3v3k - Revision history

OCA at 10:30, 1 March 2024

2024-03-01T10:30:07Z

←Older revision		Revision as of 10:30, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='3v3k' size='340' side='right'caption='[[3v3k]], [[Resolution\|resolution]] 3.49Å' scene=''>		<StructureSection load='3v3k' size='340' side='right'caption='[[3v3k]], [[Resolution\|resolution]] 3.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v3k]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Eco57 Eco57~~] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V3K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v3k]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V3K FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CASP9, MCH6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN]), ECs1815, Z6020 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.494Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase~~-~~9 Caspase-9]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~3.~~4.22.62 3.4.22.62] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3k OCA], [https://pdbe.org/3v3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v3k RCSB], [https://www.ebi.ac.uk/pdbsum/3v3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3k OCA], [https://pdbe.org/3v3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v3k RCSB], [https://www.ebi.ac.uk/pdbsum/3v3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> [[https://www.uniprot.org/uniprot/NLEF_ECO57 NLEF_ECO57]] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells.<ref>PMID:18279332</ref> <ref>PMID:23516580</ref>	+	[https://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref>

	==See Also==		==See Also==
Line 17:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caspase-9]]~~	+	[[Category: Escherichia coli O157:H7]]
-	~~[[Category~~: ~~Eco57~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Maskos, K]]	+	[[Category: Maskos K]]
-	[[Category: Moertl, M]]	+	[[Category: Moertl M]]
-	[[Category: Steuber, H]]	+	[[Category: Steuber H]]
-	~~[[Category: Caspase 9]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 08:27, 20 July 2022

2022-07-20T08:27:43Z

←Older revision		Revision as of 08:27, 20 July 2022
Line 1:		Line 1:

	==Human caspase 9 in complex with bacterial effector protein==		==Human caspase 9 in complex with bacterial effector protein==
-	<StructureSection load='3v3k' size='340' side='right' caption='[[3v3k]], [[Resolution\|resolution]] 3.49Å' scene=''>	+	<StructureSection load='3v3k' size='340' side='right'caption='[[3v3k]], [[Resolution\|resolution]] 3.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v3k]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Eco57 Eco57] and [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3V3K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v3k]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Eco57 Eco57] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V3K FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP9, MCH6 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ECs1815, Z6020 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP9, MCH6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ECs1815, Z6020 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Caspase-9 Caspase-9], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.62 3.4.22.62] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-9 Caspase-9], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.62 3.4.22.62] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3v3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3k OCA], [~~http~~://pdbe.org/3v3k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3v3k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3v3k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3k OCA], [https://pdbe.org/3v3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v3k RCSB], [https://www.ebi.ac.uk/pdbsum/3v3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> [[~~http~~://www.uniprot.org/uniprot/NLEF_ECO57 NLEF_ECO57]] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells.<ref>PMID:18279332</ref> <ref>PMID:23516580</ref>	+	[[https://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> [[https://www.uniprot.org/uniprot/NLEF_ECO57 NLEF_ECO57]] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells.<ref>PMID:18279332</ref> <ref>PMID:23516580</ref>
		+
		+	==See Also==
		+	*[[Caspase 3D structures\|Caspase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 17:		Line 20:
	[[Category: Eco57]]		[[Category: Eco57]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Maskos, K]]		[[Category: Maskos, K]]
	[[Category: Moertl, M]]		[[Category: Moertl, M]]

OCA at 10:11, 8 November 2017

2017-11-08T10:11:45Z

←Older revision		Revision as of 10:11, 8 November 2017
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> [[http://www.uniprot.org/uniprot/NLEF_ECO57 NLEF_ECO57]] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells.<ref>PMID:18279332</ref> <ref>PMID:23516580</ref>		[[http://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> [[http://www.uniprot.org/uniprot/NLEF_ECO57 NLEF_ECO57]] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells.<ref>PMID:18279332</ref> <ref>PMID:23516580</ref>
-
-	==See Also==
-	*[[Caspase\|Caspase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:05, 5 August 2016

2016-08-05T13:05:42Z

←Older revision		Revision as of 13:05, 5 August 2016
Line 1:		Line 1:
		+
	==Human caspase 9 in complex with bacterial effector protein==		==Human caspase 9 in complex with bacterial effector protein==
	<StructureSection load='3v3k' size='340' side='right' caption='[[3v3k]], [[Resolution\|resolution]] 3.49Å' scene=''>		<StructureSection load='3v3k' size='340' side='right' caption='[[3v3k]], [[Resolution\|resolution]] 3.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v3k]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_o157:h7 Escherichia coli o157:h7~~] and [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V3K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v3k]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco57 Eco57] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V3K FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP9, MCH6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), ECs1815, Z6020 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ~~Escherichia coli O157:H7~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP9, MCH6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ECs1815, Z6020 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-9 Caspase-9], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.62 3.4.22.62] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-9 Caspase-9], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.62 3.4.22.62] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v3k RCSB], [http://www.ebi.ac.uk/pdbsum/3v3k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3k OCA], [http://pdbe.org/3v3k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v3k RCSB], [http://www.ebi.ac.uk/pdbsum/3v3k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> [[http://www.uniprot.org/uniprot/~~Q8XAL7_ECO57 Q8XAL7_ECO57~~]] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells.<ref>PMID:18279332</ref> <ref>PMID:23516580</ref>	+	[[http://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> [[http://www.uniprot.org/uniprot/NLEF_ECO57 NLEF_ECO57]] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells.<ref>PMID:18279332</ref> <ref>PMID:23516580</ref>

