3v3e - Revision history

OCA at 12:16, 8 November 2023

2023-11-08T12:16:33Z

←Older revision		Revision as of 12:16, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='3v3e' size='340' side='right'caption='[[3v3e]], [[Resolution\|resolution]] 2.06Å' scene=''>		<StructureSection load='3v3e' size='340' side='right'caption='[[3v3e]], [[Resolution\|resolution]] 2.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V3E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V3E FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.06Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3v3q\|3v3q]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">NR4A1, GFRP1, HMR, NAK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3e OCA], [https://pdbe.org/3v3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v3e RCSB], [https://www.ebi.ac.uk/pdbsum/3v3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3e OCA], [https://pdbe.org/3v3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v3e RCSB], [https://www.ebi.ac.uk/pdbsum/3v3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>	+	[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	[[Category: Lin, T]]	+	[[Category: Lin T]]
-	[[Category: Shi, C]]	+	[[Category: Shi C]]
-	[[Category: Wu, Q]]	+	[[Category: Wu Q]]
-	[[Category: Yang, K]]	+	[[Category: Yang K]]
-	[[Category: Zhan, Y]]	+	[[Category: Zhan Y]]
-	[[Category: Zhang, Q]]	+	[[Category: Zhang Q]]
-	~~[[Category: Orphan nuclear receptor]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 08:27, 20 July 2022

2022-07-20T08:27:25Z

←Older revision		Revision as of 08:27, 20 July 2022
Line 1:		Line 1:

	==Crystal Structure of the Human Nur77 Ligand-binding Domain==		==Crystal Structure of the Human Nur77 Ligand-binding Domain==
-	<StructureSection load='3v3e' size='340' side='right' caption='[[3v3e]], [[Resolution\|resolution]] 2.06Å' scene=''>	+	<StructureSection load='3v3e' size='340' side='right'caption='[[3v3e]], [[Resolution\|resolution]] 2.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v3e]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3V3E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V3E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v3q\|3v3q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v3q\|3v3q]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR4A1, GFRP1, HMR, NAK1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR4A1, GFRP1, HMR, NAK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3v3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3e OCA], [~~http~~://pdbe.org/3v3e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3v3e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3v3e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3e OCA], [https://pdbe.org/3v3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v3e RCSB], [https://www.ebi.ac.uk/pdbsum/3v3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>	+	[[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Lin, T]]		[[Category: Lin, T]]

OCA at 19:18, 4 August 2016

2016-08-04T19:18:52Z

←Older revision		Revision as of 19:18, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the Human Nur77 Ligand-binding Domain==		==Crystal Structure of the Human Nur77 Ligand-binding Domain==
	<StructureSection load='3v3e' size='340' side='right' caption='[[3v3e]], [[Resolution\|resolution]] 2.06Å' scene=''>		<StructureSection load='3v3e' size='340' side='right' caption='[[3v3e]], [[Resolution\|resolution]] 2.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V3E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V3E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v3q\|3v3q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v3q\|3v3q]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR4A1, GFRP1, HMR, NAK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR4A1, GFRP1, HMR, NAK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v3e RCSB], [http://www.ebi.ac.uk/pdbsum/3v3e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3e OCA], [http://pdbe.org/3v3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v3e RCSB], [http://www.ebi.ac.uk/pdbsum/3v3e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3v3e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Lin, T]]		[[Category: Lin, T]]

OCA at 18:39, 24 December 2014

2014-12-24T18:39:34Z

←Older revision		Revision as of 18:39, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v3e RCSB], [http://www.ebi.ac.uk/pdbsum/3v3e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v3e RCSB], [http://www.ebi.ac.uk/pdbsum/3v3e PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:52, 21 December 2014

2014-12-21T06:52:09Z

←Older revision		Revision as of 06:52, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3v3e\| PDB=3v3e \| SCENE= }}~~	+	==Crystal Structure of the Human Nur77 Ligand-binding Domain==
-	===Crystal Structure of the Human Nur77 Ligand-binding Domain===	+	<StructureSection load='3v3e' size='340' side='right' caption='[[3v3e]], [[Resolution\|resolution]] 2.06Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22983157}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3v3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V3E FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3v3q\|3v3q]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR4A1, GFRP1, HMR, NAK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v3e RCSB], [http://www.ebi.ac.uk/pdbsum/3v3e PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Liver kinase B1 (LKB1) has important roles in governing energy homeostasis by regulating the activity of the energy sensor kinase AMP-activated protein kinase (AMPK). The regulation of LKB1 function, however, is still poorly understood. Here we demonstrate that the orphan nuclear receptor Nur77 binds and sequesters LKB1 in the nucleus, thereby attenuating AMPK activation. This Nur77 function is antagonized by the chemical compound ethyl 2-[2,3,4-trimethoxy-6-(1-octanoyl)phenyl]acetate (TMPA), which interacts with Nur77 with high affinity and at specific sites. TMPA binding of Nur77 results in the release and shuttling of LKB1 to the cytoplasm to phosphorylate AMPKalpha. Moreover, TMPA effectively reduces blood glucose and alleviates insulin resistance in type II db/db and high-fat diet- and streptozotocin-induced diabetic mice but not in diabetic littermates with the Nur77 gene knocked out. This study attains a mechanistic understanding of the regulation of LKB1-AMPK axis and implicates Nur77 as a new and amenable target for the design and development of therapeutics to treat metabolic diseases.

