3v2w - Revision history

OCA at 06:45, 3 April 2024

2024-04-03T06:45:44Z

←Older revision		Revision as of 06:45, 3 April 2024
Line 3:		Line 3:
	<StructureSection load='3v2w' size='340' side='right'caption='[[3v2w]], [[Resolution\|resolution]] 3.35Å' scene=''>		<StructureSection load='3v2w' size='340' side='right'caption='[[3v2w]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v2w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V2W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v2w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V2W FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ML5:{(3R)~~-~~3-AMINO-4-[(3-HEXYLPHENYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>ML5</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.35Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3v2y\|3v2y]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ML5:{(3R)-3-AMINO-4-[(3-HEXYLPHENYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>ML5</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>S1PR1, CHEDG1, EDG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2w OCA], [https://pdbe.org/3v2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v2w RCSB], [https://www.ebi.ac.uk/pdbsum/3v2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v2w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2w OCA], [https://pdbe.org/3v2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v2w RCSB], [https://www.ebi.ac.uk/pdbsum/3v2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v2w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/S1PR1_HUMAN S1PR1_HUMAN]] G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.<ref>PMID:10982820</ref> <ref>PMID:11230698</ref> <ref>PMID:11583630</ref> <ref>PMID:11604399</ref> <ref>PMID:19286607</ref> <ref>PMID:22344443</ref> <ref>PMID:8626678</ref> <ref>PMID:9488656</ref>	+	[https://www.uniprot.org/uniprot/S1PR1_HUMAN S1PR1_HUMAN] G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.<ref>PMID:10982820</ref> <ref>PMID:11230698</ref> <ref>PMID:11583630</ref> <ref>PMID:11604399</ref> <ref>PMID:19286607</ref> <ref>PMID:22344443</ref> <ref>PMID:8626678</ref> <ref>PMID:9488656</ref> [https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
-	~~<div style="background-color~~:~~#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	~~The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking, endothelial development~~ and ~~integrity, heart rate,~~ and ~~vascular tone and maturation by activating G protein-coupled sphingosine 1-phosphate receptors. Here, we present~~ the ~~crystal structure of the sphingosine 1-phosphate receptor 1 fused to T4-lysozyme (S1P(1)-T4L) in complex with an antagonist sphingolipid mimic. Extracellular access~~ to the ~~binding pocket is occluded by~~ the ~~amino terminus and extracellular loops of the receptor~~. ~~Access is gained by ligands entering laterally between helices I and VII within~~ the ~~transmembrane region of~~ the ~~receptor. This structure~~, ~~along with mutagenesis, agonist structure-activity relationship data, and modeling, provides a detailed view of~~ the ~~molecular recognition~~ and ~~requirement for hydrophobic volume that activates S1P(1), resulting in~~ the ~~modulation of immune and stromal cell responses~~.	+
-		+
-	Crystal structure of a lipid G protein-coupled receptor.,Hanson MA, Roth CB, Jo E, Griffith MT, Scott FL, Reinhart G, Desale H, Clemons B, Cahalan SM, Schuerer SC, Sanna MG, Han GW, Kuhn P, Rosen H, Stevens RC Science. 2012 Feb 17;335(6070):851-5. PMID:22344443<ref>PMID:~~22344443~~</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3v2w" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 29:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Escherichia virus T4]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Lysozyme]]~~	+	[[Category: Cahalan SM]]
-	[[Category: Cahalan~~, S M~~]]	+	[[Category: Clemons B]]
-	[[Category: Clemons, B]]	+	[[Category: Desale H]]
-	[[Category: Desale, H]]	+	[[Category: Griffith MT]]
-	~~[[Category: GPCR, GPCR Network~~]]	+	[[Category: Han GW]]
-	[[Category: Griffith~~, M T~~]]	+	[[Category: Hanson MA]]
-	[[Category: Han~~, G W~~]]	+	[[Category: Jo E]]
-	[[Category: Hanson~~, M A~~]]	+	[[Category: Kuhn P]]
-	[[Category: Jo, E]]	+	[[Category: Reinhart G]]
-	[[Category: Kuhn, P]]	+	[[Category: Rosen H]]
-	[[Category: Reinhart, G]]	+	[[Category: Roth CB]]
-	[[Category: Rosen, H]]	+	[[Category: Sanna MG]]
-	[[Category: Roth~~, C B~~]]	+	[[Category: Schuerer SC]]
-	[[Category: Sanna~~, M G~~]]	+	[[Category: Scott FL]]
-	[[Category: Schuerer~~, S C~~]]	+	[[Category: Stevens RC]]
-	[[Category: Scott~~, F L~~]]	+
-	[[Category: Stevens~~, R C]]~~	+
-	~~[[Category: Autoimmunity]]~~	+
-	~~[[Category: Edg receptor]]~~	+
-	~~[[Category: G protein coupled receptor]]~~	+
-	~~[[Category: Gpcr]]~~	+
-	~~[[Category: Gpcr network]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lipid receptor]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Multiple sclerosis]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Sphingosine]]~~	+
-	~~[[Category: Structural genomic~~]]	+