	==See Also==		==See Also==
Line 17:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Caspase-9]]		[[Category: Caspase-9]]
-	[[Category: ~~Escherichia coli o157:h7~~]]	+	[[Category: Eco57]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Maskos, K]]		[[Category: Maskos, K]]
	[[Category: Moertl, M]]		[[Category: Moertl, M]]

OCA at 02:42, 25 December 2014

2014-12-25T02:42:40Z

←Older revision		Revision as of 02:42, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v3k RCSB], [http://www.ebi.ac.uk/pdbsum/3v3k PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v3k RCSB], [http://www.ebi.ac.uk/pdbsum/3v3k PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> [[http://www.uniprot.org/uniprot/Q8XAL7_ECO57 Q8XAL7_ECO57]] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells.<ref>PMID:18279332</ref> <ref>PMID:23516580</ref>

	==See Also==		==See Also==
	*[[Caspase\|Caspase]]		*[[Caspase\|Caspase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:32, 9 December 2014

2014-12-09T14:32:33Z

←Older revision		Revision as of 14:32, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3v3k.~~jpg~~\|~~left\|200px~~]]	+	==Human caspase 9 in complex with bacterial effector protein==
		+	<StructureSection load='3v3k' size='340' side='right' caption='[[3v3k]], [[Resolution\|resolution]] 3.49Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3v3k]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V3K FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP9, MCH6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), ECs1815, Z6020 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 Escherichia coli O157:H7])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-9 Caspase-9], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.62 3.4.22.62] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v3k RCSB], [http://www.ebi.ac.uk/pdbsum/3v3k PDBsum]</span></td></tr>
		+	</table>

-	~~{{STRUCTURE_3v3k\| PDB~~=~~3v3k \| SCENE= }}~~	+	==See Also==
-		+	*[[Caspase\|Caspase]]
-	~~===Human caspase 9 in complex with bacterial effector protein~~===	+	__TOC__
-		+	</StructureSection>
-		+
-	~~==About this Structure==~~	+
-	[[~~3v3k~~]] ~~is a 16 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3K OCA].	+
	[[Category: Caspase-9]]		[[Category: Caspase-9]]
	[[Category: Escherichia coli o157:h7]]		[[Category: Escherichia coli o157:h7]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Maskos, K.]]	+	[[Category: Maskos, K]]
-	[[Category: Moertl, M.]]	+	[[Category: Moertl, M]]
-	[[Category: Steuber, H.]]	+	[[Category: Steuber, H]]
	[[Category: Caspase 9]]		[[Category: Caspase 9]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 14:18, 6 March 2013

2013-03-06T14:18:37Z

←Older revision		Revision as of 14:18, 6 March 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3v3k.jpg\|left\|200px]]

-	~~The entry~~ 3v3k ~~is ON HOLD~~ ~~until Mar 01 2014~~	+	{{STRUCTURE_3v3k\| PDB=3v3k \| SCENE= }}

-	~~Authors: Moertl, M., Maskos, K., Steuber, H.~~	+	===Human caspase 9 in complex with bacterial effector protein===

-	~~Description~~: ~~Human caspase~~ 9 ~~in complex with bacterial effector protein~~	+
		+	==About this Structure==
		+	[[3v3k]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3K OCA].
		+	[[Category: Caspase-9]]
		+	[[Category: Escherichia coli o157:h7]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Maskos, K.]]
		+	[[Category: Moertl, M.]]
		+	[[Category: Steuber, H.]]
		+	[[Category: Caspase 9]]
		+	[[Category: Hydrolase]]

OCA at 08:34, 2 January 2013

2013-01-02T08:34:19Z

←Older revision		Revision as of 08:34, 2 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3v3k is ON HOLD until ~~Paper Publication~~	+	The entry 3v3k is ON HOLD until Mar 01 2014

	Authors: Moertl, M., Maskos, K., Steuber, H.		Authors: Moertl, M., Maskos, K., Steuber, H.

	Description: Human caspase 9 in complex with bacterial effector protein		Description: Human caspase 9 in complex with bacterial effector protein

OCA at 06:50, 1 February 2012

2012-02-01T06:50:46Z

←Older revision		Revision as of 06:50, 1 February 2012
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3v3k is ON HOLD	+	The entry 3v3k is ON HOLD until Paper Publication

	Authors: Moertl, M., Maskos, K., Steuber, H.		Authors: Moertl, M., Maskos, K., Steuber, H.

	Description: Human caspase 9 in complex with bacterial effector protein		Description: Human caspase 9 in complex with bacterial effector protein

OCA: Protected "3v3k" [edit=sysop:move=sysop]

2011-12-28T06:49:17Z

Protected "3v3k" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:49, 28 December 2011