-	~~==Function==~~	+	The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK.,Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T, Wu Q Nat Chem Biol. 2012 Nov;8(11):897-904. doi: 10.1038/nchembio.1069. Epub 2012 Sep , 16. PMID:22983157<ref>PMID:22983157</ref>
-	~~[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan~~ nuclear receptor. ~~May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration~~. ~~Binds the NGFI-B response element~~ (~~NBRE~~) 5'-~~AAAAGGTCA-3' (By similarity)~~. ~~May inhibit NF-kappa-B transactivation of IL2~~.<ref>PMID:~~15466594~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3v3e]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:022983157</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, Y.]]	+	[[Category: Chen, Y]]
-	[[Category: Lin, T.]]	+	[[Category: Lin, T]]
-	[[Category: Shi, C.]]	+	[[Category: Shi, C]]
-	[[Category: Wu, Q.]]	+	[[Category: Wu, Q]]
-	[[Category: Yang, K.]]	+	[[Category: Yang, K]]
-	[[Category: Zhan, Y.]]	+	[[Category: Zhan, Y]]
-	[[Category: Zhang, Q.]]	+	[[Category: Zhang, Q]]
	[[Category: Orphan nuclear receptor]]		[[Category: Orphan nuclear receptor]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 14:22, 10 July 2013

2013-07-10T14:22:12Z

←Older revision		Revision as of 14:22, 10 July 2013
Line 1:		Line 1:
-	[[Image:3v3e.jpg\|left\|200px]]
-
	{{STRUCTURE_3v3e\| PDB=3v3e \| SCENE= }}		{{STRUCTURE_3v3e\| PDB=3v3e \| SCENE= }}
-
	===Crystal Structure of the Human Nur77 Ligand-binding Domain===		===Crystal Structure of the Human Nur77 Ligand-binding Domain===
		+	{{ABSTRACT_PUBMED_22983157}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>

	==About this Structure==		==About this Structure==
	[[3v3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA].		[[3v3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022983157</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, Y.]]		[[Category: Chen, Y.]]

OCA at 20:45, 26 September 2012

2012-09-26T20:45:07Z

←Older revision		Revision as of 20:45, 26 September 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3v3e.jpg\|left\|200px]]

-	~~The entry~~ 3v3e ~~is ON HOLD~~ ~~until Paper Publication~~	+	{{STRUCTURE_3v3e\| PDB=3v3e \| SCENE= }}

-	~~Authors: Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T.~~	+	===Crystal Structure of the Human Nur77 Ligand-binding Domain===

-	~~Description: Crystal~~ Structure ~~of the Human Nur77 Ligand~~-~~binding Domain~~	+
		+	==About this Structure==
		+	[[3v3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3E OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Chen, Y.]]
		+	[[Category: Lin, T.]]
		+	[[Category: Shi, C.]]
		+	[[Category: Wu, Q.]]
		+	[[Category: Yang, K.]]
		+	[[Category: Zhan, Y.]]
		+	[[Category: Zhang, Q.]]
		+	[[Category: Orphan nuclear receptor]]
		+	[[Category: Transcription]]

OCA at 06:01, 25 January 2012

2012-01-25T06:01:44Z

←Older revision		Revision as of 06:01, 25 January 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3v3e is ON HOLD	+	The entry 3v3e is ON HOLD until Paper Publication

-	Authors: Zhang, Q., ~~Lin~~, T., Wu, Q.	+	Authors: Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T.

	Description: Crystal Structure of the Human Nur77 Ligand-binding Domain		Description: Crystal Structure of the Human Nur77 Ligand-binding Domain

OCA at 05:45, 4 January 2012

2012-01-04T05:45:17Z

←Older revision		Revision as of 05:45, 4 January 2012
Line 3:		Line 3:
	The entry 3v3e is ON HOLD		The entry 3v3e is ON HOLD

-	Authors: ~~Qian~~ Zhang, ~~Tianwei~~ Lin, ~~Qiao~~ Wu	+	Authors: Zhang, Q., Lin, T., Wu, Q.

	Description: Crystal Structure of the Human Nur77 Ligand-binding Domain		Description: Crystal Structure of the Human Nur77 Ligand-binding Domain

OCA: Protected "3v3e" [edit=sysop:move=sysop]

2011-12-28T06:49:05Z

Protected "3v3e" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:49, 28 December 2011