OCA at 08:25, 20 July 2022

2022-07-20T08:25:58Z

←Older revision		Revision as of 08:25, 20 July 2022
Line 3:		Line 3:
	<StructureSection load='3v2w' size='340' side='right'caption='[[3v2w]], [[Resolution\|resolution]] 3.35Å' scene=''>		<StructureSection load='3v2w' size='340' side='right'caption='[[3v2w]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v2w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3V2W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v2w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V2W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ML5:{(3R)-3-AMINO-4-[(3-HEXYLPHENYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>ML5</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ML5:{(3R)-3-AMINO-4-[(3-HEXYLPHENYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>ML5</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v2y\|3v2y]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v2y\|3v2y]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S1PR1, CHEDG1, EDG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3v2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2w OCA], [~~http~~://pdbe.org/3v2w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3v2w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3v2w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3v2w ProSAT]</span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2w OCA], [https://pdbe.org/3v2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v2w RCSB], [https://www.ebi.ac.uk/pdbsum/3v2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v2w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/S1PR1_HUMAN S1PR1_HUMAN]] G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.<ref>PMID:10982820</ref> <ref>PMID:11230698</ref> <ref>PMID:11583630</ref> <ref>PMID:11604399</ref> <ref>PMID:19286607</ref> <ref>PMID:22344443</ref> <ref>PMID:8626678</ref> <ref>PMID:9488656</ref>	+	[[https://www.uniprot.org/uniprot/S1PR1_HUMAN S1PR1_HUMAN]] G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.<ref>PMID:10982820</ref> <ref>PMID:11230698</ref> <ref>PMID:11583630</ref> <ref>PMID:11604399</ref> <ref>PMID:19286607</ref> <ref>PMID:22344443</ref> <ref>PMID:8626678</ref> <ref>PMID:9488656</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

OCA at 16:36, 28 August 2019

2019-08-28T16:36:08Z

←Older revision		Revision as of 16:36, 28 August 2019
Line 1:		Line 1:

	==Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A==		==Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A==
-	<StructureSection load='3v2w' size='340' side='right' caption='[[3v2w]], [[Resolution\|resolution]] 3.35Å' scene=''>	+	<StructureSection load='3v2w' size='340' side='right'caption='[[3v2w]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3v2w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V2W FirstGlance]. <br>		<table><tr><td colspan='2'>[[3v2w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V2W FirstGlance]. <br>
Line 22:		Line 22:

	==See Also==		==See Also==
		+	*[[G protein-coupled receptor\|G protein-coupled receptor]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	== References ==		== References ==
Line 27:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Cahalan, S M]]		[[Category: Cahalan, S M]]

OCA at 09:19, 16 November 2017

2017-11-16T09:19:27Z

←Older revision		Revision as of 09:19, 16 November 2017
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[G protein-coupled receptor\|G protein-coupled receptor]]
	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]		*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	== References ==		== References ==

OCA at 10:59, 3 August 2017

2017-08-03T10:59:38Z

←Older revision		Revision as of 10:59, 3 August 2017
Line 3:		Line 3:
	<StructureSection load='3v2w' size='340' side='right' caption='[[3v2w]], [[Resolution\|resolution]] 3.35Å' scene=''>		<StructureSection load='3v2w' size='340' side='right' caption='[[3v2w]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v2w]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V2W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v2w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V2W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ML5:{(3R)-3-AMINO-4-[(3-HEXYLPHENYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>ML5</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ML5:{(3R)-3-AMINO-4-[(3-HEXYLPHENYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>ML5</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v2y\|3v2y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v2y\|3v2y]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CHEDG1, EDG1, S1PR1, S1PR1_HUMAN,E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2w OCA], [http://pdbe.org/3v2w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v2w RCSB], [http://www.ebi.ac.uk/pdbsum/3v2w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v2w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2w OCA], [http://pdbe.org/3v2w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v2w RCSB], [http://www.ebi.ac.uk/pdbsum/3v2w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v2w ProSAT]</span></td></tr>
Line 29:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Cahalan, S M]]		[[Category: Cahalan, S M]]

OCA at 22:52, 5 August 2016

2016-08-05T22:52:12Z

←Older revision		Revision as of 22:52, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A==		==Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A==
	<StructureSection load='3v2w' size='340' side='right' caption='[[3v2w]], [[Resolution\|resolution]] 3.35Å' scene=''>		<StructureSection load='3v2w' size='340' side='right' caption='[[3v2w]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v2w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V2W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v2w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V2W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ML5:{(3R)-3-AMINO-4-[(3-HEXYLPHENYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>ML5</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ML5:{(3R)-3-AMINO-4-[(3-HEXYLPHENYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>ML5</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v2y\|3v2y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v2y\|3v2y]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CHEDG1, EDG1, S1PR1, S1PR1_HUMAN,E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CHEDG1, EDG1, S1PR1, S1PR1_HUMAN,E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v2w RCSB], [http://www.ebi.ac.uk/pdbsum/3v2w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2w OCA], [http://pdbe.org/3v2w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v2w RCSB], [http://www.ebi.ac.uk/pdbsum/3v2w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v2w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3v2w" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Cahalan, S M]]		[[Category: Cahalan, S M]]

OCA at 22:37, 25 December 2014

2014-12-25T22:37:48Z

←Older revision		Revision as of 22:37, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3v2w.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A==
		+	<StructureSection load='3v2w' size='340' side='right' caption='[[3v2w]], [[Resolution\|resolution]] 3.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3v2w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V2W FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ML5:{(3R)-3-AMINO-4-[(3-HEXYLPHENYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>ML5</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v2y\|3v2y]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CHEDG1, EDG1, S1PR1, S1PR1_HUMAN,E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v2w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v2w RCSB], [http://www.ebi.ac.uk/pdbsum/3v2w PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/S1PR1_HUMAN S1PR1_HUMAN]] G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.<ref>PMID:10982820</ref> <ref>PMID:11230698</ref> <ref>PMID:11583630</ref> <ref>PMID:11604399</ref> <ref>PMID:19286607</ref> <ref>PMID:22344443</ref> <ref>PMID:8626678</ref> <ref>PMID:9488656</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking, endothelial development and integrity, heart rate, and vascular tone and maturation by activating G protein-coupled sphingosine 1-phosphate receptors. Here, we present the crystal structure of the sphingosine 1-phosphate receptor 1 fused to T4-lysozyme (S1P(1)-T4L) in complex with an antagonist sphingolipid mimic. Extracellular access to the binding pocket is occluded by the amino terminus and extracellular loops of the receptor. Access is gained by ligands entering laterally between helices I and VII within the transmembrane region of the receptor. This structure, along with mutagenesis, agonist structure-activity relationship data, and modeling, provides a detailed view of the molecular recognition and requirement for hydrophobic volume that activates S1P(1), resulting in the modulation of immune and stromal cell responses.

-	~~{{STRUCTURE_3v2w\| PDB=3v2w \| SCENE= }}~~	+	Crystal structure of a lipid G protein-coupled receptor.,Hanson MA, Roth CB, Jo E, Griffith MT, Scott FL, Reinhart G, Desale H, Clemons B, Cahalan SM, Schuerer SC, Sanna MG, Han GW, Kuhn P, Rosen H, Stevens RC Science. 2012 Feb 17;335(6070):851-5. PMID:22344443<ref>PMID:22344443</ref>

-	~~===Crystal Structure~~ of ~~a Lipid G protein-Coupled Receptor at 3~~.~~35A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22344443}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3v2w]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA].~~	+

	==See Also==		==See Also==
	*[[G protein-coupled receptor\|G protein-coupled receptor]]		*[[G protein-coupled receptor\|G protein-coupled receptor]]
-		+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-	==~~Reference~~==	+	== References ==
-	<~~ref group="xtra">PMID:022344443<~~/~~ref~~><~~references group="xtra"~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
-	[[Category: Cahalan, S M.]]	+	[[Category: Cahalan, S M]]
-	[[Category: Clemons, B.]]	+	[[Category: Clemons, B]]
-	[[Category: Desale, H.]]	+	[[Category: Desale, H]]
-	[[Category: GPCR, GPCR Network.]]	+	[[Category: GPCR, GPCR Network]]
-	[[Category: Griffith, M T.]]	+	[[Category: Griffith, M T]]
-	[[Category: Han, G W.]]	+	[[Category: Han, G W]]
-	[[Category: Hanson, M A.]]	+	[[Category: Hanson, M A]]
-	[[Category: Jo, E.]]	+	[[Category: Jo, E]]
-	[[Category: Kuhn, P.]]	+	[[Category: Kuhn, P]]
-	[[Category: Reinhart, G.]]	+	[[Category: Reinhart, G]]
-	[[Category: Rosen, H.]]	+	[[Category: Rosen, H]]
-	[[Category: Roth, C B.]]	+	[[Category: Roth, C B]]
-	[[Category: Sanna, M G.]]	+	[[Category: Sanna, M G]]
-	[[Category: Schuerer, S C.]]	+	[[Category: Schuerer, S C]]
-	[[Category: Scott, F L.]]	+	[[Category: Scott, F L]]
-	[[Category: Stevens, R C.]]	+	[[Category: Stevens, R C]]
	[[Category: Autoimmunity]]		[[Category: Autoimmunity]]
	[[Category: Edg receptor]]		[[Category: Edg receptor]]

OCA at 22:28, 20 October 2012

2012-10-20T22:28:27Z

←Older revision		Revision as of 22:28, 20 October 2012
Line 1:		Line 1:
	[[Image:3v2w.png\|left\|200px]]		[[Image:3v2w.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3v2w", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3v2w\| PDB=3v2w \| SCENE= }}		{{STRUCTURE_3v2w\| PDB=3v2w \| SCENE= }}

	===Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A===		===Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22344443}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22344443 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22344443}}		{{ABSTRACT_PUBMED_22344443}}

	==About this Structure==		==About this Structure==
-	[[3v2w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens~~,_enterobacteria_phage_t4~~ Homo sapiens~~, enterobacteria phage t4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA].	+	[[3v2w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA].
		+
		+	==See Also==
		+	*[[G protein-coupled receptor\|G protein-coupled receptor]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:022344443</ref><references group="xtra"/>		<ref group="xtra">PMID:022344443</ref><references group="xtra"/>
-	[[Category: Homo sapiens~~, enterobacteria phage t4~~]]	+	[[Category: Homo sapiens]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Cahalan, S M.]]		[[Category: Cahalan, S M.]]

OCA at 05:55, 14 March 2012

2012-03-14T05:55:10Z

←Older revision		Revision as of 05:55, 14 March 2012
Line 1:		Line 1:
-	[[Image:3v2w.~~jpg~~\|left\|200px]]	+	[[Image:3v2w.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A===		===Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22344443}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22344443 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22344443}}

	==About this Structure==		==About this Structure==
	[[3v2w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA].		[[3v2w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022344443</ref><references group="xtra"/>
	[[Category: Homo sapiens, enterobacteria phage t4]]		[[Category: Homo sapiens, enterobacteria phage t4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

OCA at 06:54, 15 February 2012

2012-02-15T06:54:35Z

←Older revision		Revision as of 06:54, 15 February 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3v2w.jpg\|left\|200px]]

-	The ~~entry 3v2w~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3v2w", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3v2w\| PDB=3v2w \| SCENE= }}

-	~~Authors: Hanson, M.A., Roth, C.B., Jo, E., Griffith, M.T., Scott, F.L., Reinhart,~~ G.~~, Desale, H., Clemons, B., Cahalan, S.M., Schuerer, S.C., Sanna, M.G., Han, G.W., Kuhn, P., Rosen, H., Stevens, R.C., GPCR Network (GPCR)~~	+	===Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A===

-	~~Description: Crystal~~ Structure of a ~~Lipid~~ G protein-~~Coupled Receptor at 3.35A~~	+
		+	==About this Structure==
		+	[[3v2w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_enterobacteria_phage_t4 Homo sapiens, enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V2W OCA].
		+	[[Category: Homo sapiens, enterobacteria phage t4]]
		+	[[Category: Lysozyme]]
		+	[[Category: Cahalan, S M.]]
		+	[[Category: Clemons, B.]]
		+	[[Category: Desale, H.]]
		+	[[Category: GPCR, GPCR Network.]]
		+	[[Category: Griffith, M T.]]
		+	[[Category: Han, G W.]]
		+	[[Category: Hanson, M A.]]
		+	[[Category: Jo, E.]]
		+	[[Category: Kuhn, P.]]
		+	[[Category: Reinhart, G.]]
		+	[[Category: Rosen, H.]]
		+	[[Category: Roth, C B.]]
		+	[[Category: Sanna, M G.]]
		+	[[Category: Schuerer, S C.]]
		+	[[Category: Scott, F L.]]
		+	[[Category: Stevens, R C.]]
		+	[[Category: Autoimmunity]]
		+	[[Category: Edg receptor]]
		+	[[Category: G protein coupled receptor]]
		+	[[Category: Gpcr]]
		+	[[Category: Gpcr network]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lipid receptor]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Multiple sclerosis]]
		+	[[Category: Psi-biology]]
		+	[[Category: Sphingosine]]
		+	[[Category: Structural genomic]]