3v4e - Revision history

OCA at 14:17, 14 March 2024

2024-03-14T14:17:27Z

←Older revision		Revision as of 14:17, 14 March 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/ATRF2_STAAC ATRF2_STAAC]		[https://www.uniprot.org/uniprot/ATRF2_STAAC ATRF2_STAAC]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of a myriad of insidious and intractable infections in humans, especially in patients with compromised immune systems and children. Here, we report the apo- and CoA-bound crystal structures of a member of the galactoside acetyltransferase superfamily from methicillin-resistant S. aureus SACOL2570 which was recently shown to be down regulated in S. aureus grown in the presence of fusidic acid, an antibiotic used to treat MRSA infections. SACOL2570 forms a homotrimer in solution, as confirmed by small-angle X-ray scattering and dynamic light scattering. The protein subunit consists of an N-terminal alpha-helical domain connected to a C-terminal LbetaH domain. CoA binds in the active site formed by the residues from adjacent LbetaH domains. After determination of CoA-bound structure, molecular dynamics simulations were performed to model the binding of AcCoA. Binding of both AcCoA and CoA to SACOL2570 was verified by isothermal titration calorimetry. SACOL2570 most likely acts as an acetyltransferase, using AcCoA as an acetyl group donor and an as-yet-undetermined chemical moiety as an acceptor. SACOL2570 was recently used as a scaffold for mutations that lead the generation of cage-like assemblies, and has the potential to be used for the generation of more complex nanostructures.
-
-	Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus.,Luo HB, Knapik AA, Petkowski JJ, Demas M, Shumilin IA, Zheng H, Chruszcz M, Minor W J Struct Funct Genomics. 2013 Sep;14(3):97-108. doi: 10.1007/s10969-013-9158-6., Epub 2013 Aug 21. PMID:23963951<ref>PMID:23963951</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3v4e" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Galactoside O-acetyltransferase\|Galactoside O-acetyltransferase]]		*[[Galactoside O-acetyltransferase\|Galactoside O-acetyltransferase]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:48, 17 January 2024

2024-01-17T12:48:30Z

←Older revision		Revision as of 12:48, 17 January 2024
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	<StructureSection load='3v4e' size='340' side='right'caption='[[3v4e]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3v4e' size='340' side='right'caption='[[3v4e]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Staac Staac~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V4E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V4E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ftt\|3ftt]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL2570 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [https://pdbe.org/3v4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [https://www.ebi.ac.uk/pdbsum/3v4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [https://pdbe.org/3v4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [https://www.ebi.ac.uk/pdbsum/3v4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4e ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ATRF2_STAAC ATRF2_STAAC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Staac~~]]	+	[[Category: Staphylococcus aureus subsp. aureus COL]]
-	[[Category: Anderson~~, W F]]~~	+	[[Category: Anderson WF]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Chruszcz M]]
-	[[Category: Chruszcz, M]]	+	[[Category: Cymborowski M]]
-	[[Category: Cymborowski, M]]	+	[[Category: Knapik AA]]
-	[[Category: Knapik~~, A A~~]]	+	[[Category: Luo H-B]]
-	[[Category: Luo, H B]]	+	[[Category: Minor W]]
-	[[Category: Minor, W]]	+	[[Category: Shumilin IA]]
-	[[Category: Shumilin~~, I A~~]]	+	[[Category: Zimmerman MD]]
-	[[Category: Zimmerman~~, M D]]~~	+
-	~~[[Category: Coa]]~~	+
-	~~[[Category: Csgid]]~~	+
-	~~[[Category: Galactoside o-acetyltransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:01, 13 April 2022

2022-04-13T10:01:22Z

←Older revision		Revision as of 10:01, 13 April 2022
Line 1:		Line 1:

	==Crystal Structure of the galactoside O-acetyltransferase in complex with CoA==		==Crystal Structure of the galactoside O-acetyltransferase in complex with CoA==
-	<StructureSection load='3v4e' size='340' side='right' caption='[[3v4e]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='3v4e' size='340' side='right'caption='[[3v4e]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3V4E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V4E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftt\|3ftt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ftt\|3ftt]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL2570 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL2570 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [~~http~~://pdbe.org/3v4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3v4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [https://pdbe.org/3v4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [https://www.ebi.ac.uk/pdbsum/3v4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4e ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 3v4e" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3v4e" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galactoside O-acetyltransferase\|Galactoside O-acetyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Staac]]		[[Category: Staac]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]

