpha1bScFv01 shares partial epitopes of IFNalpha1b with its receptor IFNAR2 but with much higher binding affinity to IFNalpha1b than IFNAR2. Thus, AIFNalpha1bIgG01 exhibits its neutralizing activity through competition with IFNAR2 to bind with IFNalpha and prevents the activation of IFNalpha-mediated signaling pathway. Our results highlight the potential use of the human antibody for modulating the activity of IFNalpha in SLE.

-	<!--	+	Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus.,Ouyang S, Gong B, Li JZ, Zhao LX, Wu W, Zhang FS, Sun L, Wang SJ, Pan M, Li C, Liang W, Shaw N, Zheng J, Zhao GP, Wang Y, Liu ZJ, Liang M J Mol Med (Berl). 2012 Feb 4. PMID:22307521<ref>PMID:22307521</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3ux9"~~, ~~creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3ux9\| PDB=3ux9 \| SCENE= }}~~	+

-	~~===Structural insights into~~ a ~~human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-		+	==See Also==
-	~~<!--~~	+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22307521}}, adds the Publication Abstract to the page~~	+	== References ==
-	~~(as it appears on PubMed at http://www.pubmed.gov), where 22307521 is the PubMed ID number.~~	+	<references/>
-	~~-->~~	+	__TOC__
-	~~{{ABSTRACT_PUBMED_22307521}}~~	+	</StructureSection>
-		+
-	==~~About this Structure~~==	+
-	[[~~3ux9~~]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UX9 OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022307521<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Liang, M F.]]	+	[[Category: Liang, M F]]
-	[[Category: Liang, W.]]	+	[[Category: Liang, W]]
-	[[Category: Liu, Z J.]]	+	[[Category: Liu, Z J]]
-	[[Category: Ouyang, S.]]	+	[[Category: Ouyang, S]]
-	[[Category: Shaw, N.]]	+	[[Category: Shaw, N]]
-	[[Category: Zhao, L X.]]	+	[[Category: Zhao, L X]]
	[[Category: Cytokine-immune system complex]]		[[Category: Cytokine-immune system complex]]
	[[Category: Five helice]]		[[Category: Five helice]]
	[[Category: Hydrophobic interaction]]		[[Category: Hydrophobic interaction]]
	[[Category: Long loop connecting helix]]		[[Category: Long loop connecting helix]]

OCA at 08:52, 29 February 2012

2012-02-29T08:52:47Z

←Older revision		Revision as of 08:52, 29 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3ux9.jpg\|left\|200px]]

-	The ~~entry 3ux9~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ux9", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ux9\| PDB=3ux9 \| SCENE= }}

-	~~Authors: Ouyang, S., Zhao, L.X., Liang, W., Shaw, N., Liu, Z.~~-~~J., Liang, M.-F.~~	+	===Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus===

-	~~Description~~: ~~Structural insights into~~ a ~~human anti~~-~~IFN antibody exerting therapeutic potential for systemic lupus erythematosus~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22307521}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22307521 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22307521}}
		+
		+	==About this Structure==
		+	[[3ux9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UX9 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022307521</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Liang, M F.]]
		+	[[Category: Liang, W.]]
		+	[[Category: Liu, Z J.]]
		+	[[Category: Ouyang, S.]]
		+	[[Category: Shaw, N.]]
		+	[[Category: Zhao, L X.]]
		+	[[Category: Cytokine-immune system complex]]
		+	[[Category: Five helice]]
		+	[[Category: Hydrophobic interaction]]
		+	[[Category: Long loop connecting helix]]

OCA at 06:44, 28 December 2011

2011-12-28T06:44:26Z

←Older revision		Revision as of 06:44, 28 December 2011
Line 3:		Line 3:
	The entry 3ux9 is ON HOLD		The entry 3ux9 is ON HOLD

-	Authors: ~~Songying~~ Ouyang, ~~Li-Xia~~ Zhao, ~~Wenguang~~ Liang, ~~Neil~~ Shaw, ~~Zhi-Jie~~ Liu, Mi-~~Fang~~ Liang	+	Authors: Ouyang, S., Zhao, L.X., Liang, W., Shaw, N., Liu, Z.-J., Liang, M.-F.

	Description: Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus		Description: Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus

OCA: Protected "3ux9" [edit=sysop:move=sysop]

2011-12-14T11:14:02Z

Protected "3ux9" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:14, 14 December 2011

OCA: New page: '''Unreleased structure''' The entry 3ux9 is ON HOLD Authors: Songying Ouyang, Li-Xia Zhao, Wenguang Liang, Neil Shaw, Zhi-Jie Liu, Mi-Fang Liang Description: Structural insights into ...

2011-12-14T11:14:01Z

New page: '''Unreleased structure''' The entry 3ux9 is ON HOLD Authors: Songying Ouyang, Li-Xia Zhao, Wenguang Liang, Neil Shaw, Zhi-Jie Liu, Mi-Fang Liang Description: Structural insights into ...

New page

'''Unreleased structure'''

The entry 3ux9 is ON HOLD

Authors: Songying Ouyang, Li-Xia Zhao, Wenguang Liang, Neil Shaw, Zhi-Jie Liu, Mi-Fang Liang

Description: Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus