3uyr - Revision history

OCA at 08:16, 20 July 2022

2022-07-20T08:16:59Z

←Older revision		Revision as of 08:16, 20 July 2022
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	==Structure of a monoclonal antibody complexed with its MHC-I antigen==		==Structure of a monoclonal antibody complexed with its MHC-I antigen==
-	<StructureSection load='3uyr' size='340' side='right' caption='[[3uyr]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3uyr' size='340' side='right'caption='[[3uyr]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3uyr]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3UYR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3uyr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UYR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3uo1\|3uo1]], [[3v4u\|3v4u]], [[3v52\|3v52]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3uo1\|3uo1]], [[3v4u\|3v4u]], [[3v52\|3v52]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3uyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyr OCA], [~~http~~://pdbe.org/3uyr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3uyr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3uyr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyr OCA], [https://pdbe.org/3uyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uyr RCSB], [https://www.ebi.ac.uk/pdbsum/3uyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE]] Involved in the presentation of foreign antigens to the immune system.	+	[[https://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE]] Involved in the presentation of foreign antigens to the immune system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Mage, M G]]		[[Category: Mage, M G]]

OCA at 09:32, 21 February 2019

2019-02-21T09:32:06Z

←Older revision		Revision as of 09:32, 21 February 2019
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:03, 5 August 2016

2016-08-05T10:03:04Z

←Older revision		Revision as of 10:03, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of a monoclonal antibody complexed with its MHC-I antigen==		==Structure of a monoclonal antibody complexed with its MHC-I antigen==
	<StructureSection load='3uyr' size='340' side='right' caption='[[3uyr]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3uyr' size='340' side='right' caption='[[3uyr]], [[Resolution\|resolution]] 1.70Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3uo1\|3uo1]], [[3v4u\|3v4u]], [[3v52\|3v52]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3uo1\|3uo1]], [[3v4u\|3v4u]], [[3v52\|3v52]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyr RCSB], [http://www.ebi.ac.uk/pdbsum/3uyr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyr OCA], [http://pdbe.org/3uyr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uyr RCSB], [http://www.ebi.ac.uk/pdbsum/3uyr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3uyr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:25, 25 December 2014

2014-12-25T01:25:58Z

←Older revision		Revision as of 01:25, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3uyr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UYR FirstGlance]. <br>		<table><tr><td colspan='2'>[[3uyr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UYR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3uo1\|3uo1]], [[3v4u\|3v4u]], [[3v52\|3v52]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3uo1\|3uo1]], [[3v4u\|3v4u]], [[3v52\|3v52]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyr RCSB], [http://www.ebi.ac.uk/pdbsum/3uyr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyr RCSB], [http://www.ebi.ac.uk/pdbsum/3uyr PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE]] Involved in the presentation of foreign antigens to the immune system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 15:
	The Peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics.,Mage MG, Dolan MA, Wang R, Boyd LF, Revilleza MJ, Robinson H, Natarajan K, Myers NB, Hansen TH, Margulies DH J Immunol. 2012 Aug 1;189(3):1391-9. Epub 2012 Jun 29. PMID:22753930<ref>PMID:22753930</ref>		The Peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics.,Mage MG, Dolan MA, Wang R, Boyd LF, Revilleza MJ, Robinson H, Natarajan K, Myers NB, Hansen TH, Margulies DH J Immunol. 2012 Aug 1;189(3):1391-9. Epub 2012 Jun 29. PMID:22753930<ref>PMID:22753930</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>

Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Mage, M G.]]	+	[[Category: Mage, M G]]
-	[[Category: Margulies, D H.]]	+	[[Category: Margulies, D H]]
-	[[Category: Natarajan, K.]]	+	[[Category: Natarajan, K]]
-	[[Category: Wang, R.]]	+	[[Category: Wang, R]]
	[[Category: 10 helix]]		[[Category: 10 helix]]
	[[Category: Ig-fold 3]]		[[Category: Ig-fold 3]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 06:29, 5 June 2014

2014-06-05T06:29:30Z

←Older revision		Revision as of 06:29, 5 June 2014
Line 1:		Line 1:
-	[[~~Image:~~3uyr.~~png~~\|~~left~~\|~~200px~~]]	+	==Structure of a monoclonal antibody complexed with its MHC-I antigen==
		+	<StructureSection load='3uyr' size='340' side='right' caption='[[3uyr]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3uyr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UYR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3uo1\|3uo1]], [[3v4u\|3v4u]], [[3v52\|3v52]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyr RCSB], [http://www.ebi.ac.uk/pdbsum/3uyr PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MHC class I (MHC-I) proteins of the adaptive immune system require antigenic peptides for maintenance of mature conformation and immune function via specific recognition by MHC-I-restricted CD8(+) T lymphocytes. New MHC-I molecules in the endoplasmic reticulum are held by chaperones in a peptide-receptive (PR) transition state pending release by tightly binding peptides. In this study, we show, by crystallographic, docking, and molecular dynamics methods, dramatic movement of a hinged unit containing a conserved 3(10) helix that flips from an exposed "open" position in the PR transition state to a "closed" position with buried hydrophobic side chains in the peptide-loaded mature molecule. Crystallography of hinged unit residues 46-53 of murine H-2L(d) MHC-I H chain, complexed with mAb 64-3-7, demonstrates solvent exposure of these residues in the PR conformation. Docking and molecular dynamics predict how this segment moves to help form the A and B pockets crucial for the tight peptide binding needed for stability of the mature peptide-loaded conformation, chaperone dissociation, and Ag presentation.

-	~~{{STRUCTURE_3uyr\| PDB=3uyr \| SCENE= }}~~	+	The Peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics.,Mage MG, Dolan MA, Wang R, Boyd LF, Revilleza MJ, Robinson H, Natarajan K, Myers NB, Hansen TH, Margulies DH J Immunol. 2012 Aug 1;189(3):1391-9. Epub 2012 Jun 29. PMID:22753930<ref>PMID:22753930</ref>

-	~~===Structure of~~ a ~~monoclonal antibody complexed with its MHC-I antigen===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_22753930}}~~	+	==See Also==
-		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3uyr~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYR OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:022753930<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Mage, M G.]]		[[Category: Mage, M G.]]

OCA at 05:04, 1 August 2012

2012-08-01T05:04:30Z

←Older revision		Revision as of 05:04, 1 August 2012
Line 1:		Line 1:
-	[[Image:3uyr.~~jpg~~\|left\|200px]]	+	[[Image:3uyr.png\|left\|200px]]

	{{STRUCTURE_3uyr\| PDB=3uyr \| SCENE= }}		{{STRUCTURE_3uyr\| PDB=3uyr \| SCENE= }}

OCA at 07:11, 25 July 2012

2012-07-25T07:11:27Z

←Older revision		Revision as of 07:11, 25 July 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3uyr.jpg\|left\|200px]]

-	~~The entry~~ 3uyr ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3uyr\| PDB=3uyr \| SCENE= }}

-	~~Authors: Margulies, D.H., Mage, M.G., Wang, R., Natarajan, K.~~	+	===Structure of a monoclonal antibody complexed with its MHC-I antigen===

-	~~Description:~~ Structure of a ~~monoclonal antibody complexed~~ with ~~its MHC~~-~~I antigen~~	+	{{ABSTRACT_PUBMED_22753930}}
		+
		+	==About this Structure==
		+	[[3uyr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYR OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022753930</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Mage, M G.]]
		+	[[Category: Margulies, D H.]]
		+	[[Category: Natarajan, K.]]
		+	[[Category: Wang, R.]]
		+	[[Category: 10 helix]]
		+	[[Category: Ig-fold 3]]
		+	[[Category: Immune system]]

OCA at 04:49, 18 July 2012

2012-07-18T04:49:38Z

←Older revision		Revision as of 04:49, 18 July 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3uyr is ON HOLD	+	The entry 3uyr is ON HOLD until Paper Publication

	Authors: Margulies, D.H., Mage, M.G., Wang, R., Natarajan, K.		Authors: Margulies, D.H., Mage, M.G., Wang, R., Natarajan, K.

	Description: Structure of a monoclonal antibody complexed with its MHC-I antigen		Description: Structure of a monoclonal antibody complexed with its MHC-I antigen

OCA: Protected "3uyr" [edit=sysop:move=sysop]

2011-12-14T11:15:49Z

Protected "3uyr" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:15, 14 December 2011

OCA: New page: '''Unreleased structure''' The entry 3uyr is ON HOLD Authors: Margulies, D.H., Mage, M.G., Wang, R., Natarajan, K. Description: Structure of a monoclonal antibody complexed with its MH...

2011-12-14T11:15:47Z

New page: '''Unreleased structure''' The entry 3uyr is ON HOLD Authors: Margulies, D.H., Mage, M.G., Wang, R., Natarajan, K. Description: Structure of a monoclonal antibody complexed with its MH...

New page

'''Unreleased structure'''

The entry 3uyr is ON HOLD

Authors: Margulies, D.H., Mage, M.G., Wang, R., Natarajan, K.

Description: Structure of a monoclonal antibody complexed with its MHC-I antigen