OCA at 07:40, 8 November 2017

2017-11-08T07:40:47Z

←Older revision		Revision as of 07:40, 8 November 2017
Line 3:		Line 3:
	<StructureSection load='3v4e' size='340' side='right' caption='[[3v4e]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3v4e' size='340' side='right' caption='[[3v4e]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V4E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftt\|3ftt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftt\|3ftt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [http://pdbe.org/3v4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [http://www.ebi.ac.uk/pdbsum/3v4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [http://pdbe.org/3v4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [http://www.ebi.ac.uk/pdbsum/3v4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4e ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Staac]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 06:56, 9 March 2017

2017-03-09T06:56:06Z

←Older revision		Revision as of 06:56, 9 March 2017
Line 3:		Line 3:
	<StructureSection load='3v4e' size='340' side='right' caption='[[3v4e]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3v4e' size='340' side='right' caption='[[3v4e]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Staac Staac]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V4E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftt\|3ftt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftt\|3ftt]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [http://pdbe.org/3v4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [http://www.ebi.ac.uk/pdbsum/3v4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [http://pdbe.org/3v4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [http://www.ebi.ac.uk/pdbsum/3v4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4e ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of a myriad of insidious and intractable infections in humans, especially in patients with compromised immune systems and children. Here, we report the apo- and CoA-bound crystal structures of a member of the galactoside acetyltransferase superfamily from methicillin-resistant S. aureus SACOL2570 which was recently shown to be down regulated in S. aureus grown in the presence of fusidic acid, an antibiotic used to treat MRSA infections. SACOL2570 forms a homotrimer in solution, as confirmed by small-angle X-ray scattering and dynamic light scattering. The protein subunit consists of an N-terminal alpha-helical domain connected to a C-terminal LbetaH domain. CoA binds in the active site formed by the residues from adjacent LbetaH domains. After determination of CoA-bound structure, molecular dynamics simulations were performed to model the binding of AcCoA. Binding of both AcCoA and CoA to SACOL2570 was verified by isothermal titration calorimetry. SACOL2570 most likely acts as an acetyltransferase, using AcCoA as an acetyl group donor and an as-yet-undetermined chemical moiety as an acceptor. SACOL2570 was recently used as a scaffold for mutations that lead the generation of cage-like assemblies, and has the potential to be used for the generation of more complex nanostructures.
		+
		+	Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus.,Luo HB, Knapik AA, Petkowski JJ, Demas M, Shumilin IA, Zheng H, Chruszcz M, Minor W J Struct Funct Genomics. 2013 Sep;14(3):97-108. doi: 10.1007/s10969-013-9158-6., Epub 2013 Aug 21. PMID:23963951<ref>PMID:23963951</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3v4e" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staac]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 07:19, 11 August 2016

2016-08-11T07:19:25Z

←Older revision		Revision as of 07:19, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the galactoside O-acetyltransferase in complex with CoA==		==Crystal Structure of the galactoside O-acetyltransferase in complex with CoA==
	<StructureSection load='3v4e' size='340' side='right' caption='[[3v4e]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3v4e' size='340' side='right' caption='[[3v4e]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V4E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftt\|3ftt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftt\|3ftt]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~46170 Staphylococcus aureus subsp. aureus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [http://www.ebi.ac.uk/pdbsum/3v4e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [http://pdbe.org/3v4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [http://www.ebi.ac.uk/pdbsum/3v4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v4e ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Staphylococcus aureus subsp. aureus~~]]	+	[[Category: Staac]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 09:18, 4 January 2015

2015-01-04T09:18:47Z

←Older revision		Revision as of 09:18, 4 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V4E FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftt\|3ftt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftt\|3ftt]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46170 Staphylococcus aureus subsp. aureus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46170 Staphylococcus aureus subsp. aureus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [http://www.ebi.ac.uk/pdbsum/3v4e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [http://www.ebi.ac.uk/pdbsum/3v4e PDBsum]</span></td></tr>
-	<table>	+	</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus subsp. aureus]]		[[Category: Staphylococcus aureus subsp. aureus]]
-	[[Category: Anderson, W F.]]	+	[[Category: Anderson, W F]]
-	[[Category: ~~CSGID, Center for~~ Structural ~~Genomics of Infectious Diseases.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Chruszcz, M.]]	+	[[Category: Chruszcz, M]]
-	[[Category: Cymborowski, M.]]	+	[[Category: Cymborowski, M]]
-	[[Category: Knapik, A A.]]	+	[[Category: Knapik, A A]]
-	[[Category: Luo, H B.]]	+	[[Category: Luo, H B]]
-	[[Category: Minor, W.]]	+	[[Category: Minor, W]]
-	[[Category: Shumilin, I A.]]	+	[[Category: Shumilin, I A]]
-	[[Category: Zimmerman, M D~~.]]~~	+	[[Category: Zimmerman, M D]]
-	~~[[Category: Center for structural genomics of infectious disease~~]]	+
	[[Category: Coa]]		[[Category: Coa]]
	[[Category: Csgid]]		[[Category: Csgid]]
	[[Category: Galactoside o-acetyltransferase]]		[[Category: Galactoside o-acetyltransferase]]
-	[[Category: Structural genomic]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 05:50, 5 June 2014

2014-06-05T05:50:57Z

←Older revision		Revision as of 05:50, 5 June 2014
Line 1:		Line 1:
-	~~[[Image:3v4e.png\|left\|200px]]~~	+	==Crystal Structure of the galactoside O-acetyltransferase in complex with CoA==
-		+	<StructureSection load='3v4e' size='340' side='right' caption='[[3v4e]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~<!--~~	+	== Structural highlights ==
-	~~The line below this paragraph, containing "STRUCTURE_3v4e", creates the "Structure Box" on the page.~~	+	<table><tr><td colspan='2'>[[3v4e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V4E FirstGlance]. <br>
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ftt\|3ftt]]</td></tr>
-	~~or leave the SCENE parameter empty for the default display.~~	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SACOL2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46170 Staphylococcus aureus subsp. aureus])</td></tr>
-	~~-->~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v4e RCSB], [http://www.ebi.ac.uk/pdbsum/3v4e PDBsum]</span></td></tr>
-	~~{{STRUCTURE_3v4e\| PDB=3v4e \| SCENE= }}~~	+	<table>
-		+	__TOC__
-	===Crystal Structure of the galactoside O-acetyltransferase in complex with CoA===	+	</StructureSection>
-		+
-		+
-	==~~About this Structure~~==	+
-	[[3v4e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA].	+
	[[Category: Staphylococcus aureus subsp. aureus]]		[[Category: Staphylococcus aureus subsp. aureus]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]

OCA at 06:29, 11 January 2012

2012-01-11T06:29:25Z

←Older revision		Revision as of 06:29, 11 January 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3v4e.png\|left\|200px]]

-	The ~~entry 3v4e~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3v4e", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3v4e\| PDB=3v4e \| SCENE= }}

-	~~Authors: Knapik, A.A., Shumilin, I.A., Luo, H.-B., Chruszcz, M., Zimmerman, M.D., Cymborowski, M., Anderson, W.F., Krajewska, W.M., Minor, W., Center for Structural Genomics~~ of ~~Infectious Diseases (CSGID)~~	+	===Crystal Structure of the galactoside O-acetyltransferase in complex with CoA===

-	~~Description: Crystal~~ Structure of ~~the galactoside O~~-acetyltransferase ~~in complex with CoA~~	+
		+	==About this Structure==
		+	[[3v4e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V4E OCA].
		+	[[Category: Staphylococcus aureus subsp. aureus]]
		+	[[Category: Anderson, W F.]]
		+	[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
		+	[[Category: Chruszcz, M.]]
		+	[[Category: Cymborowski, M.]]
		+	[[Category: Knapik, A A.]]
		+	[[Category: Luo, H B.]]
		+	[[Category: Minor, W.]]
		+	[[Category: Shumilin, I A.]]
		+	[[Category: Zimmerman, M D.]]
		+	[[Category: Center for structural genomics of infectious disease]]
		+	[[Category: Coa]]
		+	[[Category: Csgid]]
		+	[[Category: Galactoside o-acetyltransferase]]
		+	[[Category: Structural genomic]]
		+	[[Category: Transferase]]

OCA: Protected "3v4e" [edit=sysop:move=sysop]

2011-12-28T06:50:14Z

Protected "3v4e" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:50, 28 December 2011